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Aquestive Therapeutics, Inc
(NASDAQ:AQST) 

AQST stock logo

Aquestive Therapeutics, Inc., a pharmaceutical company, focuses on identifying, developing, and commercializing various products to address unmet medical needs in the United States and internationally. The company markets Sympazan, an oral soluble film formulation of clobazam for the treatment of le...

Founded: 2004
Full Time Employees: 232
Sector: Healthcare
Industry: Biotechnology
Pharmaceuticals
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At a glance:
Bull Thesis:
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Moat:
Income Statements:
Quarterly
Annual
    Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 
                                    
      revenues
    		14,446,000 13,015,000 12,807,000 10,003,000 8,720,000 11,867,000 13,542,000 20,099,000 12,053,000 13,206,000 13,002,000 13,241,000 11,134,000 10,682,000 11,463,000 13,265,000 12,270,000 11,078,000 13,287,000 15,345,000 11,122,000 7,149,000 8,260,000 21,675,000 8,765,000 16,419,000 12,418,000 11,129,000 12,643,000 16,824,000 13,267,000 13,928,000 
      costs and expenses:
    		                                
      manufacture and supply
    		3,469,000 5,836,000 4,506,000 4,561,000 3,652,000 4,520,000 4,437,000 4,526,000 4,389,000 4,679,000 4,798,000 6,617,000 4,737,000 5,305,000 4,625,000 5,242,000 4,214,000 3,366,000 4,400,000 4,466,000 2,757,000 2,788,000 2,978,000 3,539,000 3,659,000 6,792,000 4,643,000 5,420,000 3,506,000 4,787,000 5,592,000 4,973,000 
      research and development
    		4,204,000 3,196,000 4,530,000 4,105,000 5,361,000 4,917,000 5,269,000 4,162,000 5,932,000 2,888,000 3,196,000 3,473,000 3,547,000 4,278,000 3,232,000 5,198,000 4,773,000 4,400,000 4,726,000 4,262,000 3,659,000 4,425,000 7,260,000 3,847,000 4,354,000 3,057,000 5,063,000 8,151,000 4,303,000 5,683,000 4,534,000 7,994,000 
      selling, general and administrative
    		10,977,000 32,822,000 15,250,000 12,705,000 19,072,000 16,009,000 12,126,000 11,356,000 10,689,000 9,550,000 7,385,000 7,360,000 7,455,000 11,812,000 12,459,000 15,587,000 13,021,000 14,981,000 12,129,000 13,134,000 13,231,000 15,582,000 11,803,000 13,894,000 14,613,000 16,474,000 13,714,000 16,246,000 17,908,000 18,703,000 12,345,000 33,647,000 
      total costs and expenses
    		18,650,000 41,854,000 24,286,000 21,371,000 28,085,000 25,446,000 21,832,000 20,044,000 21,010,000 17,117,000 15,379,000 17,450,000 15,739,000 21,395,000 20,316,000 26,027,000 22,008,000 22,747,000 21,255,000 21,862,000 19,647,000 22,795,000 22,041,000 21,280,000 22,626,000 26,323,000 23,420,000 29,817,000 25,717,000 29,173,000 22,471,000 46,614,000 
      income from operations
    		-4,204,000 -28,839,000 -11,479,000 -11,368,000 -19,365,000 -13,579,000 -8,290,000 55,000 -8,957,000 -3,911,000 -2,377,000 -4,209,000 -4,605,000 -10,713,000 -8,853,000 -12,762,000 -9,738,000 -11,669,000 -7,968,000 -6,517,000 -8,525,000 -15,646,000 -13,781,000 395,000 -13,861,000 -9,904,000 -11,002,000 -18,688,000 -13,074,000 -12,349,000 -9,204,000 -32,686,000 
      yoy
    		-78.29% 112.38% 38.47% -20769.09% 116.20% 247.20% 248.76% -101.31% 94.51% -63.49% -73.15% -67.02% -52.71% -8.19% 11.11% 95.83% 14.23% -25.42% -42.18% -1749.87% -38.50% 57.98% 25.26% -102.11% 6.02% -19.80% 19.53% -42.83%     
      qoq
    		-85.42% 151.23% 0.98% -41.30% 42.61% 63.80% -15172.73% -100.61% 129.02% 64.54% -43.53% -8.60% -57.01% 21.01% -30.63% 31.05% -16.55% 46.45% 22.26% -23.55% -45.51% 13.53% -3588.86% -102.85% 39.95% -9.98% -41.13% 42.94% 5.87% 34.17% -71.84%  
      other income/
    		                                
