7Baggers

Capricor Therapeutics, Inc
(NASDAQ:CAPR) 

CAPR stock logo

Capricor Therapeutics, Inc., a biotechnology company, focuses on the development of transformative cell- and exosome-based therapeutics for the treatment and prevention of a broad spectrum of diseases. The company's lead candidate, CAP-1002, an allogeneic cardiac-derived cell therapy, which has comp...

Founded: 2005
Full Time Employees: 16
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
Share this website to your friends
• Market Cap:
• Exchange:
• Shs Outstanding:
• Employees:
• Beta:
• Return on Equity (ROE) ttm:
• Return on Assets (ROA) ttm:
• EPS ttm:
• Book value per Share:
• Cash per Share:
• Current ast per Share:
• P/E ttm:
• P/E forward:
• P/E ttm high:
• P/E ttm low:
• P/S ttm:
• P/B ttm:
• P/FCF ttm:
• PEG ratio:
• Cash Ratio ttm:
• Quick Ratio ttm:
• Current Ratio ttm:
• Gross Mgn ttm:
• EBITDA Mgn ttm:
• Operating Mgn ttm:
• Net Income Mgn ttm:
• Trailing Div yield:
• Forward Div yield:
• Payout Ratio ttm:
• Ex-Dividend date:
• Target Price High:
• Target Price Low:
• Target Price Mean:
• Number of Analysts:
• Debt Ratio ttm:
• Debt to Equity ttm:
• Total Net Debt:
At a glance:
Bull Thesis:
Bear Thesis:
Main Competitors:
Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 
                                                                             
      revenue
    		     11,130,509 2,261,642 3,971,438 4,906,877 12,088,089 6,185,814 3,917,467 2,986,696 959,903 1,591,566     204,082 40,816 57,830 16,863 49,864 185,693 222,100 142,071 410,353 230,504                                             
      yoy
    		NaN%  NaN% NaN% NaN% -7.92% -63.44% 1.38% 64.29% 1159.30% 288.66% NaN% NaN%  NaN% NaN% NaN%  NaN% 309.28% -78.02% -73.96% -88.13% -87.85% -19.44%                                                 
      qoq
    		  NaN% NaN% NaN% 392.14% -43.05% -19.06% -59.41% 95.42% 57.90% 31.16% 211.15% -39.69% NaN% NaN%   NaN% 400.00% -29.42% 242.94% -66.18% -73.15% -16.39% 56.33% -65.38% 78.02%                                              
      total revenue
    		     11,130,509 2,261,642 3,971,438 4,906,877 12,088,089 6,185,814 3,917,467 2,986,696 959,903 1,591,566     204,082 40,816 57,830 16,863 49,864 185,693                                                 
      operating expenses
    		                                                                         
      research and development
    		27,376,912 23,132,671 20,359,098 22,047,254 18,915,572 14,554,936 11,807,867 12,504,769 11,101,013 9,940,167 10,028,964 8,817,389 7,661,519 6,231,806 5,504,356 4,965,088 5,115,699 4,263,533 2,513,915 3,497,275 3,296,322 2,745,104 2,629,267 1,927,473 1,155,156 828,749 857,764 1,644,110 1,811,182 2,849,377 3,131,999 3,388,908 2,696,517 2,518,395 1,862,369 3,128,182 3,257,149 2,665,904 4,727,111 4,307,948 4,341,119 3,330,731 3,192,657 3,426,803 3,807,087 2,583,618 1,966,889 1,856,360 1,374,757 5,067,176 30,882 36,513 62,605 46,984 179,142 332,450 465,353 1,341,597 1,470,091 702,930 622,332 563,062 1,148,641 1,055,759 1,313,423 889,272 1,149,232 1,103,428 1,324,603 2,054,085 2,556,900 2,888,654 1,978,184 
      general and administrative
    		9,395,941 6,023,337 5,924,942 5,671,880 6,067,376 4,273,414 3,463,655 3,057,888 4,071,766 3,429,214 3,021,450 2,847,337 3,509,885 2,794,442 2,564,960 2,356,666 2,715,835 2,116,109 1,800,630 1,789,974 1,905,582 1,493,266 1,301,673 1,610,237 1,138,045 876,720 911,968 831,933 976,490 1,104,670 1,259,180 1,178,060 1,389,732 1,237,827 1,088,635 1,246,942 1,189,238 1,154,355 1,259,744 1,434,259 1,084,696 1,077,594 972,782 926,279 1,395,540 684,722 819,683 665,728 852,347 1,300,777 261,083 384,621 262,475 272,552 397,170 441,970 500,020 518,874 499,273 523,305 575,278 479,924 664,095 445,448 623,202 687,874 869,143 1,397,689 462,468 944,901 818,761 960,164 1,198,339 
      total operating expenses
    		36,772,853 29,156,008 26,284,040 27,719,134 24,982,948 18,828,350 15,271,522 15,562,657 15,172,779 13,369,381 13,050,414 11,664,726 11,171,404 9,026,248 8,069,316 7,321,754 7,831,534 6,379,642 4,314,545 5,287,249 5,201,904 4,238,370 3,930,940 3,537,710 2,293,201 1,705,469 1,769,732 2,476,043 2,787,672 3,954,047 4,391,179 4,566,968 4,086,249 3,756,222 2,951,004 4,375,124 4,446,387 3,820,259 5,986,855 5,742,207 5,425,815 4,408,325 4,165,439 4,353,082 5,202,627 3,268,340 2,786,572 2,522,088 2,227,104 6,367,953 291,965 421,134 325,080 319,536 576,312 774,420 965,373 1,860,471 1,969,364 1,226,235 1,197,610 1,042,986 1,812,736 1,501,207 1,936,625 1,577,146 2,018,375 2,501,117 1,787,071 2,998,986 3,375,661 3,848,818  
      income from operations
    		-36,772,853 -29,156,008 -26,284,040 -27,719,134 -24,982,948 -7,697,841 -13,009,880 -11,591,219 -10,265,902 -1,281,292 -6,864,600 -7,747,259 -8,184,708 -8,066,345 -6,477,750 -7,321,754 -7,831,534 -6,379,642 -4,314,545 -5,083,167 -5,161,088 -4,180,540 -3,914,077 -3,487,846 -2,107,508 -1,483,369 -1,627,661 -2,065,690 -2,557,168 -3,305,965 -4,171,932 -4,163,008 -3,686,183 -3,280,423 -2,637,733 -3,378,662 -3,565,579 -2,913,329 -5,240,074 -4,612,388 -4,210,726 -3,284,929 -2,850,555 -3,061,616 -3,414,725 -1,866,441 -1,485,105 -1,480,421 -1,185,437 -5,864,720 -291,965 -421,134 -325,080 -319,536 -576,312 -774,420 -769,873 -1,664,971 -1,156,364 -880,235 -1,197,610 -1,042,986 -1,812,736 -1,501,207 -1,936,625 -1,577,146 -2,018,375 -2,501,117 -1,787,071 -2,998,986 -3,375,661 -3,848,818 -3,176,523 
      yoy
    		47.19% 278.76% 102.03% 139.14% 143.36% 500.79% 89.52% 49.62% 25.43% -84.12% 5.97% 5.81% 4.51% 26.44% 50.14% 44.04% 51.74% 52.60% 10.23% 45.74% 144.89% 181.83% 140.47% 68.85% -17.58% -55.13% -60.99% -50.38% -30.63% 0.78% 58.16% 23.21% 3.38% 12.60% -49.66% -26.75% -15.32% -11.31% 83.83% 50.65% 23.31% 76.00% 91.94% 106.81% 188.06% -68.18% 408.66% 251.53% 264.66% 1735.39% -49.34% -45.62% -57.77% -80.81% -50.16% -12.02% -35.72% 59.64% -36.21% -41.36% -38.16% -33.87% -10.19% -39.98% 8.37% -47.41% -40.21% -35.02% -43.74%     
      qoq
    		26.12% 10.93% -5.18% 10.95% 224.54% -40.83% 12.24% 12.91% 701.21% -81.33% -11.39% -5.34% 1.47% 24.52% -11.53% -6.51% 22.76% 47.86% -15.12% -1.51% 23.46% 6.81% 12.22% 65.50% 42.08% -8.86% -21.20% -19.22% -22.65% -20.76% 0.21% 12.94% 12.37% 24.37% -21.93% -5.24% 22.39% -44.40% 13.61% 9.54% 28.18% 15.24% -6.89% -10.34% 82.95% 25.68% 0.32% 24.88% -79.79% 1908.71% -30.67% 29.55% 1.74% -44.56% -25.58% 0.59% -53.76% 43.98% 31.37% -26.50% 14.83% -42.46% 20.75% -22.48% 22.79% -21.86% -19.30% 39.96% -40.41% -11.16% -12.29% 21.16%  
      operating margin %
    		NaN% -Infinity% NaN% NaN% NaN% -69.16% -575.24% -291.86% -209.21% -10.60% -110.97% -197.76% -274.04% -840.33% -407.00% NaN% NaN% -Infinity% NaN% -2490.75% -12644.77% -7229.02% -23211.04% -6994.72% -1134.94% -667.88% -1145.67% -503.39% -1109.38% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other income
    		8,145 11,205 6,740 14,991 12,485           190,582  181,039 367,168           64,158.25 46,658 116,658 93,316 131,224 52,500               -58,877.75 11,737 -102,545 -144,705 117,466 9,771 420,890 -2,250 -513 10,411 -1,341 -168             
      investment income
    		2,904,506 2,021,214 1,713,499 1,793,352 729,542 686,572 453,152 591,437 471,829 452,199 479,380 380,680 416,442 379,699 106,635 21,761 13,440 15,984 15,570 16,741 9,165 2,608 3,953 3,692 22,690 13,951 21,061 21,956 37,823 46,086 35,792 39,460 14,653 11,768 10,393 12,052 4,282 -1,940 5,410 427 10,510 2,390 292 156 275 -1,231 1,210 1,196 153                         
      loss on disposal of fixed assets
    		-81,143  -6,846  -150,673     -653 -5,388                                                               
      total other income
    		2,831,508 -1,013,306 1,713,393 1,808,343 591,354 581,238 453,152 591,437 471,829 519,203 473,992 380,680 416,442 345,433 106,635 212,343 13,440 189,118 382,738 334,901 9,165 2,608 3,953 3,692 22,690     46,086 35,792 39,460 14,653 15,585,594 -97,260 -93,475 -101,038 -1,604,845 -93,339 -76,460 -55,615 -61,193 -61,389 -61,525 -61,406 -61,614 -58,881 -53,508 -25,174 -1,598,368 -56,488 -176,487 -157,683 117,544 10,080 421,486 -2,006 581 12,291 -295 1,818 247,329 3,243 6,686 4,803 11,427 -9,305 1,027 8,263 24,317 54,772 71,717 117,586 
      income before income taxes
    		-33,941,345                                                                         
      benefit from income taxes
    		                                                                         
