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Arrowhead Pharmaceuticals Quarterly Cash Flow Statements Chart

Quarterly
 | 
Annual
 
 Stock-Based Compensation  
 Operating Cash Flow  
 Investing Cash Flow  
 Financing Cash Flow  
 Free Cash Flow  
 Capital Expenditure  
20191231 20200331 20200630 20200930 20201231 20210331 20210630 20210930 20211231 20220331 20220630 20220930 20221231 20230331 20230630 20230930 20231231 20240331 20240630 20250630 -186.5-122.16-57.826.5270.86135.2199.53263.87Milllion

Arrowhead Pharmaceuticals Quarterly Cash Flow Statements Table

Quarterly
 | 
Annual
 
Unit: USD2025-06-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2013-05-07 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-12-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 2007-12-31 2007-09-30 2007-06-30 2007-03-31 2006-12-30 2006-09-30 2006-06-30 2006-03-31 2005-12-31 
                                                                         
  cash flows from operating activities:                                                                       
  net income-178,652,000 -173,977,000 -126,996,000 -135,376,000 -111,015,000 -104,125,000 47,676,000 -41,811,000 -85,942,000 -72,046,000 44,366,000 -62,872,000 -63,374,000 -29,924,000 -26,818,000 -20,732,000 -48,432,715 -13,611,213 -19,835,570 -2,673,728 11,704,905 20,335,709 23,896,982 12,037,253 -10,761,271 -15,606,018 -14,884,311 -13,198,878 -10,731,886 -5,519,742 -6,042,559 -12,086,108 -22,221,986 -19,420,742 -20,815,860 -19,264,414 -24,743,136 -15,936,052 -28,686,412 -22,575,282 -22,430,532 -11,626,449 -10,685,732 -6,940,018 -4,780,727 -5,600,749 -8,239,061 -5,584,114 -2,686,799 -2,946,938 -2,013,414 2,699,383 -1,231,430 -2,314,216 -1,816,429 -3,460,028 -2,528,617 -5,289,279 -8,030,468 -8,658,278 -7,502,163 -5,694,815 -5,233,774 -7,572,591 -12,477,548 -6,173,809 -3,707,170 -8,779,523 -3,974,148 -3,106,585 -3,136,953 
  adjustments to reconcile net income to net cash flow from operating activities                                                                       
  stock-based compensation13,043,000 17,050,000 17,750,000 19,694,000 18,181,000 19,947,000 20,612,000 19,390,000 29,196,000 33,390,000 33,803,000 24,504,000 34,622,000 18,549,000 15,358,000 8,144,000 15,873,325 10,046,208 12,971,703 4,491,752 5,116,448 1,957,993 2,601,348 2,717,534 2,636,488 2,268,765 1,456,813 2,092,541 2,009,694 1,713,228 1,744,231 2,424,442 4,047,849 2,750,785 2,416,839 2,380,343 3,526,888 2,486,074 2,205,079 2,014,856 1,937,909 2,038,682 521,138 355,107 395,675 404,216 415,920 169,390 251,878 297,970 346,707 334,577 397,667 542,792 302,072 697,399 555,562 695,275 727,934 617,384 1,028,516 851,906 689,591 683,717 526,855       
  depreciation and amortization6,223,000 4,782,000 4,525,000 4,263,000 3,859,000 3,276,000 2,669,000 2,689,000 2,660,000 2,594,000 2,594,000 2,573,000 2,504,000 1,997,000 1,918,000 1,848,000 1,774,391 1,536,401 1,371,588 1,259,884 1,082,375 1,003,450 1,175,967 1,177,352 1,228,395 1,176,241 1,153,466 1,141,173 1,154,525 1,162,660 1,187,644 1,185,611 843,584 818,200 803,912 794,349 855,551 741,058 449,559 290,039 270,417 276,054 403,405 448,765 449,597 447,169 423,415 423,947 454,444 64,936 66,472 14,199 122,370 146,904 174,304 202,080 265,672 239,487 287,365 283,645 267,048 297,510 285,178 286,179 252,591    229,469   
  amortization of note premiums/discounts-1,757,000   -835,000 -987,000 -948,000                                                                  
  realized loss on investments                                                                       
  non-cash interest expense on liability related to the sale of future royalties7,978,000 5,093,000 7,245,000 5,367,000 5,262,000 5,158,000 5,057,000 2,849,000                                                                
  non-cash interest expense on credit facility16,405,000                                                                       
  changes in operating assets and liabilities:                                                                       
  accounts receivable-7,476,000    1,246,000 68,188,000 -29,867,000 -38,157,000 -1,171,000 1,078,000 -1,167,000 10,105,000 -9,583,000 283,000 8,048,000 -8,157,000 20,846,891 -20,426,793 79,527 -683,937 1,382,750 11,378,229 -10,253,761 -2,841,204 -312,400 1,312 133,644 -82,134 869,516 -356,488 -520,825 15,000                                       
  prepaid expenses and other assets-1,406,000                                                                       
  accounts payable23,379,000 11,187,000 4,061,000 -12,463,000 27,997,000 -1,687,000 8,760,000 -2,072,000 -3,026,000 -4,709,000 6,535,000 -5,389,000 -580,000 4,738,000 472,000 -2,002,000 2,755,041 -9,343,823 1,216,159 4,551,611 3,019,679 568,054 125,601 1,130,491 640,366 355,300 -3,896,615 1,630,533 843,092 635,533 -340,607 -4,648,013 1,641,138 -1,597,128 2,253,576 257,216 169,444 -74,021 -1,013,092 3,415,473 421,346 -321,018 -610,284 62,180 -68,459 -116,387 183,768 87,047 137,448 75,525 253,565 -1,917,244 1,745,233 -351,228 -121,604 -385,262 -603,283 90,337 569,489 -203,551 -45,459 279,566 -468,162 -102,339 963,708 98,421 -454,871 632,965 -666,122 384,573 18,949 
  accrued expenses-10,965,000 13,097,000 -419,000 408,000 17,117,000 -4,803,000 -20,076,000 -7,203,000 16,037,000 -1,986,000 5,989,000 -2,290,000 -4,160,000 11,411,000 3,397,000 -1,126,000 2,043,713 5,370,374 -1,210,896 -4,213,695 5,927,314 -1,136,584 1,149,061 -3,489,712 5,669,379 -1,734,121 -368,049 -2,550,703 4,936,050 78,106 -3,564,937 -1,850,996 3,856,467 -624,946 -157,851 -3,945,503 6,590,817 -712,583 -116,775 -1,325,675 3,018,404 184,320 56,648 87,377 111,865 -327,748 115,330 -9,996 408,783 543,901 94,486 -2,554,449 2,368,905 -215,289 -8,866 -429,560 -95,079 -344,209 542,312 -293,361 195,809 91,035 -149,006 89,558 126,398 75,585 -423,560 -507,029 552,018 -4,501 372,694 