      interest expense
    		-2,903,000 -2,778,000 -2,779,000 -2,781,000 -2,782,000 -2,779,000 -2,780,000 -2,779,000 -2,784,000 -2,273,000 -1,256,000 -1,373,000 -1,435,000 -1,650,000 -1,649,000 -1,635,000 -1,618,000 -1,744,000 -2,787,000 -2,757,000 -2,761,000 -2,768,000 -2,778,000 -2,747,000 -2,771,000 -2,803,000 -2,652,000 -1,937,000 -1,926,000 -1,902,000 -1,933,000 -1,927,000 
      interest expense related to royalty obligations
    		-973,000 -1,433,000 -1,433,000 -1,434,000 -1,437,000 -1,384,000 -1,359,000 -1,358,000 -1,358,000                        
      interest expense related to the sale of future revenue
    		-60,000 -62,000 -61,000 -61,000 -59,000 -61,000 -59,000 -58,000 -58,000 -57,000 -56,000 -55,000 -52,000 -54,000 -2,039,000 -1,937,000 -1,861,000 -1,845,000 -3,767,000 -3,466,000 -3,334,000            
      interest income and other income
    		83,000 1,252,000 306,000 2,096,000 713,000 734,000 979,000 1,395,000 329,000           373,000 -52,000            
      net loss before income taxes
    		-8,057,000 -31,860,000 -15,446,000 -13,548,000 -22,930,000         -12,352,000 -12,536,000 -16,302,000 -13,220,000 -28,945,000 -14,555,000 -12,367,000 -14,672,000 -20,368,000 -16,551,000 -2,334,000 -16,530,000 -12,636,000 -18,412,000 -20,472,000    -36,493,000 
      net income
    		-8,057,000 -31,860,000 -15,446,000 -13,548,000 -22,930,000 -17,055,000 -11,509,000 -2,745,000 -12,828,000 -8,111,000 -2,035,000 -5,792,000 8,068,000 -12,352,000 -12,536,000 -16,302,000 -13,220,000 -28,945,000 -14,555,000 -12,367,000 -14,672,000 -20,368,000 -16,551,000 -2,334,000 -16,530,000 -12,636,000 -18,412,000 -20,472,000 -14,726,000 -13,944,000 -15,038,000 -36,493,000 
      yoy
    		-64.86% 86.81% 34.21% 393.55% 78.75% 110.27% 465.55% -52.61% -259.00% -34.33% -83.77% -64.47% -161.03% -57.33% -13.87% 31.82% -9.90% 42.11% -12.06% 429.86% -11.24% 61.19% -10.11% -88.60% 12.25% -9.38% 22.44% -43.90%     
      qoq
    		-74.71% 106.27% 14.01% -40.92% 34.45% 48.19% 319.27% -78.60% 58.16% 298.57% -64.87% -171.79% -165.32% -1.47% -23.10% 23.31% -54.33% 98.87% 17.69% -15.71% -27.97% 23.06% 609.13% -85.88% 30.82% -31.37% -10.06% 39.02% 5.61% -7.27% -58.79%  
      comprehensive loss
    		-8,057,000 -31,860,000 -15,446,000 -13,548,000 -22,930,000         -12,352,000 -12,536,000 -16,302,000 -13,220,000 -28,945,000 -14,555,000 -12,367,000 -14,672,000 -20,368,000 -16,551,000 -2,334,000 -16,530,000 -12,636,000 -18,412,000 -20,472,000    -36,493,000 
      loss per share attributable to common stockholders:
    		                                
      basic and diluted
    		-0.07 -0.27 -0.14 -0.14 -0.24                            
      weighted-average common shares outstanding:
    		                                
      basic and diluted
    		122,609,995 106,926,528 110,584,371 99,326,701 95,497,056 86,726,211                           
      loss on extinguishment of debt
    		         -88,250   -353,000                    
      net income before income taxes
    		     -6,770,500 -11,509,000 -2,745,000 -12,828,000 96,250 -2,175,000 -5,508,000 8,068,000                -14,726,000 -11,858,000 -15,038,000  
      income taxes expense
    		                                
      comprehensive income
    		     -6,770,500 -11,509,000 -2,745,000 -12,828,000 60,250 -2,035,000 -5,792,000 8,068,000                -14,726,000    
      earnings per share attributable to common stockholders:
    		                                
      basic
    		     -0.08 -0.13 -0.03 -0.17  -0.03 -0.1 0.15                    
      diluted
    		     -0.08 -0.13 -0.03 -0.17  -0.03 -0.1 0.11                    
      weighted-average common shares outstanding:
    		                                
      basic
    		      91,082,081 90,911,626 73,614,710  64,678,761 57,350,902 55,631,947                    
      diluted
    		      91,082,081 90,911,626 73,614,710  64,678,761 57,350,902 73,792,886                    
      income taxes
    		         -389,000 -140,000 284,000                     
      interest and other income
    		         4,039,000 1,514,000 129,000 14,513,000 8,500 5,000 32,000  72,000 -33,000              
      net income per share
    		             -0.22 -0.23 -0.36 -0.32 -0.73 -0.37 -0.33 -0.41 -0.61 -0.49 -0.07 -0.49 -0.46 -0.74 -0.82 -0.59 -0.51 -0.64  
      weighted-average number of common shares outstanding - basic and diluted
    		         61,255,864    48,734,377 53,424,922 45,462,516 41,465,798 38,077,660 39,224,863 37,065,300 35,563,275 33,651,127 33,619,379 33,589,174 33,569,694 25,356,098 25,031,478 24,980,861 24,963,603 20,725,526 23,646,192  
      other expenses:
    		                                
      interest and other expense
    		                -3,000                
      interest income
    		                     32,000 8,000 18,000 102,000 71,000 138,000 153,000 274,000 314,000 216,000  
      loss on the extinguishment of debt
    		                          -4,896,000      
      change in fair value of warrant
    		                              -4,116,000 -1,859,000 
      other income
    		                                
      other
    		                             500 -1,000 -21,000 
      dividends on redeemable preferred interests
    		                                
      net income attributable to common shares/members' interests
    		                             -11,858,000 -15,038,000  
      comprehensive net income
    		                             -11,858,000 -15,038,000  
      cost and expenses:
    		                                
      net loss attributable to common shares / members’ interests
    		                               -36,493,000 
      net loss per common share - basic and diluted
    		                               -1.9 
      weighted-average number of common shares / membership interests outstanding - basic and diluted
    		                               19,188,624 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 
                                      