      net income
    		-33,941,345 -30,170,914 -24,570,647 -25,910,791 -24,391,594 -7,116,603 -12,556,728 -10,999,782 -9,794,073 -762,089 -6,390,608 -7,366,579 -7,768,266 -7,720,912 -6,371,115 -7,109,411 -7,818,094 -6,190,524 -3,931,807 -4,748,266 -5,151,923 -4,177,932 -3,910,124 -3,484,154 -2,084,818 -1,469,418 -1,606,600 -2,046,454 -2,519,345 -3,259,879 -4,136,140 -4,123,548 -3,671,530 12,305,171 -2,734,993 -3,472,137 -3,666,617 -4,518,174 -5,333,413 -4,688,848 -4,266,341 -3,346,122 -2,911,944 -3,123,141 -3,476,131 -1,928,055 -1,543,986 -1,533,929 -1,210,611 -7,463,088 -348,453 -597,621 -482,763 -201,992 -566,232 -352,934 -771,879 -1,664,390 -1,144,073 -880,530 -1,195,792 -795,657 -1,809,493 -1,494,521 -1,931,822 -1,565,719 -2,027,680 -2,500,090 -1,778,808 -2,974,669 -3,320,889 -3,777,101 -3,058,937 
      yoy
    		39.15% 323.95% 95.68% 135.56% 149.04% 833.83% 96.49% 49.32% 26.08% -90.13% 0.31% 3.62% -0.64% 24.72% 62.04% 49.73% 51.75% 48.17% 0.55% 36.28% 147.12% 184.33% 143.38% 70.25% -17.25% -54.92% -61.16% -50.37% -31.38% -126.49% 51.23% 18.76% 0.13% -372.35% -48.72% -25.95% -14.06% 35.03% 83.16% 50.13% 22.73% 73.55% 88.60% 103.60% 187.14% -74.17% 343.10% 156.67% 150.77% 3594.74% -38.46% 69.33% -37.46% -87.86% -50.51% -59.92% -35.45% 109.18% -36.77% -41.08% -38.10% -49.18% -10.76% -40.22% 8.60% -47.36% -38.94% -33.81% -41.85%     
      qoq
    		12.50% 22.79% -5.17% 6.23% 242.74% -43.32% 14.15% 12.31% 1185.16% -88.07% -13.25% -5.17% 0.61% 21.19% -10.38% -9.06% 26.29% 57.45% -17.19% -7.84% 23.31% 6.85% 12.23% 67.12% 41.88% -8.54% -21.49% -18.77% -22.72% -21.19% 0.31% 12.31% -129.84% -549.92% -21.23% -5.30% -18.85% -15.29% 13.75% 9.90% 27.50% 14.91% -6.76% -10.15% 80.29% 24.88% 0.66% 26.71% -83.78% 2041.78% -41.69% 23.79% 139.00% -64.33% 60.44% -54.28% -53.62% 45.48% 29.93% -26.36% 50.29% -56.03% 21.08% -22.64% 23.38% -22.78% -18.90% 40.55% -40.20% -10.43% -12.08% 23.48%  
      net income margin %
    		NaN% -Infinity% NaN% NaN% NaN% -63.94% -555.20% -276.97% -199.60% -6.30% -103.31% -188.04% -260.10% -804.34% -400.30% NaN% NaN% -Infinity% NaN% -2326.65% -12622.31% -7224.51% -23187.59% -6987.31% -1122.72% -661.60% -1130.84% -498.71% -1092.97% -Infinity% -Infinity% -Infinity% -Infinity% Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% -Infinity% 
      other comprehensive income
    		                                                                         
      net unrealized gain on marketable securities
    		-536,881   -424,353 784,972 930,734 -58,766 -152,714 71,888 122,605 -66,485 84,707  -17,223 99,637 22,830         757 -757   -12,393 -7,814 1,922 -2,044 8,709 3,027 1,276 -2,394 6,187 2,601 -3,855 1,551  -2,564 5,414 10,475 -3,940 1,607 -733 -470 576                         
      comprehensive loss
    		-34,478,226 -30,731,882 -25,114,099 -26,335,144 -23,606,622 -6,185,869 -12,615,494 -11,152,496 -9,722,185 -639,484 -6,457,093 -7,281,872      -6,190,524 -3,931,807 -4,748,266 -5,151,923 -4,177,932 -3,910,124 -3,484,154 -2,084,061 -1,470,175 -1,606,600 -2,046,454 -2,531,738 -2,980,657.25 -4,134,218 -4,125,592 -3,662,821 -2,467,169.75 -2,733,717 -3,474,531 -3,660,430 -4,515,573 -5,337,268 -4,687,297 -4,272,498 -3,348,686 -2,906,530 -3,112,666 -3,480,071 -1,926,448 -1,544,719 -1,534,399 -1,210,035                         
      net income per share
    		-0.59 -0.62 -0.54 -0.57 -0.53 -0.11 -0.38 -0.35 -0.31 0.02 -0.25 -0.29 -0.31 -0.31 -0.26 -0.29 -0.32 -0.26 -0.17 -0.21 -0.23 -0.2 -0.2 -0.23 -0.3 -0.3 -0.43 -0.59 -0.08 -0.11 -0.14 -0.14 -0.14 0.54 -0.12 -0.16 -0.17 -0.2 -0.29 -0.26 -0.26 -0.21 -0.18 -0.19 -0.23 -0.16 -0.13 -0.13 -0.1                         
      weighted-average number of shares, basic and diluted
    		57,434,267 46,478,416 45,716,151 45,709,071 45,636,633 35,218,628 33,090,063 31,841,964 31,354,629 26,778,360 25,817,676 25,335,342 25,247,354 24,552,688 24,431,787 24,324,156 24,282,743 23,089,323 23,095,375 22,861,051 22,228,723 15,571,056 19,801,841 15,130,685 6,878,782 3,711,333 3,746,801 3,457,833 32,903,837  30,610,064 29,031,888 26,905,331  23,378,141        16,242,090 16,222,754     11,689,441                         
      net unrealized loss on marketable securities
    		 -45,708.25 -543,452          -10,258                            -6,157                                 
      comprehensive income
    		            -7,778,524 -7,738,135 -6,271,478 -7,086,581                                                          
      forgiveness of debt
    		                   318,160                                                      
      loss on disposal of fixed asset
    		                           -2,720                                              
      income
    		                                                                         
      collaboration income
    		                                   683,592 683,594 683,595 683,595 911,458 911,458 911,458 911,458 911,458 1,041,667 1,041,666 1,041,667 1,041,667 1,041,667        195,500 195,500 813,000 346,000              
      grant income
    		                             191,660.25 172,589 287,302 306,750 344,575 260,771 312,870 197,214 223,335 63,186 218,361 303,631 211,938 403,426 380,008 746,235 360,233 259,800                           
      total income
    		                             255,818.5 219,247 403,960 400,066 475,799 313,271 996,462 880,808 906,930 746,781 1,129,819 1,215,089 1,123,396 1,314,884 1,291,466 1,787,902 1,401,899 1,301,467 1,041,667 1,041,667        195,500 195,500 813,000 346,000              
      interest expense
    		                                 -80,307 -107,653 -105,527 -105,320 -102,905 -98,749 -76,887 -66,125 -63,583 -61,681 -61,681 -61,681 -60,383 -60,091 -54,704 -25,327 97,211 -68,282 -74,046 -13,018                    -137 
      other comprehensive gain
    		                                                                         
