Avadel Pharmaceuticals plc
(NASDAQ:AVDL)

Avadel Pharmaceuticals plc operates as a biopharmaceutical company in the United States. The company's lead product candidate is FT218, a formulation of sodium oxybate which is in a Phase 3 clinical trial for the treatment excessive daytime sleepiness (EDS) and cataplexy in adults with narcolepsy. T...

Website: http://www.avadel.com

Founded: 1990

Full Time Employees: 50

Sector: Healthcare

Industry: Drug Manufacturers-Specialty & Generic

Pharmaceuticals

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Quarterly

Annual

Unit: USD	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-11-12	2015-10-13	2015-07-10	2014-12-31	2014-11-17	2014-11-12	2014-08-07	2014-08-04	2014-07-08	2014-05-20	2014-04-10	2014-03-06	2014-01-15	2013-12-31	2013-12-06	2013-11-08	2013-09-19	2013-08-02	2013-05-16	2013-03-01	2012-12-31	2012-12-14	2012-11-26	2012-09-13	2012-07-27	2012-05-07	2012-03-15	2011-12-31	2011-12-23	2011-11-22	2011-11-02	2011-07-29	2011-07-25	2011-05-09	2011-03-04	2011-01-21	2010-12-31	2010-11-04	2010-10-13	2010-07-28	2010-06-18	2010-05-05	2010-03-08	2010-01-15	2009-12-31	2009-11-16	2009-09-25	2009-08-05	2009-06-12	2009-05-11	2009-03-04	2009-01-09	2008-12-31	2008-11-03	2008-09-17	2008-08-06	2008-06-18	2008-05-14	2008-03-03	2008-01-08	2007-12-31	2007-09-04	2007-08-02	2007-05-31	2007-05-14	2007-03-14	2006-12-31	2006-12-07	2006-11-06	2006-10-31	2006-08-11	2006-06-14	2006-05-16	2006-03-07	2005-12-31	2005-11-23	2005-09-09	2005-07-29	2005-07-25	2005-05-06	2004-12-31	2004-12-30	2004-07-01	2004-05-28	2003-12-31	2003-09-30	2003-07-01	2003-04-30	2003-03-31	2002-10-25

