7Baggers

Arvinas, Inc
(NASDAQ:ARVN) 

ARVN stock logo

Arvinas, Inc., a clinical-stage biopharmaceutical company, engages in the discovery, development, and commercialization of therapies to degrade disease-causing proteins. Its lead product candidates are ARV-110, a proteolysis targeting chimera (PROTAC) protein degrader that is in phase I clinical tri...

Founded: 2013
Full Time Employees: 133
Sector: Healthcare
Industry: Biotechnology

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At a glance:
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Income Statements:
Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 
                                  
      revenue
    9,500,000 41,900,000 22,400,000 188,800,000 59,200,000 102,400,000 76,500,000 25,300,000 -43,100,000 34,600,000 54,500,000 32,500,000 45,600,000 30,300,000 31,300,000 24,200,000 26,331,432 9,284,785 5,544,418 5,539,365 2,217,692 7,596,776 5,747,681 6,239,628 4,893,273 30,050,227 4,016,489 4,016,489 3,440,165 3,375,264 
      yoy
    -83.95% -59.08% -70.72% 646.25% -237.35% 195.95% 40.37% -22.15% -194.52% 14.19% 74.12% 34.30% 73.18% 226.34% 464.53% 336.87% 1087.33% 22.22% -3.54% -11.22% -54.68% -74.72% 43.10% 55.35% 42.24% 790.31%     
      qoq
    -77.33% 87.05% -88.14% 218.92% -42.19% 33.86% 202.37% -158.70% -224.57% -36.51% 67.69% -28.73% 50.50% -3.19% 29.34% -8.09% 183.60% 67.46% 0.09% 149.78% -70.81% 32.17% -7.88% 27.51% -83.72% 648.17% 0.00% 16.75% 1.92%  
      operating expenses:
                                  
      research and development
    61,100,000 64,700,000 68,600,000 90,800,000 83,300,000 86,900,000 93,700,000 84,300,000 95,200,000 85,900,000 103,400,000 95,300,000 98,300,000 77,500,000 75,300,000 64,000,000 61,918,680 40,603,631 43,010,807 34,866,882 33,200,159 30,012,918 23,416,090 21,726,686 20,414,783 16,588,050 16,000,638 14,190,359 14,562,299 13,149,879 
      general and administrative
    23,000,000 21,000,000 25,300,000 26,600,000 34,100,000 75,800,000 31,300,000 24,300,000 27,000,000 22,600,000 25,700,000 24,900,000 15,100,000 20,000,000 24,300,000 20,200,000 18,858,038 16,012,384 14,410,865 12,318,713 12,230,997 9,331,925 8,815,474 7,925,005 7,268,390 7,957,364 6,440,779 5,640,629 5,821,445 4,284,231 
      total operating expenses
    84,100,000 85,700,000 93,900,000 117,400,000 117,400,000 162,700,000 125,000,000 108,600,000 122,200,000 108,500,000 129,100,000 120,200,000 113,400,000 97,500,000 99,600,000 84,200,000 80,776,718 56,616,015 57,421,672 47,185,595 45,431,156 39,344,843 32,231,564 29,651,691 27,683,173 24,545,414 22,441,417 19,830,988 20,383,744 17,434,110 
      income from operations
    -74,600,000 -43,800,000 -71,500,000 71,400,000 -58,200,000 -60,300,000 -48,500,000 -83,300,000 -165,300,000 -73,900,000 -74,600,000 -87,700,000 -67,800,000 -67,200,000 -68,300,000 -60,000,000 -54,445,286 -47,331,230 -51,877,254 -41,646,230 -43,213,464 -31,748,067 -26,483,883 -23,412,063 -22,789,900 5,504,813 -18,424,928 -15,814,499 -16,943,579 -14,058,846 
      yoy
    28.18% -27.36% 47.42% -185.71% -64.79% -18.40% -34.99% -5.02% 143.81% 9.97% 9.22% 46.17% 24.53% 41.98% 31.66% 44.07% 25.99% 49.08% 95.88% 77.88% 89.62% -676.73% 43.74% 48.04% 34.50% -139.16%     
      qoq
    70.32% -38.74% -200.14% -222.68% -3.48% 24.33% -41.78% -49.61% 123.68% -0.94% -14.94% 29.35% 0.89% -1.61% 13.83% 10.20% 15.03% -8.76% 24.57% -3.63% 36.11% 19.88% 13.12% 2.73% -514.00% -129.88% 16.51% -6.66% 20.52%  
      operating margin %
    -785.26% -104.53% -319.20% 37.82% -98.31% -58.89% -63.40% -329.25% 383.53% -213.58% -136.88% -269.85% -148.68% -221.78% -218.21% -247.93% -206.77% -509.77% -935.67% -751.82% -1948.58% -417.92% -460.78% -375.22% -465.74% 18.32% -458.73% -393.74% -492.52% -416.53% 
      other income
                600,000 -200,000 -100,000 -100,000 796,479 219,058 1,236,657 247,806 1,162,594 144,215 307,743 390,009 595,443 405,302 191,729 243,122 -315,764 160,100 
      other expense
      -300,000  -675,000 -2,600,000 -100,000  -275,000   -1,100,000                   
      interest income
    7,400,000 9,000,000 10,300,000 11,700,000 12,900,000 14,300,000 13,600,000 14,000,000 12,200,000 10,000,000 9,000,000 7,600,000 5,700,000 3,400,000 1,800,000 1,200,000 720,912 368,545 360,160 450,383 520,632 800,236 965,851 1,299,133 1,162,991 1,112,415 1,091,331 1,190,523 1,196,113 523,338 
      total other income
    7,400,000 9,000,000 10,000,000 11,700,000 12,700,000 11,700,000 13,500,000 14,000,000 12,100,000 10,000,000 9,000,000 6,500,000 6,300,000 3,200,000 1,700,000 1,100,000 1,449,891 579,478 1,588,692 681,939 1,666,976 928,201 1,257,344 1,672,892 1,742,184 1,494,814 1,260,282 1,410,007 855,713 671,174 
      net loss before income taxes
    -3,325,000 -34,800,000           -47,375,000 -64,000,000 -66,600,000 -58,900,000               
      income tax expense
    -200,000 -300,000  -200,000         -10,800,000 -2,200,000 -3,400,000 -4,500,000               
      net income
    -67,400,000 -35,100,000 -61,200,000 82,900,000 -45,100,000 -49,200,000 -35,200,000 -69,400,000 -154,800,000 -64,000,000 -66,600,000 -81,900,000 -82,900,000 -66,200,000 -70,000,000 -63,400,000 -52,995,395 -46,751,752 -50,288,562 -40,964,291 -41,546,488 -30,819,866 -25,226,539 -21,739,171 -21,047,716 -17,675,373 -17,164,646 -14,404,492 -16,087,866 -13,387,672 
      yoy
    49.45% -28.66% 73.86% -219.45% -70.87% -23.12% -47.15% -15.26% 86.73% -3.32% -4.86% 29.18% 56.43% 41.60% 39.20% 54.77% 27.56% 51.69% 99.35% 88.44% 97.39% 74.37% 46.97% 50.92% 30.83% 32.03%     
      qoq
    92.02% -42.65% -173.82% -283.81% -8.33% 39.77% -49.28% -55.17% 141.88% -3.90% -18.68% -1.21% 25.23% -5.43% 10.41% 19.63% 13.35% -7.03% 22.76% -1.40% 34.80% 22.17% 16.04% 3.29% 19.08% 2.98% 19.16% -10.46% 20.17%  
      net income margin %
    -709.47% -83.77% -273.21% 43.91% -76.18% -48.05% -46.01% -274.31% 359.16% -184.97% -122.20% -252.00% -181.80% -218.48% -223.64% -261.98% -201.26% -503.53% -907.01% -739.51% -1873.41% -405.70% -438.90% -348.40% -430.14% -58.82% -427.35% -358.63% -467.65% -396.64% 
      loss per common share
                                  
