7Baggers

Ascendis Pharma
(NASDAQ:ASND) 

ASND stock logo

Ascendis Pharma A/S, a biopharmaceutical company, develops therapeutics for unmet medical needs. The company develops TransCon growth hormone, which completed Phase III clinical trials for growth hormone deficiency. It also develops TransCon parathyroid hormone for adult hypoparathyroidism; and Tran...

Founded: 2006
Full Time Employees: 330
Sector: Healthcare
Industry: Biotechnology

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Quarterly
Annual
    Unit: USD2025-11-12 2025-09-30 2025-08-07 2025-06-30 2025-05-01 2025-04-29 2025-03-31 2025-02-12 2024-12-31 2024-11-14 2024-09-30 2024-09-03 2024-06-30 2024-05-02 2024-03-31 2024-02-07 2023-12-31 2023-11-07 2023-09-30 2023-09-05 2023-06-30 2023-05-02 2023-04-27 2023-03-31 2023-02-16 2022-12-31 2022-11-02 2022-09-30 2022-08-10 2022-06-30 2022-05-11 2022-05-02 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-05-27 2021-04-30 2020-12-31 2020-11-12 2020-08-27 2020-05-19 2020-05-05 2019-12-31 2019-11-18 2019-08-28 2019-05-30 2019-05-01 2018-12-31 2018-11-28 2018-05-30 2017-12-31 2017-04-26 2016-12-31 2015-12-31 2015-03-27 2014-12-31 
                                                             
      consolidated statement of profit or
                                                             
      revenue
    213,634 213,634  158,045  100,954 173,916 305,808 57,833 57,833 35,998 35,998 266,718 95,894 137,703,000,000 -48,033,733,282  48,034  47,393 51,174 33,589,000,000 33,589 51,174,000,000 22,896 15,290 15,290  6,160  7,778 6,828 4,897 1,113 1,022 746 6,953 535 2,757 1,436 2,225 13,375 13,364,132 2,243 3,211 5,414 10,581 10,515 20 28  4,606   13,983  
      yoy
     5340750.00%  -9.13%  -99.99% 74.56% 383.13% 749.51% -78.32% -39.69% -100.00% -100.00%  99.64%  -101352057.64%  -100.00%  -100.00% 123.51% 219679429.10% 119.68%  271.69%  96.58%  25.79%  661.06% 815.28% -29.57% 108.04% -62.93% -48.05% 212.49% -96.00% -99.98% -35.98% -30.71% 147.04% 126203.11% -78.67% 15955.00% 19235.71%  128.29%         
      qoq
    0.00%     -100.00% -41.95% -43.13% 428.78% 0.00% 60.66% 0.00% -86.50% 178.14% -100.00% -386.68%     -7.39% -100.00% 99999900.00% -100.00% 223506189.31% 49.74% 0.00%     13.91% 39.43% 339.98% 8.90% 37.00% -89.27% 1199.63% -80.59% 91.99% -35.46% -83.36% -99.90% 595715.07% -30.15% -40.69% -48.83% 0.63% 52475.00% -28.57%        
      cost of sales
    -22,354 -22,354  31,447  611 17,517 14,023 33,057 11,201 11,201 11,465 11,465 44,395 7,569 19,457,000,000 -7,387,955,605  7,388  12,929 12,137 4,621,000,000 4,621 12,137,000,000 5,112 1,693 1,693  1,086  3,523 4,246                         
      gross profit
    191,280 191,280  126,598   83,437 159,893 272,751 46,632 46,632 24,533 24,533 222,323 88,325 118,246,000,000 -40,645,777,677  40,646  34,464 39,037 28,968,000,000 28,968 39,037,000,000   13,597    4,255                          
      yoy
       -20.82%   78.93% 551.75% 1011.77% -79.03% -47.20% -100.00% -100.00%  117.30%  -117937012.94%  -100.00%  -100.00%   113.05%    219.55%                              
      qoq
    0.00%      -47.82% -41.38% 484.90% 0.00% 90.08% 0.00% -88.97% 151.71% -100.00% -390.92%     -11.71% -100.00% 99999900.00% -100.00%                                  
      gross margin %
    89.54% 89.54% NaN% 80.10% NaN% 0% 82.65% 91.94% 89.19% 80.63% 80.63% 68.15% 68.15% 83.36% 92.11% 85.87% 84.62% NaN% 84.62% NaN% 72.72% 76.28% 86.24% 86.24% 76.28% 0% 0% 88.93% NaN% 0% NaN% 54.71% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% NaN% 0%  NaN% 0%  
      research and development expenses
    -66,879 -66,879  71,988   86,603                                                   
      selling, general, and administrative expenses
    -113,404 -113,404  107,561   101,046 80,216   69,831                      47,418    -37,247  -14,060.75 -17,523 -20,805                 
      operating profit/
    10,997 10,997      383 -24,185.75 -96,743                      -451,792                          
      share of profit/(loss) of associates
    -7,501 -7,501      -4,575                                                  
      finance income
    6,036 6,036  55,059  16 28,854 26,233 -2,670 28,279 28,279 49,052 49,052 43,857 3,575 22,727,000,000 -4,141,956,143  4,142  35,761 52,181 45,135,000,000 45,135 52,181,000,000 -21,616 20,326 20,326  71,127  59,718 13,044 15,129 21,321 145 34,430 1,812 135 136 86 11,773 17,772,715 30,547 3,362 4,620 4,182 4,262 702    1,877  
      finance expenses
    -66,904 -66,904  33,018  16 44,786 59,425 74,680 25,347 25,347 19,624 19,624 44,065 77,161 64,280,000,000 -24,518,955,935  24,519  9,334 50,487 9,840,000,000 9,840 50,487,000,000 25,106 41,247 41,247  9,434  3,911 5,399 6,491 -877 -12,141 -869 -80,842 -40,451 -39,970 -10,292 -447 -1,220,188 -368 -8,494 -194 -74 -42 -7,010    -228  
      profit/(loss) before tax
    -57,372 -57,372      -37,384 -24,544.5 -98,178                      -383,944                          
      income taxes
    -3,617 -3,617  -3,848  -1,061 -1,085        -5,791,000,000 -161,250,000  -645  429  -1,297,000,000 -1,297                                  
      net profit/(loss) for the period
    -60,989 -60,989      -38,469 -24,799.5 -99,198                                                
      attributable to owners of the company
    -60,989 -60,989  -38,855   -94,626 -38,469 -278,886 -99,198 -99,198 -109,380 -109,380 -481,447 -131,035 -86,878,000,000 162,222,518,553  -162,223  -121,433 -583,194 -110,914,000,000 -110,914 -583,194,000,000 -207,418 -168,955 -168,955  -81,319  -383,577 -125,498 -106,062 -80,348 -134,374 -62,792 -418,955 -138,965 -121,741 -94,932                 
      basic earnings/(loss) per share
    -1 -1                                                        
      diluted earnings/(loss) per share
    -1 -1                                                        
      consolidated statement of comprehensive income or
                                                             
      other comprehensive income/
                                                             
      items that may be reclassified subsequently to profit or
                                                             
      exchange differences on translating foreign operations
    -1,574 -1,574  -1,399   -75 830 908 154 154 15 15 -2,731 63 -1,498 -3,302  571  -1,016 -327 -787 -787 -327 2,211 -2,207 -2,207  -757  3,855 425 1,074 1,016 77 1,842 -42 94 -75 -147 86  -37,002 37 -594 559  33 -9 -9     -14  
      other comprehensive income/(loss) for the period, net of tax
    -1,574 -1,574      830 38.5 154                                                
      total comprehensive income/(loss) for the period, net of tax
    -62,563 -62,563      -37,639 -24,761 -99,044                                                
      commercial products
      153,663  96,028                                                     
      rendering of services and clinical supply
      3,570  3,524                                                     
      licenses
      812  1,402                                                     
      total revenue
      158,045  100,954                                                     
      commercial product revenue
                                                             