  deferred revenue-20,289,000 -866,000 -16,039,000 -14,009,000 -76,156,000 -22,979,000 -25,401,000 -32,174,000 -27,487,000 -27,439,000 11,866,000 -35,726,000 259,665,000 -12,547,000 -6,983,287 -6,900,403 -20,859,364 -28,770,642 -15,136,090 -22,681,877 -37,474,302 158,096,440 -942,600 -621,800 -310,000 -3,394,740 -8,638,265 -8,511,185 -8,345,105 25,652,536                            -37,999 -60,571 -280,075    -259,463 228,213 -37,500 -37,500 
  operating lease-1,162,000 -537,000 621,000 3,796,000                                                                    
  other-41,000        -3,607,000 2,682,000 68,000 922,000 1,929,000 -205,000 358,000 -855,000 924,235 578,371 -227,708 953,189 1,642,983 -297,283 25,105 -265,842 -102,290 -115,569 -240,341 43,907 -9,831 -125,469 96,019 -235,471 106,894 -166,031 147,491 42,789 -72,024 -2,786                                  
  net cash from operating activities-154,720,000 -115,418,000 -92,377,000 -117,840,000 -25,257,000 -21,446,000 -31,671,000 -75,516,000 -68,667,000 -68,847,000 62,730,000 -61,347,000 -24,117,000 -29,610,000 263,873,000 -38,922,000 -10,850,025 -33,427,150 -27,583,937 -23,530,458 13,809,906 10,526,762 -19,586,508 168,284,763 -2,680,318   -14,690,480 -9,203,474 -10,409,632 -14,326,057 10,000,191 -10,181,379 -18,350,203 -14,747,835 -21,148,069 -12,020,234 -13,117,797 -16,369,578 -24,200,006                           -5,090,439    -3,188,513 
  capex-2,364,000 -14,449,000 -34,075,000 -68,656,000 -63,907,000 -46,605,000 -27,314,000 -38,911,000 -32,711,000 -9,536,000 -4,752,000 -5,778,000 -8,199,000 -3,931,000 -7,166,000 -4,271,000 -1,884,352 -2,138,260 -3,609,386 -4,319,714 -7,830,940 -3,223,497 -209,301 -737,487 -709,473   -135,414 -107,444 -1,157,596 -1,356,505 -5,296,653 -2,712,489 -647,114 -94,022 -406,612 -834,961 -283,588 -297,118 -554,945                           -115,579    -96,644 
  free cash flows-157,084,000 -129,867,000 -126,452,000 -186,496,000 -89,164,000 -68,051,000 -58,985,000 -114,427,000 -101,378,000 -78,383,000 57,978,000 -67,125,000 -32,316,000 -33,541,000 256,707,000 -43,193,000 -12,734,377 -35,565,410 -31,193,323 -27,850,172 5,978,966 7,303,265 -19,795,809 167,547,276 -3,389,791   -14,825,894 -9,310,918 -11,567,228 -15,682,562 4,703,538 -12,893,868 -18,997,317 -14,841,857 -21,554,681 -12,855,195 -13,401,385 -16,666,696 -24,754,951                           -5,206,018    -3,285,157 
  cash flows from investing activities:                                                                       
  purchases of property and equipment-2,364,000 -14,449,000 -34,075,000 -68,656,000 -63,907,000 -46,605,000 -27,314,000 -38,911,000 -32,711,000 -9,536,000 -4,752,000 -5,778,000 -8,199,000 -3,931,000 -7,166,000 -4,271,000 -1,884,352 -2,138,260 -3,609,386 -4,319,714 -7,830,940 -3,223,497 -209,301 -737,487 -709,473 -198,060 -378,305 -135,414 -107,444 -1,157,596 -1,356,505 -5,296,653 -2,712,489 -647,114 -94,022 -406,612 -834,961 -283,588 -297,118 -554,945 -465,375 -644,215 -116,215                             
  purchases of investments-96,724,000 -118,629,000   -12,157,000 -41,456,000 -81,329,000 -111,199,000 -75,000,000 -82,516,000 -65,875,000 -145,508,000 -55,195,000                                                          
  proceeds from sales and maturities of investments240,478,000 140,027,000 75,120,000 133,495,000    69,416,000                                                                
  net cash from investing activities141,390,000 6,949,000 -268,937,000 64,839,000 30,509,000 -9,905,000 -36,065,000 -80,694,000 36,445,000 61,278,000 -69,755,000 -33,385,000 -118,245,000 -19,541,000 -34,050,000 30,158,000 -65,894,401 -6,033,806 -178,129,843 9,280,286 16,829,060 14,398,503 -11,217,301 -67,756,269 3,247,016 -28,854,640 16,815,695 1,356,966 -4,218,751 -12,926,204 -26,202,610 -5,296,653 -1,712,489 9,460,886 3,105,978 2,593,388 5,844,843 3,976,784 8,798,882 -4,499,671                  50,554 671,900  1,956,119 -187,926 6,846,143 -192,658 -410,565 -37,569 5,020,767 14,582,756 3,686,165 -18,633,784 -177,159 
  cash flows from financing activities:                                                                       
  proceeds from the exercises of stock options223,000 387,000 1,512,000 267,000 821,000 1,136,000 520,000 576,000 855,000 600,000 1,846,000 1,885,000 815,000 2,755,000 2,633,000 5,102,000 1,004,476 2,132,846 1,330,023 3,001,554                                                    
  proceeds from the issuance of common stock, net of offering costs                                                                      
  proceeds from the sales of future royalties                                                                       
  proceeds from the issuance of warrants                                                                      
  payments of debt issuance costs                                                                      
  proceeds from the issuance of common stock               2,235 250,476,739 10 60,521,729   -272,818 191,937 12,500,000                                        
  repayments of credit facility-50,000,000                                                                       
  proceeds from visirna credit agreement                                                                       
  net cash from financing activities-42,679,000 50,387,000 430,777,000 267,000 152,000 1,805,000 520,000 250,576,000 855,000 60,600,000 1,846,000 1,885,000 815,000 2,755,000 2,633,000 5,102,000 1,004,476 2,132,846 1,332,258 253,478,293 1,833,415 2,767,274 2,670,036 59,111,274 1,571,129 1,454,074 56,901,531 26,292 -122,343 142,069 12,035,583 53,643,773 2,205,013 -222,384 -494,585 136,932 -53,475 26,766 180,298                2,550,281 -204,593 -200,555 4,319,871 15,842,874 290,027 16,625 15,250,115 4,000 316,202 1,304,058 33,479 19,545,000 4,000 
  net increase in cash, cash equivalents and restricted cash-56,009,000  69,463,000 -52,734,000   -67,216,000 94,366,000                                                                
  effect of exchange rate on cash, cash equivalents and restricted cash93,000 -223,000 26,000 58,000 153,000 -79,000 -74,000 -122,000                                                                