      basic and diluted
    -45,000 -480,000                             
      weighted-average common shares outstanding
                                  
      basic and diluted
    70,900,000 73,200,000                             
      net income before income taxes
      -61,500,000 83,100,000                           
      income tax benefit
      300,000  -250,000 -600,000 -200,000 -100,000 175,000  300,000 400,000                   
      earnings per common share
                                  
      basic
      -840,000 1,140,000                           
      diluted
      -840,000 1,140,000                           
      weighted-average common shares outstanding
                                  
      basic
      73,000,000 72,500,000                           
      diluted
      73,000,000 72,700,000                           
      consolidated statements of comprehensive income
      2,025,000,000                            
      other comprehensive loss:
                                  
      unrealized gain on available-for-sale securities
      -500,000                            
      comprehensive income
      -61,700,000                            
      net loss before income taxes and loss from equity method investment
        -45,500,000 -48,600,000 -35,000,000 -69,300,000 -153,200,000 -63,900,000 -65,600,000 -81,200,000                   
      loss from equity method investment
             -100,000 -1,300,000 -1,100,000              -24,675,000     
      net loss per common share, basic and diluted
        -535,000 -680,000 -490,000 -970,000 -992,500 -1,180,000 -1,250,000 -1,540,000 -940,000 -1,240,000 -1,320,000 -1,200,000 -0.703 -0.94 -1.03 -0.84 -1.01 -0.79 -0.65 -0.56 -0.59 -0.54     
      weighted-average common shares outstanding, basic and diluted
         72,100,000 71,900,000 71,700,000  54,100,000 53,400,000 53,300,000  53,200,000 53,200,000 53,000,000  49,807,508 48,860,930 48,621,663 39,534,497 39,058,294 38,739,922 38,548,483 32,927,697 32,740,486     
      condensed consolidated statements of comprehensive loss
                  2,022,000,000 2,022,000,000               
      unrealized loss on available-for-sale securities
                  -3,300,000 -14,100,000               
      comprehensive loss
                  -73,300,000 -77,500,000               
      interest expense
                    -67,500 -8,125 -8,125 -16,250 -16,250 -16,250 -16,250 -16,250 -16,250 -22,903 -22,778 -23,638 -24,636 -12,264 
      change in fair value of preferred unit warrant
                                  