      revenue from commercial products
                                                             
      skytrofa®
      50,706  51,340                                                     
      yorvipath®
      102,957  44,688                                                     
      total revenue from commercial products
      153,663  96,028                                                     
      operating profit
       -52,951   -104,212    -96,743 -133,257 -133,257 -455,541 -49,145    -134,407  -140,838 -561,814  -143,685          -112,581 -96,932 -117,629 -124,650 -330,620 -95,643 -78,825 -82,947 -73,205 -226,719     -154,757     -72,920   -11,989  
      yoy
          7.72%    96.85%    -63.44%                   -65.95% 1.35% 49.23% 50.28% 351.64% -57.81%                   
      qoq
              -27.40% 0.00% -70.75% 826.93%       -74.93%             16.14% -17.60% -5.63% -62.30% 245.68% 21.34% -4.97% 13.31% -67.71%                
      operating margin %
    0% 0% NaN% -33.50% NaN% 0% -103.23% 0% 0% 0% -167.28% -370.18% -370.18% -170.79% -51.25% 0% 0% NaN% -279.82% NaN% -297.17% -1097.85% 0% -427.77% 0% 0% 0% 0% NaN% 0% NaN% 0% 0% -2298.98% -8709.07% -11509.69% -16709.12% -4755.07% -17877.20% -2859.09% -5776.25% -3290.11% -1695.10% 0% 0% 0% 0% -1462.59% 0% 0% 0% NaN% -1583.15%  NaN% -85.74%  
      share of profit of associates
       -4,097  12 26,579    -4,367  -5,322  -5,796                                           
      profit before tax
       -35,007   -93,565    -98,178 -109,151 -109,151 -474,144 -128,527    -161,578  -121,862 -577,817  -109,617          -106,176 -80,343 -134,442 -62,983 -419,174 -138,982 -121,760 -95,038 -63,394              -10,340  
      net profit for the period
       -38,855   -94,626    -99,198 -109,380 -109,380  -131,035    -162,223  -121,433   -110,914          -69,378.75 -80,348 -134,374 -62,792  -69,997.5 -121,741 -94,932 -63,317                
      basic earnings per share
                                                             
      diluted earnings per share
                                                             
      other comprehensive income
                                                             
      other comprehensive income for the period, net of tax
       -1,399   -75    154 15 15  63    571  -1,016   -787          695.25 1,016 77 1,842  -34 -75 -147 86                
      total comprehensive income for the period, net of tax
       -40,254   -94,701    -99,044 -109,365 -109,365  -130,972    -161,652  -122,449   -111,701          -68,683.5 -79,332 -134,297 -60,950  -70,031.5 -121,816 -95,079 -63,231                
      statement of profit or
                                                             
      research and development costs
         611  79,294 233,460 73,544 73,544 83,478 83,478 413,454 70,687 90,881,000,000 -111,438,586,546  111,439  105,021 379,624 106,114,000,000 106,114 379,624,000,000 108,618 97,431 97,431  90,383  295,867 83,193 526,083 -58,761 -83,306 -88,149 -260,904 -75,752 -64,059 -63,578 -57,515  -191,479,657 -46,258 -43,826 -51,259  -37,995 -31,511 -30,540    -19,698  
      selling, general and administrative expenses
         611   17,457.75 69,831  74,312 74,312 264,410 66,783 63,975,000,000 -63,613,735,590  63,614  70,281 221,227 66,539,000,000 66,539 221,227,000,000 56,552 60,671 60,671  56,584  160,180  272,056 -39,284 -35,345  -76,669                    
      net profit for the year
                 -481,447        -583,194                -418,955                  -9,658  
      basic and diluted earnings per share
                                             -1.32                
      number of shares used for calculation
          60,018,550 59,785,166 356,221 57,535,349 57,535,349 57,345,613 57,345,613 56,287,060 56,883,257 56,560,368 14,068,174.5  56,272,698  56,218,257 56,071,793 56,091,927 56,091,927 56,071,793 14,028,945.5 55,831,561 55,831,561  55,805,486  54,771,763 56,720,063 13,521,448.25 54,639,597 53,848,166 53,759,952 50,616,528 969,057 52,715,204 48,207,661 47,985,837  440,369 47,590,837 47,190,717 43,371,559  327,551 41,888,908 38,699,204       
      statement of comprehensive income or
                                                             
      other comprehensive income for the year, net of tax
                 -2,731        -327                -42                  -14  
      total comprehensive income for the year, net of tax
                 -484,178        -583,521                -418,997                  -9,672  
      basic and diluted earnings/(loss) per share
                                                             
      share of profit/(loss) of associate
            -1,091.75 -4,367                      12,041               -1,852           
      income taxes/
            -255 -1,020 -1,020 -229 -229  -2,508                                           
      consolidated statement of profit or loss
                                                             
      share of profit of associate
               -5,322  -18,395     -6,794  -7,451 -17,697  -1,227          -7,393 -3,855 -4,817 28,106 -9,524 -3,023 -3,101 -1,885 -1,515 11     12          
      items that may be reclassified subsequently to profit or loss:
                                                             
      statement of profit or loss
                                                             
      tax on profit for the year
                 -7,303        -5,377                219               682  
      statement of comprehensive income
                                                             
      items that may be reclassified subsequently to profit or loss
                                                             
      operating profit /
                   -36,610,000,000 -33,601,750,000      -143,685,000,000  -561,814,000,000 -103,607 -144,505 -144,505  -141,893   -128,029           -40,467.75 -54,015 -51,575 -56,281  -29,726 -38,287 -35,174       
      share of profit / (loss) of associate
                   -2,924,000,000 -1,698,500,000      -1,227,000,000  -17,697,000,000 -2,434 -3,696 -3,696  -1,166   -4,873           -1,363 -1,338 -2,262            
      profit / (loss) before tax
                   -81,087,000,000 -40,394,500,000      -109,617,000,000  -577,817,000,000 -93,937 -169,122 -169,122  -81,366   -125,257           -34,462.5 -25,174 -58,969 -53,707  -24,606.25 -34,067 -41,482       
      net profit / (loss) for the period
                   -86,878,000,000 -40,555,750,000      -110,914,000,000   -93,944 -168,955 -168,955  -81,319   -125,498           -34,413.5 -25,113 -58,904 -53,637  -24,529.75 -33,967 -41,375       
      basic and diluted earnings / (loss) per share
                                               -0.748 -0.53 -1.25 -1.24  -0.603 -0.81 -1.07       
      other comprehensive income /
                                                             
      other comprehensive income / (loss) for the period, net of tax
                   -1,498 142.75      -787   -634.5 -2,207 -2,207  -757   425           0.5 37 -594 559  -4 -9 -9       
      total comprehensive income / (loss) for the period, net of tax
                   -88,376 -40,413      -111,701   -94,578.5 -171,162 -171,162  -82,076   -125,073           -34,413 -25,076 -59,498 -53,078  -24,533.75 -33,976 -41,384       
      •
                                                             
      statement of comprehensive income net profit for the year
                         -583,194                                    
      tax on profit / (loss) for the year
                            -5,377,000,000                                 
      net profit / (loss) for the year
                            -583,194,000,000                                 
      other comprehensive income / (loss) for the year, net of tax
                            -327                                 
      total comprehensive income / (loss) for the year, net of tax
                            -583,521                                 
      gross profit /
                             5,313.25 13,597   5,074   2,582                         
      tax on profit / (loss) for the period
                             -7 167 167  47   -241           49 61 65 70  76.5 100 107       
      date
                                                             
      time
                                                            
      dial in
                                  844                           
      access code
                                  6,876,568                           
      tax on profit/(loss) for the year
                                   367                          
      net profit/(loss) for the year
                                   -383,577                          
      other comprehensive income/(loss) for the year, net of tax
                                   3,855                          
      total comprehensive income/(loss) for the year, net of tax
                                   -379,722                          
      consolidated interim statement of profit or loss
                                                             