  cash, cash equivalents and restricted cash:                                                                       
  beginning of period110,891,000  108,005,000                                                                
  end of period-55,916,000 -58,305,000 69,489,000 58,215,000 5,557,000 -29,625,000 -67,290,000 202,249,000                                                                
  supplementary disclosure of cash flows:                                                                       
  interest paid                   -27,437 -41,952 -42,892 -43,815 -44,722 -45,614 -46,489 -47,349 -48,195 -2,381 -3,109 -8,851 3,054 3,276 3,498 3,717 3,938 4,157 4,373 9,496 10,714 11,114   12,553 10,300   499 13,118 11,917 24,086 24,140 28,124             
  income taxes paid-48,000                                                                   
  supplemental disclosure of non-cash investing activities:                                                                       
  capital expenditures included in accrued expenses-12,000 -356,000 -4,025,000 11,290,000                                                                    
  amortization (accretion) of note premiums/discounts 6,990,000      690,000                                                                
  realized gain on investments -80,000                                                                    
  proceeds from the sale of future royalties    250,000,000                                                                
  net decrease in cash, cash equivalents and restricted cash                                                                       
  prepaid expenses and other current assets  -895,000 -1,748,000 -16,310,000 7,604,000 9,780,000 10,529,000 -10,415,000 -962,000 -6,733,000 -1,181,000 2,535,000 -682,000 980,000 -3,193,000 475,823 -909,807 -1,331,140 1,377,660 -1,317,285 -952,943 -1,319,375 -120,912 -537,087 -369,309 1,254,785 -29,223 -362,042 652,444 1,497,086 1,027,021 -133,308 -245,586                                      
  supplemental disclosure of noncash investing activities:                                                                       
  income taxes (paid) refunded   -999,000                                                                    
  adjustments to reconcile net income to net cash flow from operating activities:                                                                       
  net gain from investments                                                                       
  proceeds from investment in joint venture                                                                      
  beginning or period                                                                       
  supplementary disclosures:                                                                       
  unrealized losses on marketable securities                                                                       
  operating lease liabilities     -47,000 646,000 559,000                                                                
  proceeds from maturities of investments     78,156,000                                                                  
  proceeds from additional tenant improvement allowance                                                                       
  amortization of note premiums                                30,556 21,886 71,057 108,403 165,410 276,750                                  
  proceeds from sale of investments        69,156,000 145,814,000 17,513,000 38,268,000 35,462,000 39,585,000                                509,009 404,380 540,611     700,000         -1 80,145 
  net increase in cash and cash equivalents                                                                       
  effect of exchange rate on cash and cash equivalents                                                                       
  cash and cash equivalents at beginning of period        184,434,000 143,583,000 221,804,128                                                    
  cash and cash equivalents at end of period        -31,434,000 53,031,000 -5,179,000 91,587,000 -141,547,000 -46,396,000 232,456,000 139,921,000 -75,739,950 -37,328,110 -204,381,522 461,032,249                                                    
  unrealized (gains) losses on marketable securities         1,602,000                                                              
  amortization/(accretion) of note premiums/discounts         1,684,000 609,000 -280,000  -51,000                                                          
  net increase in cash         53,031,000 -5,179,000 -92,847,000 -141,547,000 -46,396,000 232,456,000 -3,662,000 -75,739,950 -37,328,110 -204,381,522 239,228,121  27,692,539 -28,133,773 159,639,768 2,137,827 -41,809,731 58,273,772 -13,307,222 -13,544,568 -23,335,836 -40,386,598 16,739,121 41,749,905 -6,684,304 -11,864,241 -19,049,266 -6,038,459 -9,194,488 -7,543,930 -28,519,379 -5,839,123 -4,498,127 40,598,980 382,451 -446,256  -1,312,471 -3,178,014 -734,263 3,191,081 -473,291 -677,205 -1,380,358 -2,136,283 1,789,372 111,039 -1,648,155 -4,079,502 -2,456,743 -3,729,895 -5,698,821 -5,902,016 1,304,220 -6,673,783 9,202,179 -6,675,133 246,530 11,332,253 103,304 -2,520,598 -3,361,671 
  amortization/(accretion) of note premiums               -302,000 -127,442 233,535 241,764 177,448 386,827 352,014 486,866 -156,637 -199,298 236,034 238,556 107,783 96,522 -75,654                                          
  principal payments on notes payable                    -1 -2,415,149 -53,520 -52,580 95,384 -197,790                                            
  income taxes (paid)/refunded                                                                       