        assets
      		                                
        current assets:
      		                                
        cash and cash equivalents
      		110,734,000 121,169,000 129,063,000 60,536,000 68,657,000 71,546,000 77,893,000 89,870,000 95,200,000 23,872,000 24,917,000 22,436,000 26,882,000 27,273,000 18,649,000 17,695,000 14,736,000 28,024,000 31,164,000 34,234,000 27,498,000 31,807,000 17,064,000 25,422,000 35,521,000 49,326,000 20,914,000 22,165,000 39,934,000 60,599,000 63,982,000 10,638,000 
        trade and other receivables
      		6,867,000 17,763,000 11,801,000 11,864,000 10,444,000 7,344,000 9,684,000 5,998,000 8,324,000 8,471,000 8,550,000 10,101,000 7,551,000 4,704,000 10,737,000 19,165,000 19,896,000 12,120,000 13,643,000 12,127,000 10,209,000 6,955,000 7,990,000 12,891,000 9,536,000 13,130,000 10,316,000 10,150,000 7,489,000 6,481,000   
        inventories
      		8,066,000 6,169,000 7,884,000 8,125,000 7,198,000 6,044,000 7,021,000 6,966,000 7,734,000 6,769,000 7,079,000 5,950,000 6,981,000 5,780,000 6,725,000 5,008,000 4,629,000 4,038,000 2,863,000 2,839,000 2,799,000 2,461,000 3,242,000 3,173,000 3,087,000 2,859,000 4,124,000 4,647,000 5,137,000 5,441,000 4,483,000 4,348,000 
        prepaid expenses and other current assets
      		4,516,000 4,168,000 2,925,000 1,196,000 2,870,000 3,286,000 1,972,000 1,177,000 2,121,000 1,854,000 1,911,000 1,301,000 2,292,000 2,131,000 1,976,000 1,637,000 3,324,000 3,077,000 2,540,000 1,798,000 3,937,000 3,402,000 3,388,000 2,423,000 2,944,000 2,999,000 2,706,000 2,102,000 3,398,000 1,680,000 1,444,000 5,034,000 
        total current assets
      		130,183,000 149,269,000 151,673,000 81,721,000 89,169,000 88,220,000 96,570,000 104,011,000 113,379,000 40,966,000 42,457,000 39,788,000 43,706,000 39,888,000 38,087,000 43,505,000 42,585,000 47,259,000 50,210,000 50,998,000 44,443,000 44,625,000 31,684,000 43,909,000 51,088,000 68,314,000 38,060,000 39,064,000 55,958,000 74,201,000 77,359,000 26,649,000 
        property and equipment
      		3,839,000 3,893,000 3,918,000 3,858,000 3,801,000 3,799,000 3,848,000 3,921,000 4,046,000 4,179,000 4,551,000 4,602,000 3,814,000 4,085,000 4,284,000 4,569,000 4,496,000 5,055,000 5,197,000 5,791,000 6,279,000 6,873,000 7,728,000 8,457,000 9,059,000 9,726,000 10,351,000 10,933,000 11,594,000 12,207,000 12,211,000 12,766,000 
        right-of-use assets
      		4,468,000 4,621,000 4,769,000 4,911,000 5,049,000 5,182,000 5,310,000 5,435,000 5,442,000 5,557,000 5,669,000 5,778,000 5,884,000 5,211,000 2,094,000 2,314,000 2,524,000 2,725,000 2,917,000 3,102,000 3,277,000 3,448,000 3,609,000 3,764,000 3,912,000        
        other non-current assets
      		2,635,000 2,642,000 3,199,000 3,208,000 4,215,000 4,223,000 4,230,000 4,238,000 5,417,000 5,438,000 5,454,000 5,469,000 6,485,000 6,451,000 5,893,000 5,897,000 6,886,000 6,903,000 6,905,000 6,908,000 7,835,000 7,836,000           
        total assets
      		141,125,000 160,425,000 163,559,000 93,698,000 102,234,000 101,424,000 109,958,000 117,605,000 129,523,000 57,418,000 59,448,000 56,994,000 61,285,000 57,070,000 51,845,000 56,310,000 56,529,000 61,993,000 65,293,000 66,875,000 61,923,000 62,884,000 50,423,000 63,546,000 64,487,000 78,479,000 48,818,000 50,408,000 67,979,000 86,851,000 90,010,000 39,841,000 
        liabilities and stockholders’ deficit
      		                                
        current liabilities:
      		                                