      tax on profit for the period
                                     63.25 -5 68 191  50.5 19 106 77                
      consolidated interim statement of comprehensive income
                                                             
      general and administrative expenses
                                             -17,915  -48,441,604 -10,000 -10,960 -10,436  -8,373 -6,796 -4,662    -6,274  
      profit for the period attributable to owners of the company
                                             -63,317                
      total comprehensive income for the period attributable to owners of the company
                                             -63,231                
      finance income /
                                              16,582     24,587     4,188     
      profit for the year
                                              -218,016     -130,097     -68,505     
      cash and cash equivalents
                                              598,106     277,862     180,329     
      total assets
                                              676,732     318,968     190,071     
      equity
                                              597,114     280,050     176,613     
      investments in property, plant & equipment
                                              5,159     2,648          
      return on equity (%)*
                                              -49.7     -55.7          
      equity ratio (%)*
                                              88.2     87.8          
      profit for the year attributable to owners of the company
                                                           -9,658  
      total comprehensive income for the year attributable to owners of the company
                                                           -9,672  
      profit / (loss) for the period attributable to owners of the company
                                               -34,413.5 -25,113 -58,904 -53,637  -24,529.75 -33,967 -41,375       
      total comprehensive income / (loss) for the period attributable to owners of the company
                                               -34,413 -25,076 -58,498 -53,078  -24,533.75 -33,976 -41,384       
      investment in property, plant & equipment
                                                        672     
      return on equity
                                                        -46.1     
      equity ratio
                                                        92.9     
      weighted-average number of shares used for calculation
                    56,287,060         56,071,793        54,771,763                  33,626,305   23,766,783   
      basic and diluted earnings per share, preference d and c shares
                                                           -1.07  
      basic and diluted earnings per share, preference b shares
                                                             
      basic and diluted earnings per share, ordinary shares
                                                             
      weighted-average number of d and c shares used for calculation
                                                           8,996,492  
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-09-30 2025-06-30 2025-04-29 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-05-02 2024-03-31 2023-12-31 2023-09-30 2023-09-05 2023-06-30 2023-05-02 2023-04-27 2023-03-31 2023-02-16 2022-12-31 2022-11-02 2022-09-30 2022-08-10 2022-06-30 2022-05-11 2022-05-02 2022-03-31 2022-03-02 2021-12-31 2021-11-10 2021-09-30 2021-08-25 2021-06-30 2021-05-27 2021-04-30 2021-03-31 2021-03-10 2020-12-31 2020-11-12 2020-09-30 2020-08-27 2020-06-30 2020-05-19 2020-05-05 2020-03-31 2019-12-31 2019-11-18 2019-09-30 2019-08-28 2019-06-30 2019-05-30 2019-05-01 2019-04-03 2019-03-31 2018-12-31 2018-11-28 2018-09-30 2018-08-29 2018-06-30 2018-05-30 2018-05-01 2018-03-31 2018-03-28 2017-12-31 2017-11-16 2017-09-30 2017-08-18 2017-06-30 2017-05-23 2017-04-26 2017-03-31 2017-03-22 2016-12-31 2016-11-30 2016-09-30 2016-08-31 2016-06-30 2016-05-19 2016-04-26 2016-03-31 2015-12-31 2015-11-16 2015-09-30 2015-08-25 2015-06-30 2015-03-31 2015-03-27 2014-12-31 
                                                                                            
        assets
                                                                                            
        non-current assets
                                                                                            
        intangible assets
      3,742 3,790 4,028 3,909 4,028 4,106 4,186 4,419 4,301 4,419 4,495 4,606 4,606 4,828 4,717 4,717 4,828 4,828 4,939 4,939 5,050 5,050 5,161 5,272 5,161 5,272 5,272 5,384 5,384 5,495 5,495 5,606 5,717 5,606 5,717 5,717 4,653 4,653 3,806 3,806 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 3,495 
        property, plant and equipment
      101,764 93,542 98,714 92,447 98,714 97,522 104,041 110,634 107,164 110,634 125,535 125,362 125,362 129,095 127,762 127,762 129,095 129,095 139,345 139,345 133,224 133,224 127,678 126,049 127,678 126,049 126,049 126,295 126,295 123,924 123,924 114,196 108,112 114,196 108,112 108,112 47,325 47,325 49,743 49,743 49,761 45,069 49,761 45,069 43,272 43,272 42,537 42,537 24,032 4,325 4,325 24,032 4,325 3,513 3,513 2,597 2,597 2,461 2,557 2,461 2,557 2,557 2,519 2,519 2,587 2,587 2,559 2,350 2,559 2,350 2,350 2,422 2,422 2,430 2,430 2,331 2,355 2,331 2,355 2,145 2,145 2,206 2,206 1,837 1,874 1,874 
        investments in associates
      28,303 34,902 13,575 40,938 13,575                                                                                  
        other receivables
      3,160 2,711 2,317 2,657 2,317 2,202 2,186 2,127 2,129 2,127 2,142 2,066 2,066 1,920 1,984 1,984 1,920 1,920 1,895 1,895 1,836 1,836 1,822 1,808 1,822 1,808 1,808 20,258 20,258 11,398 11,398 1,779 1,375 1,779 1,375 1,375 4,511 4,511 5,332 5,332 4,775 3,136 4,775 3,136 1,755 1,755 1,451 1,451 6,863 1,775 1,775 6,863 1,775 2,750 2,750 1,826 1,826 1,128 1,410 1,128 1,410 1,410 608 608 1,190 1,190 1,921 640 1,921 640 640 1,872 1,872 601 601 690 338 690 338 1,480 1,480 1,503 1,503 244 210 210 
        current assets
                                                                                            
        inventories
      302,022 303,381 295,609 293,071 295,609 265,433 251,199 208,931 232,681 208,931 189,132 167,919 167,919 130,673 150,850 150,850 130,673 130,673 103,975 103,975 101,322 101,322 92,436 75,405 92,436 75,405 75,405 55,270 55,270                                                          
        trade receivables
      134,734 110,452 166,280 66,685 166,280 33,098 49,163 35,874 41,092 35,874 26,794 20,212 20,212 11,910 16,121 16,121 11,910 11,910 6,655 6,655 4,369 4,369 5,808 2,200 5,808 2,200 2,200 533 533 394 394 60 387 60 387 387 2,722 2,722           21 21 17 17 34 188 34 188 188 444 444 450 450 378 287 378 287 287 419 419 392 392 888 1,064 888 1,064 737 737 1,348 1,348 850 1,292 1,292 
        income tax receivables
      2,936 2,738 1,775 1,614 1,775 1,995 1,841 802 742 802 1,644  1,360 883  1,064  883  1,630  1,128  893 1,072  893                                                            
        prepayments
      29,417 34,311 28,269 33,672 28,269 32,440 36,743 38,578 42,502 38,578 38,327 42,958 42,958 31,717 38,694 38,694 31,717 31,717 34,568 34,568 35,067 35,067 27,994 25,231 27,994 25,231 25,231 22,239 22,239 21,826 21,826 15,322 13,994 15,322 13,994 13,994 15,266 15,266 13,033 13,033 10,185 7,648 10,185 7,648 7,937 7,937 9,891 9,891 11,282 12,415 12,415 11,282 12,415 12,390 12,390 5,934 5,934 7,119 6,907 7,119 6,907 6,907 7,204 7,204 6,077 6,077 5,624 1,962 5,624 1,962 1,962 2,475 2,475 3,657 3,657 2,132 3,819 2,132 3,819 3,386 3,386 325 325 371 620 620 
        cash and cash equivalents
      539,092 494,046 559,543 517,923 559,543 625,515 258,696 392,164 320,239 392,164 441,268 394,222 394,222 444,767 501,281 501,281 444,767 444,767 608,330 608,330 672,387 672,387 755,643 446,267 755,643 446,267 446,267 692,941 692,941 384,539 384,539 495,047 584,517 495,047 584,517 584,517 763,454 763,454 240,605 240,605 534,381 598,106 534,381 598,106 658,660 658,660 690,355 690,355 696,664 277,862 277,862 696,664 277,862 310,333 310,333 352,601 352,601 348,410 195,351 348,410 195,351 195,351 206,292 206,292 127,320 127,320 157,648 180,329 157,648 180,329 180,329 74,525 74,525 90,753 90,753 101,865 119,649 101,865 119,649 128,247 128,247 137,854 137,854 153,450 50,167 50,167 
        total assets
      1,154,750 1,087,902 1,179,495 1,061,438 1,179,495 1,093,783 758,298 825,587 802,504 825,587 873,213 823,823 823,823 1,089,738 966,274 966,274 1,089,738 1,089,738 1,273,420 1,273,420 1,326,831 1,326,831 1,377,250 1,084,921 1,377,250 1,084,921 1,084,921 1,205,233 1,205,233 851,848 851,848 965,313 979,793 965,313 979,793 979,793 1,046,124 1,046,124 560,607 560,607 621,407 676,732 621,407 676,732 734,959 734,959 767,157 767,157 761,939 318,968 318,968 761,939 318,968 335,234 335,234 368,864 368,864 364,826 210,979 364,826 210,979 210,979 222,040 222,040 142,403 142,403 172,764 190,071 172,764 190,071 190,071 86,752 86,752 102,734 102,734 112,679 131,774 112,679 131,774 141,263 141,263 148,112 148,112 161,284 58,671 58,671 
        equity and liabilities
                                                                                            