  proceeds from sale of marketable securities               34,429,000  9,545,320 6,002,967 13,600,000 24,660,000 17,622,000 9,987,000 2,252,219 8,865,000 13,500,000 17,194,000 6,510,420 958,753    1,000,000 10,108,000 3,200,000 3,000,000 6,679,804 7,260,372 9,096,000 3,054,774 5,000,296 1,580,586 4,045,956                             
  change in value of derivatives                        18,598 -450,739 629,151 -63,065 27,383 -1,483,831 534,074 113,359 -369,935 23,524 -422,864 104,713 -168,974 -2,382,142 321,324 -758,468 3,519,579 29,402 -44,275 -160,553 -915,387 622,144 66,904 110,029 -373,734                     
  payment of taxes for net share settled restricted stock unit issuances                                                                       
  purchases of marketable securities                 -13,440,866   -20,995,000 -69,271,001 -4,908,511 -42,156,580 -5,018,040 -5,070,060 -15,058,571                                          
  payments of taxes for net share settled restricted stock unit issuances                          -21,698 -417,140 -193,653 -440,534                                    
  proceeds from the exercises of warrants and stock options                    1,833,405 2,767,274 2,670,037 1,004,694 1,624,649 1,506,654 275,779 224,082                                           
  income tax credits refunded                                                                   
  income tax paid                                                   4,800 4,800    3,200   7,900 
  cash and restricted cash at beginning of period                                                                       
  cash and restricted cash at end of period                                                                       
  computers, office equipment and furniture                     -12,290 600,334 600,334    601,159 -2,882 26,092 6,140 413,565    374,535                                
  research equipment                     1,542,203 -335,101 11,356,568 405,963 170,985 378,305 9,796,374    8,729,818 191,295 435,343 79,931 6,783,831    5,010,151                                
  software                     -79,290 225,092 3,847 16,751 132,078    107,871 -40,727 11,140 110,428    69,623                                
  leasehold improvements                     2,732,432 199,787 12,269,261 27,770 12,208,380    12,000,074 896,650 7,813,711 7,951 3,167,053    3,117,537                                
  total gross fixed assets                     4,274,635 -226,894 24,451,255 437,580 187,736 378,305 22,737,166    21,438,922 1,044,336 8,286,286 94,022 10,474,877    8,571,846                                
  less: accumulated depreciation and amortization                     -578,343 -315,452 -10,530,588 -531,394 -740,810 -728,358 -7,804,800    -5,273,263 2,067,604 -393,093 -378,805 -5,808,466    -4,447,405                                
  property and equipment                     3,696,292 -542,346 13,920,667 -93,814 -553,074 -350,053 14,932,366    16,165,659 3,111,940 7,893,193 -284,783 4,666,411    4,124,441    7,215,206 7,215,206                      
  cash at beginning of period                      30,133,213 24,838,567 85,366,448 81,214,354 132,510,610 19,114,444 3,377,288 7,507,389 6,847,162 2,020,224 10,093,585 24,120,097 28,020,304 22,467,016 
  cash at end of period                      -28,133,773 189,772,981 2,137,827 -41,809,731 58,273,772 11,531,345 -13,544,568 -23,335,836 -40,386,598 102,105,569 41,749,905 -6,684,304 -11,864,241 62,165,088 -6,038,459 -9,194,488 -7,543,930 103,991,231 -5,839,123 -4,498,127 59,713,424 382,451 2,931,032 1,094,647 -1,312,471 -3,178,014 6,773,126 3,191,081 -473,291 -677,205 5,466,804 -2,136,283 3,809,596 111,039 -1,648,155 -4,079,502 7,636,842 -3,729,895 -5,698,821 -5,902,016 25,424,317 -6,673,783 9,202,179 -6,675,133 28,266,834 11,332,253 103,304 -2,520,598 19,105,345 
  contingent consideration - fair value adjustments                                                                       
  noncash impairment expense                                                                       
  property and equipment purchased through tenant improvement allowance financing                                                                      
  property and equipment expenditures included in accounts payable and accrued expenses                               -1,041,276                                        
  net cash (used in) operating activities                                                                       
  (gain) loss on disposal of fixed assets                                      -45,576 26,381 53,562 54,932 -18,493                           
  acquired-in-process research and development                                                                       
  proceeds from sale of fixed assets                                    500    8,036 121,418 265,275 18,509         -23,636                
  cash paid for acquisitions                                    -3,000,000                                  
  common stock issued to novartis for asset acquisition                                                                      
  principal payments on capital leases and notes payable                             -49,868 -47,277 -54,725 -54,498 -54,275 -54,051  -53,608 -3,386 -103,168                                
  commercial notes                             11,844,262                                          
  total                             11,844,262                                          
  net income attributable to non-controlling interests                                                                       
  net income attributable to arrowhead                                    -24,743,136 -15,936,052 -28,686,412 -22,575,282 -22,430,442 -11,628,917 -10,628,312 -6,757,936 -4,614,159 -5,313,681 -7,991,510 -5,335,232 -2,485,505 -2,776,523 -1,819,917 2,905,237 -1,437,682 -2,004,106 -1,544,927                 
  gain on debt extinguishment                                                                       
  noncash gain on equity investment                                                                       