net product revenue	77,467,000	68,129,000	52,511,000	50,410,000	50,025,000	41,504,000	27,178,000	19,453,000	7,014,000	1,496,000										-22,311,666		10,091,000	12,243,000	10,995	14,229	17,554	16,437,000	-82,174,418	19,826,000	29,116,000	33,161,000
yoy	54.86%	64.15%	93.21%	159.14%	613.22%	2674.33%											NaN%	NaN%	NaN%	-203025.57%	NaN%	57385.47%	-25.52%	-100.01%	-99.93%	-99.94%	-50.43%
qoq	13.71%	29.74%	4.17%	0.77%	20.53%	52.71%	39.71%	177.35%	368.85%								NaN%	NaN%	NaN%	NaN%	NaN%	-17.58%	111250.61%	-22.73%	-18.94%	-99.89%	-120.00%	-514.48%	-31.91%	-12.20%
cost of products sold	-4,116,000	6,366,000	5,577,000	4,812,000	6,155,000	2,788,000	1,522,000	693,000	117,000	36,000										-5,736,258		3,285,000	2,457,000	2,414	2,823	3,622	3,266,000	-13,222,785	3,120,000	3,512,000	6,592,000
gross profit	81,583,000	61,763,000	46,934,000	45,598,000	43,870,000	38,716,000	25,656,000	18,760,000	6,897,000	1,460,000
yoy	85.97%	59.53%	82.94%	143.06%	536.07%	2551.78%
qoq	32.09%	31.60%	2.93%	3.94%	13.31%	50.90%	36.76%	172.00%	372.40%
gross margin %	105.31%	90.66%	89.38%	90.45%	87.70%	93.28%	94.40%	96.44%	98.33%	97.59%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	0%	NaN%	0%	0%	0%	0%	0%	0%	0%	0%	0%	0%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%
operating expenses:
research and development expenses	27,010,000	4,255,000	4,354,000	4,274,000	3,803,000	4,051,000	3,068,000	-18,341,000	2,849,000	4,223,000	3,830,000	6,235,000	2,933,000	4,541,000	6,991,000	-14,976,896	4,380,000	6,762,000	3,852,000	-15,135,558	5,569,000	4,057,000	5,530,000	7,757	7,539	10,292	7,329,000	-33,237,089	11,402,000	11,890,000	9,951,000	-22,094,193	8,095,000	6,792,000	7,206,000	5,283,750	8,143,000	7,604,000	5,388,000
selling, general and administrative expenses	52,636,000	48,624,000	45,581,000	44,621,000	40,394,000	47,406,000	48,623,000	-33,215,000	39,158,000	46,778,000	24,468,000	16,981,000	14,096,000	21,804,000	21,635,000	-47,400,505	21,283,000	15,174,000	11,012,000	-23,398,595	8,423,000	7,095,000	7,913,000	7,663	5,316	6,758	10,446,000	-77,117,501	24,829,000	27,843,000	24,487,000	-35,789,319	11,563,000	12,429,000	11,812,000	8,372,750	12,740,000	11,290,000	9,461,000
total operating expense	79,646,000	52,879,000	49,935,000	36,836,000	44,197,000	51,457,000	51,691,000	30,326,500	42,007,000	51,001,000	28,298,000	18,880,750	16,960,000	29,937,000	28,626,000	15,602,500	25,663,000	21,936,000	14,811,000	564,750	13,697,000	-30,178,000
operating income	1,937,000	8,884,000	-3,001,000	-3,297,000	-327,000	-12,741,000	-26,035,000	73,661,000	-35,110,000	-49,541,000	-28,298,000	-23,038,000	-16,960,000	-29,937,000	-28,626,000	62,324,454	-25,663,000	-21,936,000	-14,811,000	-20,069,185	-13,697,000	40,269,000	-6,497,000	-7,347	-4,147	-4,451	-8,167,000	29,310,569	-14,095,000	-2,785,000	-12,625,000	-93,490,530	26,118,000	34,126,000	33,341,000	21,953,277	-16,190,000	-11,543,000	5,542,000
yoy	-692.35%	-169.73%	-88.47%	-104.48%	-99.07%	-74.28%	-8.00%	-419.74%	107.02%	65.48%	-1.15%	-136.96%	-33.91%	36.47%	93.28%	-410.55%	87.36%	-154.47%	127.97%	273061.63%	330186.95%	-904818.04%	-20.45%	-100.03%	-99.97%	-99.84%	-35.31%	-131.35%	-153.97%	-108.16%	-137.87%	-525.86%	-261.32%	-395.64%	501.61%
qoq	-78.20%	-396.03%	-8.98%	908.26%	-97.43%	-51.06%	-135.34%	-309.80%	-29.13%	75.07%	22.83%	35.84%	-43.35%	4.58%	-145.93%	-342.86%	16.99%	48.11%	-26.20%	46.52%	-134.01%	-719.81%	88330.65%	77.16%	-6.83%	-99.95%	-127.86%	-307.95%	406.10%	-77.94%	-86.50%	-457.95%	-23.47%	2.35%	51.87%	-235.60%	40.26%	-308.28%
operating margin %	2.50%	13.04%	-5.71%	-6.54%	-0.65%	-30.70%	-95.79%	378.66%	-500.57%	-3311.56%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	Infinity%	NaN%	NaN%	NaN%	89.95%	NaN%	399.06%	-53.07%	-66.82%	-29.14%	-25.36%	-49.69%	-35.67%	-71.09%	-9.57%	-38.07%	-Infinity%	Infinity%	Infinity%	Infinity%	Infinity%	-Infinity%	-Infinity%	Infinity%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%
investment and other income	532,000	-34,000	397,000	1,036,000	610,000	1,126,000	1,378,000	-1,096,000	903,000	623,000	193,000	-1,039,000	448,000	192,000	-137,000	-1,528,874	489,000	432,000	610,000	905,168	213,000	-741,000	-378,000	-1,479	781	950	817,000	-846,684	208,000	583,000
interest expense	-2,415,000	-2,355,000	-2,238,000	-2,702,000	-2,820,000	-2,716,000	-2,592,000	9,988,000	-1,978,000	-2,295,000	-3,259,000	-3,255,000	-3,564,000	-3,506,000	-2,017,000	5,778,058	-1,929,000	-1,930,000	-1,929,000	9,673,006	-3,259,000	-3,237,000	-3,190,000	-3,190	-3,125	-3,106	-3,062,000	7,586,570	-3,000,000	-2,980,000	-1,597,000	789,089	-263,000	-263,000	-263,000	702,963	-264,000	-263,000	-175,000		-237,000	-341,000	-141,000
income before income taxes	54,000	6,495,000	-4,842,000	-4,963,000	-2,537,000	-14,331,000	-27,249,000	82,553,000	-36,185,000	-64,342,000	-31,364,000	-27,365,000	-20,076,000	-33,251,000	-30,747,000	66,407,855	-27,103,000	-23,346,000	-16,052,000	-9,053,082	-16,743,000	36,166,000	-10,375,000	-11,736	-6,630	-6,824	-13,392,000	34,599,143	-16,462,000	-3,780,000	-14,563,000	-98,243,622	27,600,000	36,297,000	34,449,000	27,710,577	-16,543,000	-12,509,000	765,000				22,120,000	-30,021,000	-10,075,000	-10,075,000	-20,800,000	-20,800,000	-29,435,000	-29,435,000	354,000	354,000	-7,597,000		-36,562,000	-7,597,000	-10,291,000	-36,562,000	-10,291,000	4,405,000		-5,916,000	-6,473,000	54,000	-3,396,000	-4,620,000	-2,032,000	-2,032,000	1,750,000	-3,396,000		-4,904,000	-3,396,000		2,787,000	-3,315,000	2,787,000		-4,337,000					-5,156,000	-2,641,500		-5,134,000	-5,134,000	-276,000	-276,000		-3,961,000	-4,679,000		-5,326,000	-5,326,000	-4,596,000		-7,197,000	-9,066,000		-13,601,000	-13,601,000	-9,075,000	-9,075,000		-8,009,000	-29,310,000			-19,095,000	-9,636,000	-9,636,000	-10,834,000	-10,834,000	-20,829,000	-8,947,000		378,000	378,000
income tax provision	34,000		78,000	-81,750	88,000	-509,000	93,000	-26,125,000	89,000	90,000		6,485,000	70,000	30,193,000						-2,314,500	-5,040,000	5,292,000										-21,837,169	5,921,000	7,370,000	8,539,000	4,553,000	3,451,000	7,449,000	7,141,000
net income	20,000	9,665,000	-4,920,000	-5,043,000	-2,625,000	-13,822,000	-27,342,000	108,678,000	-36,274,000	-64,432,000	-30,784,000	-27,450,000	-20,146,000	-63,444,000	-26,424,000	54,950,671	-22,002,000	-19,581,000	-13,445,000	-18,298,972	-11,703,000	30,874,000	-865,000	-2,739	-8,864	-8,605	-13,018,000	31,281,425	-15,771,000	-3,438,000	-12,236,000	-76,406,453	21,679,000	28,927,000	25,910,000	45,926,926	-19,994,000	-19,958,000	-6,376,000		-29,685,000	-17,400,000	11,647,000	-27,149,000	-10,046,000	-10,046,000	-21,073,000	-21,073,000	-26,638,000	-26,638,000	5,126,000	5,126,000	6,369,000		-32,854,000	-6,369,000	-8,829,000	-32,854,000	-8,829,000	9,101,000		-5,917,000	-6,425,000	12,000	-3,459,000	-4,662,000	-2,091,000	-2,091,000	1,703,000	-3,459,000		-4,927,000	-3,459,000		2,678,000	-3,339,000	2,678,000		-4,290,000		-4,024,000	-4,024,000	-5,697,000	-3,382,000	-5,697,000		-3,550,000	-3,550,000	1,190,000	1,190,000		-2,304,000	-2,726,000		-3,358,000	-3,358,000	-3,696,000		-5,445,000	-9,106,000		-13,633,000	-13,633,000	-9,061,000	-9,061,000		-64,545,000	29,344,000	11,884,000		-19,129,000	-9,661,000	-9,661,000	-6,448,000	-6,448,000	-20,929,000	-9,045,000		185,000	185,000
yoy	-100.76%	-169.92%	-82.01%	-104.64%	-92.76%	-78.55%	-11.18%	-495.91%	80.06%	1.56%	16.50%	-149.95%	-8.44%	224.01%	96.53%	-400.29%	88.00%	-163.42%	1454.34%	667989.52%	131928.43%	-358891.40%	-93.36%	-100.01%	-99.94%	-99.75%	6.39%	-140.94%	-172.75%	-111.89%	-147.23%	-266.37%	-208.43%	-244.94%	-506.37%		-32.65%	14.70%	-154.74%		195.49%	73.20%	-155.27%	28.83%	-62.29%	-62.29%	-511.10%	-511.10%	-518.24%		-115.60%	-180.48%	-172.14%		272.11%	-169.98%		455.25%	37.42%	75741.67%		26.92%	207.27%	-100.57%	-303.11%	34.78%		-57.56%	-149.23%			47.56%	-229.16%		-162.42%		-166.55%		-24.70%		-29.37%		60.48%	-4.73%	-578.74%			54.08%	-143.65%			-31.39%	-26.24%		-38.33%	-63.12%			-60.06%	0.50%			-78.88%	-130.88%	-176.25%		237.42%	-403.74%	-223.01%		196.67%	-53.84%	6.81%		-3585.41%	-11412.97%
qoq	-99.79%	-296.44%	-2.44%	92.11%	-81.01%	-49.45%	-125.16%	-399.60%	-43.70%	109.30%	12.15%	36.26%	-68.25%	140.10%	-148.09%	-349.75%	12.36%	45.64%	-26.53%	56.36%	-137.91%	-3669.25%	31480.87%	-69.10%	3.01%	-99.93%	-141.62%	-298.35%	358.73%	-71.90%	-83.99%	-452.44%	-25.06%	11.64%	-43.58%	-329.70%	0.18%	213.02%			70.60%	-249.39%	-142.90%	170.25%	0.00%	-52.33%	0.00%	-20.89%	0.00%	-619.66%	0.00%	-19.52%			415.84%	-27.86%	-73.13%	272.11%	-197.01%			-7.91%	-53641.67%	-100.35%	-25.80%	122.96%	0.00%	-222.78%	-149.23%			42.44%			-180.20%	-224.68%					0.00%	-29.37%	68.45%	-40.64%			0.00%	-398.32%	0.00%			-15.48%			0.00%	-9.15%			-40.20%			0.00%	50.46%	0.00%			-319.96%	146.92%			98.00%	0.00%	49.83%	0.00%	-69.19%	131.39%			0.00%
net income margin %	0.03%	14.19%	-9.37%	-10.00%	-5.25%	-33.30%	-100.60%	558.67%	-517.17%	-4306.95%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	Infinity%	NaN%	NaN%	NaN%	82.02%	NaN%	305.96%	-7.07%	-24.91%	-62.30%	-49.02%	-79.20%	-38.07%	-79.55%	-11.81%	-36.90%	-Infinity%	Infinity%	Infinity%	Infinity%	Infinity%	-Infinity%	-Infinity%	-Infinity%	NaN%	-Infinity%	-Infinity%	Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	Infinity%	Infinity%	Infinity%	NaN%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	Infinity%	NaN%	-Infinity%	-Infinity%	Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	Infinity%	-Infinity%	NaN%	-Infinity%	-Infinity%	NaN%	Infinity%	-Infinity%	Infinity%	NaN%	-Infinity%	NaN%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	NaN%	-Infinity%	-Infinity%	Infinity%	Infinity%	NaN%	-Infinity%	-Infinity%	NaN%	-Infinity%	-Infinity%	-Infinity%	NaN%	-Infinity%	-Infinity%	NaN%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	NaN%	-Infinity%	Infinity%	Infinity%	NaN%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	-Infinity%	NaN%	Infinity%	Infinity%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%	NaN%
net income per share		0.1	-0.05	-0.05	-0.03	-0.14	-0.3	2	-0.41	-0.83	-0.48	-0.44	-0.33	-1.07	-0.45	-0.38	-0.38	-0.33	-0.23	-0.23	-0.2	0.57	-0.02	-0.07	-0.24	-0.23	-0.35	-3.34	-0.43	-0.09	-0.32	0.76	0.54	0.7	0.63	-0.28	-0.48	-0.48	-0.15
weighted-average number of shares outstanding - basic	97,104	96,726	96,601	95,141	96,300	96,151	91,693		89,380	77,246	63,886	60,094	60,201	59,037	58,824		58,585	58,488	58,443		58,213	54,272	41,057		37,436	37,356	37,354		36,904	36,772	38,559		40,061	41,091	41,374		41,241	41,241	41,241
weighted-average number of shares outstanding - diluted	101,276	99,087	96,601	95,141	96,300	96,151	91,693		89,380	77,246	63,886	60,094	60,201	59,037	58,824		58,585	58,488	58,443		58,213	69,942	41,057		37,436	37,356	37,354		36,904	36,772	38,559		41,339	42,487	42,810		41,241	41,241	41,241
income tax benefit		-3,170,000									-580,000				-4,323,000	11,457,184	-5,101,000		-2,607,000				-9,510,000	-8,997	2,234	1,781	-374,000	3,317,718	-691,000	-342,000	-2,327,000										-8,919,000	-10,242,000	-10,473,000	638,250	29,000	29,000	-273,000	-273,000	2,797,000	2,797,000	4,772,000	4,772,000	1,228,000		3,708,000	1,228,000		3,708,000	1,462,000	4,696,000			48,000		-63,000	-42,000		-33,250	-47,000	-63,000			-63,000									-123,000		1,774,000	1,206,000		1,584,000	1,584,000	1,466,000	1,466,000		1,657,000	1,953,000		1,968,000	1,968,000	900,000		1,752,000	-40,000		-32,000	-32,000		14,000								-25,000	4,386,000	4,386,000	-100,000	-98,000		-193,000	-193,000	3,224,000	-23,000	-23,000	-23,000			-21,000		564,000
loss on extinguishment of debt										-13,129,000
restructuring expense												880,750	-69,000	3,592,000
gain from release of certain liabilities												8,250			33,000	-165,783		88,000	78,000
restructuring income																52,947
intangible asset amortization																				-405,594		203,000	203,000	206	205	204	201,000	-4,993,040	1,620,000	1,609,000	1,767,000	-1,702,229	564,000	564,000	564,000	-10,916,676	3,702,000	3,702,000	3,514,000
changes in fair value of contingent consideration																				-3,323,673	-69,000	918,000	2,478,000
gain on sale of hospital products																				45,714,240
other expense - changes in fair value of contingent consideration payable																				434,565		-125,000
restructuring costs																						24,000	159,000	1,841	1,866	1,506	1,228,000	-269,526	65,000	50,000	153,000			1,069,000	2,653,000
income tax expense																		-3,765,000																																																	-59,000								-109,000																													14,000			-8,500	-34,000			-34,000	-25,000													-5,000	-20,000
restructuring (income) costs																			-53,000	42,957	-226,000											793,250	-549,000
loss on deconsolidation of subsidiary																								162		-167	-2,673,000
gain on sale of hospital business																						-45,760,000
total operating expenses																							18,740,000	18,342	18,376	22,005	24,604,000	-111,729,545	33,921,000	32,015,000	45,918,000	-44,979,471	13,557,000	12,185,000	19,166,000
other income - changes in fair value of contingent consideration payable																							-310,000
revenues:
license revenue																												-244,558		114,000	132,000
total revenues																								10,995	14,229	17,554	16,437,000	-82,418,976	19,826,000	29,230,000	33,293,000																																																																																																		4,970,000
changes in fair value of related party contingent consideration																								-1,539	627	-377	2,134,000							-13,230,000	-6,971,000	-52,970,672	20,848,000	23,898,000
other income - changes in fair value of related party payable																								118	-139	-50	-307,000	-1,431,828	425,000	1,402,000	-395,000	-2,996,619	768,000	1,670,000	550,000	6,136,665	-1,828,000	-2,773,000
gain - changes in fair value of related party contingent consideration																												-4,259,000	-7,115,000	-12,889,000	2,968,000
investment income and other income																															54,000
product sales and services																																-137,983,381	39,147,000	47,105,000	51,757,000	-104,883,066	31,340,000	38,165,000	35,353,000		47,314,000	49,765,000	32,711,000	-2,895,000	4,747,000	4,747,000	4,128,000	4,128,000	5,940,000	5,940,000	2,150,000	2,149,000	2,501,000		2,195,000	2,500,000	2,107,000	2,195,000	2,107,000	2,163,000		2,053,000	2,063,000	3,378,000	2,290,000	3,350,000	4,242,000	4,242,000	5,239,000	2,290,000		1,624,000	2,290,000		2,210,000	1,805,000	2,210,000		1,860,000	1,860,000	2,305,000	2,305,000	4,269,000	2,651,000	4,269,000		2,529,000	2,529,000	2,422,000	2,422,000		3,023,000	2,631,000		3,173,000	3,173,000	4,722,000		4,726,000	4,824,000		4,818,000	4,818,000	5,400,000	5,400,000		2,064,000	19,000	458,000		19,000	19,000	19,000	349,000	349,000	1,408,000	950,000		408,000	408,000	762,000	2,993,000	2,118,000	949,000			1,901,000	1,037,000	898,000	1,967,000
license and research revenue																																-486,620	528,000	-794,000	750,000	-2,300,697	747,000	693,000	863,000					-1,602,000	681,000	681,000	2,270,000	2,270,000	1,433,000	1,433,000	2,434,000	2,434,000	1,192,000		1,650,000	1,192,000	1,273,000	1,650,000	1,273,000	3,450,000		2,054,000	1,710,000	2,110,000	2,482,000	2,110,000	2,170,000	2,170,000	2,700,000	2,482,000		3,214,000	2,482,000		8,839,000	4,119,000	8,839,000		3,305,000	3,305,000	3,441,000	3,441,000	4,659,000	4,726,000	4,659,000		4,341,000	4,341,000	7,089,000	7,089,000		3,140,000	3,406,000		3,157,000	3,157,000	3,544,000		3,416,000	1,973,000		1,794,000	1,794,000	3,124,000	3,124,000		5,586,000	14,677,000	2,338,000		9,401,000	4,851,000	4,851,000	5,684,000	5,684,000	15,141,000	12,803,000		7,449,000	7,449,000	17,794,000	33,099,000	20,838,000	13,301,000			6,259,000	1,962,000		10,801,000
total																																34,623,250	39,675,000	46,311,000	52,507,000	-107,183,763	32,087,000	38,858,000	36,216,000		-61,799,000	-50,972,000	-22,512,000	-23,389,000	-23,848,000	-23,848,000	-28,218,000	-28,218,000	-33,177,000	-33,177,000	-5,185,000	-5,185,000	-12,384,000		-39,916,000	-12,384,000	-14,991,000	-39,916,000	-14,991,000	-1,239,000		-10,507,000	-10,436,000	-7,406,000	-10,408,000	-12,053,000	-10,926,000	-10,926,000	-9,194,000	-10,408,000		-11,655,000	-10,408,000		-11,406,000	-11,168,000	-11,406,000		-12,243,000	-12,243,000	-12,117,000	-12,117,000	-16,528,000	-15,010,000	-11,704,000		-14,776,000	-14,776,000	-12,381,000	-12,381,000		-13,751,000	-14,381,000		-14,887,000	-14,887,000	-15,760,000		-18,128,000	-18,283,000		-21,456,000	-21,456,000	-19,144,000	-19,144,000		-16,248,000	-45,610,000			-29,561,000	-15,241,000	-15,241,000	-17,352,000	-17,352,000	-47,015,000	-31,746,000		-15,685,000	-15,685,000
cost of products and services sold																																-12,249,947	3,790,000	4,561,000	3,902,000	-10,655,162	2,844,000	3,907,000	4,395,000																																																																	-4,480,000			-1,355,000	-4,895,000			-3,053,000	-2,144,000
(gain)/loss - changes in fair value of related party contingent consideration																																-7,526,750	-9,906,000
investment income																																-2,687,785	1,110,000	527,000	1,052,000	270,000	490,000	390,000	200,000
foreign exchange gain																																125,163	-133,000	237,000		2,529	1,249,000	1,680,000	-2,941,000		160,000	-3,565,000	11,501,000	3,326,000	8,074,000	8,074,000	292,000	292,000	179,000	179,000	-118,000	-118,000	-161,000		-33,000	-161,000	24,000	-33,000	24,000	-108,000		156,000	-95,000	-133,000	20,000	-133,000	118,000	118,000	375,000	20,000		-240,000	20,000		196,000	-302,000	196,000		201,000	201,000	14,000	14,000	205,000	-140,000				-74,000	-74,000	-74,000		220,000	-73,000		-31,000	-31,000	-113,000		-143,000	-229,000		-64,000	-64,000	-18,000	-18,000		-196,000	-403,000			-399,000	-117,000	-117,000	165,000	165,000	335,000	405,000		381,000	381,000	7,500	30,000	18,000	-13,000	-783,000	-236,000	-293,000	-83,000
foreign exchange loss																																			-231,000
changes in fair value of related party acquisition-related contingent consideration																																							7,916,000
interest expense - changes in fair value of related party financing-related contingent consideration																																							-1,861,000
revenue:
other revenues																																									6,000	30,000	15,000	-5,013,000	1,600,000	1,600,000	1,684,000	1,683,000	1,802,000	1,802,000	1,595,000	1,595,000	1,891,000		1,696,000	1,891,000	1,760,000	1,696,000	1,760,000	1,697,000		1,926,000	1,625,000	1,872,000	1,981,000	1,872,000	2,237,000	2,237,000	2,495,000	1,981,000		1,926,000	1,981,000		2,402,000	2,117,000	2,402,000		2,350,000	2,350,000	2,341,000	2,341,000	1,663,000	2,521,000	1,663,000		2,705,000	2,705,000	2,543,000	2,543,000		2,972,000	3,429,000		2,823,000	2,823,000	2,599,000		2,419,000	2,222,000		837,000	837,000	1,101,000	1,101,000		132,000	542,000	292,000		413,000	228,000	228,000	228,000	228,000	788,000	496,000		248,000	248,000	162,000	600,000	388,000	103,000
total revenue																																									47,320,000	49,795,000	32,726,000	-9,510,000	7,028,000	7,028,000	8,082,000	8,081,000	9,175,000	9,175,000	6,178,000	6,177,000	5,583,000		5,541,000	5,583,000	5,140,000	5,541,000	5,140,000	7,310,000		6,033,000	5,398,000	7,360,000	6,753,000	7,332,000	8,649,000	8,649,000	10,434,000	6,753,000		6,764,000	6,753,000		13,451,000	8,041,000	13,451,000		7,515,000	7,515,000	8,087,000	8,087,000	10,591,000	9,898,000	10,591,000		9,575,000	9,575,000	12,054,000	12,054,000		9,135,000	9,466,000		9,153,000	9,153,000	10,865,000		10,561,000	9,019,000		7,449,000	7,449,000	9,625,000	9,625,000		7,782,000	15,238,000	3,088,000		9,833,000	5,098,000	5,098,000	6,261,000	6,261,000	17,337,000	14,249,000		8,105,000	8,105,000	18,718,000	36,692,000	23,344,000	14,353,000
costs and expenses:
cost of goods and services sold																																									-2,087,000	-2,756,000	-3,630,000	-1,375,250	-1,913,000	-1,913,000	-1,636,000	-1,636,000	-1,952,000	-1,952,000	-335,000	-335,000	-1,736,000		-1,283,000	-1,736,000	-995,000	-1,283,000	-995,000	-1,495,000		-1,547,000	-1,500,000	-1,318,000	-1,934,000	-1,290,000	-1,850,000	-1,108,500	-1,129,000	-1,934,000		-1,371,000	-1,934,000		-1,869,000	-1,535,000	-1,261,250		-1,585,000	-1,585,000	-1,925,000	-1,925,000	-3,610,000	-2,567,000	-1,627,000		-1,891,000	-1,891,000	-2,050,000	-2,050,000		-2,613,000	-1,815,750		-2,241,000	-2,241,000	-2,409,000		-4,877,000	-4,251,000		-3,699,000	-3,699,000		-4,480,000								-2,144,000	-525,000	-500,000	-2,000,000	-1,242,000		-337,000	-337,000	-973,000	-2,629,000	-1,715,000	-837,000			-1,811,000	-1,094,000	-835,000	-1,538,000
research and development																																									-7,221,000	-7,204,000	-6,022,000	3,566,000	-7,028,000	-7,028,000	-6,742,000	-6,742,000	-7,094,000	-7,094,000	-4,173,000	-4,173,000	-6,680,000		-7,304,000	-6,680,000	-8,529,000	-7,304,000	-8,529,000	-6,162,000		-7,722,000	-6,246,000	-5,985,000	-5,946,000	-5,706,000	-5,910,000	-5,910,000	-5,475,000	-5,946,000		-7,758,000	-5,946,000		-6,863,000	-6,702,000	-6,863,000		-7,861,000	-7,861,000	-7,261,000	-7,261,000	-8,952,000	-9,305,000	-4,128,000		-9,598,000	-9,598,000	-7,385,000	-7,385,000		-8,239,000	-9,771,000		-8,960,000	-8,960,000	-9,277,000		-9,648,000	-9,908,000		-13,204,000	-13,204,000	-10,554,000	-10,554,000		-10,322,000	-27,911,000			-18,483,000	-10,024,000	-10,024,000	-9,719,000	-9,719,000	-37,582,000	-26,042,000		-13,454,000	-13,454,000	-10,913,000	-24,446,000	-15,891,000	-7,872,000			-8,525,000	-3,843,000	-3,615,000	-8,624,000
selling, general and administrative																																									-4,568,000	-5,873,000	-4,463,000	-3,743,000	-4,105,000	-4,105,000	-4,295,000	-4,295,000	-3,555,000	-3,555,000	-5,184,000	-5,184,000	-2,925,000		-2,706,000	-2,925,000	-2,491,000	-2,706,000	-2,491,000	-2,950,000		-2,913,000	-3,107,000	-5,183,000	-2,528,000	-5,057,000	-3,166,000	-3,166,000	-2,590,000	-2,528,000		-2,526,000	-2,528,000		-2,674,000	-2,931,000	-2,674,000		-2,797,000		-2,931,000	-2,931,000	-3,966,000	-3,138,000	-3,966,000		-3,287,000	-3,287,000	-2,946,000	-2,946,000		-2,899,000	-2,252,000		-3,686,000	-3,686,000	-4,074,000		-3,603,000	-4,124,000		-4,553,000	-4,553,000	-4,110,000	-4,110,000		-4,571,000	-12,804,000			-8,025,000	-3,073,000	-3,073,000	-7,108,000	-7,108,000	-7,433,000	-4,462,000		-1,894,000	-1,894,000	-3,294,000	-4,320,000	-2,914,000	-1,287,000			-2,351,000	-1,009,000	-1,463,000	-2,536,000
fair value remeasurement of acquisition liabilities, incl. related parties																																									-44,782,000	-32,000,000	-5,254,000	-22,393,000	-7,865,000	-7,865,000	-12,607,000	-12,607,000	-14,626,000
amortisation of intangible r&d assets																																									-3,141,000	-3,139,000	-3,143,000	-2,937,000	-2,937,000	-2,937,000	-2,938,000	-2,938,000	-2,937,000	-2,937,000
acquisition note expenses, incl. related parties																																																	-3,013,000
operating profit from continuing operations																																									-14,479,000
interest income																																									407,000	653,000	798,000							-5,508,000	-600,000	-599,000				-688,000																																																457,000			658,000	1,364,000			939,000	451,000								2,310,000	-759,000	1,411,000	967,000	492,000	415,000	207,000	142,000	80,000	92,000	156,000
interest expense on debt related to the royalty agreement with related parties																																									-6,644,000	-2,726,000	-259,000	-804,000	-1,486,000	-1,486,000		-1,079,000	-156,000
other income																																									27,000	-2,000	7,000	-188,000	71,000	71,000	29,000	30,000	52,000	52,000	41,000	41,000	66,000		501,000	66,000	-35,000	501,000	-35,000	11,000		9,000	15,000	67,000	42,000	67,000	5,000	5,000	-12,000	42,000		99,000	42,000		432,000	5,000	432,000		85,000	85,000	3,000	3,000	-41,000	4,000	-41,000		2,000	2,000	7,000	7,000		58,000	22,000		70,000	70,000	31,000		143,000	16,000		33,000	33,000	5,000	5,000		30,000	101,000			93,000		173,000	-297,000	-297,000	5,300,000	5,366,000		5,267,000	5,267,000	-208,000	308,000	81,000	57,000	129,000	999,000	1,007,000	747,000		3,194,000
income before income taxes from continuing operations																																									-20,766,000	-7,158,000
net income from continuing operations																																									-29,685,000	-17,400,000	11,647,000
net income from discontinued operations
earnings per ordinary share
continuing operations																																									-730	-430	290
discontinued operations
weighted-average number of shares outstanding (in thousands) :
basic																																									40,625,000	40,353,000	40,207	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,496	25,496	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,213	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,646	24,646		24,646	24,646		24,472		24,411										24,220	24,220	24,205	24,205		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		21,548	21,548	21,514	21,434	21,415	21,404	17,762	19,292,000
diluted																																									40,625,000	40,353,000	42,879	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,824	25,824	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,314	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,971	24,646		24,646	24,646		24,941		24,411										24,220	24,220	24,372	24,372		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		23,200	23,200	23,559	24,182	24,120	23,999	17,762	19,292,000
profit from continuing operations																																										-1,177,000
profit (loss) from operations																																											10,214,000	-15,239,500	-16,820,000	-16,820,000	-20,136,000	-20,137,000	-24,002,000	-24,002,000	993,000		-6,800,000			-6,801,000	-9,851,000	-34,375,000				-4,474,000	-5,038,000	-46,000	-3,655,000							-4,891,000									-4,030,000	-4,030,000	-5,937,000
earnings per share
interest income net																																												-1,332,000	86,000	86,000	94,000	94,000	-5,508,000				-688,000		-640,000		-429,000	-640,000	-429,000	-1,569,000		-1,607,000	-1,355,000	166,000	197,000	167,000	122,000	118,000	147,000	197,000		128,000	197,000		114,000	109,000	81,500		105,000		112,000	112,000	76,000	92,000	87,250		139,000	139,000	118,000	118,000		377,000	281,750		369,000	369,000	381,000		370,000	411,000		437,000	437,000		457,000				435,000				451,000	389,000	803,500	3,214,000	2,779,000		2,310,000
basic earnings per ordinary share																																												-0.41	-0.26	-0.26	-0.55	-0.55	-0.94	-0.94	0.2		-0.25		-1.29	-0.25	-0.35	-1.29	-0.35	0.36		-0.24	-0.26		-0.14	-0.19	-0.08	-0.068	0.07	-0.14		-0.2	-0.14		0.11						-0.17	-0.17	-0.23					-0.15	0.05	0.05		-0.1	-0.098		-0.14	-0.14	-0.15		-0.23	-0.38		-0.57	-0.57	-0.38	-0.38		0.308	1.23	0.5		-0.8	-0.41	-0.41	-0.28	-0.3	-0.89	-0.4		0.01	0.01	0.32	0.26	0.13	0.2
diluted earnings per share																																												-0.41	-0.26	-0.26	-0.55	-0.55	-0.94	-0.94	0.2		-0.25		-1.29	-0.25	-0.35	-1.29	-0.35	0.36		-0.24	-0.26		-0.14	-0.19	-0.08	-0.09	0.07	-0.14		-0.2	-0.14		0.11						-0.17	-0.17	-0.23					-0.15	0.05	0.05		-0.1	-0.11		-0.14	-0.14	-0.15		-0.23	-0.38		-0.57	-0.57	-0.38	-0.38		-2.71	1.23	0.5		-0.8	-0.41	-0.41	-0.28	-0.3	-0.89	-0.4		0.01	0.01	0.3	0.23	0.11	0.18					-0.02
interest expense on debt related to the royalty agreement with related parties.																																															-1,079,000
fair value remeasurement of acquisition liabilities																																																		-14,626,000	4,507,000	4,507,000	-1,043,000		-28,623,000	-1,043,000
reimbursement of acquisition note																																																		-3,013,000
interest expense on the debt related to the royalty agreement																																																		-156,000		38,000	-13,000		-2,015,000
impairment of assets																																																												-7,170,000
interest expense on the debt related to the royalty agreements																																																			38,000
profit from operations																																																				992,000			-34,375,000				-9,851,000	6,071,000						-4,721,000	-2,277,000								2,045,000													-5,201,000	-327,000	-327,000		-4,616,000	-3,811,250		-5,734,000	-5,734,000	-4,895,000		-7,567,000	-9,264,000		-14,007,000	-14,007,000	-9,519,000	-9,519,000		-7,593,000	-30,372,000			-19,728,000	-10,143,000	-10,143,000	-11,091,000	-7,419,500	-29,678,000	-17,497,000		-7,580,000	-7,580,000	5,019,000	3,816,000	1,699,000		-1,535,500	-6,142,000	-4,159,000
earnings per share:
basic																																																				0.2
diluted																																																				0.2
weighted-average number of shares outstanding:
basic																																									40,625,000	40,353,000	40,207	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,496	25,496	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,213	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,646	24,646		24,646	24,646		24,472		24,411										24,220	24,220	24,205	24,205		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		21,548	21,548	21,514	21,434	21,415	21,404	17,762	19,292,000
diluted																																									40,625,000	40,353,000	42,879	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,824	25,824	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,314	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,971	24,646		24,646	24,646		24,941		24,411										24,220	24,220	24,372	24,372		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		23,200	23,200	23,559	24,182	24,120	23,999	17,762	19,292,000
fair value remeasurement of royalty agreement																																																								-13,000		-2,015,000
remeasurement of acquisition liabilities																																																									-2,976,000		-2,976,000	16,538,000		1,675,000	417,000	5,080,000
income tax																																																									1,462,000					-1,000		-42,000								-23,000
fair value remeasurement of acquisition liabilities .																																																										-28,623,000
income from operations																																																																				-1,826,500	1,240,000	-3,655,000			-3,655,000			-3,127,000	-2,971,250		-4,728,000	-4,728,000				-5,112,000	-2,660,000		-5,201,000																																									-2,417,000	-948,000
income tax benefit (expense)*																																																																												-24,000	-25,000		47,000
loss per share
basic loss per ordinary share																																																																												-0.14	-0.12		-0.18					-0.14	-0.06		-0.15
diluted loss per share																																																																												-0.14	-0.12		-0.18					-0.14	-0.06		-0.15
weighted average number of shares outstanding (in thousands) :
basic																																																																												24,423			24,408		24,343	24,343	24,250	24,225	24,225
diluted																																																																												24,423			24,408	24,408	24,343	24,343	24,250	24,225	24,225
* research tax credit reclassified in operational expenses for 2009
selling, general and administrative.																																																																																-2,797,000
interest income net..																																																																																105,000
loss before income taxes.																																																																																-4,337,000
income tax benefit (expense).																																																																																47,000
net loss.																																																																																-4,290,000
basic loss per ordinary share.																																																																																-0.18
diluted loss per share.																																																																																-0.18
weighted average number of shares outstanding (in thousands) :
basic.																																																																																24,408
diluted																																																																												24,423			24,408	24,408	24,343	24,343	24,250	24,225	24,225
income (loss) before income taxes																																																																																	-3,901,000	-3,901,000	-5,697,000
income tax benefit *																																																																																	-123,000
earnings (loss) per share
foreign gain																																																																																					-72,000
foreign loss																																																																																							-74,000
weighted-average number of shares outstanding
basic																																									40,625,000	40,353,000	40,207	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,496	25,496	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,213	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,646	24,646		24,646	24,646		24,472		24,411										24,220	24,220	24,205	24,205		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		21,548	21,548	21,514	21,434	21,415	21,404	17,762	19,292,000
diluted																																									40,625,000	40,353,000	42,879	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,824	25,824	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,314	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,971	24,646		24,646	24,646		24,941		24,411										24,220	24,220	24,372	24,372		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		23,200	23,200	23,559	24,182	24,120	23,999	17,762	19,292,000
euro / u.s. dollar average exchange rate
other loss																																																																																																																173,000
revenues
licence and research revenue																																																																																																																																	3,792,000
other revenue																																																																																																																															372,000	534,000
costs and expenses
total costs and expenses																																																																																																																									-8,219,000	-32,876,000	-21,645,000	-10,569,000					-5,918,000
profit/(loss) from operations
foreign exchange gain/
basic earnings/(loss) per ordinary share
diluted earnings/(loss) per ordinary share
weighted-average number of ordinary shares outstanding																																																																																																																															16,327,000	16,198,000		16,198
basic																																									40,625,000	40,353,000	40,207	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,496	25,496	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,213	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,646	24,646		24,646	24,646		24,472		24,411										24,220	24,220	24,205	24,205		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		21,548	21,548	21,514	21,434	21,415	21,404	17,762	19,292,000
diluted																																									40,625,000	40,353,000	42,879	36,214	38,767	38,767	38,438	38,438	28,312	28,312	25,824	25,824	25,465	25,450	25,421	25,465	25,415	25,421	25,415	25,314	25,135	25,157	25,157	25,012	24,646	25,012	24,737	24,669	24,971	24,646		24,646	24,646		24,941		24,411										24,220	24,220	24,372	24,372		24,077	24,082		24,067	24,061	24,056		24,024	24,017	24,024	24,005	24,005	23,991	23,991		23,812	23,768	23,640		23,768	23,737	23,737	22,995	22,999	23,640	22,351		23,200	23,200	23,559	24,182	24,120	23,999	17,762	19,292,000
stock compensation expense																																																																																																																									-370,250	-1,481,000	-1,125,000	-573,000			-4,000	-4,000	-5,000	-13,000
income, (loss) before income taxes																																																																																																																									1,391,250	5,565,000							-880,000
net income,																																																																																																																									1,385,500	5,542,000	2,742,000	4,297,000					-316,000
income,(loss) before income taxes																																																																																																																											2,765,000	4,320,000
revenue :
costs and expenses :
gain from operations																																																																																																																												3,784,000
net profit,																																																																																																																													-1,298,000	-5,192,000		-1,673,000		3,332,000
earnings per ordinary share
basic																																																																																																																													-67.5	-270
diluted																																																																																																																													-67.5	-270
net profit																																																																																																																															-3,324,000
net profit per ordinary share																																																																																																																															-200
weighted-average number of ordinary shares outstanding																																																																																																																															16,327,000	16,198,000		16,198
profit, (loss) before income taxes																																																																																																																																-1,673,000
basic profit, (loss) per ordinary share																																																																																																																																-100		210
diluted profit, (loss) per ordinary share																																																																																																																																-100
royalties and other income																																																																																																																																	280,000
foreign exchange gain,																																																																																																																																	-24,000	-75,000
basic earnings, (loss) per share																																																																																																																																	-0.02
profit, (loss) from operations																																																																																																																																		3,251,000
diluted profit per share																																																																																																																																		0.19