        equity
                                                                                            
        share capital
      8,284 8,211 8,149 8,187 8,149 8,143 7,819 7,749 7,818 7,749 7,742 7,699 7,699 7,675 7,698 7,698 7,675 7,675 7,658 7,658 7,649 7,649 7,649 7,646 7,649 7,646 7,646 7,638 7,638 7,237 7,237 7,228 7,217 7,228 7,217 7,217 7,172 7,172 6,491 6,491 6,443 6,443 6,443 6,443 6,410 6,410 6,384 6,384 6,301 5,659 5,659 6,301 5,659 5,645 5,645 5,619 5,619 5,577 4,967 5,577 4,967 4,967 4,884 4,884 4,365 4,365 4,365 4,354 4,365 4,354 4,354 3,385 3,385 3,382 3,382 3,374 3,374 3,374 3,374 3,374 3,374 3,247 3,247 3,201 2,272 2,272 
        distributable equity
      -182,359 -195,783 -113,855 -197,994 -113,855 -105,463 -328,952 -153,446 -245,997 -153,446 -81,175 57,142 57,142 255,673 159,503 159,503 255,673 255,673 443,894 443,894 600,193 600,193 665,167 875,989 665,167 875,989 875,989 985,924 985,924 680,250 680,250 795,591 831,494 795,591 831,494 831,494 944,413 944,413 470,653 470,653 542,389 590,671 542,389 590,671 654,515 654,515 668,691 668,691 710,360 274,391 274,391 710,360 274,391 298,560 298,560 326,606 326,606 341,836 182,244 341,836 182,244 182,244                         
        total equity
      -174,075 -187,572 -105,706 -189,807 -105,706 -97,320 -321,133 -145,697 -238,179 -145,697 -73,433 64,841 64,841 263,348 167,201 167,201 263,348 263,348 451,552  607,842  672,816 883,635  883,635 883,635 993,562  687,487   838,711  838,711 838,711     548,832 597,114 548,832 597,114 660,925 660,925 675,075 675,075 716,661 280,050 280,050 716,661 280,050 304,205 304,205 332,225 332,225 347,413 187,211 347,413 187,211 187,211 202,150 202,150 126,468 126,468 154,827 176,613 154,827 176,613 176,613 74,401 74,401 90,909 90,909 101,912 120,329 101,912 120,329 131,716 131,716 135,730 135,730 149,190 45,810 45,810 
        non-current liabilities
                                                                                            
        borrowings
      331,369 330,186 365,080 357,312 365,080 338,930 219,052 534,246 229,627 534,246 549,483 479,374 479,374 482,956 479,988 479,988 482,956 482,956 533,145 533,145 498,130 498,130 464,736  464,736                                                              
        contract liabilities
      692 692 5,000 692 5,000 5,000 5,000 5,949 5,000 5,949 949 949 949 14,213 3,956 3,956 14,213 14,213 13,154 13,154 3,700 3,700 2,964 2,964 2,964 2,964 2,964 36 36 145 145 254 363 254 363 363 223 223   343 858 343 858 1,373 1,373 2,156 2,156 3,073 6,902 6,902 3,073 6,902                                  
        deferred tax liabilities
      10,280 9,596 7,258 7,733 7,258 8,716 7,644 5,830 7,085 5,830                                                                             
        current liabilities
                                                                                            
        convertible notes, matures in april 2028
                                                                                            
        derivative liabilities
      233,761 186,579 150,670 174,581 150,670 168,346 159,059 143,296 197,291 143,296 93,353 86,385 86,385 157,950 116,768 116,768 157,950 157,950 132,731 132,731 102,031 102,031 141,379  141,379                                                              
        other current liabilities
                                                                                            
        trade payables and accrued expenses
      78,601 93,718 96,394 84,370 96,394 75,268 99,527 94,566 94,526 94,566 121,552 122,120 122,120 101,032 131,438 131,438 101,032 101,032 86,102 86,102 74,984 74,984 70,683 59,417 70,683 59,417 59,417 76,471 76,471 44,207 44,207 54,133 21,897 54,133 21,897 21,897 38,108 38,108                                                 
        other liabilities
      48,295 39,924 67,956 38,062 67,956 42,241 26,411 41,176 22,698 41,176 33,660 22,860 22,860 31,989 15,503 15,503 31,989 31,989 26,578 26,578 20,957 20,957 12,536  12,536 29,952       3,162  3,162 3,162                                                   
        income tax payables
      1,610 711 1,222 1,573 1,222 1,016 1,090 2,299 3,336 2,299 6,478 5,773 5,773 5,490   5,490 5,490      198  198 198                                                            
        provisions
      137,776 149,931 99,149 95,772 99,149 100,268 106,768 32,719 40,550 32,719 20,781 10,811 10,811 7,339 9,154 9,154 7,339 7,339 6,799 6,799 5,018 5,018 2,446 1,193 2,446 1,193 1,193                                                            
        total liabilities
      1,328,825 1,275,474 1,285,201 1,251,245 1,285,201 1,191,103 1,079,431 971,284 1,040,683 971,284 946,646 758,982 758,982 826,390 799,073 799,073 826,390 826,390 821,868 821,868 718,989 718,989 704,434 201,286 704,434 201,286 201,286 211,671 211,671 164,361 164,361 162,494 141,082 162,494 141,082 141,082 94,539 94,539 83,463 83,463 72,575 79,618 72,575 79,618 74,034 74,034 92,082 92,082 45,278 38,918 38,918 45,278 38,918 31,029 31,029 36,639 36,639 17,413 23,768 17,413 23,768 23,768 19,890 19,890 15,935 15,935 17,937 13,458 17,937 13,458 13,458 12,351 12,351 11,825 11,825 10,767 11,445 10,767 11,445 9,547 9,547 12,382 12,382 12,094 12,861 12,861 
        total equity and liabilities
      1,154,750 1,087,902 1,179,495 1,061,438 1,179,495 1,093,783 758,298 825,587 802,504 825,587 873,213 823,823 823,823 1,089,738 966,274 966,274 1,089,738 1,089,738 1,273,420 1,273,420 1,326,831 1,326,831 1,377,250 1,084,921 1,377,250 1,084,921 1,084,921 1,205,233 1,205,233 851,848 851,848 965,313 979,793 965,313 979,793 979,793 1,046,124 1,046,124 560,607 560,607 621,407 676,732 621,407 676,732 734,959 734,959 767,157 767,157 761,939 318,968 318,968 761,939 318,968 335,234 335,234 368,864 368,864 364,826 210,979 364,826 210,979 210,979 222,040 222,040 142,403 142,403 172,764 190,071 172,764 190,071 190,071 86,752 86,752 102,734 102,734 112,679 131,774 112,679 131,774 141,263 141,263 148,112 148,112 161,284 58,671 58,671 
        marketable securities
                   7,492   7,492 7,492 15,338 15,338 39,721 39,721 86,487 107,561 86,487 107,561 107,561 71,614 71,614 90,693 90,693 106,426 115,280 106,426 115,280 115,280 27,728 27,728 230,958 230,958                                               
        investment in associates
           16,213 20,564  24,797                                                                              
        investment in associate
             5,686  5,686 8,116 14,111 14,111 22,932 21,966 21,966 22,932 22,932 32,001 32,001 34,905 34,905 35,023 38,345 35,023 38,345 38,345 43,639 43,639 45,783 45,783 50,035 9,176 50,035 9,176 9,176 11,574 11,574 14,167 14,167 15,307 15,538 15,307 15,538 17,073 17,073 16,885 16,885 17,476 17,083 17,083 17,476 17,083                                  
        investment in group enterprises
                                                                                            