        accounts payable
      		11,889,000 29,862,000 10,865,000 11,951,000 12,280,000 10,287,000 7,572,000 5,696,000 10,523,000 8,926,000 9,994,000 10,689,000 12,440,000 9,946,000 11,072,000 8,887,000 8,496,000 8,314,000 6,215,000 8,100,000 6,687,000 7,089,000    12,274,000    20,436,000   
        accrued expenses
      		3,449,000 5,029,000 5,128,000 5,001,000 3,314,000 5,907,000 5,025,000 5,674,000 4,637,000 6,497,000 5,468,000 4,263,000 4,508,000 7,967,000 7,733,000 7,042,000 4,868,000 8,736,000 7,624,000 6,583,000 6,371,000 8,569,000    5,475,000    7,195,000   
        lease liabilities, current
      		662,000 631,000 601,000 570,000 540,000 510,000 482,000 455,000 414,000 390,000 367,000 347,000 328,000 255,000 846,000 913,000 926,000 899,000 860,000 823,000 787,000 728,000 664,000 689,000 609,000        
        deferred revenue, current
      		1,092,000 1,092,000 1,092,000 1,092,000 1,048,000 1,048,000 1,048,000 1,046,000 1,551,000  2,637,000 3,992,000 4,765,000  774,000 1,599,000 1,599,000  767,000 642,000 437,000  722,000 803,000 663,000  835,000 600,000 700,000    
        liability related to the sale of future revenue, current
      		1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 1,000,000 910,000 922,000 985,000 1,000,000 1,147,000 1,147,000 1,910,000 1,445,000 1,732,000 1,225,000 1,848,000 1,737,000 1,905,000 1,450,000           
        loans payable, current
      		13,661,000 9,994,000 6,327,000 3,177,000 27,000 26,000 25,000 24,000 23,000  4,606,000 18,362,000 17,195,000 18,700,000 14,225,000 9,750,000 6,563,000 2,025,000 7,725,000 5,150,000 3,863,000 2,575,000 1,750,000     550,000 6,850,000 4,600,000 2,750,000 1,100,000 
        total current liabilities
      		31,753,000 47,608,000 25,574,000 23,155,000 18,298,000 18,865,000 15,152,000 13,895,000 18,058,000 18,308,000 24,057,000 38,653,000 40,383,000 39,528,000 36,560,000 29,636,000 24,184,000 21,964,000 25,039,000 23,035,000 20,050,000 21,104,000 18,373,000 14,882,000 15,362,000 18,555,000 20,053,000 24,629,000 29,638,000 32,952,000 21,329,000 23,474,000 
        notes payable
      		25,099,000 27,519,000 29,940,000 31,843,000 33,746,000 32,500,000 31,253,000 30,006,000 28,759,000 27,508,000                       
        royalty obligations
      		26,914,000 25,941,000 23,948,000 22,711,000 21,559,000 20,129,000 18,835,000 17,477,000 16,119,000 14,761,000                       
        liability related to the sale of future revenue
      		62,083,000 62,023,000 61,977,000 61,924,000 62,777,000 62,718,000 62,730,000 62,684,000 63,626,000 63,568,000 63,511,000 63,455,000 64,137,000 64,112,000 63,308,000 61,839,000 60,346,000 59,059,000 56,615,000 53,003,000 50,383,000 47,524,000           
        lease liabilities
      		4,159,000 4,337,000 4,508,000 4,668,000 4,822,000 4,968,000 5,109,000 5,238,000 5,284,000 5,399,000 5,509,000 5,610,000 5,706,000 5,085,000 1,340,000 1,502,000 1,710,000 1,946,000 2,185,000 2,415,000 2,635,000 2,846,000 3,047,000 3,240,000 3,424,000        
        deferred revenue, net of current portion
      		19,118,000 19,390,000 19,663,000 19,935,000 19,744,000 20,005,000 20,266,000 21,757,000 31,957,000 32,345,000    31,417,000    7,122,000    3,633,000 3,694,000 3,867,000 4,209,000 4,348,000 2,127,000 2,266,000 2,405,000    
        other non-current liabilities
      		6,053,000 7,269,000 2,058,000 2,052,000 2,218,000 2,395,000 2,033,000 2,027,000 2,021,000 2,016,000 2,011,000 2,006,000 2,059,000 2,034,000 2,159,000 2,379,000 1,862,000 2,485,000 1,810,000 1,770,000 1,761,000 1,945,000           
        total liabilities
      		175,179,000 194,087,000 167,668,000 166,288,000 163,164,000 161,580,000 155,378,000 153,084,000 165,824,000 163,905,000 162,375,000 163,645,000 170,520,000 175,624,000 159,664,000 152,667,000 149,672,000 144,127,000 125,638,000 120,644,000 113,721,000 111,381,000 86,942,000 84,934,000 85,316,000 84,601,000 83,277,000 75,065,000 74,035,000 76,771,000 66,566,000 78,789,000 
        contingencies
      		                                
        stockholders’ deficit:
      		                                