Balance Sheets:

Quarterly

Annual

Unit: USD	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-07-10	2015-06-30	2015-03-31	2014-12-31	2014-11-17	2014-08-07	2014-07-08	2014-06-30	2014-01-15	2013-12-31	2013-12-06	2013-09-30	2013-09-19	2013-06-30	2013-03-31	2012-12-31	2012-12-14	2012-09-13	2012-06-30	2012-03-31	2011-12-31	2011-12-23	2011-11-22	2011-09-30	2011-07-29	2011-06-30	2011-03-31	2011-01-21	2010-12-31	2010-10-13	2010-06-18	2010-03-31	2010-01-21	2010-01-15	2009-12-31	2009-09-25	2009-06-30	2009-06-12	2009-03-31	2009-01-09	2008-12-31	2008-09-30	2008-09-17	2008-06-30	2008-06-18	2008-03-31	2008-01-08	2007-12-31	2007-09-30	2007-09-04	2007-06-30	2007-05-31	2007-03-31	2006-12-31	2006-12-07	2006-09-30	2006-08-11	2006-06-30	2006-06-14	2006-03-31	2005-12-31	2005-11-23	2005-09-30	2005-09-09	2005-07-25	2005-06-30	2005-03-31	2004-12-31	2004-12-30	2004-09-30	2004-06-30	2004-05-28	2004-03-31	2003-12-31	2003-09-30	2003-07-01	2003-06-30	2003-04-30	2003-03-31	2002-12-31	2001-12-31	2000-12-31