      weighted-average number of shares,
    		                                                                         
      basic and diluted
    		                                   22,135,198 21,399,019 18,551,013 18,286,816 17,952,323 16,537,502 15,902,133   14,869,746 11,696,980 11,700,136 11,692,318  10,501,416                        
      impairment of goodwill
    		                                                                         
      income:
    		                                                                         
      operating expenses:
    		                                                                         
      other income:
    		                                                                         
      interest income
    		                                                 50 57 104 40 78 309 596 244 1,094 1,880 1,046 1,986 2,851 5,954 6,726 4,846 11,427 15,194 5,886 14,686 41,981 58,451 82,848 149,436 
      basic and diluted loss per share
    		                                                 -0.008 -0.01 -0.01 -0.01  -0.01 -0.01 -0.02 -0.04 -0.03 -0.03 -0.03 -0.02 -0.05 -0.05 -0.07 -0.06 -0.08 -0.1 -0.07 -0.12 -0.14 -0.16 -0.13 
      weighted-average common shares outstanding
    		                                                  43,366,125 43,062,231 43,062,231 42,201,848 43,062,231 42,951,791 39,712,231 37,328,519 39,707,764 35,091,653 34,673,475 32,168,433 34,563,073 32,285,824 27,085,824 25,466,655 26,491,211 24,149,405 24,149,405 24,126,398 24,149,405 24,106,341 24,099,716 
      other expense
    		                                                             -698.25 -2,711 -40 -43  -24,499 -4,859 -6,423 -17,664 -3,679 -11,131 -31,713 
      total operating expense
    		                                                                        3,176,523 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 
                                                                               
        current assets
      		                                                                         
        cash and cash equivalents
      		105,421,484 287,847,312 19,510,383 23,241,199 28,794,503 11,286,996 68,377,402 10,688,363 6,214,647 14,694,857 8,984,667 9,837,133 10,605,528 9,603,242 8,413,653 16,394,067 58,333,945 34,885,274 40,839,158 38,077,964 41,879,554 32,665,874 35,300,340 36,252,623 13,217,481 3,899,328 6,827,570 5,890,963 7,170,220 4,259,266 4,377,797 6,339,148 7,169,262 6,140,135 8,897,087 8,260,897 2,750,473 3,204,378 18,020,875 8,851,129 11,766,454 5,568,306 4,218,409 5,038,260 6,939,220 8,034,765 9,805,435 11,582,186 12,979,150 1,729,537 71,028 229,205 285,032 46,716 282,507 777,182 435,730 1,039,190 2,607,336 3,259,835 2,123,861 3,378,155 4,435,833 5,563,418 2,013,394 3,175,718 4,224,183 1,770,226 3,607,302 5,500,790 7,363,926 10,347,757 13,659,576 
        marketable securities
      		173,188,430 30,281,603 79,055,588 99,559,482 115,982,893 140,228,881 16,651,222 18,773,667 33,702,431 24,792,846 19,536,805 27,956,325 34,566,342 31,818,020 38,199,859 35,022,883          5,986,050    2,997,150 5,994,120 5,995,080 5,995,380 7,984,800 4,997,850 3,998,520 8,992,980 12,990,510 2,499,975 2,499,975 2,498,425 7,999,010 12,999,445 15,494,365 15,483,890  325,318 325,791 326,226 326,494                        
        receivables
      		 59,167 59,167 59,509 59,834 10,368,489 409,682 369,975 369,000 10,371,993 547,580 547,580 547,580 547,580 547,580 547,580 356,997 391,750 180,178                                                       
        prepaid expenses and other current assets
      		4,478,895 4,751,674 2,326,543 1,266,356 1,413,754 1,500,901 385,065 837,218 1,125,844 995,776 458,417 583,835 875,092 919,892 343,684 659,269 943,246 1,159,937 278,909 653,336 736,358 1,011,209 174,186 249,876 433,975 571,382 129,161 375,419 425,943 724,184 426,422 388,118 522,346 501,164 190,278 239,331 398,175 342,892 118,225 239,263 321,421 210,603 92,476 130,724 202,984 235,523 105,100 123,061 169,579 222,763 37,975 60,088 112,743 124,912 155,842 164,665 220,387 271,298 420,653 379,877 227,823 219,095 304,076 237,187 282,945 257,732 331,693 185,368 338,574 544,834 641,247 415,944 384,554 
        total current assets
      		283,088,809 322,939,756 100,951,681 124,126,546 146,250,984 163,385,267 85,823,371 30,669,223 41,411,922 50,855,472 29,527,469 38,924,873 46,594,542 42,888,734 47,504,776 52,623,799 59,634,188 36,436,961 41,298,245 38,731,300 42,615,912 33,677,083 35,491,389 36,552,363 13,770,083 10,544,728 7,290,788 6,643,272 7,904,007 8,471,299 11,392,646 13,541,193 14,613,165 15,712,676 15,232,420 13,640,187 13,464,672 18,108,340 22,404,446 11,808,728 14,889,931 13,989,857 17,713,755 21,642,939 25,420,259 11,607,545 14,196,136 16,409,568 14,030,944 3,680,840 109,003 289,293 404,281 171,628 438,349 941,847 656,117 1,310,488 3,027,989 3,639,712 2,351,684 3,597,250 4,739,909 5,800,605 2,296,339 3,433,450 4,555,876 1,955,594 3,945,876 6,045,624 8,005,173 10,763,701 14,044,130 
        property and equipment
      		28,502,617 18,312,238 11,068,078 7,995,259 6,133,870 5,561,597 5,315,385 5,617,523 5,893,552 5,560,641 5,139,680 4,789,786 4,811,044 4,588,030 3,591,397 2,629,114 2,328,565 1,795,696 1,513,575 1,110,051 838,705 850,847 603,719 486,815 410,913 442,806 474,699 506,724 541,730 574,206 622,277 507,396 535,241 372,096 394,031 399,035 411,877 435,336 351,507 355,284 344,957 318,566 332,143 263,059 253,768 229,455     828 994 1,159 3,488 4,938 6,387 7,951 9,744 10,886 12,698 14,571 16,765 16,777 19,855 23,486 27,486 31,871 59,810 66,278 73,699 79,849 86,000 88,042 
        other assets
      		1,533,591 1,159,480 488,738 508,002 253,374 221,700 319,246 319,558 293,722 268,172 268,172 268,172 268,172 268,172 268,172 268,172 275,722 275,722 288,701 88,701 88,701 88,701 88,701 82,446 107,380 119,608 124,614 128,715 132,816 151,788 157,302 207,072 157,787 95,969 61,396 61,166 61,426 61,426 61,426 61,556 71,146 70,146 133,201 69,455 69,455 55,320                            
        lease right-of-use assets
      		13,158,500 13,537,820 13,929,710 939,204 1,127,745 1,312,522 1,493,611 1,671,149 1,845,246 2,050,042 2,217,009 2,028,367 2,189,651 2,349,974 2,563,762 2,544,489 2,683,443 2,821,944                                                        
        total assets
      		326,283,517 355,949,294 126,438,207 133,569,011 153,765,973 170,481,086 92,951,613 38,277,453 49,444,442 58,734,327 37,152,330 46,011,198 53,863,409 50,094,910 53,928,107 58,065,574 64,921,918 41,330,323 43,100,521 39,930,052 43,544,401 34,618,796 36,187,057 37,125,954 14,293,789 11,113,637 7,907,415 7,306,844 8,617,505 9,247,065 12,232,816 14,327,071 15,388,422 16,273,789 15,793,539 14,218,267 14,068,041 18,747,355 24,471,820 13,892,196 16,984,850 16,069,572 19,882,289 23,690,830 27,471,047 13,632,072 16,282,719 18,437,454 15,976,704 5,537,907 114,366 294,822 415,308 227,054 495,225 1,000,172 716,006 1,372,170 3,090,813 3,704,348 2,418,193 3,665,953 4,808,624 5,872,398 2,371,763 3,619,704 4,829,355 2,253,894 4,262,818 6,435,469 8,408,902 11,189,610 14,486,641 
        liabilities and stockholders’ equity
      		                                                                         