        common stock
      		124,000 122,000 121,000 99,000 99,000 91,000 91,000 91,000 90,000 69,000 67,000  56,000 55,000 54,000 53,000 41,000 41,000 40,000 39,000 36,000 35,000 34,000 34,000 34,000 34,000 25,000 25,000 25,000 25,000 25,000 20,000 
        additional paid-in capital
      		420,877,000 413,214,000 410,908,000 327,003,000 325,115,000 302,967,000 300,648,000 299,080,000 295,514,000 212,521,000 207,972,000 202,218,000 193,848,000 192,598,000 190,982,000 189,908,000 176,833,000 174,621,000 167,466,000 159,488,000 149,095,000 137,725,000 129,336,000 127,916,000 126,141,000 124,318,000 83,354,000 74,744,000 72,873,000 71,431,000 70,851,000 -6,574,000 
        accumulated deficit
      		-455,055,000 -446,998,000 -415,138,000 -399,692,000 -386,144,000 -363,214,000 -346,159,000 -334,650,000 -331,905,000 -319,077,000 -310,966,000 -308,931,000 -303,139,000 -311,207,000 -298,855,000 -286,318,000 -270,017,000 -256,796,000 -227,851,000 -213,296,000 -200,929,000 -186,257,000 -165,889,000 -149,338,000 -147,004,000 -130,474,000 -117,838,000 -99,426,000 -78,954,000 -61,376,000 -47,432,000 -32,394,000 
        total stockholders’ deficit
      		-34,054,000 -33,662,000 -4,109,000 -72,590,000 -60,930,000 -60,156,000 -45,420,000 -35,479,000 -36,301,000 -106,487,000 -102,927,000 -106,651,000 -109,235,000 -118,554,000 -107,819,000 -96,357,000 -93,143,000 -82,134,000 -60,345,000 -53,769,000 -51,798,000 -48,497,000 -36,519,000 -21,388,000 -20,829,000        
        total liabilities and stockholders’ deficit
      		141,125,000 160,425,000 163,559,000 93,698,000 102,234,000 101,424,000 109,958,000 117,605,000 129,523,000 57,418,000 59,448,000 56,994,000 61,285,000 57,070,000 51,845,000 56,310,000 56,529,000 61,993,000 65,293,000 66,875,000 61,923,000 62,884,000 50,423,000 63,546,000 64,487,000        
        royalty obligations, current
      		  561,000 364,000 89,000 87,000                           
        intangible assets
      		        1,239,000 1,278,000 1,317,000 1,357,000 1,396,000 1,435,000 1,487,000 25,000 38,000 51,000 64,000 76,000 89,000 102,000     165,000 178,000 191,000 204,000 216,000 229,000 
        deferred revenue
      		         1,551,000 32,732,000 33,120,000 33,039,000 1,513,000 17,622,000 13,490,000 13,890,000 765,000 7,316,000 6,351,000 4,699,000 693,000    806,000    721,000 781,000 1,234,000 
        notes payable, current
      		         22,000                       
        loans payable
      		          34,555,000 20,801,000 25,196,000 33,448,000 38,675,000 43,821,000 47,680,000 51,551,000 32,673,000 34,070,000 34,193,000 34,329,000 60,346,000 61,505,000 60,922,000 60,338,000 59,775,000 46,884,000 40,742,000 42,603,000 44,054,000 45,330,000 
        common stock ,0.001 par value. authorized 250,000,000 shares; 61,615,959 and 54,827,734 shares issued and outstanding at june 30, 2023 and december 31, 2022, respectively
      		           62,000                     
        intangible assets, net and other assets
      		                      7,402,000 7,416,000 428,000 439,000       
        accounts payable and accrued expenses
      		                      15,237,000 13,390,000 14,090,000  19,218,000 23,479,000 22,088,000  17,798,000 21,140,000 
        asset retirement obligations
      		                      1,482,000 1,440,000 1,399,000 1,360,000 1,322,000 1,286,000 1,250,000 1,216,000 1,183,000 1,150,000 
        liabilities and stockholders’ (deficit)/equity
      		                                
        commitments and contingencies
      		                                
        stockholders’ (deficit)/equity:
      		                                
        total stockholders’ (deficit)/equity
      		                         -6,122,000 -34,459,000      
        total liabilities and stockholders’ (deficit)/equity
      		                         78,479,000 48,818,000      
        other assets
      		                          242,000 233,000 236,000 239,000 224,000 197,000 
        revenues
      		                          12,418,000 11,129,000 12,643,000   13,928,000 
        costs and expenses:
      		                                
        manufacture and supply
      		                          4,643,000 5,420,000 3,506,000   4,973,000 
        research and development
      		                          5,063,000 8,151,000 4,303,000   7,994,000 
        selling, general and administrative
      		                          13,714,000 16,246,000 17,908,000   33,647,000 
        total costs and expenses
      		                          23,420,000 29,817,000 25,717,000   46,614,000 
        income from operations
      		                          -11,002,000 -18,688,000    -32,686,000 
        other income/
      		                                
        interest expense
      		                          -2,652,000 -1,937,000 -1,926,000   -1,927,000 
        interest income
      		                          138,000 153,000 274,000    
        loss on the extinguishment of debt
      		                          -4,896,000      
        change in fair value of warrant
      		                               -1,859,000 
        net income before income taxes
      		                          -18,412,000 -20,472,000    -36,493,000 
        income taxes
      		                                
        net income
      		                          -18,412,000 -20,472,000    -36,493,000 
        comprehensive loss
      		                          -18,412,000 -20,472,000    -36,493,000 
        net income per share
      		                          -740 -820     
        weighted-average number of common shares outstanding - basic and diluted
      		                          25,031,478,000 24,980,861,000 24,963,603,000    
        liabilities and shareholders’ (deficit)/equity
      		                                
        shareholders’ (deficit)/equity:
      		                                
        total shareholders’ (deficit)/equity
      		                           -24,657,000 -6,056,000    
        total liabilities and shareholders’ (deficit)/equity
      		                           50,408,000 67,979,000    
        (loss)/income from operations
      		                            -13,074,000    
        net (loss)/income before income taxes
      		                            -14,726,000    
        net (loss)/income
      		                            -14,726,000    
        comprehensive (loss)/income
      		                            -14,726,000    
        net (loss)/income per share – basic and diluted
      		                            -590    
        liabilities and shareholders’ equity/members’ deficit
      		                                
        warrant liability
      		                               8,835,000 
        redeemable preferred a-3 interests and accrued dividends
      		                                
        redeemable preferred a-2 interests and accrued dividends
      		                                
        shareholders/members’ equity/
      		                                
        preferred a interests, no par value. authorized 100,000,000 units; 16,886,750 units issued and outstanding at december 31, 2017
      		                                
        preferred a-1 interests, no par value. authorized 100,000,000 units; 21,526,850 units issued and outstanding at december 31, 2017
      		                                