  non-controlling interest                                        -90                               
  purchase of marketable securities                                        -19,075,306                             
  proceeds from the exercise of warrants and stock options                                1,467,065 2,259,511   190,761 133 30,152 283,466 504,039                               
  common stock issued to galloway limited in settlement of services agreement                                                                       
  receivables                                   -1,054,719    -127,000  115,266 -105,891 -6,295 19,580 -22,660 172,230    -4,528,308 -49,401 14,376 248,539 -227,002 90,355 -172,550 73,866 333,415 -91,529 -127,127 109,197 -383,061 35,017 36,997 -37,637 5,623 -5,500 -3,252 
  prepaid expenses                                   -490,057    -3,874,051 111,436 -57,640 -74,455 34,525 157,208 -185,749 32,559 -155,271 -30,070 93,820 47,954 -99,482 56,714                   
  income from discontinued operations                                                                       
  acquired in-process research and development                                                                     
  noncash gain in equity investment                                                                       
  other receivables                                    -168,695 -340,895 -269,994 -9,506 492,119 93,374 -11,825   -2,111,702 1,871,747 -278,986 -419,238 -258,483 -82,208 -481,672 86,110 -144,804                 
  other current assets                                    2,899,876 320,750      -201,877 -12,441 23,433   -1   96,363 -45,883                  
  principal payments on capital leases                                        31,772 -52,730 -54,715 -53,497 -53,098 -52,701 -52,307 -51,658 -39,940                       
  proceeds from issuance of common stock and preferred stock                                        -49                               
  cash flows from discontinued operations:                                                                       
  operating cash flows                                           -336 -18 -55 677 -482 -420 -355 -56,959   18,095 -15,767                 
  investing cash flows                                                     430,000                 
  financing cash flows                                                                       
  net cash from discontinued operations:                                           -336 -18    -420 -355 -56,959   18,095 414,233                 
  3,321,383 shares of common stock issued to novartis for asset acquisition                                                                       
  131,579 shares of common stock issued to galloway limited in settlement of services agreement                                                                       
  239,894 shares of common stock issued to roche for stock and asset acquisition                                                                       
  intangible assets - patents                                                                       
  intangible assets – license                                                                       
  acquired in-process research and development - pre-clinical candidates                                                                       
  total purchase consideration                                           5,268,814 84,935 5,183,879                       
  amortization/accretion of note premiums/discounts                                       347,703                                
  other liabilities                                       -802 98,737 209,849 -222,811 12,308 14,208             -173,994 5,544 -129,757 228,261 -322,465 64,758 751,502 325,071 -43,046 135,538 158,852 -135,535 -54,371 83,656 
  other investing activities                                       -7,000,000                                
  cash flows from operating activities of continuing operations:                                                                       
  net (income) loss attributable to non-controlling interests                                        90                               
  (income) income from discontinued operations                                           336 18 55 -677 482 220 362 68,742 -5,358,760 -2,953                   
  realized and unrealized (gain) loss on investments                                             58,091 122,732                      
  charge for bad debt allowance                                                                       
  (gain) loss on purchase of roche madison                                             -1,576,107                       
  non-cash gain in equity investment                                                                      
  non-cash impairment expense                                             187,000                          
  equity in income of unconsolidated affiliates                                           157,612 63,557  34,573 64,261 106,527                       
  other assets                                        -1,885                               
  net cash from operating activities of continuing operations                                        -10,919,806 -9,776,513 -7,022,332 -4,466,764 -3,837,586 -4,587,800 -3,889,848 -4,157,086 -2,705,356 -1,662,944 -967,034 -3,602,378 -1,423,637 -2,531,027 -1,617,843                 
  cash flows from investing activities of continuing operations:                                                                       
  cash transferred in acquisitions/divestitures                                                                       
  net cash from investing activities of continuing operations                                        4,544,921 936,371 -15,145,565 1,146,188 111,979 178,364 -76,052 -201,288 539,620 404,380 536,817                     