assets
current assets:
cash and cash equivalents	79,813,000	63,402,000	56,370,000	51,371,000	28,582,000	28,847,000	35,794,000	31,167,000	51,811,000	49,985,000	83,391,000	73,981,000	60,715,000	54,128,000	60,873,000	50,708,000	58,169,000	67,142,000	59,172,000	71,722,000	83,109,000	102,174,000	73,506,000	9,774,000	12,867,000	17,111,000	9,630,000	9,325,000	17,837,000	12,477,000	40,911,000	16,564,000	37,449,000	43,507,000	32,236,000	39,215,000	18,780,000	23,899,000	37,870,000	55,236,000	38,535,000	55,236,000	38,535,000	39,760,000	24,006,000	54,104,000	55,505,000	54,104,000	7,807,000	6,636,000	8,336,000	7,807,000	14,010,000	8,336,000	14,010,000	2,742,000	4,755,000	4,348,000	4,755,000	4,348,000	3,456,000	6,729,000	11,584,000	6,729,000	5,831,000	11,584,000	5,831,000	3,909,000	8,184,000	3,570,000	995,000	995,000	3,909,000	4,784		7,205,000	7,205,000	17,853,000	17,853,000	28,405,000	27,021,000	28,405,000	22,701,000	22,701,000	31,608,000	31,608,000	29,538,000	26,313,000	29,538,000	36,820,000	36,820,000	44,444,000	44,444,000	51,827,000	564,000	564,000	5,544,000	5,544,000	2,598,000	2,598,000	1,018,000	1,606,000	1,606,000	914,000	1,332,000	914,000	1,332,000	4,591,000	95,697,000	95,697,000	100,850,000	105,435,000	105,435,000	109,617,000	22,076,000	11,649,000	11,649,000					10,137,000
marketable securities	11,764,000	18,145,000	10,114,000	22,406,000	37,225,000	42,535,000	52,995,000	73,944,000	101,368,000	110,525,000	17,532,000	22,518,000	45,760,000	49,993,000	62,608,000	106,513,000	122,924,000	135,701,000	145,803,000	149,680,000	148,467,000	136,380,000	39,977,000	54,384,000	59,587,000	62,151,000	70,221,000	90,590,000	107,425,000	134,629,000	157,269,000	77,511,000	78,161,000	130,290,000	146,978,000	114,980,000	130,887,000	130,964,000	122,084,000	60,884,000	74,637,000	60,884,000	74,637,000	53,074,000	52,496,000	23,753,000	28,018,000	23,753,000	1,473,000	401,000	1,387,000	1,473,000	1,358,000	1,387,000	1,358,000	6,413,000	15,686,000	18,376,000	15,686,000	18,376,000	21,035,000	22,728,000	21,395,000	22,728,000	20,172,000	21,395,000	20,172,000	28,132,000	23,160,000	30,155,000	34,377,000	34,377,000	28,132,000	44,026		37,862,000	37,862,000	21,209,000	21,209,000	4,414,000	10,057,000	4,414,000	11,787,000	11,787,000	7,670,000	7,670,000	11,218,000	14,749,000	11,218,000	10,145,000	10,145,000	8,274,000	8,274,000	10,944,000	66,015,000	66,015,000	63,598,000	63,598,000	72,608,000	72,608,000	82,756,000	87,812,000	87,812,000	101,680,000	107,497,000	101,680,000	107,497,000	100,783,000
accounts receivable	42,444,000	40,631,000	41,581,000	34,097,000	37,102,000	33,377,000	22,692,000	12,103,000	6,239,000	1,775,000												5,692,000	8,797,000	8,281,000	8,725,000	10,172,000	11,772,000	11,330,000	9,725,000	14,940,000	16,677,000	14,785,000	24,080,000	19,285,000	13,463,000	17,839,000	15,395,000	9,488,000	4,865,000	3,498,000		3,498,000		1,679,000	2,988,000	3,637,000	4,040,000	3,637,000	6,326,000	6,204,000	5,038,000	6,326,000	5,249,000	5,038,000	5,249,000	5,464,000	5,570,000	5,580,000	5,570,000	5,580,000	7,765,000	6,200,000	5,787,000	6,200,000	7,398,000	5,787,000	7,398,000	10,227,000	7,480,000	6,186,000	7,221,000	7,221,000	10,227,000	7,337		8,686,000	8,686,000	10,127,000	10,127,000	7,131,000	6,979,000	7,131,000	6,137,000	6,137,000	6,410,000	6,410,000	7,764,000	4,987,000	7,764,000	6,922,000	6,922,000	5,875,000	5,875,000	5,583,000	7,176,000	7,176,000	5,928,000	5,928,000	3,207,000	3,207,000	2,583,000	6,238,000	6,238,000	7,255,000	8,458,000	7,255,000	8,458,000	8,203,000	7,737,000	7,737,000	5,212,000	7,754,000	7,754,000	8,367,000	4,347,000	6,008,000	6,008,000
inventories	23,905,000	23,484,000	20,406,000	20,298,000	16,097,000	13,313,000	11,928,000	10,380,000	5,286,000	1,439,000													3,523,000	3,570,000	2,260,000	2,601,000	4,258,000	4,770,000	6,030,000	5,724,000	5,948,000	6,157,000	5,870,000	5,747,000	5,406,000	3,258,000	3,909,000	3,640,000	5,312,000
prepaid expenses and other current assets	14,300,000	13,443,000	10,787,000	6,036,000	8,252,000	6,781,000	11,333,000	5,286,000	6,352,000	6,532,000	6,264,000	2,096,000	4,670,000	19,387,000	34,873,000	32,826,000	22,234,000	25,308,000	34,231,000	38,726,000	47,054,000	32,773,000	3,337,000	4,264,000	5,163,000	5,165,000	6,556,000	8,836,000	6,859,000	7,206,000	11,128,000	8,958,000	3,373,000	5,522,000	6,529,000	5,894,000	8,883,000	9,657,000	9,975,000	5,189,000	4,347,000	5,189,000	4,347,000	4,418,000	3,380,000	2,831,000	1,991,000	2,831,000	2,933,000	2,481,000	1,789,000	2,933,000	1,761,000	1,789,000	1,761,000	2,314,000	2,672,000	2,397,000	2,672,000	2,397,000	2,642,000	2,585,000	2,229,000	2,585,000	2,571,000	2,229,000	2,571,000	4,555,000	3,372,000	4,264,000	4,624,000	4,624,000	4,555,000	3,038		2,657,000	2,657,000	2,282,000	2,282,000	2,634,000	2,181,000	2,634,000	3,568,000	3,568,000	3,175,000	3,175,000	4,849,000	2,800,000	4,849,000	5,086,000	5,086,000	5,856,000	5,856,000	4,478,000	3,050,000	3,050,000	3,108,000	3,108,000	3,595,000	3,595,000	3,873,000	4,777,000	4,777,000	5,971,000	5,005,000	5,971,000	5,005,000	5,598,000	3,378,000	3,378,000	3,694,000	3,668,000	3,668,000	1,694,000	1,620,000	936,000	936,000
total current assets	172,226,000	159,105,000	139,258,000	134,208,000	127,258,000	125,780,000	136,035,000	134,202,000	172,255,000	171,230,000	109,470,000	100,843,000	113,222,000	125,713,000	160,741,000	192,490,000	205,820,000	230,702,000	242,314,000	263,454,000	281,688,000	277,019,000	130,975,000	82,380,000	88,602,000	97,200,000	102,437,000	124,851,000	147,876,000	174,976,000	231,933,000	123,975,000	148,933,000	204,351,000	204,612,000	181,186,000	177,854,000	177,648,000	180,474,000						99,248,000	105,121,000	108,725,000	105,121,000	32,932,000	33,623,000	34,949,000	32,932,000	39,244,000	34,949,000	39,244,000	25,085,000	30,282,000	32,604,000	30,282,000	32,604,000	36,652,000	40,023,000	41,989,000	40,023,000	36,913,000	41,989,000	36,913,000	50,246,000	45,362,000	47,223,000	56,780,000	56,780,000	50,246,000	69,239		59,002,000	59,002,000	59,192,000	59,192,000	49,601,000	59,189,000	49,601,000	52,265,000	52,265,000	56,977,000	56,977,000	61,605,000	56,110,000	61,605,000	62,668,000	62,668,000	68,148,000	68,148,000	76,779,000	78,750,000	78,750,000	80,037,000	80,037,000	83,708,000	83,708,000	91,988,000	101,604,000	101,604,000	116,786,000	123,421,000	116,786,000	123,421,000	120,772,000	108,113,000	108,113,000	111,066,000	117,848,000	117,848,000	120,735,000	28,588,000
property and equipment	467,000	472,000	307,000	453,000	469,000	484,000	526,000	585,000	648,000	715,000	782,000	839,000	896,000	252,000	268,000	285,000	304,000	321,000	344,000	359,000	373,000	407,000	472,000	544,000	770,000	934,000	1,749,000	1,911,000	2,288,000	2,439,000	2,722,000	3,001,000	3,180,000	3,328,000	3,382,000	3,320,000	3,186,000	3,104,000	3,100,000	1,978,000	1,777,000	1,978,000	1,777,000	1,776,000	15,182,000	16,605,000	17,170,000	16,605,000	17,352,000	17,435,000	17,271,000	17,352,000	17,271,000	17,271,000	17,271,000	18,238,000	18,041,000	19,645,000	18,041,000	19,645,000	19,383,000	20,409,000	22,462,000	20,409,000	22,744,000	22,462,000	22,744,000	22,677,000	21,425,000	20,438,000	22,547,000	22,547,000	22,677,000	25,936		25,734,000	25,734,000	25,065,000	25,065,000	29,890,000	27,601,000	29,890,000	34,473,000	34,473,000	36,115,000	36,115,000	34,201,000	35,140,000	34,201,000	31,013,000	31,013,000	27,739,000	27,739,000	25,705,000	22,376,000	22,376,000	23,433,000	23,433,000	22,262,000	22,262,000	22,317,000	20,460,000	20,460,000	19,863,000	16,108,000	19,863,000	16,108,000	18,162,000	16,007,000	16,007,000	11,747,000	8,331,000	8,331,000	5,085,000	3,658,000	3,431,000	3,431,000	3,342,000	3,342,000
operating lease right-of-use assets	2,544,000	2,721,000	2,896,000	1,702,000	1,930,000	2,154,000	2,374,000	2,591,000	2,804,000	1,235,000	1,475,000	1,713,000	1,947,000	2,180,000	2,410,000	2,652,000	2,070,000	2,249,000	2,427,000	2,604,000	2,866,000	3,117,000	3,365,000	3,612,000	4,385,000	5,454,000	5,802,000
goodwill	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	16,836,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	19,134,000	18,669,000	24,055,000	18,491,000	18,491,000	18,491,000	18,491,000	18,491,000	18,490,000	18,491,000	18,491,000	18,491,000	18,490,000	18,491,000	18,491,000	18,490,000	18,491,000	18,491,000	18,491,000	18,491,000	20,461,000	20,461,000	20,461,000	20,461,000
other non-current assets	7,375,000	8,023,000	8,652,000	11,037,000	11,760,000	12,015,000	11,768,000	10,152,000	10,148,000	10,540,000	10,931,000	11,322,000	11,720,000	11,770,000	39,635,000	33,777,000	38,098,000	31,500,000	27,717,000	24,939,000	22,264,000	37,615,000	47,524,000	39,274,000	34,927,000	34,573,000	36,124,000	36,146,000	24,844,000	22,244,000	20,241,000	10,249,000
total assets	199,448,000	187,157,000	167,949,000	164,236,000	158,253,000	157,521,000	167,899,000	164,698,000	203,100,000	200,976,000	140,739,000	132,785,000	145,758,000	157,938,000	221,127,000	247,265,000	264,089,000	282,591,000	292,941,000	311,637,000	327,635,000	341,401,000	207,725,000	151,436,000	155,888,000	165,709,000	173,622,000	190,300,000	269,006,000	295,236,000	351,861,000	253,277,000	277,427,000	259,160,000	258,688,000	245,482,000	247,985,000	249,706,000	255,010,000						164,386,000	174,631,000	181,742,000	174,631,000	116,515,000	116,252,000	118,408,000	116,515,000	122,733,000	118,408,000	122,733,000	117,311,000	133,715,000	137,411,000	133,715,000	137,411,000	69,402,000	72,697,000	76,114,000	72,697,000	69,980,000	76,114,000	69,980,000	77,384,000	74,614,000	70,480,000	81,255,000	81,255,000	77,384,000	97,921	94,296,000	93,253,000	93,253,000	91,080,000	91,080,000	88,767,000	91,861,000	88,767,000	101,091,000	101,091,000	105,197,000	105,197,000	103,911,000	101,401,000	103,911,000	106,435,000	106,435,000	108,461,000	108,461,000	114,894,000	111,262,000	111,262,000	113,648,000	113,648,000	116,278,000	116,278,000	124,351,000	127,972,000	127,972,000	142,585,000	145,950,000	142,585,000	145,950,000	145,608,000	125,574,000	125,574,000	124,230,000	127,590,000	127,590,000	127,252,000	33,022,000	23,856,000	23,856,000			23,076,000	18,144,000	20,360,000
liabilities and shareholders’ equity
current liabilities:
current portion of operating lease liability	740,000	723,000	706,000	582,000	725,000	866,000	953,000	934,000	916,000	783,000	871,000	960,000	1,011,000	932,000	917,000	900,000	504,000	494,000	484,000	474,000	520,000	563,000	604,000	645,000	1,596,000	999,000	982,000
accounts payable	12,581,000	10,114,000	9,116,000	7,328,000	7,917,000	9,794,000	18,961,000	11,433,000	13,263,000	11,786,000	10,023,000	7,890,000	2,479,000	7,318,000	6,048,000	7,679,000	6,874,000	5,116,000	2,824,000	2,934,000	2,660,000	4,879,000	6,790,000	6,100,000	3,538,000	4,798,000	4,150,000	3,503,000	11,399,000	11,169,000	15,906,000	7,477,000	8,564,000	12,321,000	7,962,000	7,105,000	8,966,000	7,043,000	17,674,000	11,403,000	9,037,000	11,403,000	9,037,000	8,024,000	7,007,000		6,358,000		4,115,000	5,099,000	3,268,000	4,115,000	3,425,000	3,268,000	3,425,000	3,596,000	4,758,000	4,675,000	4,758,000	4,675,000	3,920,000	3,432,000	3,982,000	3,432,000	4,705,000	3,982,000	4,705,000	5,156,000	4,941,000	5,262,000	5,169,000	5,169,000	5,156,000	4,899		4,272,000	4,272,000	5,299,000	5,299,000	4,912,000	5,760,000	4,912,000	7,303,000	7,303,000	8,306,000	8,306,000	12,933,000	8,568,000	12,933,000	13,071,000	13,071,000	10,252,000	10,252,000	9,702,000	6,941,000	6,941,000	7,400,000	7,400,000	9,023,000	9,023,000	11,497,000	11,069,000	11,069,000	15,486,000	7,811,000	15,486,000	7,811,000	9,660,000	4,879,000	4,879,000	6,961,000	7,020,000	7,020,000	4,397,000	2,357,000	2,388,000	2,388,000
accrued expenses	44,156,000	42,776,000	40,917,000	40,651,000	33,907,000	33,711,000	27,642,000	24,227,000	17,957,000	17,582,000	7,683,000	7,334,000	7,965,000	9,675,000	9,432,000	7,151,000	8,738,000	7,524,000	4,297,000	6,501,000	16,398,000	15,820,000	14,858,000	19,810,000	17,017,000	15,737,000	14,689,000	21,695,000	20,698,000	21,493,000	45,948,000	50,926,000	47,997,000	30,339,000	19,936,000	17,222,000	13,032,000	10,592,000	3,346,000	3,096,000	4,354,000	3,096,000	4,354,000	5,667,000	5,710,000	5,345,000	5,165,000	5,345,000	6,269,000	6,527,000	5,074,000	6,269,000	4,838,000	5,074,000	4,838,000	5,013,000	4,790,000	5,098,000	4,790,000	5,098,000	5,478,000	5,253,000	5,409,000	5,253,000	5,069,000	5,409,000	5,069,000	5,974,000	6,004,000	4,994,000	4,862,000	4,862,000	5,974,000	6,009		5,701,000	5,701,000	4,698,000	4,698,000	5,086,000	5,905,000	5,086,000	5,786,000	5,786,000	5,521,000	5,521,000	5,554,000	5,369,000	5,554,000	5,684,000	5,684,000	4,758,000	4,758,000	5,505,000	5,043,000	5,043,000	4,532,000	4,532,000	3,586,000	3,586,000	4,457,000	4,693,000	4,693,000	3,493,000	3,173,000	3,493,000	3,173,000	4,329,000	3,259,000	3,259,000	2,831,000	2,444,000	2,444,000	3,159,000	2,404,000	1,897,000	1,897,000
other current liabilities	5,010,000	3,452,000	194,000	273,000	234,000	242,000	252,000	261,000	731,000	500,000	269,000	1,941,000	3,757,000	2,051,000	1,442,000	5,270,000	1,471,000	3,146,000	1,515,000	5,200,000	3,431,000	3,488,000	1,932,000	3,875,000	1,989,000	3,677,000	1,927,000	3,453,000	2,116,000	3,052,000	2,212,000	597,000								349,000	5,009,000	349,000	5,009,000	5,659,000	6,503,000	7,207,000	7,485,000	7,207,000	1,324,000	8,310,000	1,248,000	1,324,000	1,228,000	1,248,000	1,228,000	1,133,000	1,716,000	1,835,000	1,716,000	1,835,000	1,995,000	2,688,000	2,874,000	2,688,000	3,819,000	2,874,000	3,819,000	4,023,000	3,433,000	3,717,000	4,535,000	4,535,000	4,023,000	4,442		2,380,000	2,380,000	5,987,000	5,987,000	4,740,000	6,452,000	4,740,000	5,290,000	5,290,000	7,056,000	7,056,000	6,723,000	5,875,000	6,723,000	5,049,000	5,049,000	3,627,000	3,627,000	4,731,000	6,087,000	6,087,000	5,978,000	5,978,000	6,568,000	6,568,000	7,547,000	3,121,000	3,121,000	8,100,000	10,547,000	8,100,000	10,547,000	5,889,000	281,000	281,000	69,000	276,000	276,000	88,000	307,000	112,000	112,000
total current liabilities	62,487,000	57,065,000	50,933,000	48,834,000	42,783,000	44,613,000	47,808,000	36,855,000	54,054,000	51,502,000	79,361,000	55,793,000	41,511,000	46,217,000	44,023,000	21,000,000	17,587,000	16,280,000	9,120,000	15,109,000	23,009,000	27,018,000	32,336,000	35,984,000	31,763,000	33,580,000	31,358,000	38,383,000	47,019,000	51,613,000	87,185,000	86,539,000	97,308,000	88,709,000	84,049,000	62,421,000	59,185,000	58,188,000	60,943,000						47,720,000	37,841,000	37,297,000	37,841,000	33,607,000	40,595,000	17,102,000	33,607,000	13,516,000	17,102,000	13,516,000	14,359,000	16,244,000	17,176,000	16,244,000	17,176,000	18,314,000	17,642,000	18,910,000	17,642,000	18,461,000	18,910,000	18,461,000	24,362,000	19,421,000	18,478,000	20,496,000	20,496,000	24,362,000	21,484		16,204,000	16,204,000	19,361,000	19,361,000	18,548,000	20,255,000	18,548,000	22,305,000	22,305,000	25,612,000	25,612,000	27,024,000	24,955,000	27,024,000	25,024,000	25,024,000	19,740,000	19,740,000	21,314,000	20,015,000	20,015,000	19,266,000	19,266,000	20,326,000	20,326,000	24,896,000	21,580,000	21,580,000	30,490,000	23,449,000	30,490,000	23,449,000	23,326,000	23,101,000	23,101,000	18,980,000	19,376,000	19,376,000	17,868,000	7,868,000
long-term operating lease liability	1,810,000	2,002,000	2,189,000	1,122,000	1,216,000	1,308,000	1,449,000	1,690,000	1,928,000	490,000	638,000	780,000	1,026,000	1,263,000	1,500,000	1,707,000	1,460,000	1,589,000	1,717,000	1,840,000	1,968,000	2,087,000	2,205,000	2,319,000	2,866,000	3,617,000	3,889,000
royalty financing obligation	34,828,000	35,318,000	35,518,000	35,249,000	34,437,000	35,493,000	34,333,000	32,760,000	31,151,000
other non-current liabilities	2,098,000	2,063,000	5,239,000	5,183,000	5,154,000	5,819,000	5,925,000	5,654,000	5,818,000	5,792,000	5,767,000	5,743,000	5,727,000	5,716,000	3,847,000	3,917,000	3,999,000	4,068,000	4,139,000	4,212,000	4,938,000	5,292,000	5,664,000	8,873,000	13,972,000	11,675,000	12,577,000	14,002,000	14,150,000	13,989,000	14,252,000	7,084,000
total liabilities	101,223,000	96,448,000	93,879,000	90,388,000	83,590,000	87,233,000	89,515,000	76,959,000	92,951,000	57,784,000	178,905,000	153,930,000	158,198,000	161,270,000	165,895,000	169,021,000	165,132,000	163,711,000	156,437,000	149,371,000	156,435,000	159,276,000	175,658,000	180,635,000	182,851,000	183,486,000	183,204,000	187,520,000	203,264,000	216,690,000	264,807,000	167,697,000	180,964,000	182,432,000	199,606,000	203,413,000	211,152,000	197,868,000	185,311,000
shareholders’ equity:
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; zero issued and outstanding at september 30, 2025 and december 31, 2024
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 97,235 issued and outstanding at september 30, 2025 and 96,518 issued and outstanding at december 31, 2024	972,000
additional paid-in capital	910,391,000	902,970,000	896,663,000	891,791,000	886,787,000	880,202,000	874,018,000	855,452,000	851,865,000	848,626,000	603,215,000	589,783,000	572,626,000	560,025,000	553,859,000	549,349,000	546,565,000	544,094,000	542,093,000	566,916,000	565,440,000	615,207,000	497,249,000	434,391,000	434,055,000	434,254,000	434,199,000	433,756,000	433,097,000	430,141,000	427,383,000	393,478,000	391,416,000	389,451,000	387,105,000	385,020,000	374,724,000	368,897,000	366,459,000	352,423,000	348,571,000	352,423,000	348,571,000	346,582,000	329,677,000	326,397,000	324,378,000	326,397,000	211,002,000	211,473,000	210,406,000	211,002,000	209,649,000	210,406,000	209,649,000	209,158,000	207,602,000	206,757,000	207,602,000	206,757,000	205,489,000	204,697,000	203,726,000	204,697,000	202,998,000	203,726,000	202,998,000	201,571,000	202,462,000	200,577,000	199,384,000	199,384,000	201,571,000	197,456		195,862,000	195,862,000	194,442,000	194,442,000	191,086,000	193,085,000	191,086,000	189,856,000	189,856,000	187,253,000	187,253,000	182,756,000	185,173,000	182,756,000	180,192,000	180,192,000	176,669,000	176,669,000	173,479,000	169,591,000	169,591,000	166,658,000	166,658,000	164,441,000	164,441,000	161,120,000	160,667,000	160,667,000	159,364,000	155,817,000	159,364,000	155,817,000	148,389,000	148,269,000	148,269,000	148,019,000	147,828,000	147,828,000	147,679,000	82,209,000	71,854,000	71,854,000
accumulated deficit	-789,562,000	-789,582,000	-799,247,000	-794,328,000	-789,285,000	-786,660,000	-772,838,000	-745,496,000	-716,710,000	-680,436,000	-616,004,000	-585,220,000	-557,770,000	-537,624,000	-474,180,000	-447,756,000	-425,455,000	-403,453,000	-383,872,000	-384,187,000	-372,909,000	-361,206,000	-392,080,000	-391,215,000	-388,476,000	-379,612,000	-371,007,000	-357,989,000	-294,130,000	-278,359,000	-274,921,000	-262,685,000	-254,440,000	-276,119,000	-305,046,000	-319,800,000	-324,534,000	-304,540,000	-286,169,000	-326,205,000	-308,805,000	-326,205,000	-308,805,000	-320,452,000	-293,303,000	-283,257,000	-262,184,000	-283,257,000	-240,668,000	-235,546,000	-234,304,000	-240,668,000	-201,450,000	-234,304,000	-201,450,000	-192,621,000	-195,298,000	-189,381,000	-195,298,000	-189,381,000	-189,393,000	-187,302,000	-189,005,000	-187,302,000	-185,546,000	-189,005,000	-185,546,000	-183,297,000	-180,619,000	-179,958,000	-175,668,000	-175,668,000	-183,297,000	-165,947		-162,565,000	-162,565,000	-159,015,000	-159,015,000	-157,479,000	-160,205,000	-157,479,000	-155,175,000	-155,175,000	-151,817,000	-151,817,000	-142,184,000	-148,121,000	-142,184,000	-133,078,000	-133,078,000	-119,445,000	-119,445,000	-110,384,000	-104,527,000	-104,527,000	-94,312,000	-94,312,000	-84,844,000	-84,844,000	-75,183,000	-68,735,000	-68,735,000	-56,851,000	-47,663,000	-56,851,000	-47,663,000	-47,806,000	-54,333,000	-54,333,000	-57,133,000	-55,578,000	-55,578,000	-59,875,000	-61,573,000	-59,704,000	-59,704,000
accumulated other comprehensive loss	-23,576,000	-23,646,000	-24,312,000	-24,580,000	-23,802,000	-24,215,000	-23,756,000	-23,167,000	-25,951,000	-25,943,000	-26,026,000	-26,341,000	-27,909,000	-26,328,000	-25,042,000	-23,940,000	-22,744,000	-22,350,000	-22,306,000	-21,051,000	-21,918,000	-22,518,000	-23,627,000	-22,806,000	-22,972,000	-22,848,000	-23,203,000	-23,416,000	-23,651,000	-23,659,000	-23,255,000	-23,266,000	-23,421,000	-22,680,000	-23,391,000	-23,565,000	-19,688,000	-18,850,000	-16,922,000
total shareholders’ equity	98,225,000	90,709,000	74,070,000	73,848,000	74,663,000	70,288,000	78,384,000	87,739,000	110,149,000	143,192,000					55,232,000	78,244,000	98,957,000	118,880,000	136,504,000	162,266,000	171,200,000	182,125,000	32,067,000					2,780,000	65,742,000	78,546,000	87,054,000	85,580,000																																												49,953,000	49,953,000	49,044,000	49,044,000	50,663,000	48,546,000	50,663,000	56,860,000	56,860,000	57,324,000	57,324,000	55,432,000	54,627,000	55,432,000	58,985,000	58,985,000	68,018,000	68,018,000	73,026,000	71,920,000	71,920,000	79,374,000	79,374,000	82,495,000	82,495,000	86,654,000	94,525,000	94,525,000	105,107,000	116,953,000	105,107,000	116,953,000	116,757,000	98,086,000	98,086,000	92,773,000	94,006,000	94,006,000	92,061,000	20,479,000
total liabilities and shareholders’ equity	199,448,000	187,157,000	167,949,000	164,236,000	158,253,000	157,521,000	167,899,000	164,698,000	203,100,000	200,976,000					221,127,000	247,265,000	264,089,000	282,591,000	292,941,000	311,637,000	327,635,000	341,401,000	207,725,000					190,300,000	269,006,000	295,236,000	351,861,000	253,277,000																																												93,253,000	93,253,000	91,080,000	91,080,000	88,767,000	91,861,000	88,767,000	101,091,000	101,091,000	105,197,000	105,197,000	103,911,000	101,401,000	103,911,000	106,435,000	106,435,000	108,461,000	108,461,000	114,894,000	111,262,000	111,262,000	113,648,000	113,648,000	116,278,000	116,278,000	124,351,000	127,972,000	127,972,000	142,585,000	145,950,000	142,585,000	145,950,000	145,608,000	125,574,000	125,574,000	124,230,000	127,590,000	127,590,000	127,252,000	33,022,000	23,856,000	23,856,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; zero issued and outstanding at june 30, 2025 and december 31, 2024
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 96,777 issued and outstanding at june 30, 2025 and 96,518 issued and outstanding at december 31, 2024		967,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; zero issued and outstanding at march 31, 2025 and december 31, 2024
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 96,632 issued and outstanding at march 31, 2025 and 96,518 issued and outstanding at december 31, 2024			966,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; zero issued and outstanding at december 31, 2024 and 5,194 issued and outstanding at december 31, 2023
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 96,518 issued and outstanding at december 31, 2024 and 89,825 issued and outstanding at december 31, 2023				965,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; zero issued and outstanding at september 30, 2024 and 5,194 issued and outstanding at december 31, 2023
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 96,338 issued and outstanding at september 30, 2024 and 89,825 issued and outstanding at december 31, 2023					963,000
research and development tax credit receivable						927,000	1,293,000	1,322,000	1,199,000	974,000	2,283,000	2,248,000	2,077,000	2,205,000	2,387,000	2,443,000	2,493,000	2,551,000	3,108,000	3,326,000	3,058,000		1,835,000	2,107,000	7,694,000	7,833,000	7,591,000	7,272,000	6,168,000	6,124,000	5,903,000	5,272,000	3,547,000	3,039,000	2,396,000			4,034,000		1,609,000		1,609,000																																																												5,773,000	5,773,000	5,800,000	6,242,000	5,800,000	6,242,000	6,533,000	1,324,000	1,324,000	1,297,000	1,304,000	1,304,000	1,348,000	699,000	686,000	686,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; zero issued and outstanding at june 30, 2024 and 5,194 issued and outstanding at december 31, 2023