      change in fair value of redeemable convertible preferred units
                                  
      net loss attributable to common shares
                            -21,047,716 -17,675,373     
      net loss attributable to common shares/units
                              -17,164,646 -14,404,492 -16,087,866 -125,438,281 
      net loss per common share/unit, basic and diluted
                              -0.55 -0.46 90.17 -62.38 
      weighted-average common shares/units outstanding, basic and diluted
                              31,440,051 31,325,516 9,422,799 2,010,807 
      income before income taxes
                                -6,348,150 -13,387,672 
      benefit from income taxes
                                  
      change in fair value of redeemable convertible preferred stock/units
                                -49,591,689 -112,050,609 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 
                                     
        assets
                                     
        current assets:
                                     
        cash and cash equivalents
      87,300,000 142,900,000 101,500,000 114,900,000 81,000,000 100,500,000 85,200,000 154,800,000 88,000,000 311,700,000 113,700,000 90,600,000 130,200,000 81,300,000 132,600,000 93,200,000 62,300,000 108,300,000 255,662,835 48,726,443 346,068,406 588,373,232 88,988,921 21,593,656 36,106,323 9,211,057 12,135,475 11,342,178 28,786,247 3,190,056 6,191,004 
        marketable securities
      527,600,000 542,500,000 686,100,000 746,300,000 873,300,000 938,900,000 1,036,400,000 1,073,900,000 1,081,300,000 949,300,000 884,800,000 948,200,000 993,300,000 1,124,000,000 1,138,100,000 1,250,000,000 1,366,100,000 1,394,300,000 1,288,814,399 551,849,110 305,203,086 100,157,618 159,574,963 221,103,306 226,728,165 271,661,456 178,375,159 147,831,005 146,175,265 184,637,640 83,602,865 
        accounts receivable
      1,800,000 1,000,000 20,300,000 500,000 400,000 5,700,000 7,300,000    15,700,000 100,000  1,000,000 1,000,000 1,400,000  15,000,000 1,880,180             
        other receivables
      4,600,000 5,400,000 6,500,000 10,600,000 8,000,000 8,000,000 7,500,000 10,000,000 7,100,000 7,200,000 4,900,000 4,700,000 4,700,000 7,000,000 5,800,000 6,700,000 6,700,000 10,700,000 6,755,720 7,415,611 5,175,378 7,443,654 3,511,633 3,564,317 3,878,438 6,280,828 5,142,227 1,402,085 2,469,514 2,255,966  
        prepaid expenses and other current assets
      9,400,000 8,900,000 11,900,000 17,200,000 17,000,000 14,200,000 13,100,000 12,500,000 8,400,000 6,500,000 8,400,000 7,600,000 14,500,000 21,400,000 21,700,000 20,600,000 17,400,000 19,700,000 18,537,587 15,242,798 8,209,888 6,113,122 3,459,862 3,320,609 3,482,238 3,727,294 3,951,152 2,685,820 2,304,852 2,818,286 3,545,309 
        total current assets
      630,700,000 700,700,000 826,300,000 889,500,000 979,700,000 1,067,300,000 1,149,500,000 1,256,700,000 1,190,300,000 1,280,200,000 1,033,000,000 1,056,700,000 1,148,200,000 1,240,200,000 1,304,700,000 1,376,400,000 1,457,000,000 1,552,500,000 1,576,150,721 627,733,962 664,656,758 703,087,626 257,979,829 249,581,888 270,195,164 290,880,635 199,663,343 163,261,088 179,735,878 195,677,779 95,518,056 
        property, equipment and leasehold improvements
      5,500,000 5,200,000 5,400,000 6,100,000 6,700,000 7,000,000 6,800,000 9,800,000 10,400,000 11,500,000 12,700,000 13,200,000 13,400,000 13,400,000 14,000,000 13,600,000 13,400,000 12,700,000 11,628,051 11,699,480 12,210,324 12,259,515 11,712,403 10,541,408 9,575,768 8,455,411 7,152,151 6,366,491 4,227,487 3,583,036 3,347,242 
        operating lease right-of-use assets
      7,800,000  8,700,000 9,300,000 9,900,000                           
        collaboration contract asset and other assets
      3,500,000 3,800,000 3,900,000 4,400,000 4,800,000 8,100,000 9,800,000 11,600,000 9,900,000 10,400,000 9,600,000 10,100,000 10,300,000 10,800,000 11,300,000 11,700,000 12,100,000 12,500,000 12,835,975             
        total assets
      647,500,000 717,900,000 844,300,000 909,300,000 1,001,100,000 1,091,400,000 1,167,100,000 1,279,600,000 1,212,600,000 1,304,600,000 1,058,300,000 1,083,500,000 1,175,800,000 1,268,800,000 1,334,800,000 1,407,000,000 1,488,300,000 1,581,600,000 1,604,865,210 644,026,885 681,772,443 717,368,587 271,947,431 262,581,573 282,449,799 301,641,426 209,093,798 172,046,128 186,568,127 199,281,575 98,886,058 
        liabilities and stockholders' equity
                                     