        current liabilities
      		                                                                         
        accounts payable
      		3,927,941 1,654,754 2,719,416 4,812,356 5,253,636                                              339,245 397,577 249,351 182,916 210,050 121,719 327,154 437,837 504,333 237,760 478,859 332,380 591,553 154,028 164,545 150,628 305,620 200,287 453,091 738,895 558,522 695,905 815,851 
        accrued expenses
      		10,528,351 15,557,646 9,932,488 7,359,232 4,241,118                                                                     
        lease liabilities, current
      		841,135 202,376 120,094 849,505 842,101 834,799 813,634 792,694 771,506 749,112 729,567 707,425 693,652 682,039 697,561 579,672 498,374 417,632                                                        
        cirm liability, current
      		6,339,862 6,421,984 3,376,259 3,376,259                                                                      
        deferred revenue, current
      		12,000,000 12,000,000 12,000,000 12,000,000 12,000,000 12,000,000 13,130,509 15,392,151 19,363,589 24,270,465 25,405,084 29,312,439 31,012,773 17,980,599 18,560,430 15,745,576 9,726,501                    683,592 1,367,186 2,050,781 2,734,376 3,645,833 3,645,834 3,645,834 3,645,834 4,166,667 4,166,667                            
        total current liabilities
      		33,637,289 35,836,760 28,148,257 28,397,352 22,336,855 21,026,176 20,475,506 22,354,779 26,383,752 31,269,818 32,926,601 35,153,674 37,132,157 23,586,555 23,194,503 19,547,219 14,323,297 4,133,391 2,988,292 3,173,663 3,751,888 2,971,282 2,277,960 1,917,508 1,324,896 897,992 960,722 1,566,802 1,500,944 1,255,219 1,876,135 1,320,008 1,477,899 1,670,675 16,688,054 16,644,327 3,299,189 4,895,183 6,670,268 6,204,701 7,340,746 6,528,668 6,534,168 6,863,403 7,545,301 6,299,633 6,192,239 6,492,261 6,299,284 2,052,922 1,181,927 1,015,586 649,128 330,983 287,143 267,055 485,347 541,447 717,817 436,274 743,736 1,069,085 1,504,748 1,149,738 889,212 637,554 844,909 440,390 778,414 1,331,851 918,148 999,542 1,311,164 
        long-term liabilities
      		                                                                         
        lease liabilities, net of current
      		13,943,595 14,320,389 14,422,695 194,603 407,392 616,315 834,889 1,044,109 1,249,493 1,486,783 1,683,656 1,518,173 1,699,682 1,878,070 2,082,849 2,158,677 2,306,197 2,452,707                                                        
        total long-term liabilities
      		13,943,595 14,320,389 14,422,695 194,603 3,783,651 3,992,574 4,211,148 4,420,368 4,625,752 4,863,042 6,013,385 8,126,361 10,525,003 14,722,261 15,307,112 19,789,360 25,955,955 5,828,966 3,376,259 3,376,259 3,411,728 3,447,730 3,501,178 3,554,492 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 4,160,316 17,960,646 17,855,326 17,752,421 12,803,672 10,727,009 10,572,678 11,422,455 12,272,232 12,601,202 13,581,162 14,562,445 15,029,844 11,336,860 4,019,867                        
        total liabilities
      		47,580,884 50,157,149 42,570,952 28,591,955 26,120,506 25,018,750 24,686,654 26,775,147 31,009,504 36,132,860 38,939,986 43,280,035 47,657,160 38,308,816 38,501,615 39,336,579 40,279,252 9,962,357 6,364,551 6,549,922 7,163,616 6,419,012 5,779,138 5,472,000 4,701,155 4,274,251 4,336,981 4,943,061 4,877,203 4,631,478 5,252,394 4,696,267 4,854,158 5,046,934 20,064,313 20,804,643 21,259,835 22,750,509 24,422,689 19,008,373 18,067,755 17,101,346 17,956,623 19,135,635 20,146,503 19,880,795 20,754,684 21,522,105 17,636,144 6,072,789 1,681,920 1,527,673 1,057,970 394,367 467,993 457,918                 1,378,739 
        commitments and contingencies
      		                                                                         
        stockholders’ equity
      		                                                                         
        preferred stock, 0.001 par value...
      		                                                                         
        common stock, 0.001 par value...
      		57,665 57,371 45,717 45,712 45,677 45,582 40,332 31,984 31,600 31,148 25,855 25,764 25,255 25,241 24,703 24,335 24,324 24,185 24,149 22,998 22,798 20,577 20,212 19,698   4,175 3,467 33,661 31,388 30,749 29,994 27,971 26,271    21,399     16,255 16,223     11,690  43,521 43,062  43,062 43,062 43,062  39,712 39,708 39,708 34,699  34,630 34,561   27,002 24,150 24,150  24,150 24,150 24,100 
        additional paid-in capital
      		617,718,525 610,330,105 357,684,987 353,680,694 350,013,996 344,224,338 260,846,342 191,476,543 187,257,063 181,701,859 156,678,545 154,740,362 150,934,085 148,735,420 144,638,221 141,669,614 140,496,715 139,404,060 138,581,576 131,295,080 129,547,669 116,216,966 114,247,534 111,583,959 86,048,994 81,215,647 76,477,572 73,665,029 72,964,900 71,310,720 70,408,501 68,925,422 65,705,313 62,736,783 59,548,523 54,501,710 50,422,955 49,951,165 49,487,877 38,988,747 38,334,722 34,115,052 33,723,806 33,446,837 33,103,520 16,054,697 15,905,010 15,747,613 15,638,420 15,552,946 46,525,778 46,512,487 46,505,056 46,497,642 46,490,195 46,438,985 45,777,806 45,605,991 45,483,878 45,234,882 42,765,744 42,492,432 42,403,783 42,013,143 37,285,990 36,853,767 36,290,428 32,094,658 31,265,468 31,105,874 30,518,341 29,896,766 29,037,549 
        accumulated other comprehensive income
      		-253,727 283,154 844,122 1,387,574 1,811,927 1,026,955 96,221 154,987 307,701 235,813 113,208 179,693 94,986 105,244 122,467 22,830          -757    12,393 20,207 18,285 20,329 11,620 8,593 7,317 9,711 3,524 923 4,778 3,228 9,385 11,949 6,535                              
        accumulated deficit
      		-338,819,830 -304,878,485 -274,707,571 -250,136,924 -224,226,133 -199,834,539 -192,717,936 -180,161,208 -169,161,426 -159,367,353 -158,605,264 -152,214,656 -144,848,077 -137,079,811 -129,358,899 -122,987,784 -115,878,373 -108,060,279 -101,869,755 -97,937,948 -93,189,682 -88,037,759 -83,859,827 -79,949,703 -76,465,549 -74,380,731 -72,911,313 -71,304,713 -69,258,259 -66,738,914 -63,479,035 -59,342,897 -55,219,349 -51,547,819 -63,852,990 -61,117,998 -57,645,859 -53,979,242 -49,461,068 -44,127,654 -39,438,807 -35,172,466 -31,826,344 -28,914,400 -25,791,258 -22,315,127                            
        total stockholders’ equity
      		278,702,633 305,792,145 83,867,255 104,977,056 127,645,467 145,462,336 68,264,959 11,502,306 18,434,938 22,601,467 -1,787,656 2,731,163 6,206,249 11,786,094 15,426,492 18,728,995 24,642,666 31,367,966 36,735,970 33,380,130 36,380,785                                               1,813,504 3,484,404 5,103,618 7,490,754 10,190,068 13,107,902 
        total liabilities and stockholders’ equity
      		326,283,517 355,949,294 126,438,207 133,569,011 153,765,973 170,481,086 92,951,613 38,277,453 49,444,442 58,734,327 37,152,330 46,011,198 53,863,409 50,094,910 53,928,107 58,065,574 64,921,918 41,330,323 43,100,521 39,930,052 43,544,401                                               2,253,894 4,262,818 6,435,469 8,408,902 11,189,610 14,486,641 
        cirm liability, net of current
      		                                                                         
        cirm liability
      		    3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,376,259 3,100,000 3,100,000 3,100,000 3,100,000                                   
        accounts payable and accrued expenses
      		     8,191,377 6,531,363 6,169,934 6,248,657 6,222,762 6,771,772 5,115,182 5,407,016 4,834,683 3,852,356 3,127,836 3,523,574 3,116,371 2,988,292 3,173,663 3,469,197 2,724,593 2,084,719 1,777,581 1,296,267 875,677 947,608 1,520,590 1,462,878 1,148,853 1,743,788 1,206,338 1,408,338 1,496,251 1,264,325 2,177,280 2,505,801 3,038,780 3,920,305 2,923,600 3,224,044 2,530,500 2,308,677 2,678,848 2,745,935 1,699,254 1,613,066 1,683,356 1,518,595 1,506,509                        
        accounts payable and accrued expenses, related party
      		         27,479 20,178 18,628 18,716 89,234 84,156 94,135 574,848 599,388       28,629 22,315 13,114 46,212 38,066 106,366 132,347 113,670 69,561 174,424 99,903 311,190 109,796 489,217 699,182 546,725 470,869 352,334 579,657 538,721 632,699 433,712 300,855 500,095 481,643 382,142                        
        deferred revenue, net of current
      		          953,470 3,231,929 5,449,062 9,467,932 9,848,004 14,254,424 20,273,499                                                         
        intangible assets, net of accumulated amortization of 259,682 and 257,517, respectively
      		                                                                         
        note payable, current
      		                    282,691 246,689 193,241 139,927                                                  
        note payable, net of current
      		                    35,469 71,471 124,919 178,233                                                  
        intangible assets, net of accumulated amortization of 258,599 and 257,517, respectively
      		                    1,083                                                     
        grant receivable
      		                      16,863 49,864 118,627 87,968 101,254 144,087 122,621 204,868 172,589 287,302 306,750 344,575 537,030 312,870 197,214   218,361 303,631 211,938 403,425 380,008 746,235 360,233 259,800                           
        intangible assets, net of accumulated amortization of 257,517 and 253,187, respectively
      		                     2,165                                                    
        liabilities and stockholders' equity
      		                                                                         