        receivables from group enterprises
                                                                                            
        lease liabilities
             84,619  84,619 90,103             97,966  97,966 97,966 95,553 95,553 94,059 94,059 89,568 85,116 89,568 85,116 85,116 26,952 26,952 29,092 29,092 30,760 30,720 30,760 30,720 31,503 31,503 31,461 31,461 13,213   13,213                                   
        payables to group enterprises
                                                                                            
        non-current assets - sum
                140,288 146,145 146,145 166,267 156,429 156,429 166,267 166,267  193,518 214,736 214,736    279,035 279,035  248,645 267,597   239,660   239,660 92,523  68,984  69,833   65,565 65,309           7,207   6,345      6,360   6,113      6,187   6,120        5,509  
        current assets - sum
                732,925 677,678 677,678 923,471 809,845 809,845 923,471 923,471  1,079,902 1,112,095 1,112,095    805,886 805,886  956,588 584,251   740,133   740,133 953,601  491,623  551,574   611,167 669,650           361,657   204,634      136,043   183,958      96,547   125,654        53,162  
        non-current liabilities - sum
                733,888 566,708 566,708 655,119 600,712 600,712 655,119 655,119  679,030 603,861 603,861    100,930 100,930  95,553 94,059   88,278   88,278 30,112  29,092  30,760                                              
        current liabilities - sum
                212,758 192,274 192,274 171,271 198,361 198,361 171,271 171,271  142,838 115,128 115,128    100,356 100,356  116,118 70,302   52,804   52,804 64,427  54,371  41,815   47,990 42,531           36,639   23,768      15,935   13,458      11,825   11,445        12,861  
        income tax receivable
                 1,360   1,064  883  1,630  1,128  1,072   893                                                             
        income taxes payable
                    6,873 6,873   126 126 90 90 499  499   501 501 377 377 373 301 373 301 301 219 219 186 186 209 119 209 119 24 24 52 52 39 39 25 25      205 205 305 305 349 286 349 286 286 117 117 141 141 103  103         
        equity - sum
                         451,552  607,842       993,562        951,585  477,144                                                
        deposits
                                 1,713 1,713 1,702 1,702      1,243 1,243 1,268 1,268 1,270 1,463 1,270 1,463 1,469 1,469 1,410 1,410 1,161 1,158 1,158 1,161 1,158 1,241 1,241 1,115 1,115 1,112 293 1,112 293 293 284 284 278 278 267 268 267 268 268 265 265 262 262 297 270 297 270 265 265 153 153 150 140 140 
        other payables
                                 32,362  18,623       3,160 3,160    908  908 11,364 11,364 32,337 32,337 5,445 12,267 12,267 5,445 12,267                                  
        income taxes receivable
                                          1,305 1,305 1,107 1,107 921 1,473 921 1,473 1,298 1,298 1,133 1,133 962 849 849 962 849 1,491 1,491 1,279 1,279 1,067 778 1,067 778 778 1,194 1,194 1,006 1,006 872 740 872 740 740 1,279 1,279 1,144 1,144 981 784 981 784 1,508 1,508 1,228 1,228 887 873 873 
        receivable from associate
                                            588 588 1,312  1,312 804                                           
        trade payables
                                            31,575 31,575 27,277 27,765 27,277 27,765 24,346 24,346 21,235 21,235 19,237 19,740 19,740 19,237 19,740                                  
        investments in group enterprises
                                                                                            
        trade receivable from associate
                                               804                                             
        trade payables and other payables
                                                           31,021 31,021 36,614 36,614 17,413 23,768 17,413 23,768 23,768 19,591 19,591 15,536 15,536 17,494 13,078 17,494 13,078 13,078 11,396 11,396 10,101 10,101 8,337 8,373 8,337 8,373 5,387 5,387 6,974 6,974 5,438 4,956 4,956 
        deferred income
                                                                    94 94 94 94 94 94 94 94 94 838 838 1,583 1,583 2,327 3,072 2,327 3,072 4,160 4,160 5,408 5,408 6,656 7,905 7,905 
        other reserves
                                                                    19,969 19,969 18,061 18,061 15,714 13,005 15,714 13,005 13,005 11,167 11,167 9,550 9,550 7,779 5,678 7,779 5,678 5,069 5,069 4,954 4,954 4,516 3,979 3,979 
        retained earnings
                                                                    177,297 177,297 104,042 104,042 134,748 159,254 134,748 159,254 159,254 59,849 59,849 77,977 77,977 90,759 111,277 90,759 111,277 123,273 123,273 127,529 127,529 141,473   
        summary of significant accounting policies
                                                                                            
        critical accounting judgments and key sources of estimation uncertainty
                                                                                            
        commitments and contingencies
                                                                                            
        financial risk management and financial instruments
                                                                                            
        related party transactions
                                                                                            
        ownership
                                                                                            
        retained earnings/
                                                                                          39,559 39,559 
        finance lease liabilities
                                                                                            
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-12-31 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 
                        
          •
                        
          item 4
                        
          a.
                        
          b.
                        
          1.
                        
          2.
                        
          3.
                        
          4.
                        
          5.
                        
          6.
                        
          7.
                        
          8.
                        
          9.
                        
          1
                        
          c.
                        
          d.
                        
          location
                        
          denmark
                        
          tuborg boulevard, hellerup
                        
          germany
                        
          technologiepark, heidelberg
                        
          grundbuch von heidelberg blatt, heidelberg
                        
          kurfürstendamm, berlin
                        
          united states
                        
          emerson street, palo alto, california
                        
          redwood city, california
                        
          page mill, palo alto, california
                        
          west windsor township, new jersey
                        
          item 4a
                        
          item 5
                        
          revenue
                        
          cost of sales
                        
          gross profit
                        
          research and development costs
                        
          selling, general and administrative expenses
                        
          operating profit/
                        
          share of profit/(loss) in associate
                        
          finance income
                        
          finance expenses
                        
          profit/(loss) before tax
                        
          tax on profit/(loss) for the year
                        
          net profit/(loss) for the year
                        
          sale of commercial products
                        
          rendering of services
                        
          sale of clinical supply
                        
          “right-to-use” licenses
                        
          total revenue
                        
          marketable securities specified by investment grade credit rating
                        
          prime
                        
          high grade
                        
          upper medium grade
                        
          lower medium grade
                        
          total marketable securities
                        
          december 31, 2021
                        
          liquidity and capital resources
                        
          marketable securities
                        
          cash and cash equivalents
                        
          total liquidity and capital resources
                        
          classification in consolidated statement of financial position
                        
          non-current assets
                        
          current assets
                        
          cash flows from/(used in) operating activities
         -101,582               
          cash flows from/(used in) investing activities
         7,155               
          cash flows from/(used in) financing activities
        117,434,189 18,423               
          net increase in cash and cash equivalents
                        
          e.
                        
          item 6
                        
          name of board member
                        
          albert cha, m.d., ph.d.
                        