        current liabilities:
                                     
        accounts payable and accrued liabilities
      62,300,000 69,500,000 55,500,000 53,100,000 71,100,000 71,800,000 75,900,000 78,100,000 76,400,000 92,200,000 91,000,000 74,800,000 66,000,000 74,700,000 49,700,000 42,100,000                
        deferred revenue
      51,800,000 71,300,000 87,700,000 102,900,000 141,000,000 156,200,000 199,200,000 267,900,000 162,900,000 163,000,000 224,200,000 230,100,000 214,900,000 218,600,000 193,100,000 194,400,000 197,500,000 206,200,000 162,943,830 22,150,861 22,150,861 22,150,861 21,358,989 22,964,819 22,464,819 19,979,525 20,294,456 14,815,957 15,440,957 16,065,957 13,501,056 
        current portion of operating lease liabilities
      1,800,000  1,700,000 1,800,000 1,900,000  800,000 1,200,000 1,500,000             952,840    673,896      
        total current liabilities
      115,900,000 142,500,000 144,900,000 157,800,000 214,000,000 229,800,000 275,900,000 347,200,000 240,800,000 257,100,000 317,300,000 306,900,000 282,900,000 295,100,000 244,600,000 238,200,000 238,000,000 261,700,000 182,507,756 41,820,346 40,371,914 49,085,420 39,530,518 33,719,801 33,168,990 32,813,152 29,396,265 20,945,773 20,600,172 22,979,878 19,847,631 
        long-term debt
      300,000  400,000 500,000 500,000  600,000                         
        operating lease liabilities
      6,300,000  7,200,000 7,600,000 8,100,000  100,000 200,000 400,000             1,087,422    1,714,111      
        total liabilities
      260,700,000 284,000,000 279,900,000 300,000,000 341,000,000 529,700,000 581,100,000 679,400,000 602,900,000 644,600,000 601,100,000 619,900,000 664,800,000 703,900,000 713,300,000 736,400,000 765,000,000 799,900,000 787,128,053 61,079,711 66,474,423 75,111,075 66,827,464 64,800,149 70,742,686 74,955,145 74,934,200 55,540,868 58,830,434 62,614,592 62,561,581 
        commitments and contingencies
                                     
        stockholders’ equity:
                                     
        preferred stock, 0.001 par value...
                                     
        common stock, 0.001 par value...
      100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000 100,000   52,766 48,995 48,786 48,455 40,096 38,825 38,672 38,461 33,076 31,524 31,369 31,236 3,684 
        accumulated deficit
      -1,670,000,000 -1,612,400,000 -1,545,000,000 -1,509,900,000 -1,448,700,000 -1,531,600,000 -1,486,500,000 -1,437,300,000 -1,402,100,000 -1,332,700,000 -1,177,900,000 -1,113,900,000 -1,047,300,000 -965,400,000 -882,500,000 -816,300,000 -746,300,000 -682,900,000 -629,893,515 -583,141,763 -532,853,201 -491,888,910 -450,342,422 -419,522,556 -394,296,017 -372,556,846 -351,509,130 -333,833,758 -316,669,111 -302,264,619 -286,176,753 
        additional paid-in capital
      2,149,000,000 2,136,900,000 2,128,200,000 2,118,100,000 2,107,200,000 2,092,200,000 2,068,300,000 2,041,200,000 2,016,100,000 1,995,700,000 1,644,200,000 1,589,600,000 1,570,800,000 1,549,400,000 1,528,700,000 1,508,800,000 1,488,300,000 1,469,200,000 1,448,254,555 1,166,526,486 1,148,345,190 1,133,537,171 654,342,486 615,601,031 606,567,072 599,097,090 485,439,007 450,007,344 444,295,404 439,118,089 7,377,913 
        accumulated other comprehensive income
      -400,000 1,200,000 1,400,000 1,000,000 1,500,000 1,000,000 4,100,000           -4,600,000 -676,649 -486,544 -242,755 560,796 1,079,807 1,664,124 -602,614 107,576 196,645 300,150 80,031   
        treasury stock
      -91,900,000 -91,900,000 -20,300,000                             
        total stockholders’ equity
      386,800,000  564,400,000 609,300,000 660,100,000  586,000,000 600,200,000 609,700,000  457,200,000 463,600,000 511,000,000  621,500,000 670,600,000 723,300,000  817,737,157 582,947,174 615,298,020  205,119,967 197,781,424 211,707,113  134,159,598 116,505,260 127,737,693   
        total liabilities and stockholders’ equity
      647,500,000  844,300,000 909,300,000 1,001,100,000  1,167,100,000 1,279,600,000 1,212,600,000  1,058,300,000 1,083,500,000 1,175,800,000  1,334,800,000 1,407,000,000 1,488,300,000  1,604,865,210 644,026,885 681,772,443  271,947,431 262,581,573 282,449,799  209,093,798 172,046,128 186,568,127   
        operating lease right of use assets
       8,200,000    9,000,000 1,000,000 1,500,000 2,000,000 2,500,000 3,000,000 3,500,000 3,900,000 4,400,000 4,800,000 5,300,000 5,800,000 3,900,000 4,250,463 4,564,666 4,876,584 1,992,669 2,226,422 2,429,500 2,650,090 2,278,623 2,257,544 2,397,789 2,584,002   
        current portion of operating lease liability
       1,700,000    1,800,000    1,900,000 1,900,000 1,900,000 1,900,000 1,800,000 1,800,000 1,700,000 1,700,000 1,100,000 1,123,101 1,221,152 1,216,914  939,761 920,765 899,653  597,014 647,872 534,340   
        long term debt
       400,000    600,000  700,000 700,000 800,000 800,000 900,000 900,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 2,000,000  2,000,000 2,000,000 2,000,000       
        operating lease liability
       6,800,000    7,300,000    500,000 1,100,000 1,600,000 2,100,000 2,700,000 3,100,000 3,600,000 4,100,000 2,900,000 3,191,132 3,396,563 3,701,991  1,351,476 1,590,758 1,842,901  1,767,775 1,893,359 2,137,037   
        stockholders' equity:
                                     