        common interests, no par value. authorized 500,000,000 units; 121,228,353 units issued and outstanding at december 31, 2017
      		                                
        total shareholders’ equity/members’
      		                             10,080,000   
        total liabilities and shareholders’ equity/ members’ deficit
      		                             86,851,000   
        accounts receivable
      		                              7,450,000 6,629,000 
        liabilities and shareholders' equity/members’ deficit
      		                                
        shareholders'/members’ deficit:
      		                                
        preferred a interests, no par value. authorized 100,000,000 units; 16,886,750 units issued and outstanding december 31, 2017
      		                                
        total shareholders' equity/members’ deficit
      		                              23,444,000  
        total liabilities and shareholders' equity/members’ deficit
      		                              90,010,000  
        assets:
      		                                
        liabilities and shareholders’ / members’ deficit
      		                                
        shareholders’ /members’ deficit
      		                                
        total shareholders‘/members’ deficit
      		                               -38,948,000 
        total liabilities and shareholders’ / members’ deficit
      		                               39,841,000 
        cost and expenses:
      		                                
        other income
      		                                
        other
      		                               -21,000 
        dividends on redeemable preferred interests
      		                                
        net income attributable to common shares / members’ interests
      		                               -36,493,000 
        net income per common share - basic and diluted
      		                               -1,900 
        weighted-average number of common shares / membership interests outstanding - basic and diluted
      		                               19,188,624,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 
                                       
          operating activities:
        		                               
          net loss
        		-8,057,000 -31,860,000 -15,446,000 -13,548,000 -22,930,000           -16,302,000 -13,220,000 -28,945,000 -14,555,000 -12,367,000 -14,672,000 -20,368,000 -16,551,000 -2,334,000 -16,530,000 -12,636,000 -18,412,000     
          adjustments to reconcile net loss to net cash from operating activities:
        		                               
          depreciation, amortization, and impairment
        		113,000  139,000 140,000 139,000 147,000 159,000 205,000 207,000 467,000 264,000 289,000 325,000 397,000 596,000 667,000 727,000 731,000 736,000 742,000 755,000           
          share-based compensation
        		2,318,000 1,376,000 2,777,000 1,884,000 1,587,000 2,403,000 1,577,000 1,539,000 1,580,000 940,000 774,000 631,000 344,000 714,000 535,000 2,219,000 913,000 1,691,000 1,900,000 1,721,000 1,507,000 1,529,000 1,427,000 1,765,000 1,860,000 1,872,000 1,869,000 1,810,000 1,520,000   
          issuance of warrants
        		916,000                               
          amortization of debt issuance costs and discounts
        		2,286,000 2,749,000 2,748,000 2,748,000 2,750,000 2,699,000 2,673,000 2,669,000 2,673,000 1,798,000 59,000 59,000 56,000 58,000 48,000 69,000 40,000 127,000 1,216,000 1,204,000 1,184,000 829,000 591,000 583,000 584,000 591,000 557,000 392,000 389,000 399,000 374,000 
          other
        		6,000   -57,000 46,000 33,000 52,000 -13,000 32,000 35,000 28,000 -7,000 -260,000 -112,000 221,000 -61,000 -100,000 -51,000 -123,000 -292,000 167,000      31,000 36,000 -51,000   
          changes in operating assets and liabilities:
        		                               
          trade and other receivables
        		10,896,000  63,000 -1,347,000 -3,129,000  -3,714,000 2,339,000 147,000  1,551,000 -2,511,000 -2,217,000  8,206,000 729,000 -7,678,000  -1,334,000 -2,018,000 -3,374,000  4,728,000      -963,000   
          inventories
        		-1,896,000 1,714,000 241,000 -927,000 -1,154,000 977,000 -55,000 768,000 -965,000 310,000 -1,129,000 1,031,000 -1,201,000 944,000 -1,717,000 -379,000 -591,000 -1,175,000 -24,000 -40,000 -338,000 781,000 -69,000 -86,000 -228,000 1,265,000 523,000 490,000 304,000 -958,000 -135,000 
          prepaid expenses and other assets
        		-340,000 -685,000 -1,721,000 2,681,000 423,000 -1,306,000 -788,000 2,124,000 -253,000 73,000 -595,000 2,007,000 -195,000 -712,000 -335,000 2,676,000 -230,000 -535,000 -739,000 3,067,000 -535,000 -852,000 -675,000        -710,000 
          accounts payable
        		-17,973,000 19,247,000 -1,306,000 -323,000 1,905,000 2,636,000 1,876,000 -3,014,000 1,284,000 -1,068,000 -695,000 -1,751,000 2,494,000 -1,125,000 2,184,000 392,000 182,000 2,099,000 -1,885,000 1,413,000 -402,000           
          accrued expenses and other liabilities
        		-2,803,000 5,090,000 118,000 600,000 -2,776,000 916,000 -662,000 127,000 -1,873,000 954,000 1,174,000 -1,171,000 -3,472,000 5,000 -336,000 1,942,000 -3,963,000 1,202,000 925,000 -470,000 -2,501,000           
          deferred revenue
        		-272,000 -272,000 -273,000 235,000 -261,000 -261,000 -1,489,000 -10,705,000 -388,000 -1,473,000 -1,743,000 -692,000 4,874,000 14,534,000 3,307,000 -400,000 7,602,000 -196,000 1,090,000 1,857,000 810,000 -90,000 -254,000 -202,000 -282,000 2,192,000 96,000 -239,000 -448,000 -60,000 -453,000 
          net cash from operating activities
        		-14,806,000 -8,469,000 -12,649,000 -7,914,000 -23,400,000 -6,489,000 -11,880,000 -7,006,000 -10,384,000 -4,942,000 -2,347,000 -7,907,000 8,816,000 8,446,000 2,809,000 -6,562,000 -14,482,000 -8,061,000 -9,065,000 -1,756,000 -14,097,000 -13,512,000 -8,313,000 -9,997,000 -13,637,000 -10,575,000 -14,789,000 -17,166,000 -17,680,000 -2,812,000 -11,475,000 
          investing activities:
        		                               