        stockholders' equity
      		                                                                         
        total stockholders' equity
      		                     28,199,784 30,407,919 31,653,954 9,592,634 6,839,386 3,570,434 2,363,783 3,740,302 4,615,587 6,980,422 9,630,804 10,534,264 11,226,855 -4,270,774 -6,586,376 -7,191,794 -4,003,154 49,131 -5,116,177 -1,082,905 -1,031,774 1,925,666 4,555,195 7,324,544 -6,248,723 -4,471,965 -3,084,651 -1,659,440      27,232 542,254 230,659 830,723 2,372,996 3,268,074 1,674,457 2,596,868 3,303,876 4,722,660 1,482,551 2,982,150 3,984,446       
        total liabilities and stockholders' equity
      		                     34,618,796 36,187,057 37,125,954 14,293,789 11,113,637 7,907,415 7,306,844 8,617,505 9,247,065 12,232,816 14,327,071 15,388,422 16,273,789 15,793,539 14,218,267 14,068,041 18,747,355 24,471,820 13,892,196 16,984,850 16,069,572 19,882,289 23,690,830 27,471,047 13,632,072 16,282,719 18,437,454 15,976,704    415,308 227,054 495,225 1,000,172 716,006 1,372,170 3,090,813 3,704,348 2,418,193 3,665,953 4,808,624 5,872,398 2,371,763 3,619,704 4,829,355       
        intangible assets, net of accumulated amortization of 256,434 and 253,187, respectively
      		                      3,248                                                   
        intangible assets, net of accumulated amortization of 255,352 and 253,187, respectively
      		                       4,330                                                  
        intangible assets, net of accumulated amortization of 254,269 and 253,187, respectively
      		                        5,413                                                 
        and 5,227,398 shares issued and outstanding, respectively
      		                        9,189                                                 
        restricted cash
      		                          232,803 232,803 185,223 285,831 421,718 531,545 619,427 742,002 610,175 828,569 1,125,830 1,347,225 602,185     599,582 2,047,930 2,977,024 3,699,660 4,378,300 555,232 1,401,859                        
        intangible assets, net of accumulated amortization of 253,187 and 209,910, respectively
      		                         6,495                                                
        and 3,138,748 shares issued and outstanding, respectively
      		                         5,227                                                
        assets
      		                                                                         
        intangible assets, net of accumulated amortization of 242,368 and 209,910, respectively
      		                          17,314                                               
        intangible assets, net of accumulated amortization of 231,549 and 209,910, respectively
      		                           28,133                                              
        intangible assets, net of accumulated amortization of 220,730 and 209,910, respectively
      		                            38,952                                             
        intangible assets, net of accumulated amortization of 209,910 and 166,634, respectively
      		                             49,772                                            
        intangible assets, net of accumulated amortization of 199,091 and 166,634, respectively
      		                              60,591                                           
        intangible assets, net of accumulated amortization of 188,272 and 166,634, respectively
      		                               71,410                                          
        intangible assets, net of accumulated amortization of 177,453 and 166,634, respectively
      		                                82,229                                         
        intangible assets, net of accumulated amortization of 166,634 and 147,429, respectively
      		                                 93,048                                        
        deferred revenue
      		                                                                         
        loan payable
      		                                    13,905,857 13,905,857 13,905,857 12,155,857 10,155,857 9,155,857 9,155,857 9,155,857 9,155,857 9,155,857 9,155,857 8,641,680 3,961,733 3,961,733                        
        accrued interest
      		                                   1,060,316 954,789 849,469 746,564 647,815 571,152 505,363 443,682 382,001 320,346 258,639 198,256 138,165 83,461 58,134                        
        intangible assets, net of accumulated amortization of 183,990 and 147,429, respectively
      		                                  105,692                                       
        loan payable, current
      		                                  14,155,857 14,155,857                                      
        accrued interest, current
      		                                  1,167,969                                       
        and 21,399,019 shares issued and outstanding, respectively
      		                                  25,100 22,595                                      
        intangible assets, net of accumulated amortization of 171,803 and 147,429, respectively
      		                                   117,879                                      
        intangible assets, net of accumulated amortization of 159,616 and 147,429, respectively
      		                                    130,066                                     
        issued and outstanding at march 31, 2017 and december 31, 2016
      		                                    21,399                                     
        awards receivable
      		                                     223,335 1,163,186                                   
        intangible assets, net of accumulated amortization of 147,429 and 98,679, respectively
      		                                     142,253                                    
        in-process research and development, net of accumulated amortization of 0
      		                                      1,500,000 1,500,000 1,500,000 1,500,000 1,500,000 1,500,000 1,500,000 1,500,000   1,500,000 1,500,000                        
        deferred revenue, net of current portion
      		                                         911,458 1,822,916 2,734,374 3,124,999 4,166,666                            
        intangible assets, net of accumulated amortization of 135,241 and 98,679, respectively
      		                                      154,441                                   
        and 16,254,985 shares issued and outstanding, respectively
      		                                      21,399 17,952 17,952                                 
        intangible assets, net of accumulated amortization of 123,054 and 98,679, respectively
      		                                       166,628                                  
        intangible assets, net of accumulated amortization of 110,866 and 98,679, respectively
      		                                        178,816                                 
        intangible assets, net of accumulated amortization of 98,679 and 49,930, respectively
      		                                         191,003                                
        and 11,707,051 shares issued and outstanding, respectively
      		                                         16,255   16,222                             
        intangible assets, net of accumulated amortization of 86,492 and 49,930, respectively
      		                                          203,190                               
        intangible assets, net of accumulated amortization of 74,305 and 49,930, respectively
      		                                           215,377                              
        intangible assets, net of accumulated amortization of 62,118 and 49,930, respectively
      		                                            227,565                             
        accumulated other comprehensive loss
      		                                            -3,940  -1,607 -874 -404 -980                        
        intangible assets, net of accumulated amortization of 49,930 and 39,197, respectively
      		                                             239,752                            
        and 11,687,747 shares issued and outstanding, respectively
      		                                             11,707                            
        interest receivable
      		                                              823 230 757 187                        
        property and equipment, at cost
      		                                                                         
        furniture and equipment
      		                                              38,850 38,850 38,850 38,850                        
        laboratory equipment
      		                                              262,451 232,222 208,667 115,766                        
        leasehold improvements
      		                                              23,744 23,744                          
        property and equipment, at cost - sum
      		                                              325,045 294,816 247,517 154,616                        
        less accumulated depreciation
      		                                              -100,499 -90,813 -83,978 -80,429                        
        net property and equipment
      		                                              224,546 204,003 163,539 74,187                        
        patents, net of accumulated amortization of 35,722 and 32,475 at september 30, 2014
      		                                                                         
        and december 31, 2013, respectively
      		                                              288,474 248,952                          
        loan fees, net of accumulated amortization of 11,757 and 6,722 at september 30, 2014
      		                                                                         
        in-process research and development, net of accumulated amortization of 0 at
      		                                                                         
        september 30, 2014 and december 31, 2013
      		                                              1,500,000                           
        deposits
      		                                              55,320 55,320 25,728 25,728    51,938 51,938                   
        sub-award payable, related party
      		                                                 41,855                        
        accrued royalties
      		                                              111,651 142,143 132,379 122,416                        
        deferred income, current
      		                                              4,166,667 4,166,667 4,166,667                         
        deferred income, net of current portion
      		                                              5,208,332 6,249,999 7,291,666                         
        and 11,687,747 shares issued and outstanding at september 30, 2014 and
      		                                                                         
        december 31, 2013, respectively
      		                                              11,704 11,695                          
        deficit accumulated during the development stage
      		                                              -20,387,072 -18,843,085 -17,309,146 -16,098,535 -48,136,853 -47,788,400 -47,190,780 -46,708,017 -46,506,025 -45,939,793 -45,586,859 -44,814,980 -43,150,590 -42,006,516 -41,125,986 -39,930,194 -39,134,537 -37,325,044 -35,830,525 -33,898,703 -32,332,984 -30,305,304 -27,805,214 -26,026,406 -23,051,737 -19,730,848 -15,953,747 
        patents, net of accumulated amortization of 34,640 and 32,475 at june 30, 2014
      		                                                                         
        loan fees, net of accumulated amortization of 10,389 and 6,722 at june 30, 2014
      		                                                                         
        june 30, 2014 and december 31, 2013
      		                                               1,500,000                          
        and 11,687,747 shares issued and outstanding at june 30, 2014 and
      		                                                                         
        patents, net of accumulated amortization of 33,557 and 32,475 respectively
      		                                                228,382                         
        loan fees, net of accumulated amortization of 8,556 and 6,722, respectively
      		                                                28,111                         
        grants receivable
      		                                                                         
        patents, net of accumulated amortization of 32,475 and 28,145 respectively
      		                                                 227,207                        
        loan fees, net of accumulated amortization of 6,722 and 0, respectively
      		                                                 29,945                        
        liabilities and shareholders' equity
      		                                                                         
        shareholders' equity
      		                                                                         
        common stock
      		                                                                         
        authorized, respectively, 11,687,747 and 10,351,294
      		                                                                         
        shares issued and outstanding, respectively
      		                                                 11,687                        
        subscription receivable
      		                                                                         