        total stockholders' equity
       433,900,000    561,700,000    660,000,000    564,900,000    781,700,000    642,257,512    226,686,281      
        total liabilities and stockholders' equity
       717,900,000    1,091,400,000    1,304,600,000    1,268,800,000    1,581,600,000    717,368,587    301,641,426      
        restricted cash
             5,500,000 5,500,000 5,500,000 5,500,000 5,500,000 5,500,000 5,500,000 5,500,000 4,500,000 4,500,000 4,500,000 4,500,000 4,500,000            
        accumulated other comprehensive loss
             -3,800,000 -4,400,000 -3,100,000 -9,200,000 -12,200,000 -12,600,000 -19,200,000 -24,800,000 -22,000,000 -18,700,000             -217,723 -47,223 
        current portion of long term debt
                200,000 100,000 100,000                   
        accounts payable
                      8,600,000 31,300,000 4,671,605 4,975,367 9,002,938 7,121,879 5,088,034 2,429,757 3,020,794 4,556,827 2,277,824 1,411,471 1,563,909 2,758,184 1,300,760 
        accrued expenses
                      30,200,000 23,100,000 13,769,220 13,472,966 8,001,201 18,859,840 12,143,734 7,404,460 6,783,724 7,602,904 6,226,971 3,998,974 2,947,556 4,001,276 4,851,146 
        account receivable
                           1,000,000 2,444,450    59,330   2,775,831  
        other assets
                         28,777 28,777 28,777 28,777 28,777 28,777 26,757 20,760 20,760 20,760  20,760 
        long term debt, net of current portion
                           2,000,000    2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 2,000,000 
        current portion of long-term debt
                                 71,499 113,410 154,461 194,669 
        other non-current liability
                                   150,000  
        other noncurrent liability
                                     
        other assets:
                                     
        deposits
                                   20,760  
        liabilities and members’/stockholders' equity
                                     
        preferred unit warrant liability
                                     
        series a redeemable convertible preferred units, no par value, at redemption value, 22,463,665 units issued and outstanding as of december 31, 2017
                                     
        series b redeemable convertible preferred units, no par value, at redemption value, 24,977,489 units issued and outstanding as of december 31, 2017
                                     
        stockholders'/members' equity:
                                     
        common units, no par value, 1,897,544 units issued and outstanding as of december 31, 2017
                                     
        incentive units, no par value, 3,669,963 units issued as of december 31, 2017
                                     
        total stockholders'/members’ equity
                                   136,666,983  
        total liabilities and stockholders'/members’ equity
                                   199,281,575  
        other receivable
                                    2,178,878 
        liabilities and stockholders'/members’ equity
                                     
        series a redeemable convertible preferred units, no par value, at redemption value, 22,463,665 units issued and outstanding at december 31, 2017
                                     
        series b redeemable convertible preferred units, no par value, at redemption value, 24,977,489 units issued and outstanding at december 31, 2017
                                     