          lisa bright
                        
          james i. healy, m.d., ph.d.
                        
          lars holtug
                        
          jan møller mikkelsen
                        
          rafaèle tordjman, m.d., ph.d.
                        
          name
                        
          vibeke miller breinholt, ph.d.
                        
          jesper høiland
                        
          flemming steen jensen
                        
          michael wolff jensen, l.l.m.
                        
          sigurd okkels, ph.d.
                        
          dana pizzuti, m.d.
                        
          juha punnonen, m.d., ph.d.
                        
          peter rasmussen
                        
          stina singel, m.d., ph.d.
                        
          scott t. smith
                        
          lotte sønderbjerg
                        
          kennett sprogøe, ph.d.
                        
          birgitte volck, m.d., ph.d.
                        
          board diversity matrix
                        
          country of principal executive offices
                        
          foreign private issuer
                        
          disclosure prohibited under home country law
                        
          total number of directors
                        
          part i: gender identity
                        
          directors
                        
          part ii: demographic background
                        
          underrepresented individual in home country
                        
          lgbtq+
                        
          did not disclose demographic background
                        
          birgitte volck
                        
          vibeke miller breinholt
                        
          dana pizzuti
                        
          sigurd okkels
                        
          juha punnonen
                        
          michael wolff jensen
                        
          kennett sprogøe
                        
          total
                        
          december 31, 2020
                        
          december 31, 2019
                        
          selling, general and administration function includes business and corporate development, and pre-commercial activities.
                        
          item 7
                        
          name and address of beneficial owner
                        
          entities affiliated with artisan partners lp
                        
          entities affiliated with ra capital management, l.p.
                        
          entities affiliated with fmr llc
                        
          t. rowe price associates, inc.
                        
          baker bros. advisors lp
                        
          entities affiliated with wellington management group llp
                        
          entities affiliated with janus henderson group plc
                        
          senior management and board members
                        
          stina singel, m.d, ph.d.
                        
          lars holtug, m.sc.
                        
          *
                        
          item 8
                        
          item 9
                        
          f.
                        
          item 10
                        
          g.
                        
          h.
                        
          i.
                        
          item 11
                        
          item 12
                        
          persons depositing or withdrawing ordinary shares or adss must pay:
                        
          5.00
                        
          0.05 (or less) per ads
                        
          a fee equivalent to the fee that would be payable if securities distributed to you had been ordinary shares and the shares had been deposited for issue of adss
                        
          0.05 (or less) per ads per calendar year
                        
          registration or transfer fees
                        
          expenses of the depositary
                        
          taxes and other governmental charges the depositary or the custodian have to pay on any ads or share underlying an ads, for example, share transfer taxes, stamp duty or withholding taxes
                        
          any charges incurred by the depositary or its agents for servicing the deposited securities
                        
          item 13
                        
          item 14
                        
          item 15
                        
          item 16a
                        
          item 16b
                        
          item 16c
                        
          audit fees
                        
          tax fees
                        
          all other fees
                        
          item 16d
                        
          item 16e
                        
          period
                        
          november 1, 2021 – november 9, 2021
                        
          item 16f
                        
          item 16g
                        
          item 16h
                        
          item 16i
                        
          item 17
                        
          item 18
                        
          reports of independent registered public accounting firm
                        
          consolidated statements of profit or loss and other comprehensive income for the years ended december 31, 2021, 2020 and 2019
                        
          consolidated statements of financial position as of december 31, 2021 and 2020
                        
          consolidated statements of changes in equity at december 31, 2021, 2020 and 2019
                        
          consolidated cash flow statements for the years ended december 31, 2021, 2020 and 2019
                        
          notes to the consolidated financial statements
                        
          consolidated statement of profit or loss
                        
          share of profit/(loss) of associate
                        
          attributable to owners of the company
                        
          basic and diluted earnings/(loss) per share
                        
          weighted-average number of shares used for calculation
                        
          consolidated statement of comprehensive income
                        
          other comprehensive income/
                        
          items that may be reclassified subsequently to profit or loss:
                        
          exchange differences on translating foreign operations
                        
          other comprehensive income/(loss) for the year, net of tax
                        
          total comprehensive income/(loss) for the year, net of tax
                        
          assets
                        
          intangible assets
                        
          property, plant and equipment
                        
          investment in associate
                 -10,187     
          other receivables
                        
          inventories
         -23,750 -19,799 -21,213 -17,068 -20,178 -26,697 -2,654         
          trade receivables
                        
          income tax receivables
                        
          prepayments
         -3,904 -5,175 6,541 -2,603 -10,176 2,460 768  -414 -6,503 -1,329  -2,233 -2,848 -2,537 
          total assets
                        
          equity and liabilities
                        
          equity
                        
          share capital
                        
          distributable equity
                        
          total equity
                        
          non-current liabilities
                        
          lease liabilities
                        
          contract liabilities
         -950 2,153 -115 -8,862 -256 -2,079 12,592  -109 -109 -109  223 -343 -515 
          other liabilities
                        
          current liabilities
                        
          trade payables and accrued expenses
                        
          income tax payables
                        
          provisions
                        
          total liabilities
                        
          total equity and liabilities
                        
          equity at january 1, 2019
                        
          loss for the year
                        
          other comprehensive income/(loss), net of tax
                        
          total comprehensive income/
                        
          transactions with owners
                        
          share-based payment
         17,281 15,908 17,184 19,880 13,688 13,873 13,537  13,288 16,320 23,076  10,417 13,415 14,949 
          capital increase
                   1,982  617,213   
          cost of capital increase
                        
          equity at december 31, 2019
                        
          equity at december 31, 2020
                        
          acquisition of treasury shares
                        
          equity at december 31, 2021
                        
          operating activities
                        
          reversal of finance income
         -3,575 33,128 3,389 -35,239 -45,135 21,616 10,374  -21,321 11,162 -34,430  319 9,777 -11,773 
          reversal of finance expenses
         77,161 8,425 16,988 8,812 9,840 25,106 10,548  877 834 869  39,515 429 447 
          reversal of tax charge
              5,349 -167  -68 -191  -19 -106 -77 
          increase/(decrease) in provisions
         7,076               
          adjustments for non-cash items:
                        
          non-cash consideration regarding revenue
                        
          depreciation
         4,359 4,827 4,632 4,534 4,435 4,526 4,404  3,672 3,509 3,603  2,270 2,199 1,993 
          amortization
         118 150 111 111 111 111 111  111 111 111     
          changes in working capital:
                        
          receivables
         -11,286 -8,523 -13,535 -1,107 -9,608 -5,457 -376  -5,260 -4,145 110  -1,138 -1,741 797 
          trade payables, accrued expenses and other payables
         -19,025 -10,053 4,288 -4,920 14,236 23,415 14,568    17,573     
          cash flows generated from/(used in) operations
         -104,087               
          finance income received
         3,588 4,471 4,174 4,524 3,879 1,463 2,980  1,004    -123 321 1,455 
          finance expenses paid
         -877 -7,040 -886 -6,840 -906 -7,268 -784  -357    -354 -431 -367 
          income taxes received/
         -206               
          investing activities
                        
          acquisition of property, plant and equipment
         -199 63 -976 -444 -1,085 -3,782 -3,163  -11,300 -3,582 -4,025  -4,871 -4,584 -6,141 
          reimbursement for acquisition of property, plant and equipment
                        
          development expenditures
                 -530  -423   
          purchase of marketable securities
              -53,003 -71,139  -11,186 -36,914 -39,444  -106,945   
          settlement of marketable securities
         7,354 6,583 23,150 47,401 211,731 55,988 88,401  42,912 51,531 24,069     
          financing activities
                        
          payment of principal portion of lease liabilities
          -2,735 -2,618 -2,517 -2,568 -1,779 -1,414  -1,514       
          proceeds from exercise of warrants
         21,209 2,018 6,194 208 1,866 3,130 1,337  4,427       
          net proceeds from follow-on public offerings
                        