          capital expenditures
        		-52,000 -85,000 -235,000 -107,000 -135,000 -15,000 -80,000 -35,000 -29,000 -16,000 -151,000 -826,000 -2,000 -26,000 -217,000 -677,000 -104,000 -533,000 -83,000 -194,000 -103,000 -236,000 -38,000 -112,000 -131,000 -86,000 -91,000 -110,000 -376,000 -490,000 -448,000 
          free cash flows
        		-14,858,000 -8,554,000 -12,884,000 -8,021,000 -23,535,000 -6,504,000 -11,960,000 -7,041,000 -10,413,000 -4,958,000 -2,498,000 -8,733,000 8,814,000 8,420,000 2,592,000 -7,239,000 -14,586,000 -8,594,000 -9,148,000 -1,950,000 -14,200,000 -13,748,000 -8,351,000 -10,109,000 -13,768,000 -10,661,000 -14,880,000 -17,276,000 -18,056,000 -3,302,000 -11,923,000 
          net cash from investing activities
        		-52,000 -85,000 -235,000 -107,000 -135,000 -15,000 -80,000 -35,000 -29,000 -16,000 -151,000 -826,000 -2,000 -26,000 -1,717,000 -677,000 -104,000 -533,000 -83,000 -194,000 -103,000 -236,000 -38,000 -112,000 -131,000  -91,000     
          financing activities:
        		                               
          proceeds from common stock issued under public equity offering-atm
        		4,759,000  -9,000 -124,000 21,360,000                           
          proceeds from exercise of stock options
        		1,000 924,000 339,000   0 193,000 0 539,000                       
          repayment of debt principal including lease liabilities
        		-8,000 -5,000 -7,000 -8,000 -6,000 -5,000 -8,000 -5,000 -5,000  -5,000                     
          payments for royalty obligations
        		 0 0 -6,000 -5,000                           
          payments for taxes on share-based compensation
        		-329,000 -18,000 -70,000 -19,000 -703,000 -1,000 -202,000 -5,000 -893,000 0 0 -3,000 -8,000 0    -1,000 -9,000   -3,000 -7,000 -52,000 -37,000 -104,000 -59,000 -55,000 -2,609,000 -124,000 -280,000 
          net cash from financing activities
        		4,423,000 660,000 81,411,000 -100,000 20,646,000 157,000 -17,000 1,711,000 81,741,000 3,913,000 4,979,000 4,287,000 -9,205,000 204,000 -138,000 10,198,000 1,298,000 5,454,000 6,078,000 8,686,000 9,891,000 28,491,000 -7,000 10,000 -37,000 39,073,000 13,629,000   -81,000 65,267,000 
          net increase in cash and cash equivalents
        		-10,435,000 -7,894,000 68,527,000 -8,121,000 -2,889,000 -6,347,000 -11,977,000 -5,330,000 71,328,000  2,481,000 -4,446,000 -391,000  954,000           28,412,000    -3,383,000 53,344,000 
          cash and cash equivalents:
        		                               
          cash and cash equivalents at beginning of period
        		121,169,000  0 0 71,546,000  0 0 23,872,000  0 0 27,273,000  0 0 28,024,000  0             
          cash and cash equivalents at end of period
        		110,734,000  68,527,000 -8,121,000 68,657,000  -11,977,000 -5,330,000 95,200,000  2,481,000 -4,446,000 26,882,000  954,000 2,959,000 14,736,000  -3,070,000             
          supplemental disclosures of cash flow information:
        		                               
          cash payments for interest
        		1,524,000 1,524,000 1,524,000 1,525,000 1,525,000 1,531,000 3,038,000 1,525,000 1,003,000 1,775,000 7,000 1,354,000 1,466,000 4,827,000 0 0 1,609,000 1,610,000 1,609,000 1,609,000 1,610,000 1,929,000 2,187,000 2,187,000 2,188,000 2,187,000 2,576,000 1,568,000 1,009,000 1,538,000 1,541,000 
          costs associated with public offering-atm in accounts payable
        		                               
          cash flows from operating activities:
        		                               
          depreciation and amortization
        		                      653,000 797,000 887,000 762,000 696,000 711,000 736,000 748,000 733,000 
          gain on contract termination
        		     0 0                         
          trade receivables and other receivables
        		                        3,738,000       
          cash flows from investing activities:
        		                               
          cash flows from financing activities:
        		                               
          proceeds from issuance of common stock under public equity offering-atm
        		                               
          proceeds from common stock issued under public equity offering
        		 -268,000    0 0 1,848,000 70,126,000  184,000 4,174,000 916,000  544,000                 
          proceeds from exercise of warrants
        		 0                              
          proceeds from shares issued under employee stock purchase plan
        		 60,000 0   37,000 0   8,000 0   19,000 0   82,000 0    0         
          beginning of period
        		                    31,807,000 0 0 0 49,326,000 0 0 0 60,599,000 0 0 
          end of period
        		                    27,498,000 14,743,000 -8,358,000 -10,099,000 35,521,000 28,412,000 -1,251,000 -17,769,000 39,934,000 -3,383,000 53,344,000 
          cash payments for income taxes
        		     0 0                         
          cash refunds received for income taxes
        		                               