        series a redeemable convertible preferred stock, 0.001 par value...
                                    111,132,408 
        series b redeemable convertible preferred stock, 0.001 par value...
                                    122,965,984 
        series c redeemable convertible preferred stock, 0.001 par value...
                                    81,068,464 
        stockholders’/members’ equity:
                                     
        common units, no par value, 1,897,544 units issued and outstanding
                                     
        incentive units, no par value, 3,066,734 units issued as of december 31, 2017
                                     
        total members’/stockholders’ equity
                                    -278,842,379 
        total liabilities and members’/stockholders’ equity
                                    98,886,058 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 
                                      
          cash flows from operating activities:
                                      
          net income
        -57,600,000   -61,200,000 82,900,000                          
          adjustments to reconcile net income to net cash from operating activities:
                                      
          depreciation and amortization
        700,000 700,000 800,000 800,000 700,000 1,100,000 1,100,000 1,200,000 1,200,000 1,200,000 1,200,000 1,200,000 1,200,000 1,700,000 1,600,000 1,500,000 1,500,000 1,288,002 1,198,603 1,165,385 1,148,010 1,052,274 861,292 635,104 617,469 536,712 468,226 310,460 246,159 222,948 
          net accretion of bond discounts/premiums
        -1,700,000 -2,400,000 -3,100,000 -3,500,000 -3,800,000 -4,700,000 -5,900,000 -5,700,000 -5,500,000 -5,000,000 -4,600,000 -3,600,000 -3,400,000 -800,000 700,000 2,500,000 3,300,000 4,158,794 2,567,842 1,695,232 978,132 249,890 580,932 457,562 366,132 263,892 -21,018 -94,235 5,383  
          amortization of right-of-use assets
        400,000 500,000 500,000 600,000 600,000 500,000 500,000 500,000 500,000 500,000 500,000 400,000 500,000 400,000 500,000 400,000 600,000              
          amortization of collaboration contract asset
        300,000 200,000 400,000 400,000 3,300,000 1,000,000 1,900,000 1,300,000 400,000 -700,000 500,000 900,000 600,000 500,000 500,000 500,000 300,000 337,110             
          stock-based compensation
        12,100,000 8,500,000 10,200,000 10,300,000 15,000,000 23,300,000 24,700,000 21,600,000 18,600,000 16,700,000 16,700,000 18,300,000 19,900,000 20,100,000 18,800,000 20,000,000 16,600,000 16,979,494 15,224,632 14,568,216 10,327,658  8,246,921 7,754,959 6,119,711      
          changes in operating assets and liabilities:
                                      
          accounts receivable
        -800,000 19,300,000 -19,800,000 -100,000 5,300,000 1,600,000    15,700,000 -15,600,000 -100,000 1,000,000 400,000 -1,400,000 15,000,000 -13,119,820             
          other receivables
        800,000 1,100,000 4,100,000   -500,000 2,500,000 -2,900,000 100,000 -2,400,000 -200,000 100,000 2,300,000 -1,200,000 900,000 -100,000 4,100,000 -3,987,934 659,891 -2,240,233 2,268,276 -3,932,021 52,684 314,121 2,402,390 -1,138,601 -3,740,142 1,067,429 -213,548  
          prepaid expenses and other assets
        -600,000 3,000,000 5,400,000 -400,000 -2,700,000                          
          accounts payable and accrued liabilities
        -6,800,000 16,000,000 -100,000 -16,800,000 -800,000 -4,900,000 -2,400,000 1,800,000 -15,700,000 1,300,000 16,600,000 8,200,000 -8,800,000 25,200,000 7,700,000                
          operating lease liability
        -400,000  -600,000 -500,000 -500,000  -600,000 -500,000 -500,000  -500,000 -500,000 -500,000  -500,000 -400,000 -600,000              
          deferred revenue
        -15,600,000 -9,500,000 -21,800,000 -22,400,000 -188,900,000 -55,500,000 -95,500,000 75,300,000 -25,300,000 43,100,000 -34,600,000 -53,200,000 -29,900,000 -34,000,000 -30,300,000 -31,300,000 -21,200,000 -22,783,901 726,359,332 -5,537,716 -2,537,715 -215,365 -5,149,950 -5,741,205 -2,211,793 -3,657,209 16,546,923 -4,016,489 -4,016,489 -664,335 
          net cash from operating activities
        -69,200,000 -30,400,000 -59,100,000 -95,400,000 -88,900,000 -84,100,000 -128,000,000 50,300,000 -97,500,000 -83,100,000 -84,800,000 -88,700,000 -91,200,000 -71,200,000 -66,600,000 -78,600,000 -57,100,000 -35,754,902 681,526,548 -47,403,181 -38,968,465 -29,021,152 -22,383,835 -21,401,986 -16,949,961 -16,178,523 1,853,633 -13,569,083 -12,732,369 -12,254,130 
          capital expenditures
         -100,000 -1,200,000 -300,000 -700,000 -700,000  -1,100,000 -300,000 -1,000,000 -200,000 -2,400,000 -1,000,000 -2,000,000 -1,470,532 -1,568,972 -279,511 -880,985 -2,109,846 -781,361 -2,046,994 -986,622 -1,737,356 -1,122,174 -3,323,908 129,322 -784,356 
          free cash flows
         -30,400,000 -59,200,000 -96,600,000 -89,200,000 -84,100,000 -128,700,000 49,600,000  -83,100,000 -85,900,000 -89,000,000 -92,200,000 -71,400,000 -69,000,000 -79,600,000 -59,100,000 -37,225,434 679,957,576 -47,682,692 -39,849,450 -31,130,998 -23,165,196 -23,448,980 -17,936,583 -17,915,879 731,459 -16,892,991 -12,603,047 -13,038,486 
          cash flows from investing activities:
                                      