          acquisitions of treasury shares, net of transaction costs
                        
          increase/(decrease) in cash and cash equivalents
         -76,004               
          cash and cash equivalents at january 1
         392,164 444,767  584,517  598,106 
          effect of exchange rate changes on balances held in foreign currencies
         4,079 -7,230 6,187 1,421 -6,386 -22,430 20,753  14,890 -7,733 22,246  -28,413 -7,611 10,319 
          cash and cash equivalents at december 31
                        
          cash and cash equivalents include:
                        
          bank deposits
         320,239 -49,104 47,046 -107,059 501,281 -176,208 -66,226  309,868 -111,974 495,047  536,545 -33,772 216,925 
          short-term marketable securities
              12,645 2,169      -13,696 -260,004 317,456 
          process plant and machinery
                        
          other equipment
                        
          leasehold improvements
                        
          right-of-use assets
                        
          revenue from external customers
                        
          commercial sale of products
                        
          attributable to
                        
          commercial customers
                        
          collaboration partners and license agreements
                        
          specified by timing of recognition
                        
          recognized over time
                        
          recognized at a point in time
                        
          specified per geographical location
                        
          north america
                        
          china
                        
          non-current segment assets
                        
          total non-current segment assets
                        
          total non-current assets
                        
          employee costs
                        
          wages and salaries
                        
          pensions
                        
          social security costs
                        
          total employee costs
                        
          included in the profit or loss
                        
          average number of employees
                        
          compensation
                        
          total compensation
                        
          outstanding at january 1, 2021
                        
          granted, december 2021
                        
          outstanding at december 31, 2021
                        
          vested at the reporting date
                        
          outstanding at january 1, 2019
                        
          granted during the year
                        
          exercised during the year
                        
          forfeited during the year
                        
          expired during the year
                        
          outstanding at december 31, 2019
                        
          outstanding at december 31, 2020
                        
          granted in 2012-2017
                        
          granted in 2018
                        
          granted in 2019
                        
          granted in 2020
                        
          granted in 2021
                        
          expected volatility
                        
          risk-free interest rate
                        
          expected life of warrants
                        
          weighted-average exercise price
                        
          fair value of warrants granted in the year
                        
          principal accountant fees and services
                        
          total principal accountant fees and services
                        
          tax on profit/(loss) for the year:
                        
          current tax (expense)/income
                        
          tax for the year can be explained as follows:
                        
          tax at the danish corporation tax rate of 22%
                        
          tax effect of:
                        
          non-deductible costs
                        
          additional tax deductions
                        
          impact from associate
                        
          other effects including effect of different tax rates
                        
          deferred tax asset, not recognized
                        
          effective tax rate
                        
          specification of deferred tax assets
                        
          tax deductible losses
                        
          other temporary differences
                        
          total deferred tax assets at december 31
                        
          cost:
                        
          at january 1, 2020
                        
          additions
                        
          disposals
                        
          foreign exchange translation
                        
          at december 31, 2020
                        
          at december 31, 2021
                        
          accumulated amortization and impairments:
                        
          amortization charge
                        
          impairment charge
                        
          carrying amount:
                        
          accumulated depreciation:
                        
          depreciation charge
                        
          depreciation charges
                        
          total depreciation charges
                        
          principal place of business
                        
          statement of profit or loss
                        
          profit/(loss) for the year from continuing operations
                        
          total comprehensive income
                        
          statement of financial position
                        
          company’s share of equity before eliminations
                        
          elimination of internal profit and other equity method adjustments
                        
          company’s share of equity
                        
          investment in associate at december 31
                        
          present ownership at december 31
                        
          transactions and outstanding balances as of december 31
                        
          sale of goods and services to associate
                        
          trade receivables from associate
                        
          raw materials and consumables
                        
          work in progress
                        
          finished goods
                        
          total inventories
                        
          lease expense
                        
          expenses relating to short term leases and leases of low value assets
                        
          lease interest
                        
          total lease expenses
                        
          financial assets
                        
          financial assets measured at amortized cost
                        
          financial liabilities
                        
          financial liabilities measured at amortized cost
                        
          interest income
                        
          exchange rate gains
                        
          total finance income
                        
          interest expenses
                        
          exchange rate losses
                        
          total finance expenses
                        
          changes in share capital
                        
          at january 1
                        
          increase through cash contributions
                        
          at december 31
                        
          treasury shares
                        
          at january 1, 2021
                        
          acquired from third-parties
                        
          usd/eur
                        
          gbp/eur
                        
          marketable securities specified by rate structure
                        
          fixed rate
                        
          floating rate
                        
          zero-coupon
                        
          marketable securities specified by security type
                        
          u.s. treasury bills
                        
          u.s. government bonds
                        
          commercial papers
                        
          corporate bonds
                        
          agency bonds
                        
          classified based on maturity profiles
                        
          total financial liabilities
                        
          subsidiaries
                        
          ascendis pharma gmbh
                        
          ascendis pharma, inc.
                        
          ascendis pharma endocrinology, inc.
                        
          ascendis pharma ophthalmology division a/s
                        
          ascendis pharma endocrinology division a/s
                        
          ascendis pharma bone diseases a/s
                        
          ascendis pharma growth disorders a/s
                        
          ascendis pharma oncology division a/s
                        
          associate
                        
          visen pharmaceuticals
                        
          item 19
                        
          exhibit number
                        
          1.1
                        
          2.1
                        
          2.2
                        
          2.3
                        
          4.1
                        
          4.2
                        
          4.3
                        
          4.4
                        
          4.5
                        
          4.6†
                        
          4.7†
                        
          4.8*
                        
          4.9*
                        
          4.10*
                        
          4.11*
                        
          4.12*
                        
          4.13*
                        
          4.14*
                        
          4.15*
                        
          4.16*
                        
          4.17*
                        
          4.18*
                        
          4.19*
                        
          4.20*
                        
          4.21*
                        
          4.22*
                        
          4.23
                        
          8.1
                        
          12.1
                        
          12.2
                        
          13.1
                        
          13.2
                        
          15.1
                        
          ex-101.ins
                        
          ex-101.sch
                        
          ex-101.cal
                        
          ex-101.def
                        
          ex-101.iab
                        
          ex-101.pre
                        
          104
                        
          †
                        
          ascendis pharma a/s
                        
          by:
                        
          date: march 2, 2022
                        
          persons depositing or withdrawing ordinary shares or for: adss must pay:
                        
          if we:
                        
          •  change the nominal or par value of our ordinary shares
                        
          •  reclassify, split up or consolidate any of the deposited securities
                        
          •  distribute securities on the ordinary shares that are not distributed to you
                        
          •  recapitalize, reorganize, merge, liquidate, sell all or substantially all of our assets, or take any similar action
                        
          ☒
                        
          item 1
                        
          item 2
                        
          item 3
                        
          general and administrative expenses
                        
          operating profit /
                        
          profit / (loss) before tax
                        
          tax on profit / (loss) for the period
                        
          net profit / (loss) for the period
           -162,223 -121,432 -110,914  -168,958    -62,792  -121,741 -94,932 -63,317 
          other comprehensive income
                        
          other comprehensive income / (loss) for the period, net of tax
                        
          total comprehensive income / (loss) for the period, net of tax
                        
          profit / (loss) for the year attributable to owners of the company
                        
          total comprehensive income / (loss) for the year attributable to owners of the company
                        
          basic earnings per share
                        
          diluted earnings per share
                        
          retained earnings/
                        
          cash flows used in investing activities
                        
          cash flows from /(used in) financing activities
                        
          year ended december 31
                        
          2012
                        
          2013
                        
          2014
                        
          2015
                        
          2016
                        
          month ended
                        
          september 30, 2016
                        
          october 31, 2016
                        
          november 30, 2016
                        
          december 31, 2016
                        
          january 31, 2017
                        
          february 28, 2017
                        
          march 2017
                        
          internal rare disease endocrinology pipeline
                        
          product candidate
                        
          transcon growth hormone
                        
          transcon pth
                        
          transcon cnp
                        
          current/potential strategic collaborations
                        
          transcon ranibizumab
                        
          transcon peptides
                        
          transcon treprostinil
                        
          **
                        
          • height velocity:
                        