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 96,204 issued and outstanding at june 30, 2024 and 89,825 issued and outstanding at december 31, 2023						961,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; zero issued and outstanding at march 31, 2024 and 5,194 issued and outstanding at december 31, 2023
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 96,097 issued and outstanding at march 31, 2024 and 89,825 issued and outstanding at december 31, 2023							960,000
current portion of long-term debt									21,187,000	20,851,000	20,515,000	37,668,000	26,299,000	26,241,000	26,184,000										35,000	105,000	104,000	106,000	107,000	108,000	114,000	111,000	301,000	291,000	272,000	268,000	286,000	283,000	454,000					42,332,000					20,365,000	19,194,000	6,797,000	20,365,000	3,252,000	6,797,000	3,252,000	3,351,000	1,971,000	2,092,000	1,971,000	2,092,000	2,026,000	2,117,000	2,266,000	2,117,000	2,463,000	2,266,000	2,463,000	2,158,000	2,317,000	734,000	806,000	806,000	2,158,000	720		726,000	726,000	654,000	654,000	703,000	684,000	703,000	775,000	775,000	777,000	777,000		724,000							394,000	394,000	395,000	395,000	376,000	376,000	449,000	193,000	193,000		208,000		208,000	218,000								99,000	99,000
long-term debt											93,139,000	91,614,000	109,934,000	108,074,000	116,525,000	142,397,000	142,086,000	141,774,000	141,461,000	128,210,000	126,520,000	124,879,000	123,258,000													547,000
shareholders’ equity																																																																											44,863,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 5,194 issued and outstanding at december 31, 2023 and 488 issued and outstanding at december 31, 2022								52,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 89,825 issued and outstanding at december 31, 2023 and 62,878 issued and outstanding at december 31, 2022								898,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 5,194 issued and outstanding at september 30, 2023 and 488 issued and outstanding at december 31, 2022									52,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 89,398 issued and outstanding at september 30, 2023 and 62,878 issued and outstanding at december 31, 2022									893,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 5,194 issued and outstanding at june 30, 2023 and 488 issued and outstanding at december 31, 2022										52,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 89,321 issued and outstanding at june 30, 2023 and 62,878 issued and outstanding at december 31, 2022										893,000
liabilities and shareholders’ (deficit) equity
proceeds received in advance of series b preferred shares issuance											40,000,000
shareholders’ (deficit) equity:
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at march 31, 2023 and 488 issued and outstanding at december 31, 2022											5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 64,478 issued and outstanding at march 31, 2023 and 62,878 issued and outstanding at december 31, 2022											644,000
total shareholders’ (deficit) equity											-38,166,000	-21,145,000	-12,440,000	-3,332,000										-29,199,000	-26,963,000	-17,777,000	-9,582,000
total liabilities and shareholders’ (deficit) equity											140,739,000	132,785,000	145,758,000	157,938,000										151,436,000	155,888,000	165,709,000	173,622,000
balance, december 31, 2022											62,878,000
net income																																																																											-11,439,000																																													3,005,000
other comprehensive income
issuance of common stock under at-the-market offering program, net of issuance costs											1,564,000		1,768,000
amortization of deferred issuance costs
vesting of restricted shares											22,000		119,000	119,000												1,000	1,000
employee share purchase plan share issuance											14,000		18,000	18,000												42,000	42,000
share-based compensation expense
balance, march 31, 2023											64,478,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at december 31, 2022 and 2021, respectively												5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 62,878 and 58,620 issued and outstanding at december 31, 2022 and 2021, respectively												628,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at september 30, 2022 and 488 issued and outstanding at december 31, 2021													5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 60,885 issued and outstanding at september 30, 2022 and 58,620 issued and outstanding at december 31, 2021													608,000
balance, december 31, 2021													58,620,000	58,620,000
other comprehensive loss
exercise of stock options													275,000	275,000
balance, march 31, 2022													59,032,000	59,032,000
change in fair value of october 2023 notes conversion feature
balance, june 30, 2022													59,038,000	59,038,000
balance, september 30, 2022													60,885,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at june 30, 2022 and 488 issued and outstanding at december 31, 2021														5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 59,038 issued and outstanding at june 30, 2022 and 58,620 issued and outstanding at december 31, 2021														590,000
stock-based compensation expense
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at march 31, 2022 and 488 issued and outstanding at december 31, 2021, respectively															5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 59,032 issued and outstanding at march 31, 2022 and 58,620 issued and outstanding at december 31, 2021															590,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at december 31, 2021 and 2020, respectively																5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 58,620 and 58,396 issued and outstanding at december 31, 2021 and 2020, respectively																586,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at september 30, 2021 and 488 issued and outstanding at december 31, 2020, respectively																	5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 58,616 issued and outstanding at september 30, 2021 and 58,396 issued and outstanding at december 31, 2020																	586,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at june 30, 2021 and 488 issued and outstanding at december 31, 2020, respectively																		5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 58,488 issued and outstanding at june 30, 2021 and 58,396 issued and outstanding at december 31, 2020																		584,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at march 31, 2021 and 488 issued and outstanding at december 31, 2020, respectively																			5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 58,488 issued and outstanding at march 31, 2021 and 58,396 issued and outstanding at december 31, 2020																			584,000
intangible assets																							610,000	813,000	1,019,000	1,224,000	1,428,000	1,629,000	69,339,000	70,962,000	72,571,000	92,289,000	94,256,000	21,709,000	22,274,000	22,837,000	25,508,000	29,209,000	32,911,000	22,107,000	25,248,000	22,107,000	25,248,000	28,389,000	31,327,000	34,264,000	37,201,000	34,264,000	41,094,000	40,139,000	41,259,000	41,094,000	41,424,000	41,259,000	41,424,000	41,589,000	49,089,000	49,250,000	49,089,000	49,250,000
current portion of long-term contingent consideration payable																						1,914,000	5,855,000
long-term contingent consideration payable, less current portion																							12,195,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at december 31, 2020 and 0 issued and outstanding at december 31, 2019																				5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 58,396 issued and outstanding at december 31, 2020, and 42,927 issued and 37,520 outstanding at december 31, 2019																				583,000
treasury shares, at cost, 0 and 5,407 shares held at december 31, 2020 and december 31, 2019, respectively
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at september 30, 2020 and none issued and outstanding at december 31, 2019, respectively																					5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 58,243 issued and outstanding at september 30, 2020 and 42,927 issued and 37,520 outstanding at december 31, 2019																					582,000
treasury shares, at cost, 0 and 5,407 shares held at september 30, 2020 and december 31, 2019, respectively
income taxes																						354,000	2,297,000					73,000				414,000	7,026,000	1,455,000	9,738,000	1,200,000		6,286,000	5,844,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at june 30, 2020 and none issued and outstanding at december 31, 2019, respectively																						5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 63,536 issued and 58,129 outstanding at june 30, 2020 and 42,927 issued and 37,520 outstanding at december 31, 2019																						635,000
treasury shares, at cost, 5,407 shares held at june 30, 2020 and december 31, 2019, respectively																						-49,998,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; 488 issued and outstanding at march 31, 2020 and none issued and outstanding at december 31, 2019, respectively																							5,000
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 51,812 issued and 46,404 outstanding at march 31, 2020 and 42,927 issued and 37,520 outstanding at december 31, 2019																							518,000
treasury shares, at cost, 5,407 shares held at march 31, 2020 and december 31, 2019, respectively																							-49,998,000
current portion of long-term related party payable																								5,554,000	7,588,000	8,264,000	9,391,000	9,439,000	10,979,000	14,067,000	21,121,000	25,007,000	30,986,000	40,615,000	43,699,000	34,177,000	33,359,000	29,500,000
long-term debt, less current portion																								121,686,000	120,132,000	118,631,000	117,178,000	115,734,000	114,382,000	113,038,000	111,724,000	156,000	614,000	594,000	555,000		734,000	788,000	710,000					76,135,000					65,398,000	66,320,000	77,975,000	65,398,000	50,772,000	77,975,000	50,772,000	33,278,000	47,840,000	47,763,000	47,840,000	47,763,000	1,689,000	1,689,000	1,447,000	1,689,000	1,646,000	1,447,000	1,646,000	1,789,000	1,547,000	2,815,000	2,755,000	2,755,000	1,789,000	2,387		2,273,000	2,273,000	2,170,000	2,170,000	2,332,000	2,269,000	2,332,000	2,570,000	2,570,000	2,578,000	2,578,000	3,009,000	2,400,000	3,009,000	2,866,000	2,866,000	2,826,000	2,826,000	2,795,000	2,293,000	2,293,000	2,302,000	2,302,000	2,302,000	2,302,000	2,333,000	3,153,000	3,153,000	1,604,000	1,512,000	1,604,000	1,512,000	1,589,000	1,645,000	1,645,000	1,613,000	1,622,000	1,622,000	1,675,000	1,546,000	1,516,000	1,516,000	1,445,000	1,445,000
long-term related party payable, less current portion																								11,773,000	14,118,000	15,983,000	18,202,000	19,401,000	27,713,000	38,050,000	51,646,000	73,918,000	76,131,000	86,844,000	109,514,000		146,926,000	136,021,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; none issued or outstanding at december 31, 2019 and december 31, 2018, respectively
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 42,927 issued and 37,520 outstanding at december 31, 2019, and 42,720 issued and 37,313 outstanding at december 31, 2018																								429,000
treasury shares, at cost, 5,407 shares held at december 31, 2019 and december 31, 2018, respectively																								-49,998,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; none issued or outstanding at september 30, 2019 and december 31, 2018, respectively
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 42,857 issued and 37,450 outstanding at september 30, 2019 and 42,720 issued and 37,313 outstanding at december 31, 2018																									428,000
treasury shares, at cost, 5,407 shares held at september 30, 2019 and december 31, 2018, respectively																									-49,998,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; none issued or outstanding at june 30, 2019 and december 31, 2018, respectively
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 42,763 issued and 37,356 outstanding at june 30, 2019 and 42,720 issued and 37,313 outstanding at december 31, 2018																										427,000
treasury shares, at cost, 5,407 shares held at june 30, 2019 and december 31, 2018, respectively																										-49,998,000
balance, december 31, 2018																										42,720,000	42,720,000
balance, march 31, 2019																										42,763,000	42,763,000
balance, june 30, 2019																										42,763,000
deferred revenue																											115,000	114,000	1,720,000	1,724,000	1,884,000	2,007,000	1,927,000	2,455,000	1,617,000	2,223,000	3,115,000	3,820,000	4,611,000	21,000	3,545,000	21,000	3,545,000	1,336,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; none issued or outstanding at march 31, 2019 and december 31, 2018, respectively
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 42,762 issued and 37,355 outstanding at march 31, 2019 and 42,720 issued and 37,313 outstanding at december 31, 2018																											427,000
treasury shares, at cost, 5,407 shares held at march 31, 2019 and december 31, 2018, respectively																											-49,998,000
preferred shares, nominal value of 0.01 per share; 50,000 shares authorized; none issued or outstanding at december 31, 2018 and december 31, 2017, respectively
ordinary shares, nominal value of 0.01 per share; 500,000 shares authorized; 42,720 issued and 37,313 outstanding at december 31, 2018, and 41,463 issued and 39,346 outstanding at december 31, 2017																												427,000
treasury shares, at cost, 5,407 and 2,117 shares held at december 31, 2018 and december 31, 2017, respectively																												-49,998,000
preferred shares, 0.01 nominal value; 50,000 shares authorized at september 30, 2018 and december 31, 2017, respectively; none issued or outstanding at september 30, 2018 and december 31, 2017, respectively
ordinary shares, nominal value of 0.01; 500,000 shares authorized; 42,420 issued and 37,012 outstanding at september 30, 2018 and 41,463 issued and 39,346 outstanding at december 31, 2017																													424,000
treasury shares, at cost, 5,408 and 2,117 shares held at september 30, 2018 and december 31, 2017, respectively																													-49,998,000
preferred shares, 0.01 nominal value; 50,000 shares authorized at june 30, 2018 and december 31, 2017, respectively; none issued or outstanding at june 30, 2018 and december 31, 2017, respectively
ordinary shares, nominal value of 0.01; 500,000 shares authorized; 42,148 issued and 36,740 outstanding at june 30, 2018 and 41,463 issued and 39,346 outstanding at december 31, 2017																														421,000
treasury shares, at cost, 5,408 and 2,117 shares held at june 30, 2018 and december 31, 2017, respectively																														-49,998,000
preferred shares, 0.01 nominal value; 50,000 shares authorized at march 31, 2018 and december 31, 2017, respectively; none issued or outstanding at march 31, 2018 and december 31, 2017, respectively
ordinary shares, nominal value of 0.01; 500,000 shares authorized; 42,066 issued and 37,642 outstanding at march 31, 2018 and 41,463 issued and 39,346 outstanding at december 31, 2017																															420,000
treasury shares, at cost, 4,424 and 2,117 shares held at march 31, 2018 and december 31, 2017, respectively																															-42,573,000
income tax deferred charge																																				10,342,000	11,243,000	11,381,000	11,964,000	11,685,000	11,444,000	11,685,000	11,444,000	13,102,000
preferred shares, 0.01 nominal value; 50,000 shares authorized; none issued or outstanding at december 31, 2017 and december 31, 2016, respectively
ordinary shares, nominal value of 0.01; 500,000 shares authorized; 41,463 issued and 39,346 outstanding at december 31, 2017, and 41,371 issued and outstanding at december 31, 2016																																414,000
treasury shares, at cost, 2,117 and 0 shares held at december 31, 2017 and december 31, 2016, respectively																																-22,361,000
other																																	9,020,000	8,242,000	7,533,000	7,531,000	6,820,000	5,661,000	16,000
liabilities and shareholders' equity
shareholders' equity:
preferred shares, 0.01 nominal value; 50,000 shares authorized; none issued or outstanding at september 30, 2017 and december 31, 2016, respectively
ordinary shares, nominal value of 0.01; 500,000 shares authorized; 41,435 and 41,371 issued and outstanding at september 30, 2017 and december 31, 2016, respectively																																	414,000
treasury shares, at cost, 1,673 and 0 shares held at september 30, 2017 and december 31, 2016, respectively																																	-17,506,000
total shareholders' equity																																	96,463,000	76,728,000	59,082,000	42,069,000	36,833,000	51,838,000	69,699,000	13,637,000	22,246,000	13,637,000	22,246,000	24,895,000	40,048,000	57,863,000	78,129,000	57,863,000	-15,405,000	-9,512,000	-10,064,000	-15,405,000	21,682,000	-10,064,000	21,682,000	30,504,000	25,361,000	31,985,000	25,361,000	31,985,000	29,794,000	32,363,000	31,894,000	32,363,000	34,019,000	31,894,000	34,019,000	33,468,000	36,305,000	32,364,000	38,910,000	38,910,000	33,468,000	50,070
total liabilities and shareholders' equity																																	277,427,000	259,160,000	258,688,000	245,482,000	247,985,000	249,706,000	255,010,000						164,386,000	174,631,000	181,742,000	174,631,000	116,515,000	116,252,000	118,408,000	116,515,000	122,733,000	118,408,000	122,733,000	117,311,000	133,715,000	137,411,000	133,715,000	137,411,000	69,402,000	72,697,000	76,114,000	72,697,000	69,980,000	76,114,000	69,980,000	77,384,000	74,614,000	70,480,000	81,255,000	81,255,000	77,384,000	97,921
preferred shares, 0.01 nominal value; 50,000 shares authorized; none issued or outstanding at june 30, 2017 and december 31, 2016, respectively
ordinary shares, nominal value of 0.01; 500,000 shares authorized; 41,435 and 41,371 issued and outstanding at june 30, 2017 and december 31, 2016, respectively																																		414,000
treasury shares, at cost, 1,351 and 0 shares held at june 30, 2017 and december 31, 2016, respectively																																		-14,338,000
preferred shares, 0.01 nominal value; 50,000 shares authorized at march 31, 2017 and december 31, 2016,respectively; none issued or outstanding at march 31, 2017 and december 31, 2016, respectively
ordinary shares, nominal value of 0.01; 500,000 shares authorized; 41,380 and 41,371 issued and outstanding at march 31, 2017 and december 31, 2016, respectively																																			414,000
long-term related party payable																																				135,170,000			15,000,000
preferred shares, 0.01 nominal value; 50,000 shares authorized at december 31, 2016, none authorized at december 31, 2015; none issued or outstanding at december 31, 2016 and december 31, 2015, respectively
ordinary shares, nominal value of 0.01 and €0.122; 500,000 and 53,178 shares authorized; 41,371 and 41,241 issued and outstanding at december 31, 2016 and 2015, respectively																																				414,000
ordinary shares, nominal value of 0.122 euro per share; 53,178 shares authorized; 41,241 issued and outstanding at september 30, 2016 and december 31, 2015																																					6,331,000
ordinary shares, nominal value of 0.122 euro per share; 53,178 shares authorized; 41,241 issued and outstanding at june 30, 2016 and december 31, 2015																																						6,331,000
research and development tax credit receivable - current portion																																							368,000
research and development tax credit receivable - less current portion																																							2,490,000
current portion of long-term related party contingent consideration payable																																							28,403,000
long-term related party contingent consideration payable, less current portion																																							102,656,000
deferred taxes																																							3,507,000
ordinary shares, nominal value of 0.122 euro per share; 53,178 shares authorized; 41,241 issued and outstanding at march 31, 2016 and december 31, 2015, respectively																																							6,331,000
inventory																																								5,751,000	5,497,000	5,751,000	5,497,000	6,729,000	6,473,000	5,564,000	5,132,000	5,564,000	2,892,000	3,762,000	1,854,000	2,892,000	1,884,000	1,854,000	1,884,000	1,520,000	1,599,000	1,903,000	1,599,000	1,903,000	1,675,000	1,699,000	906,000	1,699,000	854,000	906,000	854,000	1,070,000	862,000	932,000	826,000	826,000	1,070,000	2,157		2,592,000	2,592,000	2,093,000	2,093,000	1,683,000	1,837,000	1,683,000	2,194,000	2,194,000	2,218,000	2,218,000	2,948,000	1,771,000	2,948,000	3,064,000	3,064,000	3,077,000	3,077,000	3,332,000	1,354,000	1,354,000	1,265,000	1,265,000	974,000	974,000	1,050,000	1,171,000	1,171,000	966,000	1,129,000	966,000	1,129,000	1,597,000	1,301,000	1,301,000	1,310,000	991,000	991,000	1,057,000	545,000	1,069,000	1,069,000
total current assets from continuing operations																																								132,167,000	128,394,000	132,167,000	128,394,000	111,592,000
total current assets from assets held for sale																																									940,000		940,000	730,000
other assets:
other long-term assets																																								117,000		117,000			139,000	150,000	155,000	150,000	156,000	154,000	177,000	156,000	199,000	177,000	199,000	183,000	173,000	175,000	173,000	175,000	164,000	172,000	184,000	172,000	197,000	184,000	197,000	189,000	186,000	171,000	194,000	194,000	189,000	221		210,000	210,000	198,000	198,000	221,000	191,000	221,000	241,000	241,000	236,000	236,000	891,000	219,000	891,000	846,000	846,000	831,000	831,000	811,000	1,157,000	1,157,000	1,162,000	1,162,000	1,125,000	1,125,000	1,096,000	135,000	135,000	136,000	179,000	136,000	179,000	141,000	130,000	130,000	120,000	107,000	107,000	84,000	77,000	77,000	77,000
total long term assets from continuing operations																																								54,378,000	57,075,000	54,378,000	57,075,000
total assets including "assets held for sale"																																								186,545,000	186,409,000	186,545,000	186,409,000	174,205,000
liabilities
current portion of long-term debt, incl to related parties																																								37,803,000	44,623,000	37,803,000	44,623,000		27,811,000	18,055,000	18,090,000	18,055,000
income tax payable																																								77,000	10,926,000	77,000	10,926,000	7,643,000
total current liabilities from continuing operations																																								52,749,000	77,503,000	52,749,000	77,503,000	70,674,000
total current liabilities from liabilities held for sale																																									149,000		149,000	168,000
long-term debt, less current portion, incl. to related parties																																								111,882,000	78,554,000	111,882,000	78,554,000		68,028,000	69,401,000	56,570,000	69,401,000
deferred tax liabilities																																								6,071,000	5,863,000	6,071,000	5,863,000						7,670,000	2,806,000	8,897,000	7,670,000	12,634,000	8,897,000	12,634,000	14,130,000	20,733,000	20,859,000	20,733,000	20,859,000