  cash flows from financing activities of continuing operations:                                                                       
  proceeds from sale of stock in subsidiary                                               8,000 -226    300,000  2,000,000 2,000,000 -3,000,000 10,013,897         
  net cash from financing activities of continuing operations                                        535,762 4,342,015 62,766,877 3,703,363 3,279,369 5,504,138 2,652,752 1,180,842 1,431,893 4,450,000 13,885 1,719,157 43,279 319,056 2,992,982                 
  amortization (accretion) of note discounts                                         146,979 28,443 36,359 572 30,023 -26,918 2,502 3,783 4,549                      
  amortized cost                                                                       
  net (income) loss attributable to noncontrolling interests                                                                       
  (gain) income from sale of subsidiary                                                                       
  stock issued for professional services                                                                       
  purchased in-process research and development                                                                       
  gain on sale of stock in subsidiary                                                                       
  noncontrolling interest                                          -57,420 -182,082 -166,568 -287,068 -247,551 -248,882 -201,294 -170,415 -193,497 -205,854 206,252 -310,110 -271,502                 
  purchase of masa energy, llc                                                                      
  minority equity investment                                                                       
  cash paid for interest in insert                                                               -5,150,000     
  cash obtained from interest in insert                                                               5,150,000     
  proceeds from sale of subsidiaries                                                                       
  payment for patents                                                                     43,217 -160,660 
  restricted cash                                                                       
  proceeds from issuance of common stock, preferred stock and warrants                                          62,821,592                             
  proceeds from issuance of calando debt                                                                       
  taxes paid                                                 742,500                   
  purchase of property and equipment                                           -22,029 -9,439 -86,911 -115,559 -207,816 -69,424 -3,794     -12,145 -28,100 -175,175 -153,256 -187,926 -167,754 -192,658 -410,565    -223,062   
  proceeds from issuance of common stock and warrants                                           3,756,860 3,332,467 5,556,839 2,705,059 1,232,500 1,463,833 4,450,226 -1,705,273 1,719,157 43,279 93,901 3,205,896     6,968,986 290,027 16,625 15,250,115    33,479   
  net (income) loss attributable to nonconrolling interests                                          57,420  166,568    201,294   205,854 -206,252                   
  write down of note receivable                                                                       
  purchase of marketable securities - us treasury bills                                                                       
  proceeds from sale of marketable securities - us treasury bills                                                                       
  current assets                                           432,709 432,709 -164,000 -237,000 133,000 289,000                   
  intangible assets                                           1,174,935 84,935 1,090,000               4,200,000        
  other noncurrent assets                                           6,264 6,264                       
  current liabilities                                           -414,122 -414,122                       
  noncurrent liabilities                                           -1,570,072 -1,570,072                       
  gain on purchase                                           -1,576,106 -1,576,106                       
  deposits                                                     14,808 7,966 111,200 28,995 -3,520 -116,931 -25,000 70,696 -25,520 -30,365 -42,390 16,514 48,158 2,956 19,004 -19,380 -53,670 
  purchase of marketable securities—us treasury bills                                                                       
  notes payable                                                                       
  proceeds from sale of marketable securities—us treasury bills                                                                       
  loss on disposal of fixed assets                                             169,616                          
  equity in (income)loss of unconsolidated affiliates                                                                       
  cash transferred in acquisition/divestitures                                             20,998 100,035                       
  proceeds from issuance of stock in subsidiary                                                                      
  net increase(decrease) in cash                                                                       
  stock issued as gift                                                                       
  stock issued for in-process research and development                                                       630,982               
  purchased in-process research and development - nanoconduction                                                                       
  accrued severance and other liabilities                                              -106,463 490,683 346,551 -32,047 32,349 35,661 -20,212 -13,486 78,935 604,068                