        total shareholders' equity
      		                                                 -534,882                        
        total liabilities and shareholders' equity
      		                                                 5,537,907                        
        other noncurrent assets
      		                                                  4,535 4,535 9,868   51,938 51,938 51,938 51,938 51,938 51,938 51,938 51,938 51,938 51,938 51,938 109,066 107,066 106,924  106,109 105,623  
        liabilities and stockholders' deficit
      		                                                                         
        accrued expenses and other current liabilities
      		                                                  497,886 346,295 202,203 131,928 69,027 108,888 59,902 64,718 177,317 161,143 181,275 652,275 837,957 916,808 649,205 402,772 457,628 159,666 322,211 586,256 355,514 300,355 332,002 
        notes payable, net of unamortized discount of 123,204
      		                                                  326,796                       
        due to related party
      		                                                  18,000 13,200 6,600 16,139 8,066 36,448 98,291 38,892 36,167 37,371 83,602 84,430 75,238 78,902 75,462 84,154  80,437 3,112 6,700 4,112 3,282 92,379 
        warrant liability
      		                                                  499,993 512,087 408,842 63,384 180,850 190,863                  
        stockholders' deficit
      		                                                                         
        total stockholders' deficit
      		                                                  -1,567,554 -1,232,851                      
        total liabilities and stockholders' deficit
      		                                                  114,366 294,822                      
        notes payable, net of unamortized discount of 191,486
      		                                                   258,514                      
        deferred financing fees
      		                                                    6,506                     
        notes payable, net of unamortized discount of 259,026
      		                                                    190,974                     
        stockholders' (deficit) equity
      		                                                                         
        none issued and outstanding
      		                                                                         
        43,062,231 shares issued and outstanding
      		                                                    43,062                     
        total stockholders' (deficit) equity
      		                                                    -642,662 -167,313                    
        39,712,231 and 39,712,231 shares issued and outstanding
      		                                                        39,712                 
        intangible assets
      		                                                                 106,830 132,542 131,424 143,740 209,549 217,771 234,286 235,602 
        34,629,794 and 27,085,824 shares issued and outstanding
      		                                                             34,630            
        27,085,824 shares issued and outstanding
      		                                                                27,086         
        27,085,824 and 24,149,405 shares issued and outstanding
      		                                                                 27,086        
        due to related parties
      		                                                                  81,661       
        other non-current assets
      		                                                                     106,597   118,867 
        24,149,405 and 24,099,716 shares issued and outstanding
      		                                                                     24,150    
        accrued lease obligation
      		                                                                        70,932 
        long-term portion of accrued lease obligation
      		                                                                        67,575 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-07-05 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 
                                                                                 
          cash flows from operating activities:
        		                                                                         
          net loss
        		-33,941,345 -30,170,914 -24,570,647 -25,910,791 -24,391,594 -7,116,603 -12,556,728 -10,999,782 -9,794,073 -762,089 -6,390,608 -7,366,579 -7,768,266 -7,720,912 -6,371,115 -7,109,411 -7,818,094 -6,190,524 -3,931,807 -4,748,266 -5,151,923 -4,177,932 -3,910,124 -3,484,154 -2,084,818 -1,469,418 -1,606,600 -2,046,454 -2,519,345  -4,136,138 -4,123,548 -3,671,530  -2,734,992 -3,472,139 -3,666,617 -4,518,174 -5,333,414 -4,688,847 -4,266,341 -3,346,122 -2,911,944 -3,123,142 -3,476,131 -1,928,055  -1,533,939 -1,210,611 -7,463,088 -348,453 -597,620 -482,763 -201,992 -566,232 -352,934 -771,879 -1,664,390 -1,144,074 -880,530 -1,195,792 -795,657 -1,809,493 -1,494,519 -1,931,822 -1,565,719 -2,027,680 -2,500,090 -1,778,808 -2,974,669 -3,320,889 -3,777,101 -3,058,937 
          adjustments to reconcile net loss to net cash from operating activities:
        		                                                                         
          depreciation and amortization
        		534,670 502,587 494,726 486,278 405,450 375,705 361,168 356,935 331,406 307,608 276,471 254,702 230,101 191,602 137,028 112,011 92,490 78,645 64,720 52,195 50,137 42,076 36,200 32,639 32,975 42,711 42,844 43,106 43,295 43,295 41,395 38,902 34,060 34,579 33,540 37,283 38,772 33,907 26,715 33,493 31,604 31,078 28,783 26,202 24,802 13,544 6,465 9,751 6,465 25,570 166 165 1,022 1,450 1,449 1,564 1,793 1,628 1,812 1,873 2,194 2,217 3,078 3,631 4,000 29,840 26,911 26,869 75,969 29,326 30,647 28,905 24,411 
          stock-based compensation
        		5,918,055 3,841,360 3,997,348 3,647,153 5,481,938 2,295,676 2,051,283 2,152,793 3,265,412 1,861,707 1,717,193 1,618,712 2,194,784 1,148,212 1,087,133 1,157,904 1,065,329 780,150 720,281 712,299 752,962 473,745 486,777 704,350 287,807 128,333 225,268 124,217 223,166 390,811 430,434 446,733 457,612 413,336 427,482 398,090 471,790 463,288 554,566 654,025 290,586 391,246 266,927 342,930 572,121 149,457 84,544 107,662 84,544 248,748 0 7,431 7,414 7,447 51,210 82,218 171,815 119,616 248,996 170,541 267,174 88,649 384,502 217,929 432,223 489,544 767,853 829,190 159,594 587,533 621,575 859,267 966,907 
          restricted stock awards granted
        		 0 0 0 257,461                                                                     
          amortization/accretion of note premiums/discounts
        		-358,625                                                                         
          changes in lease liabilities
        		641,285 371,867 377,280 -16,844 -16,844 -16,320 -10,742 -10,099 -10,100 -10,361 -1,017 -6,452 -6,452 -6,514 22,788                                                           
          other
        		-6,591                                                                         
          changes in operating assets and liabilities:
        		                                                                         
          receivables
        		59,167 0 342 325 10,308,655 -9,958,807 -39,707 -975 10,002,993     0 0 -190,583 34,753 -211,572    16,863 33,001 68,763 -30,659 13,286 42,833 -21,466 82,247 -32,279 114,713 19,448 37,825 -83,804 52,099 -115,656 26,121 -160,149 155,175 85,270 -91,693 191,487                                
          prepaid expenses and other assets
        		979,776                                                                         
          accounts payable and accrued expenses
        		-3,081,283 2,168,179 971,647 1,528,898 1,315,268 1,660,014 361,429 -78,723 -1,584 -549,011 1,656,590 -291,834 572,333 982,327 724,520 -395,738 407,203 137,051 -185,371 -295,533 744,603 639,874 307,138 458,999 420,590 -71,930 -572,982 57,711 314,026 -594,935 537,450 -202,000 -87,913 231,926 -912,955 -328,065 -532,979 -881,525 996,705 -300,444 693,544 221,823 -370,171 -67,087 1,046,681 -36,228 12,086 164,761 12,086                         
          net cash from operating activities
        		-29,254,891 -23,566,743 -19,688,787 -20,122,211 -6,433,520 -14,796,329 -11,642,474 -12,288,499 -1,268,440 -11,594,052 -8,794,829 -9,417,750 4,210,086 -6,902,052 -5,685,606 -6,542,271 24,046,566 -5,627,583 -3,337,928 -4,514,443 -3,329,370 -3,842,397 -2,977,573 -2,016,684 -1,218,156 -1,785,032 -1,651,376 -1,777,395 -1,607,698 -3,771,216 -2,982,003 -3,691,413 -3,417,809 -2,667,297 -3,189,637   -4,223,015 -2,513,659 -4,883,693 -4,181,253 -3,642,660 -3,244,579 -1,878,043 -2,052,004 -2,146,340 11,342,994 -6,016,127 11,342,994 -5,785,813 -158,177 -55,827 -144,184 -235,791 -494,675 -852,755 -603,460 -1,568,660 -652,499 -1,167,632 -1,260,501 -1,055,473 -1,133,792 -966,675 -1,162,324 -1,122,601 -953,153 -1,828,991 -1,890,749 -1,848,182 -2,975,850 -3,274,618 -2,541,394 
          capital expenditures
        		-5,121,709 -1,664,873 -55,843 -287,738 -896,007 -488,798 -9,145 -60,340 -608,588 -558,604 -269,493 -135,873 -347,690 -694,044 -557,624 -180,959 -567,616 -368,671 -468,244 -322,459 -36,912 -288,121 -152,022 0 0 0 0 0 0 15,595 -145,457 -238 -186,386 0 -16,349   -105,548 -10,751 -29,863 -45,808 -5,314 -73,623 -23,305 -27,455 0 -92,901 -23,555 -92,901 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0  0 0 -18,322 -26,992 
          free cash flows
        		-34,376,600 -25,231,616 -19,744,630 -20,409,949 -7,329,527 -15,285,127 -11,651,619 -12,348,839 -1,877,028 -12,152,656 -9,064,322 -9,553,623 3,862,396 -7,596,096 -6,243,230 -6,723,230 23,478,950 -5,996,254 -3,806,172 -4,836,902 -3,366,282 -4,130,518 -3,129,595 -2,016,684 -1,218,156 -1,785,032 -1,651,376 -1,777,395 -1,607,698 -3,755,621 -3,127,460 -3,691,651 -3,604,195 -2,667,297 -3,205,986   -4,328,563 -2,524,410 -4,913,556 -4,227,061 -3,647,974 -3,318,202 -1,901,348 -2,079,459 -2,146,340 11,250,093 -6,039,682 11,250,093 -5,785,813 -158,177 -55,827 -144,184 -235,791 -494,675 -852,755 -603,460 -1,568,660 -652,499 -1,167,632 -1,260,501 -1,055,473 -1,133,792 -966,675 -1,162,324 -1,122,601 -953,153 -1,828,991  -1,848,182 -2,975,850 -3,292,940 -2,568,386 
          cash flows from investing activities:
        		                                                                         