other long-term liabilities																																								2,206,000	2,094,000	2,206,000	2,094,000	2,333,000	8,554,000	9,456,000	9,626,000	9,456,000	24,986,000	15,940,000	24,276,000	24,986,000	23,845,000	24,276,000	23,845,000	24,680,000	22,277,000	17,890,000	22,277,000	17,890,000	17,823,000	18,612,000	20,119,000	18,612,000	12,564,000	20,119,000	12,564,000	14,015,000	13,961,000	12,837,000	14,299,000	14,299,000	14,015,000	18,520		19,484,000	19,484,000	15,106,000	15,106,000	17,119,000	20,494,000	17,119,000	19,233,000	19,233,000	19,442,000	19,442,000	18,341,000	19,039,000	18,341,000	19,403,000	19,403,000	17,658,000	17,658,000	17,437,000	16,489,000	16,489,000	12,113,000	12,113,000	10,615,000	10,615,000	9,838,000	7,974,000	7,974,000	4,057,000	2,363,000	4,057,000	2,363,000	2,287,000	952,000	952,000	770,000	715,000	715,000	1,187,000	1,063,000	1,144,000	1,144,000	884,000	884,000
total long-term liabilities from continuing operations																																								120,159,000	86,511,000	120,159,000	86,511,000	78,468,000
ordinary shares: 40,191,264 issued and outstanding at december 31, 2014 and 40,498,764 at june 30, 2015 (shares authorised 52,549,354) at nominal value of 0.122 euro																																								6,229,000		6,229,000
accumulated other comprehensive income																																								-18,810,000	-23,716,000	-18,810,000	-23,716,000	-7,423,000	-2,324,000	8,790,000	10,047,000	8,790,000	10,539,000	10,815,000	10,112,000	10,539,000	9,769,000	10,112,000	9,769,000	10,253,000	9,384,000	10,936,000	9,384,000	10,936,000	10,057,000	11,379,000	13,584,000	11,379,000	12,978,000	13,584,000	12,978,000	11,641,000	10,873,000	8,192,000	11,654,000	11,654,000	11,641,000	15,042		13,137,000	13,137,000	10,101,000	10,101,000	13,556,000	12,150,000	13,556,000	18,686,000	18,686,000	18,395,000	18,395,000	11,372,000	14,085,000	11,372,000	8,383,000	8,383,000	7,314,000	7,314,000	6,451,000	3,404,000	3,404,000	3,576,000	3,576,000	-549,000	-549,000	-2,719,000	-834,000	-834,000	-804,000	6,517,000	-804,000	6,517,000	14,161,000	2,156,000	2,156,000	141,000	530,000	530,000	3,564,000
total liabilities and shareholders' equity including held for sale																																								186,545,000	186,409,000	186,545,000	186,409,000
research and development tax credit receivable short term																																									5,378,000		5,378,000		9,905,000	15,232,000	14,039,000	15,232,000	11,500,000		16,545,000	11,500,000	14,982,000	16,545,000	14,982,000							82,000	88,000	82,000	87,000	88,000	87,000	2,353,000		2,116,000	8,737,000	8,737,000	2,353,000	7,897				5,628,000	5,628,000								5,288,000		5,288,000	631,000	631,000				591,000	591,000	594,000	594,000	726,000	726,000	708,000
other long-term assets from continuing operations																																									115,000		115,000	125,000
total long term assets from assets held for sale
current portion of capital lease obligations																																									9,000		9,000	13,000	77,000	69,000	42,000	69,000	82,000	85,000	78,000	82,000	76,000	78,000	76,000	77,000	85,000	88,000	85,000	88,000	97,000	108,000	108,000	108,000	94,000	108,000	94,000	34,000	59,000	30,000	32,000	32,000	34,000	29		28,000	28,000	26,000	26,000	102,000	69,000	102,000	156,000	156,000	214,000	214,000	301,000	256,000	301,000	336,000	336,000	377,000	377,000	420,000	401,000	401,000	400,000	400,000	379,000	379,000	379,000	378,000	378,000	369,000	385,000	369,000	385,000	334,000	281,000	281,000	231,000	354,000	354,000	257,000	241,000	190,000	190,000
total long-term liabilities from liabilities held for sale
ordinary shares: 40,191,264 issued and outstanding at december 31, 2014 and 40,253,014 at march 31, 2015 (shares authorised 52,549,354) at nominal value of 0.122 euro																																									6,196,000		6,196,000
research and development tax credit receivable current portion																																												5,932,000						14,139,000						6,632,000					79,000								2,304,000											5,334,000	11,114,000	5,334,000	5,878,000	5,878,000	5,896,000	5,896,000		5,490,000				622,000	622,000	615,000
research and development tax credit receivable less current portion																																																		6,410,000						13,725,000					13,203,000								7,641,000											9,055,000	4,880,000	9,055,000	14,112,000	14,112,000	11,869,000	11,869,000		9,932,000				11,743,000	11,743,000	11,599,000
total long-term assets from continuing operations																																												61,883,000
total long term from assets held for sale
advances from customers																																														44,000		44,000	452,000	116,000	447,000	452,000	428,000	447,000	428,000	575,000	436,000	408,000	436,000	408,000	1,962,000	861,000	558,000	861,000	129,000	558,000	129,000	4,488,000	139,000	691,000	1,479,000	1,479,000	4,488,000	919		1,446,000	1,446,000	1,025,000	1,025,000	1,586,000	587,000	1,586,000	1,176,000	1,176,000	1,319,000	1,319,000	929,000	1,215,000	929,000	748,000	748,000	398,000	398,000	394,000	412,000	412,000	414,000	414,000	394,000	394,000	385,000	300,000	300,000	2,247,000	323,000	2,247,000	323,000	368,000	309,000	309,000	311,000	312,000	312,000	344,000	290,000	284,000	284,000
capital lease obligations, less current portion																																													36,000	70,000	120,000	70,000	122,000	103,000	138,000	122,000	155,000	138,000	155,000	179,000	208,000	240,000	208,000	240,000	251,000	281,000	335,000	281,000	252,000	335,000	252,000	35,000	133,000	40,000	53,000	53,000	35,000	78		82,000	82,000	84,000	84,000	105,000	96,000	105,000	123,000	123,000			105,000	44,000	105,000	157,000	157,000	211,000	211,000	272,000	362,000	362,000	465,000	465,000	540,000	540,000	630,000	740,000	740,000	840,000	1,013,000	840,000	1,013,000	789,000	665,000	665,000	380,000	116,000	116,000	261,000
shareholders' equity :
ordinary shares: 25,612,5500 issued and outstanding at december 31, 2013 and 40,191,264 at december 31, 2014 (shares authorised 52,683,254) at nominal value of 0.122 euro																																												6,188,000
total liabilities and shareholder's equity including held for sale																																												174,205,000
research and development tax credit receivable long term																																																	6,491,000		6,261,000	6,491,000	6,104,000	6,261,000	6,104,000		15,669,000	15,276,000	15,669,000	15,276,000		12,093,000	11,479,000	12,093,000	10,126,000	11,479,000	10,126,000	4,272,000		2,648,000	1,734,000	1,734,000	4,272,000	2,525		8,307,000	8,307,000	6,625,000	6,625,000								7,214,000		7,214,000	11,908,000	11,908,000				8,979,000	8,979,000	9,016,000	9,016,000	9,183,000	9,183,000	8,950,000
current portion of deferred revenue																																													612,000	954,000	157,000	954,000	1,001,000	1,264,000	190,000	1,001,000	269,000	190,000	269,000	614,000	2,488,000	2,980,000	2,488,000	2,980,000	2,836,000	3,183,000	3,713,000	3,183,000	2,182,000	3,713,000	2,182,000	2,529,000	2,528,000	3,050,000	3,613,000	3,613,000	2,529,000	4,466		1,651,000	1,651,000	1,672,000	1,672,000	1,419,000	798,000	1,419,000	1,819,000	1,819,000	2,419,000	2,419,000	584,000	2,948,000	584,000	136,000	136,000	328,000	328,000	562,000	737,000	737,000	147,000	147,000			182,000	1,826,000	1,826,000	795,000	1,002,000	795,000	1,002,000	2,528,000	14,092,000	14,092,000	8,577,000	8,970,000	8,970,000	9,623,000	2,269,000	2,826,000	2,826,000
total long-term liabilities																																													76,618,000	78,927,000	66,316,000	78,927,000	98,313,000	85,169,000	111,370,000	98,313,000	87,535,000	111,370,000	87,535,000	72,448,000	92,110,000	88,250,000	92,110,000	88,250,000	21,294,000	22,692,000	25,310,000	22,692,000	17,500,000	25,310,000	17,500,000	19,554,000	18,888,000	19,638,000	21,849,000	21,849,000	19,554,000	26,367		27,096,000	27,096,000	22,675,000	22,675,000	19,556,000	23,060,000	19,556,000	21,926,000	21,926,000	22,261,000	22,261,000	21,455,000	21,819,000	21,455,000	22,426,000	22,426,000	20,703,000	20,703,000	20,554,000	19,327,000	19,327,000	15,008,000	15,008,000	13,457,000	13,457,000	12,801,000	11,867,000	11,867,000	6,988,000	5,548,000	6,988,000	5,548,000	5,525,000	4,387,000	4,387,000	12,477,000	14,208,000	14,208,000	17,323,000	4,675,000	5,419,000	5,419,000
ordinary shares: 25,612,550 issued and outstanding at december 31, 2013 and 38,936,300 at sept 30, 2014 (shares authorised 51,866,390) at nominal value of 0.122 euro																																													5,998,000
accounts payable.																																														6,167,000		6,167,000
ordinary shares: 25,612,550 issued and outstanding at december 31, 2013 and 38,581,300 at june 30, 2014 (shares authorised 46,267.940) at nominal value of 0.122 euro																																														5,933,000		5,933,000
ordinary shares: 25,612,550 issued and outstanding at december 31, 2013 and 38,267,550 at march 31, 2014 (shares authorised 46,730,190) at nominal value of 0.122 euro																																															5,888,000
total other assets																																																	6,647,000		6,438,000	6,647,000	6,303,000	6,438,000	6,303,000		15,842,000	15,451,000	15,842,000	15,451,000		12,265,000	11,663,000	12,265,000	10,323,000	11,663,000	10,323,000	4,461,000		2,819,000	1,928,000	1,928,000	4,461,000	2,746		8,517,000	8,517,000	6,823,000	6,823,000	9,276,000		9,276,000	14,353,000	14,353,000	12,105,000	12,105,000	8,105,000		8,105,000	12,754,000	12,754,000	12,574,000	12,574,000		10,136,000	10,136,000	10,178,000	10,178,000	10,308,000	10,308,000		5,908,000	5,908,000	5,936,000	6,421,000	5,936,000	6,421,000		1,454,000	1,454,000	1,417,000	1,411,000	1,411,000	1,432,000	776,000
deferred revenue, less current portion																																																	136,000		84,000	136,000	129,000	84,000	129,000	181,000	1,052,000	1,498,000	1,052,000	1,498,000	1,531,000	2,110,000	3,409,000	2,110,000	3,038,000	3,409,000	3,038,000	3,715,000	3,247,000	3,946,000	4,742,000	4,742,000	3,715,000	5,382		5,257,000	5,257,000	5,315,000	5,315,000		201,000				241,000	241,000		336,000				8,000	8,000	50,000	183,000	183,000	128,000	128,000						487,000	660,000	487,000	660,000	860,000	1,125,000	1,125,000	9,714,000	11,755,000	11,755,000	14,200,000	2,025,000	2,678,000	2,678,000	2,905,000	2,905,000
commitments and contingencies:
ordinary shares: 25,415,400 issued and outstanding at december 31, 2012 and 25,465,400 at september 30, 2013 (shares authorised 34,587,690) at nominal value of 0.122 euro																																																	3,722,000			3,722,000
ordinary shares: 25,415,400 issued and outstanding at december 31, 2012 and 25,612,550 at december 31, 2013 (shares authorised 34,379,690) at nominal value of 0.122 euro																																																		3,746,000
ordinary shares: 25,415,400 issued and outstanding at december 31, 2012 and 25,465,400 at june 30, 2013 (shares authorised 34,753,740) at nominal value of 0122 euro																																																			3,722,000			3,722,000
ordinary shares: 25,415,400 issued and outstanding at december 31, 2012 and march 31, 2013 (shares authorised 33,691,240) at nominal value of 0.122 euro																																																					3,714,000		3,714,000
note receivable
ordinary shares: 24,962,250 issued and outstanding at december 31, 2011 and 25,415,400 at december 31, 2012 (shares authorised 33,931,990) at nominal value of 0.122 euro																																																								3,714,000
ordinary shares: 24,962,250 issued and outstanding at december 31, 2011 and 25,157,250, at june 30, 2012 (shares authorised 34,012,490) at nominal value of 0.122 euro																																																									3,673,000		3,673,000
ordinary shares: 24,962,250 issued and outstanding at december 31, 2011 and 25,157,250, at march 31, 2012 (shares authorised 29,745,490) at nominal value of 0.122 euro																																																										3,673,000		3,673,000
ordinary shares: 24,645,650 issued and outstanding at december 31, 2010 and 24,962,250 at december 31, 2011 (shares authorised 29,845,490) at nominal value of 0.122 euro																																																													3,641,000
ordinary shares: 24,645,650 issued and outstanding at december 31, 2010 and september 30, 2011 (shares authorised 29,844,540) at nominal value of 0.122 euro																																																														3,589,000		3,589,000
ordinary shares: 24,645,650 issued and outstanding at december 31, 2010 and june 30, 2011 (shares authorised 29,576,040) at nominal value of 0.122 euro																																																															3,589,000			3,589,000
ordinary shares: 24,645,650 issued and outstanding at december 31, 2010 and march 31, 2011 (shares authorised 29,426,040) at nominal value of 0.122 euro																																																																	3,589,000		3,589,000
ordinary shares: 24,342,600 issued and outstanding at december 31, 2009 and 24,422,600 at september 30, 2010 (shares authorised 29,650,790) at nominal value of 0.122 euro																																																																				3,553,000					3,553,000
ordinary shares: 24,342,600 issued and outstanding at december 31, 2009 and 24,645,650 at december 31, 2010 (shares authorised 29,509,790) at nominal value of 0.122 euro																																																																					3,589,000
ordinary shares: 24,342,600 issued and outstanding at december 31, 2009 and 24,422,600 at june 30, 2010 (shares authorised 29,450,340) at nominal value of 0.122 euro																																																																						3,553,000
ordinary shares: 24,342,600 issued and outstanding at december 31, 2009 and march 31, 2010 (shares authorised 28,678,090) at nominal value of 0.122 euro																																																																							3,540,000	3,540,000
ordinary shares: 24,205,350 issued and outstanding at december 31, 2008 and 24,225,350 at september 30, 2009																																																																										3,519
revenues																																																																											42,118,000																																													18,406,000
cost and expenses																																																																											-53,871,000																																													-18,629,000
income (loss) from operations																																																																											-11,753,000
interest and foreign exchange gain																																																																											342,000																																													149,000
other income																																																																											-28,000																																													2,525,000
income (loss) before income tax																																																																											-11,439,000
income tax benefit (expense)¤
income (loss) from operations per ordinary share																																																																											-490
basic earnings per ordinary share																																																																											-470
diluted earnings per ordinary share																																																																																																																								180		-620
basic weighted-average number of shares outstanding																																																																											24,225,000
diluted weighted-average number of shares outstanding																																																																											24,225,000																																													16,711,000		15,331,000
dividends per share
cash, cash equivalents & marketable securities																																																																											44,068,000																																													14,527,000	5,309,000
working capital**																																																																											44,185,000																																													12,202,000
long term liabilities																																																																											20,744,000																																													2,329,000	1,299,000	1,891,000
ordinary shares: 24,205,350 issued and outstanding at december 31, 2008 and 24,225,350 at june 30, 2009																																																																												3,519,000	3,519,000
ordinary shares: 24,205,350 issued and outstanding at december 31, 2008 and march 31, 2009																																																																														3,516,000	3,516,000
ordinary shares: 24,051,590 issued and outstanding at december 31, 2007 and 24,106,600 at september 30, 2008																																																																																3,500,000		3,500,000
shareholders’ equity :
ordinary shares: 24,051,590 issued and outstanding at december 31, 2007 and 24,205,350 at december 31, 2008 (shares authorised 28,402,757) at nominal value of 0.122 euro																																																																																	3,516,000
ordinary shares: 24,051,590 issued and outstanding at december 31, 2007 and 24,066,600 at june 30, 2008																																																																																			3,493,000	3,493,000
ordinary shares: 24,051,590 issued and outstanding at december 31, 2007 and 24,066,590 at march 31, 2008																																																																																					3,493,000	3,493,000
ordinary shares : 23,990,590 issued and outstanding at december 31, 2006 and 24,041,590 at september 30, 2007																																																																																							3,488,000		3,488,000
deferred compensation																																																																																																									-1,008,000		-1,008,000	-1,122,000	-1,126,000	-1,126,000	-1,342,000	-1,859,000	-1,859,000	-2,388,000	-10,000	-10,000	-10,000
ordinary shares: 23,990,590 issued and outstanding at december 31, 2006 and 24,051,590 at december 31, 2007																																																																																								3,490,000
ordinary shares : 23,990,590 issued and outstanding at december 31, 2006 and 24,041,590 at june 30, 2007																																																																																										3,488,000	3,488,000
ordinary shares: 23,990,590 issued and outstanding at december 31, 2006 and march 31, 2007																																																																																												3,480,000	3,480,000
ordinary shares: 23,706,590 issued and outstanding at december 31, 2005 and 23,990,590 at december 31, 2006																																																																																														3,480,000
ordinary shares: 23,706,590 issued and outstanding at december 31, 2005 and 23,813,590 at september 30, 2006																																																																																															3,452,000	3,452,000
ordinary shares: 23,706,590 issued and outstanding at december 31, 2005 and 23,811,090 at june 30, 2006																																																																																																	3,452,000	3,452,000
ordinary shares: 23,706,590 issued and outstanding at december 31, 2005 and 23,781,590 at march 31, 2006																																																																																																			3,447,000	3,447,000
ordinary shares: 21,751,590 issued and outstanding at december 31, 2004 and 23,706,590 at december 31, 2005																																																																																																					3,436,000
ordinary shares: 21,751,590 issued and outstanding at december 31, 2004 and 23,639,590 at september 30, 2005																																																																																																						3,427,000	3,427,000
other assets
ordinary shares: 21,751,590 issued and outstanding at december 31, 2004 and 23,436,595 at june 30, 2005																																																																																																								3,398,000		3,398,000
ordinary shares: 21,751,590 issued and outstanding at december 31, 2004 and 22,701,595 at march 31, 2005																																																																																																									3,290,000		3,290,000
ordinary shares: 21,391,590 issued and outstanding at december 31, 2003 and 21,751,590 at december 31, 2004																																																																																																												3,135,000
ordinary shares: 21,391,590 issued and outstanding at december 31, 2003 and 21,651,590 at september 30, 2004																																																																																																													3,120,000	3,120,000
ordinary shares: 21,391,590 issued and outstanding at december 31, 2003 and 21,446,590 at june 30, 2004																																																																																																															3,088,000
ordinary shares: 21,391,590 issued and outstanding at december 31, 2003 and 21,416,590 at march 31, 2004																																																																																																																3,085,000	3,085,000
ordinary shares: 16,197,590 issued and outstanding at december 31, 2002 and 21,391,000 at december 31, 2003																																																																																																																		3,081,000
capital lease obligation, less current portion																																																																																																																			41,000	81,000	81,000
ordinary shares																																																																																																																			2,779,000	2,384,000	2,384,000
cumulative other comprehensive income																																																																																																																			-2,926,000	-3,883,000	-3,883,000
current assets :
other assets :
current liabilities :
capîtal lease obligation, less current portion																																																																																																																						116,000	116,000
income from operations																																																																																																																								-223,000
income before income tax																																																																																																																								2,452,000
income tax benefit																																																																																																																								553,000
basic earnings per ordinary share.																																																																																																																								190
basic weighted-average number of shares outstanding (in thousands).																																																																																																																								16,198,000		15,331,000
*
balance sheet data: *																																																																																																																								2,002,000
shareholders equity																																																																																																																								12,286,000	7,509,000	10,882,000
**
working capital***																																																																																																																									7,338,000	7,948,000
***
balance sheet data*																																																																																																																										2,000,000