          non-cash investing activities: capital expenditures in accounts payable
        		 12,000 -43,000                             
          non-cash financing activities: accrued taxes on share-based compensation
        		                               
          costs associated with public offering in accounts payable
        		        313,000                       
          costs associated with public equity offering in accounts payable
        		                               
          costs associated with public equity offering-atm in accounts payable
        		    89,000                           
          loss on the extinguishment of debt
        		                               
          proceeds from issuance of debt
        		                               
          proceeds from issuance of royalty rights agreements
        		                               
          payments for financing costs
        		                               
          premium paid to retire debt
        		         -1,075,000 0 0 -1,027,000 -675,000 -675,000           0      
          net income
        		      -11,509,000 -2,745,000 -12,828,000  -2,035,000 -5,792,000 8,068,000                -14,726,000   
          adjustments to reconcile net income to net cash from operating activities:
        		                               
          proceeds from common stock issued under public equity offering, net - atm
        		      0 -157,000 11,974,000                       
          proceeds from issuance and exercise of warrants
        		          4,800,000    -4,000                 
          interest expense related to the sale of future revenue
        		             0 1,961,000 1,886,000 1,836,000 1,796,000 3,728,000 3,427,000 3,302,000           
          notes payable
        		                               
          additions to intangible assets
        		             0                  
          proceeds from issuance of common stock under public equity offering
        		                               
          proceeds from common stock and warrants issued under private equity offering
        		                               
          debt repayments
        		                               
          net decrease in cash and cash equivalents
        		                -13,288,000 -3,140,000   -4,309,000 14,743,000 -8,358,000 -10,099,000 -13,805,000   -17,769,000 -20,665,000   
          loans payable
        		             0                  
          proceeds from common stock issued under private equity offering
        		             0 0                 
          repayment of debt principal
        		            -9,086,000                   
          proceeds from issuance of common stock under public equity offering, warrants and warrant exercises
        		                               
          proceeds from issuance of common stock
        		                1,298,000  6,087,000 8,614,000 9,891,000           
          proceeds from issuance of common stock and warrant exercises
        		                               
          proceeds from sale of future revenue
        		                               
          debt repayment
        		                         0 -49,450,000     
          debt issued in lieu of prepayment penalty
        		                               
          cash flows used for operating activities:
        		                               
          cash flows used for investing activities:
        		                               
          cash flows used for financing activities:
        		                               
          net decrease in capital expenditures included in accounts payable and accrued expenses
        		                    -71,000           
          adjustments to reconcile net loss to net cash (used for) operating activities:
        		                               
          all other non-cash expenses
        		                     154,000 173,000 5,000 -144,000       
          net increase in capital expenditures included in accounts payable and accrued expenses:
        		                               
          deferred financing costs charged to additional paid in capital
        		                               
          warrants issued in connection with long-term debt
        		                         0      
          loss on extinguishment of debt
        		                               
          accounts payable and accrued expenses
        		                      1,664,000 -662,000 -3,575,000  -3,803,000 1,477,000 -3,306,000  -839,000 
          proceeds from issuance of long-term debt
        		                               
          payments for loan acquisition costs
        		                               
          net increase in offering costs included in accounts payable and accrued expenses
        		                               
          net (decrease) in capital expenditures included in accounts payable and accrued expenses
        		                               
          net increase in financing costs included in accounts payable and accrued expenses
        		                           -161,000 311,000   
          non-cash interest expense
        		                          -481,000 -22,000 527,000   
          prepaid expenses and other current assets
        		                        53,000   1,299,000 -1,715,000   
          net (decrease) in accrued capital expenditures
        		                        -84,000       
          accrued withholding tax for share based compensation
        		                        -1,000    -4,000 814,000  
          change in fair value of warrant
        		                             0 4,116,000 
          accrued expenses
        		                               
          net cash (used for) investing activities
        		                            -376,000 -490,000 -448,000 
          noncash component of warrants exercised
        		                             0  
          asset retirement obligation accretion
        		                          36,000 36,000 34,000 28,000 33,000 
          amortization of intangible
        		                          13,000 13,000 13,000 12,000 13,000 
          bad debt provision
        		                          6,000 24,000 6,000 -17,000 -11,000 
          accounts receivable
        		                              -810,000 
          proceeds from initial offering of common stock
        		                             0  
          proceeds from common stock issued via employee stock purchase plan
        		                               
          payments for deferred offering costs
        		                               
          proceeds from common stock issued under employee stock purchase plan
        		                               
          payments for deferred financing costs
        		                               
          net increase in accrued capital expenditures
        		                           -60,000 -253,000   
          net cash (used for) financing activities
        		                            -2,609,000   
          proceeds from warrant exercise
        		                               
          accrued series a-2 and a-3 preferred dividends
        		                               
          share-based compensation expenses
        		                              1,236,000 
          noncash interest expense
        		                               
          net increase in capital expenditures included in accounts payable and accrued expenses
        		                              -270,000 
          net (decrease) in deferred offering costs included in accounts payable and accrued expenses
        		                               
          reclass of deferred offering costs charged to additional paid in capital
        		                               
          accrued withholding tax for share-based compensation