          purchase of marketable securities
        		-174,893,062 -14,999,760 -58,214,848 -59,996,190 -18,181,600 -139,363,857 -19,793,658 -16,072,950 -33,210,697 -24,775,685 -19,801,965 -18,060,276 -34,803,580 -32,043,384 -33,163,300       0 0 0 -6,130,193 -5,986,807 0 0 -15,243 -3,010,844 -5,997,118 -6,001,744 -3,001,871 -7,983,923 -4,998,054 -2,007,934 -3,996,283 -12,987,934 -2,503,855 0 -2,505,572 -2,129 -2,499,666 0 -15,487,830  -226,998 -99,926 -226,998                         
          proceeds from sales and maturities of marketable securities
        		30,998,448 63,212,777 78,175,291 75,995,248 43,212,559 16,716,932 21,857,337 30,849,000 24,373,000 19,642,249 28,155,000 24,755,000 32,045,000 38,408,000 30,085,961       0 0 0 12,117,000 0 0 0 3,000,000 6,000,000 6,000,000 6,000,000 5,000,000 5,000,000 4,000,000 7,000,000 8,000,000 2,500,000 2,500,000 0 8,000,000 5,000,000    326,925 227,842 99,891 227,842                         
          purchases of property and equipment
        		-5,121,709 -1,664,873 -55,843 -287,738 -896,007 -488,798 -9,145 -60,340 -608,588 -558,604 -269,493 -135,873 -347,690 -694,044 -557,624 -180,959 -567,616 -368,671 -468,244 -322,459 -36,912 -288,121 -152,022       15,595 -145,457 -238 -186,386 0 -16,349 -12,710 -3,126 -105,548 -10,751 -29,863 -45,808 -5,314 -73,623 -23,305 -27,455                             
          payments for leasehold improvements
        		-921,752 0 -8,531 -130,729 -244,279 -245,924 -49,885 -20,566 -55,729 -170,618 -362,260 -97,570 -105,425 -528,456 -541,687 -231,601 -57,744                     0 0   0 -12,057 0 -9,473                             
          payments for construction in progress
        		-4,703,521 -3,459,884 -3,945,048                                                                       
          net cash from investing activities
        		-154,641,596 43,088,260 15,951,021 14,549,327 23,890,673 -123,381,647 2,004,649 14,695,144 -9,502,014 -5,862,658 7,721,282 6,461,281 -3,211,695 5,142,116 -4,176,650 -35,412,613 -625,360 -368,671 -468,244 -322,459 -36,912 -288,121 -152,022 -107,458 5,986,807 -5,986,807 0 0 2,984,757 3,004,751 -142,575 -1,982 1,811,743 -2,983,923 -1,014,403   -10,593,482 -14,606 -31,632 5,448,620 4,992,557 2,414,654 -23,305 -15,524,758 375,437 -94,314 -68,987 -94,314                 257 -23,659 -8,085 -2,739 -14,954 -7,981 -37,201 -32,494 
          cash flows from financing activities:
        		                                                                         
          proceeds from exercise of stock options
        		1,470,659                                                                         
          net cash from financing activities
        		1,470,659 248,815,412 6,950 19,580 50,354 81,087,570 67,326,864 2,067,071 2,290,244 23,166,900 221,081 2,188,074 3,895 2,949,525 1,881,842 15,006 27,465 42,370 6,567,366 1,035,312 12,579,962 1,496,052 2,177,312 25,159,284 4,549,502 4,610,794 2,587,983 545,718 1,433,287 512,047 1,053,400 2,775,399 2,512,618 3,026,095 4,621,836   0 11,698,011 2,000,000 4,930,781 0 10,074 388 16,481,217 233 933 4,688,150 933 3,542,566 0 0 382,500 0 0   2,501 0 2,303,606 6,207 0 6,207   73,879        
          net increase in cash and cash equivalents
        		-182,425,828 268,336,929 -3,730,816 -5,553,304 17,507,507 -57,090,406 57,689,039 4,473,716 -8,480,210   -768,395 1,002,286 1,189,589 -7,980,414 -41,939,878 23,448,671 -5,953,884 2,761,194 -3,801,590 9,213,680                  9,169,746 -2,915,325 6,198,148 1,349,897 -819,851 -1,900,960 -1,095,545  11,249,613  11,249,613 1,535,119 -158,177 -55,827 238,316 -235,791 -494,675 341,452 -603,460 -1,568,146 -652,499 1,135,974 -1,254,294 -1,057,678 -1,127,585 3,550,024 -1,162,324 -1,048,465 2,453,957 -1,837,076 -1,893,488 -1,863,136 -2,983,831 -3,311,819 -2,573,888 
          cash and cash equivalents balance at beginning of period
        		287,847,312 0 0 0 11,286,996 0 0 0 14,694,857 0 0 0 9,603,242 0 0 0 34,885,274 0 0 0 32,665,874                 0 0 0 5,568,306 0 0 0 8,034,765 0 1,729,537 0 1,729,537                         
          cash and cash equivalents balance at end of period
        		105,421,484 268,336,929 -3,730,816 -5,553,304 28,794,503 -57,090,406 57,689,039 4,473,716 6,214,647 5,710,190 -852,466 -768,395 10,605,528 1,189,589 -7,980,414 -41,939,878 58,333,945 -5,953,884 2,761,194 -3,801,590 41,879,554                 -14,816,497 9,169,746 -2,915,325 11,766,454 1,349,897 -819,851 -1,900,960 6,939,220 -1,770,670 12,979,150 -1,396,964 12,979,150                         
          supplemental disclosures of cash flow information:
        		                                                                         
          interest paid in cash
        		                                     0 0                                   
          income taxes paid in cash
        		                                                                         
          loss on disposal of fixed assets
        		 0 6,846 0 150,673     653                                                                
          non-cash interest expense on cirm liability
        		                                                                         
          deferred revenue
        		     -1,130,509 -2,261,642 -3,971,438 -4,906,876 -2,088,089 -6,185,814 -3,917,467 9,013,304 -959,903 -1,591,566 0 30,000,000                 0 0 -683,592 -683,594 -683,595 -683,595 -911,457 -911,459 -911,458 -911,458 -911,458 -1,041,667 -1,041,666 11,458,333 -1,041,667 11,458,333                         
          net proceeds from sale of common stock
        		     80,839,614 67,205,869 1,985,849 2,290,244 23,163,873 221,081   2,923,210    -1,543 6,562,153 1,035,312 12,578,526 1,434,800 1,952,820 19,495,239 4,460,210 4,610,344 2,587,983 543,139 1,433,287 512,047 1,053,400 2,775,399 2,373,478 2,769,455 4,621,836   0 9,935,022 0 3,929,795 0 0 0 16,446,218                             
          proceeds from exercise of stock awards and warrants
        		 11,781,474 6,950 19,580 50,354 247,956                                                                    
          initial recognition of right-of-use asset
        		 0                                                                        
          prepaid expenses and other current assets
        		  -966,329 111,096 87,147  452,153 288,626 -130,068 -537,359 125,418 291,257 44,800 -576,208 315,585 283,977 216,691 -881,028 374,427 83,022 274,851 -837,023 75,690 184,099 137,407 -442,221 246,258 50,524 298,241 -297,762 -38,304 134,228 -21,182 -310,886 49,053 158,844 -55,283 -224,667 121,038 82,158 -110,818 -118,127 38,248 72,260 32,539 -130,236 53,184 46,518 53,184 -248,554 29,763 52,655 4,519 30,930 8,823 55,722 50,911 149,355 -40,776 -152,054 -8,728 84,981 -66,889 45,758 -25,213 73,961 -146,325 153,206 206,260 96,413 -225,303 -31,390 141,749 
          other assets
        		    -31,674  312 -25,836 -25,550     0 0   12,979    0 -6,255 24,934 12,228 5,006 4,101 4,101 18,972 5,514 49,770 -49,285 -61,818 -34,573 -230   0 130 9,590 -1,000 63,055 -63,746 0 -14,135                             
          proceeds from exercise of stock awards
        		         3,027 0 57,679 3,895 26,315 1,518 15,006 27,465                                                         
          accounts payable and accrued expenses, related party
        		         7,302 1,550 -89 -70,518 5,078 -9,979 -480,713 -24,540        6,314 9,201 -33,098 8,146 -68,300 -25,981 18,677 44,109 -104,863 74,521 -211,287 201,394 -379,421 -209,965 152,457 75,856 118,535 -227,323 40,936 -93,978 198,987 91,002 99,501 18,452 99,501                         
          net decrease in cash and cash equivalents
        		                                                                         