Cashflow Statements:

Quarterly

Annual

Unit: USD	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-07-10	2015-06-30	2015-03-31	2014-12-31	2014-11-17	2014-08-07	2014-07-08	2014-06-30	2014-03-31	2013-09-19	2013-06-30	2013-03-31	2012-12-14	2012-09-13	2012-03-31	2011-12-31	2011-12-23	2011-07-29	2011-06-30	2011-03-31	2010-09-30	2010-06-30	2010-03-31	2009-12-31	2009-09-30	2009-06-30	2009-06-12	2009-03-31	2008-12-31	2008-09-30	2008-06-30	2008-06-18	2007-12-31	2007-09-30	2007-06-30	2007-05-31	2007-03-31	2006-12-31	2006-09-30	2006-06-30	2006-06-14	2006-03-31	2005-12-31	2005-09-30	2005-09-09	2005-07-25	2004-12-31	2004-09-30	2004-06-30	2004-05-28	2004-03-31	2003-12-31	2003-09-30	2003-06-30	2003-04-30	2003-03-31

cash flows from operating activities:
net income	20,000															-22,301,000	-22,002,000			-11,278,000	-11,703,000	30,874,000	-865,000	-2,739,000	-8,864,000	-8,605,000	-13,018,000	-63,859,000	-15,771,000	-3,438,000	-12,236,000	-8,245,000	21,679,000	28,927,000	25,910,000	4,734,000	-19,994,000	-19,640,000	-6,376,000	-17,400	11,647	-17,400,000	11,647,000	-84,848,243	-10,046	-21,073	-26,638	-21,073,000	-26,638,000	-8,829,000	-32,854,000	-8,829,000	-5,905,000	12,000	12,000	-2,091,000	1,703,000	-4,927,000	-8,381,073	-4,927	-3,339,000	-4,290,000	-4,024,000	-5,697,000		-3,550,000	1,190,000	1,190,000	-2,726,000	-2,304,000	-3,358,000	-3,696,000	-5,937,000	-9,106,000	-13,633,000	-9,061,000	-9,061,000	-64,545,000	48,473,000	-9,468,000	-9,661,000	-9,661,000	-6,448,000	-11,884,000	-9,230,000	185,000	6,957,000	2,800,000	-1,555,000	4,297,000	4,297,000
adjustments to reconcile net income to net cash from operating activities:
depreciation and amortization	1,115,000	1,068,000	825,000	668,000	1,035,000	437,000	541,000	-18,000	595,000	601,000	588,000	586,000	401,000	247,000	259,000	201,000	197,000	199,000	218,000	393,000	322,000	519,000	456,000	796,000	626,000	695,000	369,000	1,805,000	1,815,000	1,825,000	1,985,000	2,219,000	1,053,000	774,000	837,000	2,934,000	3,874,000	3,927,000	3,754,000															708,000	708,000																																						635,000	145,000	459,000	459,000
share-based compensation expense	4,919,000	5,327,000	4,183,000	4,126,000	5,410,000	5,462,000	5,389,000	3,518,000	3,127,000	7,644,000	1,522,000	1,927,000
acquired in-process research & development expense
other adjustments	-262,000	-856,000	70,000	224,000	156,000	-489,000	-719,000	1,611,000	-391,000	43,000	-1,000	503,000	300,000	537,000	702,000	216,000	299,000	196,000	561,000	-164,000	-171,000	-96,000	573,000	97,000	620,000	-462,000	-550,000	1,248,000	-134,000	256,000	-5,000
net changes in assets and liabilities
accounts receivable	-1,813,000	950,000	-7,484,000	3,005,000	-3,725,000	-10,685,000	-10,589,000	-5,864,000	-4,464,000											0	5,692,000	3,106,000	-517,000	445,000	1,447,000	1,600,000	-1,021,000	-1,607,000	5,216,000	1,734,000	-1,891,000	9,294,000	-4,794,000	-5,822,000	4,376,000	-2,456,000	-5,905,000	-3,809,000	2,120,000	-2,391	1,376	-2,391,000	1,376,000	3,423,083	397	367	2,153	367,000	2,153,000	63,000	318,000	63,000	2,295,000	2,735,000	2,735,000	-1,901,000	-830,000	535,000	2,266,465	535	-3,165,000	402,000	920,000	-1,495,000	1,624,000	1,994,000	-3,380,000	-3,380,000	40,000	-1,658,000	225,000	-999,000	2,829,000	-485,000	-952,000	-225,000	-225,000	1,740,000	-1,289,000	-2,487,000	-553,000	-553,000	4,150,000	592,000	687,000	-658,000	177,000	-2,390,000	2,393,000	352,000	352,000
inventories	-681,000	-3,295,000	-66,000	-3,964,000	-2,991,000	-1,004,000	-1,260,000	-4,246,000	-3,847,000											0	1,000	-1,400,000	47,000	-1,310,000	341,000	1,657,000	467,000	1,259,000	-306,000	224,000	-466,000	-287,000	-123,000	-341,000	-2,148,000	-249,000	-265,000	1,133,000	1,212,000
prepaid expenses and other current assets	842,000	612,000	-3,016,000	2,031,000	-58,000	4,536,000	-6,093,000	1,150,000	123,000	-269,000	-4,131,000	2,867,000	14,643,000	15,363,000	-2,058,000	-385,000	3,052,000	630,000	-3,736,000	104,000	2,908,000	-2,048,000	899,000	672,000	-30,000	1,399,000	-3,228,000	1,383,000	607,000	3,872,000	-2,285,000	-5,665,000	2,188,000	1,090,000	-1,354,000	2,741,000	125,000	752,000	-206,000	-1,092	-368	-1,092,000	-368,000	-2,328,837	-413	-886	136	-886,000	136,000	520,000	-7,000	520,000	309,000	702,000	702,000	-172,000	-461,000	1,025,000	1,487,975	1,025	374,000	-23,000	-666,000	-1,025,000	-281,000	-224,000	-192,000	-192,000	401,000	645,000	-394,000	-160,000	1,475,000	719,000	1,166,000	-1,306,000	-1,306,000	-1,235,000	57,000	655,000	377,000	377,000	848,000	1,246,000	-1,392,000	327,000	-1,749,000	390,000	-1,716,000	-368,000	-368,000
accounts payable & other current liabilities	2,289,000	999,000	1,779,000	-577,000	-1,878,000	-9,166,000	7,528,000	-2,292,000	1,367,000	2,002,000	468,000	8,521,000	-7,172,000	1,156,000	-5,613,000	4,433,000	-377,000	3,965,000	-3,789,000	1,263,000	-2,501,000	-363,000	-1,187,000	4,382,000	-2,868,000	2,375,000	752,000	-6,344,000	-894,000	-1,168,000	6,374,000	-209,000	-4,127,000	3,475,000	1,456,000	-1,725,000	1,639,000	-4,377,000	4,029,000
accrued expenses	-3,572,000	1,859,000	218,000	6,744,000	196,000	6,069,000	3,415,000	6,271,000	375,000	9,898,000	348,000	-4,050,000	1,718,000	245,000	2,314,000	-1,526,000	1,222,000	3,311,000	-2,112,000	-6,601,000	281,000	-2,001,000	-4,905,000	2,736,000	1,358,000	1,013,000	-4,750,000	1,020,000	-1,829,000	-3,977,000	-5,854,000	3,863,000	-3,423,000	10,033,000	2,714,000	4,064,000	1,923,000	1,586,000	-809,000	-1,280	-858	-1,280,000	-858,000	-263,865	712	-1,864	17	-1,864,000	17,000	-203,000	-217,000	-203,000	-714,000	-677,000	-677,000	-447,000	563,000	-1,283,000	-605,717	-1,283	3,914,000	-90,000	-377,000	363,000	-466,000	1,031,000	-475,000	-475,000	-10,000	379,000	133,000	-220,000	-134,000	-251,000	1,172,000	-796,000	-796,000	215,000	517,000	387,000	-732,000	-732,000	-562,000	-568,000	3,831,000	-1,888,000	1,751,000	564,000	310,000	-557,000	-557,000
other assets and liabilities	-652,000	-3,632,000	179,000	659,000	-1,959,000	8,000	-557,000	661,000	1,036,000	-139,000	-116,000	-320,000	-431,000	-1,011,000	-1,667,000	-1,561,000	-1,207,000	-403,000	-618,000	211,000	121,000	-310,000	-3,148,000	-2,628,000	2,230,000	-1,811,000	-1,818,000	-13,000	905,000	-1,881,000	-1,012,000
net cash from operating activities	22,205,000	12,697,000	-8,232,000	7,873,000	-6,890,000	-18,186,000	-29,704,000	-28,029,000	-38,226,000	-32,023,000	-30,233,000	-15,366,000	-6,803,000	-14,090,000	-34,045,000	-22,506,000	-21,238,000	-10,153,000	-23,413,000	-19,125,000	-10,192,000	-7,781,000	-11,636,000	-8,253,000	-7,419,000	-1,447,000	-21,206,000	-24,526,000	-20,248,000	-19,934,000	-18,008,000	-13,816,000	-3,058,000	8,228,000	25,308,000	7,741,000	-4,761,000	-6,577,000	22,498,000	14,026	25,275	14,026,000	25,275,000	-10,613,694	3,497	-5,405	-2,398	-5,405,000	-2,398,000	-7,598,000	-5,864,000	-7,598,000	-13,002,000	-4,585,000	-4,585,000	-3,721,000	-1,828,000	-4,330,000	-4,769,670	-4,330	-4,264,000	2,235,000	-3,416,000	-5,515,000	1,820,000	3,943,000	7,947,000	7,947,000	-2,683,000	3,132,000	-4,573,000	-3,384,000	-1,635,000	-3,323,000	-6,797,000	-7,486,000	-7,486,000	-1,781,000	-7,868,000	-9,757,000	-10,420,000	-10,420,000	-9,206,000	-5,909,000	996,000	-5,270,000					3,140,000
capital expenditures	-9,000	0	0	0	0	0	0	0	0	0	0	0	0	0		0	0	0	-26,000	-65,000	0	0		0	0	1,000	-30,000	-11,000	-68,000	-58,000	-41,000	-58,000	-212,000	13,000	-334,000	-201,000	-240,000	-300,000	-460,000	-425	-234	-425,000	-234,000	-1,726,596	-689	-316	-399	-316,000	-399,000	-422,000	-93,000	-422,000	-514,000	-336,000	-336,000	-319,000	-302,000	-901,000	-1,281,099	-901	-1,143,000	-1,374,000	-736,000	-238,000	-557,000	-564,000	-411,000	-411,000	0	-1,813,000	-435,000	-1,188,000	-74,000	-5,012,000	-2,988,000	-3,198,000	-3,198,000	-4,253,000	-275,000	-1,190,000	-676,000	-676,000	-3,627,000	-1,865,000	-4,805,000	-1,029,000					-4,036,000
free cash flows	22,196,000	12,697,000	-8,232,000	7,873,000	-6,890,000	-18,186,000	-29,704,000	-28,029,000	-38,226,000	-32,023,000	-30,233,000	-15,366,000	-6,803,000	-14,090,000		-22,506,000	-21,238,000	-10,153,000	-23,439,000	-19,190,000	-10,192,000	-7,781,000		-8,253,000	-7,419,000	-1,446,000	-21,236,000	-24,537,000	-20,316,000	-19,992,000	-18,049,000	-13,874,000	-3,270,000	8,241,000	24,974,000	7,540,000	-5,001,000	-6,877,000	22,038,000	13,601	25,041	13,601,000	25,041,000	-12,340,290	2,808	-5,721	-2,797	-5,721,000	-2,797,000	-8,020,000	-5,957,000	-8,020,000	-13,516,000	-4,921,000	-4,921,000	-4,040,000	-2,130,000	-5,231,000	-6,050,769	-5,231	-5,407,000	861,000	-4,152,000	-5,753,000	1,263,000	3,379,000	7,536,000	7,536,000	-2,683,000	1,319,000	-5,008,000	-4,572,000	-1,709,000	-8,335,000	-9,785,000	-10,684,000	-10,684,000	-6,034,000	-8,143,000	-10,947,000	-11,096,000	-11,096,000	-12,833,000	-7,774,000	-3,809,000	-6,299,000					-896,000
cash flows from investing activities:
purchases of property and equipment	-9,000											0				0	0	0	-26,000	-65,000				0	0	1,000	-30,000	-11,000	-68,000	-58,000	-41,000	-58,000	-212,000	13,000	-334,000	-201,000	-240,000	-300,000	-460,000	-425	-234	-425,000	-234,000	-1,726,596	-689	-316	-399	-316,000	-399,000	-422,000	-93,000	-422,000		-336,000	-336,000	-319,000	-302,000	-901,000	-1,281,099	-901	-1,143,000	-1,374,000	-736,000	-238,000	-557,000	-564,000	-411,000	-411,000		-1,813,000	-435,000	-1,188,000	-74,000	-5,012,000	-2,988,000	-3,198,000	-3,198,000	-4,253,000	-275,000	-1,190,000	-676,000	-676,000	-3,627,000	-1,865,000	-4,805,000	-1,029,000	-1,213,000	-4,970,000	-3,618,000	-4,036,000	-4,036,000	-2,041,000	-432,000	-49,000	-319,000	-319,000
proceeds from sales of marketable securities	11,800,000	28,130,000	17,808,000	28,952,000	90,994,000	88,769,000	119,066,000	61,638,000	99,880,000	10,323,000	15,295,000	23,955,000	3,372,000	12,160,000	44,341,000	18,498,000	17,513,000	25,477,000	40,736,000	6,209,000	14,359,000	928,000	14,788,000	6,004,000	5,040,000	17,338,000	34,864,000	51,492,000	54,490,000	59,125,000	194,400,000	35,611,000	101,578,000	37,401,000	14,419,000	25,063,000	20,470,000	16,247,000	9,766,000	18,379	2,817	18,379,000	2,817,000	13,665,383	8,283	3,977	357	3,977,000	357,000	5,018,000	0	5,018,000	7,851,000	3,618,000	3,618,000	4,498,000	10,008,000	7,985,000	11,868,015	7,985	16,897,000	20,386,000	33,444,000	37,825,000	41,331,000	89,828,000	-30,508,000	-30,508,000	122,496,000	-12,111,000	-55,426,000	20,257,000	24,003,000	19,355,000	22,335,000	29,014,000	29,014,000			76,828,000	85,550,000	85,550,000	769,274,000	-572,398,000	116,072,000	118,107,000
purchases of marketable securities	-5,224,000	-36,203,000	-5,491,000	-14,039,000	-86,064,000	-78,219,000	-97,679,000	-33,710,000	-90,059,000	-103,231,000	-10,229,000	-1,080,000	-132,000	-112,000	-2,090,000	-3,178,000	-5,219,000	-15,603,000	-37,769,000	-7,153,000	-26,376,000	-96,316,000	-1,562,000	-834,000	-1,823,000	-8,547,000	-13,444,000	-35,274,000	-28,398,000	-37,540,000	-275,098,000	-35,112,000	-48,150,000	-21,669,000	-46,074,000
upfront license payment for acquired in-process research & development
net cash from investing activities	-8,433,000	-8,254,000	12,317,000	14,913,000	4,930,000	10,550,000	21,387,000	27,928,000	9,821,000	-92,908,000	5,066,000	22,875,000	2,524,000	12,048,000	42,251,000	15,320,000	12,294,000	18,124,000	11,191,000	7,241,000	-9,300,000	-80,888,000	13,226,000	5,170,000	3,217,000	8,946,000	21,390,000	16,207,000	26,024,000	1,527,000	-80,739,000	-531,000	1,077,000	15,745,000	-31,989,000	13,458,000	26,000	-9,127,000	-40,987,000	12,873	-23,429	12,873,000	-23,429,000	-43,025,938	-32,932	3,661	-27,791	3,661,000	-27,791,000	4,597,000	-87,000	4,597,000	6,270,000	4,641,000	4,641,000	462,000	-2,975,000	3,406,000	2,158,594	3,406	3,988,000	-172,000	-2,047,000	7,966,000	-5,215,000	-15,291,000	-11,722,000	-11,722,000	-6,478,000	4,938,000	-4,178,000	6,629,000	-2,816,000	-5,434,000	-4,608,000	-373,000	-373,000	51,114,000	-2,214,000	11,773,000	11,995,000	11,995,000	280,000	11,033,000	-5,559,000	-10,254,000				-4,036,000	-4,036,000
cash flows from financing activities:
proceeds from issuance of shares off the at-the-market offering program				0	0	0	9,250,000	0	0	0	11,913,000	14,786,000
proceeds from stock option exercises and employee share purchase plan	2,507,000	982,000	690,000	880,000	1,177,000	723,000	3,940,000	52,000	462,000	1,750,000	29,000	490,000	183,000	0	2,009,000
net cash from financing activities	2,507,000	982,000	690,000	880,000	1,177,000	723,000	13,190,000	-21,111,000	30,460,000	91,544,000	34,442,000	6,622,000	10,715,000	-4,803,000	2,009,000	0	114,000	0	149,000	183,000	-16,000	117,306,000	62,210,000	-41,000	-41,000	-37,000	92,000	-76,000	-425,000	-9,755,000	122,915,000	-6,026,000	-3,934,000	-12,952,000	-406,000	58,000	-624,000	1,718,000	-9,106,000	-10,793	-79	-10,793,000	-79,000	95,911,932	2,149	845	80,074	845,000	80,074,000	14,322,000	247,000	14,322,000	8,140,000	741,000	741,000	140,000	526,000	-1,838,000	5,480,838	-1,838	216,000	714,000	-1,888,000	1,663,000	774,000	23,000	-4,044,000	-4,044,000	8,431,000	279,000	243,000	-71,000	-94,000	-76,000	3,167,000	26,000	26,000	-451,000	5,260,000	711,000	-39,000	-39,000	8,585,000	-4,201,000	4,100,000	12,595,000	4,052,000	571,000			278,000
effect of foreign currency exchange rate changes on cash and cash equivalents	132,000	1,607,000	224,000	-877,000	518,000	-34,000	-246,000	568,000	-229,000	-19,000	135,000	-865,000	151,000	100,000	-50,000	-275,000	-143,000	-1,000	-477,000	314,000	443,000	31,000	-68,000	31,000	-1,000	19,000	29,000	-117,000	9,000	-272,000	179,000	-512,000	-143,000	250,000	108,000
net change in cash and cash equivalents	16,411,000	7,032,000	4,999,000	22,789,000	-265,000	-6,947,000	4,627,000	-20,644,000	1,826,000	-33,406,000	9,410,000	13,266,000	6,587,000	-6,745,000	10,165,000	-7,461,000	-8,973,000	7,970,000	-12,550,000	-11,387,000	-19,065,000	28,668,000	63,732,000	-3,093,000	-4,244,000	7,481,000	305,000	-8,512,000	5,360,000	-28,434,000	24,347,000
cash and cash equivalents at january 1,	0	0	51,371,000		0	0	31,167,000		0	0	73,981,000		0	0	50,708,000		0	0	71,722,000		0	0	9,774,000		0	0	9,325,000		0	0	16,564,000		0	0	39,215,000
cash and cash equivalents at september 30,
supplemental disclosures of cash flow information:
interest paid	2,555,000	1,969,000	1,890,000	3,876,000	1,557,000	1,018,000	730,000	730,000	0	1,470,000	3,050,000	0	3,205,000	924,000	5,531,000	0	3,235,000	0	3,234,000	0	3,235,000	0	3,234,000	0	3,235,000	0	3,234,000	0	2,965,000	131,000	263,000									1,184	183	1,184,000	183,000	4,425,259	383	-244	5,602	-244,000	5,602,000
cash and cash equivalents at june 30,
net loss			-4,920,000	-5,043,000	-2,625,000	-13,822,000	-27,342,000	-28,786,000	-36,274,000	-64,432,000	-30,784,000	-27,450,000	-20,146,000	-63,444,000	-26,424,000				-13,445,000
adjustments to reconcile net loss to net cash from operating activities:
cash and cash equivalents at march 31,			56,370,000				35,794,000				83,391,000				60,873,000				59,172,000				73,506,000				9,630,000				40,911,000				32,236,000
amortization of debt discount and debt issuance costs								0	336,000	587,000	1,873,000	1,905,000	1,918,000	1,917,000	312,000	311,000	312,000	313,000	312,000	1,689,000	1,642,000	1,620,000	1,573,000	1,571,000	1,506,000	1,473,000	1,445,000	1,428,000	1,383,000	1,362,000	657,000
changes in deferred taxes
loss on extinguishment of debt								0	0
proceeds from april 2023 public offering, net of issuance costs								2,000	-2,000
payments for february 2023 notes								0	0	0	-17,500,000
payments for october 2023 notes
payments for debt issuance costs								0	0			-1,000	0															0	-430,000	-369,000	-5,391,000
proceeds from royalty purchase agreement								0
cash and cash equivalents at january 1																																				0	0	0	65,064,000
cash and cash equivalents at december 31
income taxes refunded
research and development tax credit receivable						468,000	-17,000	-34,000	-209,000			3,000	-3,000	49,000	-19,000	-283,000	1,000	2,998,000	80,000	177,000	0	1,876,000	160,000	-265,000	-156,000	-144,000	-449,000	-1,195,000	-347,000			-1,565,000	-401,000	-459,000	-716,000	2,191,000	-164,000	-1,267,000	-363,000	3,934	-127	3,934,000	-127,000	13,200,520	4,348	-1,330	6,462	-1,330,000	6,462,000	-1,371,000	-1,265,000	-1,371,000	-2,830,000	-1,537,000	-1,537,000	-1,683,000	-1,430,000	347,000	-825,347	347	-1,337,000	5,026,000	666,000	-1,674,000	-1,774,000	4,535,000	2,977,000	2,977,000	-2,127,000	4,007,000	-2,237,000	-1,137,000	-2,262,000	628,000	0	-14,000	-14,000	-1,943,000	-193,000				-4,224,000			-25,000
proceeds received in advance of series b preferred shares issuance											40,000,000
proceeds from the disposition of the hospital products																0	0	8,250,000	8,250,000	8,250,000
income taxes (refunded) paid
income taxes refund
income taxes paid																	61,000								0	68,000	72,000		4,000	319,000	90,000
changes in deferred tax
payments for extinguishment of february 2023 notes
change in deferred taxes													46,000	30,193,000	-4,323,000
gain from release of certain liabilities													0	0	-33,000
income taxes (refund) paid													-18,227,000							87,000	7,000
stock-based compensation expense														658,000	2,505,000		2,359,000	2,001,000	1,728,000		194,000	769,000	742,000		-229,000	55,000	351,000	662,000	2,832,000	2,224,000	2,134,000	2,053,000	1,964,000	2,008,000	2,047,000	4,138,000	5,628,000	2,438,000	2,475,000
remeasurement of acquisition-related contingent consideration																				0	-69,000	918,000	2,478,000
remeasurement of financing-related contingent consideration																				0	0	125,000	310,000
gain on the disposition of the hospital products																				0
loss on deconsolidation of subsidiary																								0	0	0	1,750,000
gain from the release of certain liabilities																-51,000	0	-88,000	-78,000
deferred revenue																																67,000	-515,000	838,000	-606,000	-725,000	-737,000	-703,000	-758,000	-3,491	2,177	-3,491,000	2,177,000	-54,221	-382	842	-1,239	842,000	-1,239,000	-519,000	-122,000	-519,000	-2,260,000	-1,617,000	-1,617,000	1,360,000	-1,422,000	-886,000	918,886	-886	-1,455,000	-632,000	-928,000	212,000	2,630,000	-495,000	5,904,000	5,904,000	-341,000	-237,000	-825,000	-823,000	2,492,000	413,000	-206,000	-278,000	-278,000	-323,000	637,000	261,000	-185,000	-185,000	-1,678,000	609,000	-255,000	-1,581,000	-12,269,000	-3,406,000	-2,297,000	-2,386,000	-2,386,000
earn-out payments for contingent consideration in excess of acquisition-date fair value																				0	-1,587,000	-1,962,000	-1,774,000
royalty payments for contingent consideration payable in excess of original fair value																				0	-258,000	-317,000	-291,000
proceeds from disposal of property and equipment																																														0	3	0	3,000	1,000	6,000	1,000	67,000	67,000	67,000	0	174,000	11,000	10,989	11													33,000	0				82,000	8,000				52,000	-90,000	35,000	157,000	320,000	104,000
proceeds from the february 2020 private placement																				0	-69,000	-94,000	60,733,000
proceeds from the may 2020 public offering																				0	-50,000
proceeds from issuance of ordinary shares
other financing activities																								-36,000	-72,000	-129,000	92,000	-76,000	-37,000	-41,000	47,000
income taxes paid (refund)
gain from the disposition of the hospital products
proceeds from stock option exercises and employee stock purchase plan																	114,000	0	149,000
change in deferred tax and income tax deferred charge																		-3,694,000	-2,534,000		-4,743,000	8,601,000	-8,440,000		-567,000	2,122,000	-222,000	-14,477,000	-1,428,000	-396,000	-2,851,000	3,234,000	0			1,680,000	-652,000	-3,346,000	-1,682,000
accrued income taxes																						-1,932,000	2,253,000				-46,000	-113,000			32,000	-6,612,000	5,571,000	-8,283,000	8,538,000			765,000	5,520,000
impairment of intangible asset
purchase of intangible assets																																-972,000
proceeds from debt issuance																												0	0	0	143,750,000
exercise of warrants																															2,911,000
share repurchases																												0	0	-9,637,000	-18,000,000	-5,654,000	-3,626,000
loss on disposal of property and equipment																									0												0	8,000	102,000															-67,000		0	0	-11,000																																					-362,000
proceeds from the disposal of property and equipment																									0
proceeds from stock option exercises and espp																					103,000	426,000	1,477,000
gain on the disposition of the hospital business
proceeds from the disposition of the hospital business
amortization of premiums on marketable securities																								316,000	-292,000	8,000	9,000	-66,000	1,196,000
remeasurement of related party acquisition-related contingent consideration																								-1,539,000	627,000	-377,000	2,134,000	-5,695,000	-7,115,000	-12,889,000	2,968,000	-933,000	-9,906,000	-13,230,000	-6,971,000	-3,704,000	20,848,000	24,225,000	7,916,000
remeasurement of related party financing-related contingent consideration																								-118,000	139,000	50,000	307,000	-467,000	-425,000	-1,402,000	395,000	917,000	-768,000	-1,670,000	-550,000		1,828,000	2,446,000	1,861,000
earn-out payments for related party contingent consideration in excess of acquisition-date fair value																								-2,348,000	-2,850,000	-2,609,000	-3,181,000	-3,214,000	-5,141,000	-5,323,000	-5,790,000	-6,907,000	-8,214,000	-9,349,000	-7,166,000	-5,766,000	-6,717,000