          purchases of marketable securities
        -178,900,000  -110,000,000 -118,000,000 -119,600,000  -160,400,000 -192,500,000 -247,900,000  -173,400,000 -316,600,000 -175,700,000  -233,100,000 -205,900,000 -263,200,000              
          maturities of marketable securities
        165,000,000 120,000,000 173,600,000 248,000,000 189,500,000 106,000,000 211,600,000 206,200,000 120,200,000 230,500,000 234,500,000 358,600,000 280,300,000 204,700,000 316,300,000 282,000,000 273,900,000 228,017,691 117,924,309 48,883,000 33,675,000 58,716,490 27,149,000 35,790,968 52,462,085 49,853,000 44,576,816 33,250,000 42,016,000 19,260,526 
          sales of marketable securities
        28,900,000          10,000,000 7,200,000 35,100,000  24,800,000        33,541,119        
          purchases of property, equipment and leasehold improvements
        -1,300,000  -100,000 -1,200,000 -400,000  -700,000 -700,000 -100,000  -1,100,000 -600,000 -1,100,000  -2,200,000 -1,400,000 -2,100,000              
          net cash from investing activities
        13,700,000 145,800,000 63,500,000   98,900,000 50,500,000 13,100,000 -127,800,000 -53,700,000 70,000,000 48,600,000 138,600,000 19,400,000 105,800,000 109,000,000 8,600,000 -115,633,512 -741,097,364 -249,052,071 -207,817,053 56,861,873 59,283,295 5,610,166 42,494,745 -95,427,922 -31,814,671 -4,228,072 38,374,102 -101,861,703 
          cash flows from financing activities:
                                      
          repayments of long-term debt
        -100,000 -100,000 -100,000 -100,000                    -77,666 -46,402 -45,542  
          net cash from financing activities
        -100,000 -74,000,000 -17,800,000 500,000 -100,000 500,000 2,400,000 3,400,000 1,600,000 334,800,000 37,900,000 500,000 1,500,000 500,000 1,200,000 500,000 2,500,000 3,998,811 266,507,208 3,613,289 4,480,692 471,543,590 30,495,805 1,279,153 1,350,482 108,682,027 30,754,335 353,086 -45,542 111,114,885 
          net decrease in cash and cash equivalents
        -55,600,000                              
          cash and cash equivalents, beginning of the period
        142,900,000                    588,373,232 9,211,057 3,190,056 
          cash and cash equivalents, end of the period
        87,300,000                    346,068,406 499,384,311 67,395,265 -14,512,667 36,106,323 -2,924,418 793,297 -17,444,069 28,786,247 -3,000,948 
          supplemental disclosure of cash flow information:
                                      
          purchases of property, equipment and leasehold improvements unpaid at period end
            100,000       300,000 100,000 -200,000 -200,000 400,000 100,000 424,467 -220,899 187,515 108,917 -255,230 625,463 -223,125 375,602 51,308 65,856 -437,222 509,966 -162,807 
          net loss
         -67,400,000    -45,100,000 -49,200,000 -35,200,000 -69,400,000 -154,800,000 -64,000,000 -66,600,000 -81,900,000 -82,900,000 -66,200,000 -70,000,000 -63,400,000 -52,995,395 -46,751,752 -50,288,562 -40,964,291 -41,546,488 -30,819,866 -25,226,539 -21,739,171 -21,047,716 -17,675,372 -17,164,647 -14,404,492 -16,087,866 
          adjustments to reconcile net loss to net cash from operating activities:
                                      
          loss on sale of marketable securities
                 900,000 300,000   173,945             
          net loss on disposal of property, equipment and leasehold improvements
                                      
          collaboration contract asset
                       -29,912             
          operating lease liabilities
                           -301,190 -310,412 -250,975 -246,087 -236,272 -186,824 -182,351 -176,442 -130,145 -93,023  
          purchase of marketable securities
                         -341,733,744 -864,896,060 -297,468,045 -240,502,151 -1 -32,591,049 -8,605,116 -143,492,258 -75,203,457 -34,591,386 -3,261,254 -120,500,680 
          sale of marketable securities
                                      