          forgiveness of debt
        		                 0 0                                                       
          non-cash lease expense
        		                158,086                                                         
          change in assets - decrease:
        		                                                                         
          change in liabilities - increase:
        		                                                                         
          operating lease liabilities
        		                -85,352                                                         
          proceeds from note payable
        		                     0 0                                                   
          proceeds from exercise of warrants
        		                                                                         
          supplemental disclosures:
        		                                                                         
          proceeds from stock options
        		                   0 1,436 0 30,706   0 0   0 0 0 139,140                                         
          loss on disposal of fixed asset
        		                         0 0                                               
          repurchase of fractional shares pursuant to reverse stock split
        		                         0 0                                               
          proceeds from exercise of pre-funded common stock warrants and warrants
        		                      193,786 5,344,188 89,292                                                 
          net increase in cash, cash equivalents, and restricted cash
        		                      -952,283    936,607   -254,418 -2,071,178 -917,996 906,552                                         
          cash, cash equivalents, and restricted cash balance at beginning of period
        		                      0 0 3,899,328 0 0 0 4,545,097 0 0 0 6,882,137 0 0 0 4,551,603                                     
          cash, cash equivalents, and restricted cash balance at end of period
        		                      -952,283 23,035,142 13,217,481 -3,161,045 936,607 -1,231,677 7,355,443 -254,418 -2,071,178 -917,996 7,788,689 -2,625,125 417,796 5,213,163 3,876,303                                     
          net decrease in cash, cash equivalents,
        		                                                                         
          and restricted cash
        		                        9,318,153    2,810,346       5,213,163 -675,300                                     
          proceeds from exercise of pre-funded common stock warrants
        		                                                                         
          net increase in cash, cash equivalents,
        		                                                                         
          net income
        		                                              -1,210,611                           
          adjustments to reconcile net income to net cash from operating activities:
        		                                                                         
          forgiveness of loan payable
        		                                                                         
          accrued interest
        		                                 80,307 107,653 105,527 105,320 102,905 98,749 76,663 65,789 61,681 61,681 61,655 61,707 60,383 25,327 54,704 25,327                         
          cirm liability
        		                                     1,100,000                                    
          proceeds from loan payable
        		                                 250,000 0   0 1,750,000 2,000,000 1,000,000     0                            
          non-cash impairment
        		                                                                         
          proceeds from stock awards, warrants, and options
        		                                     0 12,989 0 986  10,074 388 34,999                             
          change in liabilities - increase
        		                                                                         
          net cash used in operating activities
        		                                    -4,675,891                                     
          net cash provided by investing activities
        		                                    4,000,591                                     
          net cash provided by financing activities
        		                                                                         
          restricted cash
        		                                     -745,040    0 599,582 1,448,348 929,094 722,636 846,627 -3,823,068 846,627                         
          proceeds from stock awards, warrants and options
        		                                                                         
          other investing activities
        		                                                                         
          grants receivable
        		                                           366,227 -386,002 -100,433                            
          adjustments to reconcile net loss to net cash from (used in) operating activities:
        		                                                                         
          adjustments to reconcile net loss to net cash from
        		                                                                         
          operating activities:
        		                                                                         
          impairment of goodwill
        		                                                                         
          proceeds from stock options and awards
        		                                             233                            
          net increase in cash and
        		                                                                         
          cash equivalents
        		                                             -1,770,670                            
          interest receivable
        		                                              -570 527 -570                         
          deposits
        		                                                                         
          sub-award payable, related party
        		                                              -41,855 0 -41,855                         
          accrued royalties
        		                                              9,963 9,764 9,963                         
          payments for purchase of property and equipment
        		                                              -92,901 -23,555 -92,901                         
          purchase of leasehold improvements
        		                                                                         
          payments for patents
        		                                              -2,257 -21,653 -2,257                         
          proceeds from sale of common stock
        		                                                                         
          gain on sale of property and equipment
        		                                                                         
          common stock issued for services
        		                                                                         
          change in assets - increase:
        		                                                                         
          proceeds from sale of property and equipment
        		                                                                         
          proceeds from reverse merger
        		                                                                         
          proceeds from the sale of series a-1 preferred stock
        		                                                                         
          proceeds from the sale of series a-2 preferred stock
        		                                                                         
          proceeds from the sale of series a-3 preferred stock
        		                                                                         
          proceeds from stock option exercises
        		                                              933 1,536 933                         
          costs related to the issuance of preferred stock and warrants
        		                                                                         
          cash flows from operating activities
        		                                                                         
          adjustment to reconcile net loss to net cash from operating activities
        		                                                                         
          conversion of warrants to common stock
        		                                                                         
          warrant liability
        		                                                  -12,094 103,245 142,058 -117,466 -10,013                   
          write-off of intangible assets
        		                                                             0 0 0 106,830         
          warrants issued in connection with note conversion
        		                                                                         
          note discount arising from beneficial conversion feature
        		                                                                         
          loss on disposal of assets
        		                                                  0 0 1,307             0    0 0   
          noncash interest expense
        		                                                  60,632 74,046 13,018                     
          changes in operating assets and liabilities
        		                                                                         
          other non-current assets
        		                                                  0 5,333 42,070               -142 -327     
          accounts payable
        		                                                  -58,332 148,226 66,435 -27,134 88,331 -205,435 -110,683 -66,496 266,573 -241,099 146,479 -259,173 437,525 -10,517 13,917 -154,992 105,333 -252,804 -285,804 180,373 -137,383 -119,946 157,078 
          accrued expenses and other current liabilities
        		                                                  151,591 144,092 70,275 62,901 -39,861 48,986 -4,816 -112,599 16,174 -20,132 -471,000 -185,682 -78,851 267,603 246,433 -54,856 297,962 -162,545 -264,045 230,742 55,159 -31,648 -583,416 
          due to related party
        		                                                  4,800 6,600 -9,539 8,073 -28,382 -61,843 59,399 2,725 -1,204 -46,231 -828 9,192 -3,664 3,440 -8,692 2,493 1,224 77,325 -3,588 2,588    
          cash flows from investing activities
        		                                                                         
          purchase of property and equipment
        		                                                                 0    0 0 -18,322 -26,992 
          proceeds from sale of assets
        		                                                                 0        
          cash paid for intangible assets
        		                                                                 257 -21,737 -8,085 -2,739 -14,954 -7,981 -18,879 -5,502 
          cash flows from financing activities
        		                                                                         
          proceeds from issuance of notes payable
        		                                                  0 0 382,500                     
          repayment of notes payable
        		                                                                         
          proceeds from exercise of stock options and warrants
        		                                                         2,501 0 5,040 6,207 0    73,879        
          proceeds from sale of common stock to founders
        		                                                                         
          proceeds from sale of common stock in private placement
        		                                                     0 0   0 0   0 0   0        
          cash and cash equivalents at beginning of period
        		                                                  0 0 46,716 0 0 0 1,039,190 0 0 0 3,378,155 0 0 0 3,175,718 0 0 0 5,500,790 0 0 0 16,233,464 
          cash and cash equivalents at end of period
        		                                                  -158,177 -55,827 285,032 -235,791 -494,675 341,452 435,730 -1,568,146 -652,499 1,135,974 2,123,861 -1,057,678 -1,127,585 3,550,024 2,013,394 -1,048,465 2,453,957 -1,837,076 3,607,302 -1,863,136 -2,983,831 -3,311,819 13,659,576 
          supplemental schedule of cash flows information:
        		                                                                         
          cash paid for interest
        		                                                                         
          supplemental schedule of non-cash investing and financing activities:
        		                                                                         
          warrants issued in satisfaction of accrued liability
        		                                                                         
          warrants issued to placement agent and investors in connection with private placements
        		                                                                         
          warrants issued to investors in connection with registered direct offering
        		                                                     0                    
          conversion of notes payable and interest to common stock
        		                                                                         
          common shares of smi issued in reverse merger transaction
        		                                                                         
          adjustment to reconcile net loss to net cash used
        		                                                                         
          in operating activities
        		                                                                         
          warrants issued to investors in connection with offering
        		                                                                         
          warrants issued to placement agent and investors, in connection with private placement
        		                                                         0    0    0        
          adjustment to reconcile net loss to net cash used in operating activities
        		                                                                         
          warrants issued in sastisfaction of accrued liability
        		                                                                     0    
          warrants issued to placement agents and investors, in connection with financings
        		                                                                         
          warrants issued to placement agent and investors, in connection with public offering
        		                                                                         
          other noncurrent assets
        		                                                                      -486 13,245 -104,868 
          accrued lease obligation
        		                                                                        138,507 
          adjustments to reconcile net loss to net cash from operating activities
        		                                                                         
          warrants issued to noteholders
        		                                                                         
          note discount due to beneficial conversion feature
        		                                                                         
          non-cash interest expense
        		                                                                         
          non cash interest expense
        		                                                                         
          due to related parties
        		                                                                       -89,097 -222,825 
          warrants issued in settlement of accrued liability
        		                                                                        334,992