  net cash from discontinued operations                                              677                         
  cash paid for interest                                                                       
  cash paid for income taxes                                                                       
  loss on sale/donation of fixed assets                                                       -3,375                
  purchased in-process research and development—nanoconduction                                                                       
  gain on renegotiation of accrued severance                                                                       
  non-cash (gain) income from equity investment                                                 66,813 70,367 74,826 -48,826                   
  cash transferred in sale of subsidiary                                                                     
  non-current assets                                                 -15,000 -8,000                     
  liabilities                                                 112,000 60,000 436,000 647,000                   
  equity                                                 -291,000 -305,000 -326,000 -227,000                   
  revenue                                                    495,000                   
  operating expenses                                                    275,000                   
  cash flows used in operating activities                                                                       
  cash flows used in investing activities                                                    -15,000                   
  cash flows from financing activities                                                                       
  realized and unrealized (gain) loss on investment                                                       -700,000          -124,549   
  amortization of note discount                                                                       
  gain from sale of subsidiary                                                                      
  stock issued as gift to caltech                                                                       
  stock issued as gift to rice university                                                                     
  change in percentage of ownership in subsidiary                                                                       
  change in value of derivative liability                                                    -465,270                   
  cash paid for interest in calando                                                                  -2,109,332 -890,668   
  cash paid for interest in unidym                                                       -1,037,003 -875,000   -2,000,000 -3,000,000         
  cash obtained from interest in calando                                                                  3,000,000   
  cash obtained from interest in unidym                                                       1,037,003 875,000   2,000,000           
  proceeds from sale of subsidiary                                                                      
  net cash from (used) in investing activities of continuing operations                                                                       
  non-current assets 529                                                    131,000                   
  cash flows from operating activities                                                    294,000                   
  plus: net income attributable to noncontrolling interests                                                     310,110                  
  (income)/income from discontinued operation                                                     -18,095                  
  realized and unrealized gain on investment                                                                       
  (gain)/loss on disposal of fixed assets                                                                       
  non-cash income from equity investment                                                     53,813 48,638 48,090 48,302 60,030 69,382             
  increase of cash flow from:                                                                       
  other prepaid expenses                                                     97,904 110,156 133,698 1,661 -85,817 15,317 156,126 -68,434 -175,625 114,178 174,318 -158,774 -225,902 116,356 -4,942 18,538 -256,780 72,516 
  cash paid for interest in nanotechnica                                                                       
  cash paid for interest in aonex                                                                     
  cash paid/obtained for interest in tego                                                                       
  cash obtained from interest in nanotechnica                                                                       
  cash obtained from interest in aonex                                                                     
  cash paid/obtained from interest in tego                                                                       
  payments of capital leases                                                     -74,845 -212,914 -208,712 -204,593 -200,555 -196,596             
  change in value of derivative liabillity                                                                       
  exercise prices                                                                       
  5.04                                                      1,397,500      1,397,500   1,397,500     
  7.06                                                      712,362      712,362         
  2.00                                                      3,863,989                 
  0.50                                                      9,684,522                 