          purchase of property, equipment and leasehold improvements
                         -1,894,999 -1,348,073 -467,026 -989,902 -1,854,616 -1,406,824 -1,823,869 -1,362,224 -1,788,664 -1,188,030 -2,886,686 -380,644 -621,549 
          proceeds from disposal of property, equipment and leasehold improvements
                                      
          proceeds from issuance of common stock and pre-funded warrants
                                      
          payment of common stock offering costs
                             -26,733,480         
          repurchase of common shares
         -74,100,000                             
          proceeds from exercise of stock options and issuance of espp shares
         200,000   600,000 2,400,000 3,500,000 1,800,000 600,000 1,900,000 500,000 1,500,000                  
          net increase in cash, cash equivalents and restricted cash
             15,300,000 -75,100,000 66,800,000 -223,700,000 198,000,000 23,100,000 -39,600,000 48,900,000 -51,300,000    -147,389,603 206,936,392            
          cash, cash equivalents and restricted cash, beginning of the period
         100,500,000 317,200,000 86,800,000 112,800,000 26,768            
          cash, cash equivalents and restricted cash, end of the period
           33,900,000 81,000,000 15,300,000 -75,100,000 66,800,000 93,500,000 198,000,000 23,100,000 -39,600,000 135,700,000 -51,300,000 40,400,000 30,900,000 66,800,000 -147,362,835 206,936,392            
          net loss on disposal of property, plant and equipment
                                      
          proceeds from disposal of property, equipment and leaseholds improvements
                                     
          net increase in cash and cash equivalents
                            -242,304,826 499,384,311 67,395,265 -14,512,667 26,895,266 -2,924,418 793,297 -17,444,069 25,596,191  
          repurchases of common shares unpaid at period end
                                      
          cash paid for taxes
             700,000 100,000 300,000 1,200,000 2,000,000 100,000   3,000,000                 
          net cash from by investing activities
            69,500,000                          
          net decrease in cash, cash equivalents and restricted cash
            -19,500,000           30,900,000 -46,000,000              
          prepaid expenses and other current assets
              -400,000 -4,100,000 -1,900,000 1,800,000 -800,000 6,200,000 6,900,000 200,000 -1,000,000 -3,300,000 2,300,000 -1,175,535 -3,294,789 -7,032,910 -2,096,766 -2,653,260 -139,253 161,629 243,036 217,861 -1,265,332 -380,968 363,434 63,771 
          proceeds from issuance of common stock
                         33,584        108,231,973     
          payment of common stock issuance costs
                                      
          repayments of long term debt
               -100,000 -200,000                     -44,698 
          forgiveness of debt income
                                    
          cash paid for interest
                         64,792 24,375 -5,417 16,250 16,250 16,250 16,250 16,250 10,834 22,152 12,871 24,563 20,145 
          proceeds from sale of common stock in at-the-market offering
                             34,807,935         
          payment of common stock offering costs for at-the-market offering
                                      
          proceeds from exercise of stock options
                     500,000 1,200,000 500,000 2,500,000 3,935,315 6,570,704 3,613,289 4,480,692 5,053,822 577,303 1,279,153 1,350,482 1,047,185 1,377,968    
          accounts payable
                        -22,600,000 26,225,807 -82,863 -4,215,086 1,772,142 2,289,075 2,032,814 -367,912 -1,911,635 2,227,695 800,497 284,784 -1,704,241 1,297,930 
          accrued expenses
                        7,000,000 9,290,620 296,254 5,471,765 -10,858,639 6,266,293 4,739,274 620,736 -819,180 1,375,933 2,227,997 1,051,418 -1,053,720 135,683 
          amortization of right to use assets
                           311,918 305,140 233,753 228,879 225,831 169,904 184,490 140,245 186,212 180,398  
          adjustments to reconcile net loss to net cash used in operating activities:
                                      
          account receivable
                           1,000,000 1,444,450    59,330 -59,330 2,775,831 -2,775,831 
          amortization of debt discount
                                 6,167 4,491 4,491 4,490 
          change in fair value of preferred unit warrant liability
                                     
          gain on sale of marketable securities
                             -68,045         
          non-cash share/unit-based compensation
                                      
          proceeds from long-term debt
                                      
          proceeds from issuance of series c redeemable convertible preferred units
                                      
          proceeds from exercise of warrant
                                      
          increase in redemption value of preferred units
                                      
          deferred liability
                                      
          adjustments to reconcile net loss to net cash from (used in) operating activities:
                                      
          non-cash compensation
                                  4,601,214 5,312,607 5,177,448  
          proceeds from long term debt
                                     
          proceeds from sale of redeemable convertible preferred units
                                      
          proceeds from exercise of redeemable convertible preferred warrant
                                      
          deferred offering costs included in accrued expenses
                                      
          change in redemption value of preferred units
                                      
          net accretion of bond discounts/
                                      
          other receivable