          • mode of action:
                        
          • safety:
                        
          • tolerability:
                        
          • device:
                        
          tax on profit / (loss) for the year
                        
          net profit / (loss) for the year
                        
          revenue from the rendering of services
                        
          license income
                        
          contractual obligations:
                        
          operating lease obligations
                        
          total contractual obligations
                        
          martin olin
                        
          jonathan t. silverstein, j.d.
                        
          jonathan leff, m.d.
                        
          grethe rasmussen, ph.d.
                        
          dr. harald rau
                        
          harald rau
                        
          jonathan leff
                        
          grethe rasmussen
                        
          jonathan t. silverstein, j.d
                        
          5% and greater shareholders
                        
          sofinnova capital v fcpr
                        
          entities affiliated with ra capital management, llc
                        
          orbimed private investments v, l.p.
                        
          sofinnova venture partners ix, l.p.
                        
          entities affiliated with vivo capital
                        
          board members and senior management
                        
          year ended december 31,
                        
          quarter ended
                        
          march 31, 2015
                        
          june 30, 2015
                        
          september 30, 2015
                        
          december 31, 2015
                        
          march 31, 2016
                        
          june 30, 2016
                        
          audit-related fees
                        
          4.1†
                        
          4.2†
                        
          4.4(a)#
                        
          4.4(b)#
                        
          4.4(c)#
                        
          4.5#
                        
          4.6
                        
          4.7
                        
          4.8
                        
          #
                        
          president, chief executive officer, board member and executive director
                        
          date: march 22, 2017
                        
          senior vice president, chief financial officer
                        
          report of independent registered public accounting firm
                        
          consolidated statements of profit or loss and other comprehensive income for the years ended december 31, 2016, 2015 and 2014
                        
          consolidated statements of financial position as of december 31, 2016 and 2015
                        
          consolidated statements of changes in equity at december 31, 2016, 2015 and 2014
                        
          consolidated cash flow statements for the years ended december 31, 2016, 2015 and 2014
                        
          /s/ jens sejer pedersen
                        
          state-authorised public accountant
                        
          profit/(loss) for the year attributable to owners of the company
                        
          total comprehensive income/(loss) for the year attributable to owners of the company
                        
          basic earnings/(loss) per share
                        
          diluted earnings/(loss) per share
                        
          number of shares used for calculation
                        
          deposits
                        
          income taxes receivable
                        
          other reserves
                        
          retained earnings
                        
          trade payables and other payables
                      16,880 -8,872 
          deferred income
                        
          income taxes payable
                        
          equity at january 1, 2014
                        
          other comprehensive loss, net of tax
                        
          equity at december 31, 2014
                        
          equity at december 31, 2015
                        
          equity at december 31, 2016
                        
          adjustments for:
                        
          depreciation and amortization
                        
          income taxes received /
           -370 -992 26  -268   -121 -28  -145 -103 718 
          cash flows from / (used in) financing activities
           143,358 -2,309 -702  -76    20  584,666 8,787 -1,117 
          increase / (decrease) in cash and cash equivalents
           40,859 -108,480 62,900  -84,810    -111,716  551,262 -286,165 -74,044 
          other fixtures and fittings, tools and equipment
                        
          usa
                        
          switzerland
                        
          pension costs
                        
          total salary expenses
                        
          compensation to key management personnel
                        
          total compensation to key management personnel
                        
          outstanding at january 1, 2014
                        
          outstanding at december 31, 2014
                        
          outstanding at december 31, 2015
                        
          outstanding at december 31, 2016
                        
          vested at the balance sheet date
                        
          total warrant compensation costs
                        
          granted in december
                        
          granted in march, june, september and december
                        
          granted in january, march, june and november
                        
          granted in march, may, june, july, august, november and december
                        
          granted in september
                        
          granted in march and december
                        
          granted in october and december
                        
          interest expense
                        
          current tax
                        
          change of deferred tax
                        
          tax credit
                        
          other effects
                        
          change in unrecognized deferred tax assets
                        
          unrecognized deferred tax asset:
                        
          unrecognized deferred tax asset
                        
          at january 1, 2015
                        
          accumulated impairment:
                        
          at december 31, 2015
                        
          at december 31, 2016
                        
          depreciation charges are recognized as:
                        
          company
                        
          beginning of year
                        
          increase through cash contribution
                        
          end of year
                        
          at january 1, 2014
                        
          at december 31, 2014
                        
          within 1 year
                        
          within 1 to 5 years
                        
          after 5 years
                        
          total commitments held under operating leases
                        
          danish kroner
                        
          us dollars
                        
          euro
                        
          british pounds
                        
          other
                        
          profit or income before tax
                        
          ascendis pharma, endocrinology division a/s
                        
          ascendis pharma, ophthalmology division a/s
                        
          net profit/(loss) for the period
         -131,035               
          reversal of (gain)/loss on disposal of property, plant and equipment
         -91               
          reversal of income taxes
         2,508 5,790 645 -429 1,297           
          non-cash consideration relating to revenue
         -24,770 -580 -571 -589 -614 -634 -638         
          share of (profit)/loss of associates
                        
          impairment of property, plant and equipment
                        
          trade payables, accrued expenses and other liabilities
                        
          acquisition of intangible assets and property, plant and equipment
                        
          proceeds from disposal of property, plant and equipment
                       
          repayment of borrowings
         -2,786               
          net proceeds from borrowings
          -3,526              
          proceeds from follow-on public offering
                        
          acquisition of treasury shares, net of transaction costs
                       
          payment of withholding taxes under stock incentive programs
                        
          cash and cash equivalents at september 30
                        
          costs of follow-on public offering
                        
          acquisitions of treasury shares, net of transactions costs
                        
          share of profit/(loss) of associates
         5,796               
          cash and cash equivalents at march 31
         320,239    501,281      495,047    534,381 
          reversal of gain and loss on disposal of property, plant and equipment
            21         
          increase / (decrease) in provisions
           9,469 1,642 1,983  1,425         
          share of profit / (loss) of associate
           6,794 7,450 1,227  3,697         
          cash flows generated from / (used in) operations
           -127,637 -149,820 -150,043  -100,761    -82,192  -57,197 -56,398 -68,592 
          cash flows from / (used in) operating activities
           -124,719 -153,128 -147,044  -98,833    -81,619  -57,819 -56,611 -66,786 
          reimbursement from acquisition of property, plant and equipment
                       
          cash flows from / (used in) investing activities
           22,220 46,957 210,646  14,099    -30,117  24,415 -238,341 -6,141 
          net proceeds from convertible senior notes
                      
          cash and cash equivalents at june 30
                        
          net profit for the period
                 -80,349       
          reversal of non-cash consideration relating to revenue
                 -594 -578 -577  -635 -1,013 -1,202 
          reversal of share of profit of associate
                 3,855       
          cash flows generated from operations
                 -98,108       
          income taxes received
                        
          cash flows from operating activities
                 -97,519       
          cash flows from investing activities
                 20,426       
          net-proceeds from follow-on public offerings
                        
          cash flows from financing activities
                 370,605       
          increase in cash and cash equivalents
                 293,512       
          reversal of share of profit / (loss) of associate
                   -28,106  3,101   
          interest received
                   975     
          interest paid
                   -374     
          payment of lease liabilities
                   -1,962     
          trade payables, accrued expenses, and other payables
                        
          payment of finance lease liabilities
                      -1,189 -1,117 
          reversal of share of profit/(loss) of associate
                       1,515 
          cash flows from / used in investing activities
                        
          restricted cash included in cash and cash equivalents
                        
          reversal of non-cash consideration regarding revenue
                        
          installments on long-term financial liabilities
                        
          income taxes paid
                        
          capital increase, net of expenses