  0.51                                                      5,083,430                 
  1.65                                                                       
  total warrants outstanding                                                                       
  plus: net income attributable to nonconrolling interests                                                      271,502                 
  income from discontinued operation                                                      -414,233                 
  prepaid research expense                                                          -9,319 25,006 33,499 26,625 414,481 -160,020 135,596 -171,642 62,075 -4,197 86,731 -143,987 -212,501 
  minority interests                                                           -2,970,483 -1,994,088 -1,144,995 -1,335,976 -3,683,681 -681,467 -1,934,532 -453,352 285,644 -221,298 -584,499 -796,437 
  gain on negotiation of accrued expenses                                                                       
  change in operating assets and liabilities                                                                       
  preferred stock liability                                                               -1,162,000     
  net cash from (used) in investing activities                                                       -23,636                
  proceeds of issuance of calando debt                                                       2,516,467             
  •                                                                       
  purchased-in-process research and development—nanoconduction                                                                       
  net cash (used) in operating activities                                                                       
  cash paid for interest in tego                                                        1,700,000 100,000 -2,500,000         
  cash obtained from interest in tego                                                        -1,700,000 -100,000 2,500,000         
  subscription receivable                                                          -750,000             
  sale of property and equipment                                                                       
  purchased-in-process research and development - nanoconduction                                                                       
  net cash provided (used) in operating activities                                                          -7,448,514 -8,383,697 -7,654,940 -5,714,090 -5,831,950 -6,497,750 -5,637,371    -3,616,340   
  decrease/increase in:                                                                       
  net cash (used) in investing activities                                                                       
  cash and cash equivalents                                                                      
  rent deposit and other assets                                                                      
  total assets acquired                                                                       
  liabilities assumed                                                                       
  consideration transferred                                                                       
  series b preferred share of unidym                                                                       
  series a preferred share of unidym                                                                       
  goodwill expensed to in-process research & development                                                                      
  cni purchase expensed to in-process research & development                                                                       
  impairment of goodwill                                                                       
  proceeds from sale of marketable securities -us treasury bills                                                                       
  proceeds from sale of insert therapeutic’s stocks                                                                5,136,346     
  total assets                                                                       
  stockholders equity                                                                       
  goodwill impaired                                                                       
  proceeds from sale of investments payment for patents                                                                       
  realized (gain) loss on investment                                                                      -3,266 
  compensation expense related to stock option issuance                                                                  480,812 371,939 365,776 352,986 278,777 
  depreciation & amortization                                                                  230,578    228,474 
  purchase of property & equipment                                                                  -115,579    -96,644 
  cash obtained from interest in nanopolaris                                                                       
  proceeds from issuance of common stock & warrants                                                                  316,202    4,000 
  exercise price                                                                       
  loss on disposal of assets                                                                       
  realized/unrealized (gain) loss on investment                                                                       
  purchase of marketable securities – us treasury bills                                                                       
  proceed from sale of marketable securities – us treasury bills                                                                       
  cash paid for interest in nanopolaris                                                                       

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