royalty payments for related party payable in excess of original fair value																								-374,000	-457,000	-410,000	-507,000	-476,000	-744,000	-793,000	-825,000	-983,000	-1,159,000	-1,284,000	-1,003,000	-679,000	-631,000
earn-out payments for related party contingent consideration																												0	0	-243,000	-402,000	-285,000	-296,000	-221,000	-444,000	-58,000	-262,000
income tax paid																																												402,769	-50	242	39	242,000	39,000
purchase of intangible asset																													0
proceeds from issuance of ordinary shares and warrants																									31,000
proceeds from exercise of warrants
acquisitions of businesses, including cash acquired and other adjustments
royalty payments for related party payable																																				-108,000	-301,000
proceeds from the issuance of ordinary shares and warrants
foreign exchange loss																																	-1,177,000
cash proceeds from the issuance of ordinary shares and warrants
gain on sale of marketable securities																															662,000		-469,000						285,000
(gain) loss on sale of marketable securities
foreign exchange gain																																																																																															-83,000
grants recognized in research and development expenses
other long-term assets and liabilities																																-4,244,000	-437,000	-311,000	231,000	-1,497,000	1,762,000	-207,000	477,000	-139	198	-139,000	198,000	-10,730,227	-21	-288	536	-288,000	536,000	25,000	80,000	25,000	-302,000	-312,000	-312,000	-95,000	18,000	-375,000	206,375	-375	-249,000	-181,000	-241,000	821,000	-1,630,000	-865,000	-414,000	-414,000	-385,000	-348,000	-171,000	-957,000	-900,000	-203,000	-239,000	-118,000	-118,000	56,000	-689,000	391,000	1,420,000	1,420,000	-6,344,000	4,091,000	2,213,000	-70,000	217,000	329,000	1,857,000	-2,234,000	-2,234,000
reimbursement of loans
reimbursement of conditional r&d grants
excess tax benefit from stock-based compensation
cash proceeds from issuance of ordinary shares and warrants																																28,000	0	338,000	38,000						247		247,000	132,141,198	2,650	1,764	114,388	1,764,000	114,388,000				602,000	602,000	602,000	96,000					225,000			0	262,000				0	174,000	335,000	31,000	41,000	0				1,186,000	236,000	237,000	958,000	958,000	255,000	1,333,000	4,475,000	7,583,000	135,000	281,000	195,000	153,000	153,000
net increase in cash and cash equivalents																																				20,435,000	-5,119,000			16,701	-1,225	16,701,000	-1,225,000	33,106,630	-30,098	-1,402	48,870	-1,402,000	48,870,000	11,269,000	-5,675,000	11,269,000	1,299,000	892,000	892,000	-3,273,000	-4,855,000	-2,353,000	3,402,353	-2,353	339,000	2,575,000	-7,721,000				-9,168,000	-9,168,000	-1,384,000	5,704,000	-8,907,000	5,295,000	-3,227,000	-7,281,000	-7,624,000	-7,383,000	-7,383,000	51,263,000	-4,980,000	2,946,000	1,580,000	1,580,000	-588,000	692,000	-418,000	-3,259,000	17,312,000	-5,152,000	-4,586,000	-4,182,000	-4,182,000	87,541,000	10,420,000	-2,663,000	-208,000	-208,000
increase in cash from:
acquisitions of businesses																																					467,000	0	161,000
net decrease in cash and cash equivalents																																			-6,979,000				-27,194,000																										-2,421,000
loss on sale of marketable securities																																			-287,000	160,000	211,000
gain on disposal of property and equipment																																																							-67,000				-10,989	-11														0					-8,000				-19,000	118,000	-35,000	-157,000						-7,000
unrealized foreign currency exchange gain
gains on waiver of research and development grants and other
remeasurement of related party financing-related royalty agreements
principal payments on capital lease obligations																																									-3		-3,000	-160,938	-15	-21	-26	-21,000	-26,000	-19,000	-19,000	-19,000	-48,000	-31,000	-31,000	-25,000	-27,000	-20,000	-43,980	-20	-9,000	-6,000	-9,000	-7,000	-8,000	-6,000	-46,000	-46,000	-183,000	105,000	-92,000	-102,000	-120,000	-108,000	-108,000	-105,000	-105,000	-104,000	-123,000	-98,000	-94,000	-94,000	-10,000	-126,000	-129,000	-132,000	-132,000	-503,000	270,000	-24,000	-24,000				-56,000	-56,000
effect of exchange rate changes on cash and cash equivalents																																				-822,000	240,000	15,000	401,000	595	-2,992	595,000	-2,992,000	-9,165,670	-2,812	-503	-1,015	-503,000	-1,015,000	-52,000	29,000	-52,000	-109,000	95,000	95,000	-154,000	-578,000	409,000	532,591	409	399,000	-202,000	-370,000	-182,000	200,000	677,000	-1,349,000	-1,349,000	-654,000	-2,645,000	-399,000	2,121,000	1,318,000	1,552,000	614,000	450,000	450,000	2,381,000	-158,000	221,000	42,000	42,000	-247,000	-231,000	45,000	-330,000						8,752,000	310,000	715,000	579,000	579,000
purchase of marketable securities																																					-20,671,000	-25,074,000	-50,454,000	-5,081	-26,012	-5,081,000	-26,012,000	-68,206,725	-40,523	0	-27,752	0	-27,752,000				-2,905,000	-339,000	-339,000	-3,717,000	-12,855,000	-3,689,000	-8,439,311	-3,689	-11,766,000	-19,184,000	-34,755,000	-29,621,000	-45,989,000	-104,555,000	19,197,000	19,197,000	-128,887,000	18,862,000	51,683,000	-12,440,000	-26,778,000	-19,777,000	-23,969,000	-26,189,000	-26,189,000			-63,867,000	-72,879,000	-72,879,000	-765,419,000	585,386,000	-116,861,000	-127,489,000
repayment of debt
reimbursement of conditional grants
cash and cash equivalents at september 30
unrealized exchange gain																																						-1,680,000	2,941,000		-11,296		-11,296,000
grants recognized in research and development expenses and operating income
cash and cash equivalents at june 30
earn-out payments for related party acquisition-related contingent consideration																																							-8,014,000
royalty payments for related party financing-related contingent consideration																																							-1,092,000
cash and cash equivalents at march 31																																							37,870,000
depreciation of property and equipment and intangible assets																																								3,271	3,260	3,271,000	3,260,000	14,130,361	3,426
gains on sales of marketable securities																																								714	-489	714,000	-489,000										-4,000	-4,000	-4,000	-7,000	-15,000	-12,000	-18,988	-12	-18,000	-19,000	-22,000	-35,000	-33,000	-51,000	-34,000	-34,000	-53,000	-91,000	-117,000	-66,000	-101,000	-103,000	-56,000	-58,000	-58,000	-53,000	-388,000	-441,000	-454,000	-454,000	-399,000	-442,000	-479,000	-2,330,000
grants recognized in other income and income from operations																																												-588,500	-163	-169	-168	-169,000	-168,000	-168,000	-166,000	-168,000	-585,000	-397,000	-397,000	-1,049,000	-275,000	-50,000	-1,902,950	-50	-113,000	-116,000	-599,000	-1,740,000	0	0	-782,000	-782,000	48,000	8,000
remeasurement of acquisition liabilities																																								32,002	5,254	32,002,000	5,254,000							2,976,000		2,976,000	-6,755,000	-5,080,000	-5,080,000
interest expenses on debt related to the royalty agreement including related party																																								2,727	259	2,727,000	259,000
unrealized exchange gains
stock compensation expense																																								2,559	1,593	2,559,000	1,593,000	2,688,211	682	335	772	335,000	772,000	496,000	465,000	496,000	1,491,000	685,000	685,000	725,000	779,000	519,000	1,274,481	519	722,000	731,000	875,000	1,185,000	1,477,000	1,461,000	1,376,000	1,376,000	2,040,000	1,162,000	2,701,000	2,383,000	2,737,000	2,763,000	3,195,000	3,309,000	3,309,000	2,821,000	2,802,000	2,034,000	2,332,000	2,332,000	209,000	-4,000	210,000	131,000	-93,000	358,000	551,000	573,000	573,000	351,000	0	8,000	-4,000	4,000
income tax																																								592	5,864	592,000	5,864,000		0	0	-2,807	0	-2,807,000	-1,492,000	-3,737,000	-1,492,000
inventory																																								-32	1,207	-32,000	1,207,000	-3,109,159	-1,025	-447	-1,369	-447,000	-1,369,000	-415,000	64,000	-415,000	37,000	-133,000	-133,000	-49,000	-891,000	60,000	22,940	60	-31,000	-187,000	182,000	1,078,000	516,000	-355,000	-330,000	-330,000	-212,000	330,000	10,000	-299,000				288,000	288,000	-1,836,000	-94,000	-232,000	103,000	103,000	99,000	-228,000	120,000	360,000	-160,000	37,000	-329,000	33,000	33,000	-447,000
accounts payable and other current liabilities
reimbursment of conditional grants																																												-354,655	-194
earnout payments on acquisition related debt to related parties
cash and cash equivalents, beginning of period																																								0	39,760	0	39,760,000		0	1	6,635	1,000	6,635,000	2,742,000	0	2,742,000	3,456,000	3,456,000	3,456,000		0	8,184,000	8,175,816	8,184	0	0	8,716,000		0	0	27,021,000	27,021,000																				0	0	109,617,000	109,617,000		0	0	14,527,000	14,527,000
cash and cash equivalents, end of period																																								16,701	38,535	16,701,000	38,535,000		-30,098	-1,401	55,505	-1,401,000	55,505,000	14,011,000	-5,675,000	14,011,000	4,755,000	4,348,000	4,348,000		-4,855,000	5,831,000	11,578,169	5,831	339,000	2,575,000	995,000		-2,421,000	-10,648,000	17,853,000	17,853,000																				-5,153,000	-4,585,000	105,435,000	105,435,000		10,427,000	-2,670,000	14,319,000	14,319,000
accounts payable																																									1,487		1,487,000	1,090,481	1,309	1,882	-1,672	1,882,000	-1,672,000	102,000	-449,000	102,000	713,000	373,000	373,000	471,000	-287,000	-463,000	-1,008,537	-463	-606,000	906,000	-682,000	764,000	613,000	-1,373,000	28,000	28,000	948,000	-438,000	-1,003,000	235,000	-5,851,000	1,161,000	1,234,000	433,000	433,000	2,317,000	-479,000	-2,071,000	-2,754,000	-2,754,000	650,000	-4,331,000	8,382,000	-1,398,000	3,938,000	-2,204,000	-72,000	2,828,000	2,828,000
other current liabilities																																									4,091		4,091,000	6,998,160	-164	-209	213	-209,000	213,000	303,000	-128,000	303,000	10,000	24,000	24,000	528,000	3,000	163,000	-132,163	163	-103,000	-428,000	233,000	-109,000	1,410,000	348,000	602,000	602,000	-2,020,000	-67,000	-264,000	707,000	1,777,000	-387,000	295,000	-1,138,000	-1,138,000	465,000	104,000	-618,000	-1,417,000	-1,417,000	3,306,000	3,629,000	-4,486,000	962,000
reimbursment of loans
earnout payments for acquisition																																									-323		-323,000							-66,000	-9,000	-66,000
remeasurement of acquisition liabilities and royalty agreements
impairment of assets
calculated interest on amortized method
change in deferred tax
cash transferred on acquisition																																																					1,771,000	1,631,000	1,631,000
proceeds from loans or conditional grants
earn-out payment for acquisition
cash and cash equivalents, beginning of year																																																																					0	0	0	26,313,000
cash and cash equivalents, end of year																																																																					-1,384,000	5,704,000	-8,907,000	31,608,000
the supplemental schedule of non cash investing and financing activities is as follows
capital lease obligations incurred
fair value of assets acquired at acquisition date:
liabilities assumed at acquisition date:
gain on disposal of property, equipment and inventory																																													0	0	3	0	3,000		-7,000	92,000
exchange gain
remeasurement of acquisition liabilities including related parties																																													7,865
interest expenses on debt related to the royalty agreement incl. related parties																																													1,339
proceeds from loan or conditional grants																																																		14,407,000	1,000	14,407,000	5,855,000	170,000	170,000
reimbursment of loan																																													92	-136	-34,288	-136,000	-34,288,000
earnout payments for acquisition including related parties																																													-384
depreciation of property and equipment																																															3,570		3,570,000	822,000	762,000	822,000	1,534,000			689,000	717,000	1,028,000	1,938,972	1,028	1,142,000	1,136,000	1,247,000	1,837,000	1,116,000	1,487,000	1,477,000	1,477,000	1,714,000	1,744,000	2,143,000	1,648,000	1,666,000	1,528,000	1,526,000	1,478,000	1,478,000	1,920,000	1,288,000	1,152,000	1,279,000	1,279,000	1,206,000	1,260,000	1,405,000	872,000	863,000	700,000	365,000	602,000	602,000
remeasurement of acquisition liabilities and royalty agreement																																															17,633		17,633,000
loss on disposal of property, equipment and inventory																																																		92,000			-36,000
reimbursment of loan or conditional grants
interest expense on debt related to the royalty agreements
reimbursment of loans or conditional grants																																																								0	0	-1,818,000	-1,908,182	-1,818		0	-1,879,000	-1,000	0	0	-3,998,000	-3,998,000
calculated interests on amortized method
supplemental disclosures of cashflow information:
fair value of assets acquired:
liabilities assumed:
adjustments to reconcile net income
to net cash from operating activities:
research and development tax credit receivable ..
net cash from investing activities .
cash and cash equivalents, beginning of year .
purchases of property and equipment and acquisition																																																					-514,000
calculated interest expense on consideration																																																					1,731,000
non cash transactions:
prceeds from loans or conditional grants
increase (decrease) in cash from:
reimbursement of loans or conditional grants
provision for losses on accounts receivable
loss (gain) on disposal of property and equipment
funding from partner gsk																																																																									-720,000	31,000				46,000					939,000	-198,000	6,671,000	4,899,000
new capital lease obligation
proceeds from conditional grants
purchases of property and equipment .
use of funds received from partners (gsk) or relating to conditional grants
grants recognized in other income																																																																														-1,000	82,000	-89,000	-175,000	-175,000
purchase of held to maturity securities
proceeds from loans or conditional grant																																																																										1,000	2,000	131,000	131,000		2,000	4,000	196,000	196,000
cash and cash equivalents, beginning of the period																																																																										0	0	51,827,000	51,827,000		0	0	1,018,000	1,018,000		0	0	4,591,000
cash and cash equivalents, end of the period																																																																										-7,281,000	-7,624,000	44,444,000	44,444,000		-4,980,000	2,946,000	2,598,000	2,598,000		692,000	-418,000	1,332,000
balance at january 1, 2007
subscription of warrants
issuance of ordinary shares on exercise of stock -options
unrealized losses on available-for-sale securities
foreign currency translation adjustment
comprehensive loss
balance at june 30, 2007
purchase of available for sale securities
proceeds from sales of available for sale securities
use of funds received from partners or relating to conditional grants																																																																															168,000	568,000	-1,099,000	-1,099,000
shares issuance costs
supplemental disclosures of cash flow information
repayment of loans or advances																																																																																				-7,037,000	-6,908,000	-214,000
proceeds from loans or capital leases																																																																																				1,827,000	-9,000	459,000	171,000	793,000	-280,000	149,000	149,000
provision for accounts receivables and others
net cash from in operating activities.
net cash from in investing activities.
cash proceeds from sale of ordinary shares																																																																																													11,004,000
effect of exchange rate changes on cash and cash equivalents.																																																																																										-3,564,000	-3,564,000
benefit from accounts receivables and others
net cash from in operating activities
net cash from in investing activities
provision for accounts receivable
net cash provided by (used in) operating activities																																																																																										3,140,000
net cash provided by (used in) financing activities																																																																																										278,000
see notes to unaudited condensed consolidated financial statements.
benefit from accounts receivable
net profit																																																																																													-3,542,000
adjustments to reconcile net profit to net cash from operating activities:
loss on recognition of grants																																																																																													-101,000		-747,000
disposal of short-term investments
cash proceeds from new loans
principal payments on loans and capital lease obligations																																																																																													-38,000
revenue:
license and research revenue																																																																																															1,962,000
product sales and services																																																																																															1,037,000
other revenue																																																																																															534,000
costs and expenses:
cost of goods and services sold																																																																																															-1,094,000
research and development																																																																																															-3,843,000
selling, general and administrative																																																																																															-1,009,000
profit from operations
other income																																																																																															747,000
interest income																																																																																															80,000
income tax benefit
net profit per ordinary share
weighted-average number of ordinary shares outstanding																																																																																															16,198,000
current assets:
cash and cash equivalents
property and equipment
other assets:
other long-term assets
total assets
current liabilities:
current portion of long-term debt
current portion of capital lease obligations
current portion of deferred revenue
advances from customers
long-term debt, less current portion
other long-term liabilities
deferred revenue, less current portion
capital lease obligation, less current portion
total long-term liabilities
shareholders’ equity:
ordinary shares
additional paid-in capital
accumulated deficit
deferred compensation
cumulative other comprehensive income
total liabilities and shareholders’ equity
cash flows from operating activities :
net profit,																																																																																														-1,650,000	-1,673,000	-1,673,000
adjustments to reconcile net loss to net cash from operating activities :
increase in cash from :
cash flows from investing activities :
disposal of property and equipment																																																																																														10,000	362,000	362,000
cash flows from financing activities :
proceeds of loans																																																																																														4,000	131,000	131,000
adjustments to reconcile net income to net cash from operating activities :
(gain) loss on disposal of property and equipment																																																																																																-362,000
(gain) loss on recognition of grants																																																																																																-747,000
revenue :
costs and expenses :
loss from operations																																																																																															-2,417,000
profit, (loss) before income taxes																																																																																															-1,673,000
basic profit, (loss) per ordinary share																																																																																															-100
diluted profit, (loss) per ordinary share																																																																																															-100
current assets :
other assets :
current liabilities :
capîtal lease obligation, less current portion
shareholders’ equity :
adjustments to reconcile net profit,
to net cash from operating activities :

Avadel Pharmaceuticals plc(NASDAQ:AVDL)

Avadel Pharmaceuticals plc
(NASDAQ:AVDL)