7Baggers

Amgen Inc
(NASDAQ:AMGN) 

AMGN stock logo

Amgen Inc. discovers, develops, manufactures, and delivers human therapeutics worldwide. It focuses on inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology and neuroscience areas. The company's products include Enbrel to treat plaque psoriasis, rheumatoid arthritis, and...

Founded: 1980
Full Time Employees: 23,400
Sector: Healthcare
Industry: Drug Manufacturers-General

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Quarterly
Annual
    Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 
                                                                           
      revenues:
                                                                           
      product sales
    9,367,000,000 9,137,000,000 8,771,000,000 7,873,000,000 8,716,000,000 8,151,000,000 8,041,000,000 7,118,000,000 7,833,000,000 6,548,000,000 6,683,000,000 5,846,000,000 6,552,000,000 6,237,000,000 6,281,000,000 5,731,000,000 6,271,000,000 6,320,000,000 6,114,000,000 5,592,000,000 6,334,000,000 6,104,000,000 5,908,000,000 5,894,000,000 5,881,000,000 5,463,000,000 5,574,000,000 5,286,000,000 6,001,000,000 5,510,000,000 5,679,000,000 5,343,000,000 5,569,000,000 5,453,000,000 5,574,000,000 5,199,000,000 5,663,000,000 5,516,000,000 5,474,000,000 5,239,000,000 5,329,000,000 5,516,000,000 5,225,000,000 4,874,000,000 5,174,000,000 4,848,000,000 4,949,000,000 4,356,000,000 4,799,000,000 4,647,000,000 4,595,000,000 4,151,000,000 4,337,000,000 4,201,000,000 4,200,000,000 3,901,000,000 3,877,000,000 3,893,000,000 3,618,000,000 3,760,000,000 3,759,000,000 3,613,000,000 3,528,000,000 3,743,000,000 3,736,000,000 3,634,000,000 3,238,000,000 3,674,000,000 3,784,000,000 3,692,000,000 3,537,000,000 
      other revenues
    499,000,000 420,000,000 408,000,000 276,000,000 370,000,000 352,000,000 347,000,000 329,000,000 363,000,000 355,000,000 303,000,000 259,000,000 287,000,000 415,000,000 313,000,000 507,000,000 575,000,000 386,000,000 412,000,000 309,000,000 300,000,000 319,000,000 298,000,000 267,000,000 316,000,000 274,000,000 297,000,000 271,000,000 229,000,000 394,000,000 380,000,000 211,000,000 233,000,000 320,000,000 236,000,000 265,000,000 302,000,000 295,000,000 214,000,000 288,000,000 207,000,000 207,000,000 145,000,000 159,000,000 157,000,000 183,000,000 231,000,000 165,000,000 212,000,000 101,000,000 84,000,000 87,000,000 84,000,000 118,000,000 277,000,000 147,000,000 67,000,000 66,000,000 88,000,000 81,000,000 57,000,000 191,000,000 64,000,000 66,000,000 76,000,000 79,000,000 70,000,000 77,000,000 91,000,000 72,000,000 76,000,000 
      total revenues
    9,866,000,000 9,557,000,000 9,179,000,000 8,149,000,000 9,086,000,000 8,503,000,000 8,388,000,000 7,447,000,000 8,196,000,000 6,903,000,000 6,986,000,000 6,105,000,000 6,839,000,000 6,652,000,000 6,594,000,000 6,238,000,000 6,846,000,000 6,706,000,000 6,526,000,000 5,901,000,000 6,634,000,000 6,423,000,000 6,206,000,000 6,161,000,000 6,197,000,000 5,737,000,000 5,871,000,000 5,557,000,000 6,230,000,000 5,904,000,000 6,059,000,000 5,554,000,000 5,802,000,000 5,773,000,000 5,810,000,000 5,464,000,000 5,965,000,000 5,811,000,000 5,688,000,000 5,527,000,000 5,536,000,000 5,723,000,000 5,370,000,000 5,033,000,000 5,331,000,000 5,031,000,000 5,180,000,000 4,521,000,000 5,011,000,000 4,748,000,000 4,679,000,000 4,238,000,000 4,421,000,000 4,319,000,000 4,477,000,000 4,048,000,000 3,944,000,000 3,959,000,000 3,706,000,000 3,841,000,000 3,816,000,000 3,804,000,000 3,592,000,000 3,809,000,000 3,812,000,000 3,713,000,000 3,308,000,000 3,751,000,000 3,875,000,000 3,764,000,000 3,613,000,000 
      yoy
    8.58% 12.40% 9.43% 9.43% 10.86% 23.18% 20.07% 21.98% 19.84% 3.77% 5.94% -2.13% -0.10% -0.81% 1.04% 5.71% 3.20% 4.41% 5.16% -4.22% 7.05% 11.96% 5.71% 10.87% -0.53% -2.83% -3.10% 0.05% 7.38% 2.27% 4.29% 1.65% -2.73% -0.65% 2.14% -1.14% 7.75% 1.54% 5.92% 9.82% 3.85% 13.75% 3.67% 11.32% 6.39% 5.96% 10.71% 6.68% 13.35% 9.93% 4.51% 4.69% 12.09% 9.09% 20.80% 5.39% 3.35% 4.07% 3.17% 0.84% 0.10% 2.45% 8.59% 1.55% -1.63% -1.35% -8.44%     
      qoq
    3.23% 4.12% 12.64% -10.31% 6.86% 1.37% 12.64% -9.14% 18.73% -1.19% 14.43% -10.73% 2.81% 0.88% 5.71% -8.88% 2.09% 2.76% 10.59% -11.05% 3.29% 3.50% 0.73% -0.58% 8.02% -2.28% 5.65% -10.80% 5.52% -2.56% 9.09% -4.27% 0.50% -0.64% 6.33% -8.40% 2.65% 2.16% 2.91% -0.16% -3.27% 6.57% 6.70% -5.59% 5.96% -2.88% 14.58% -9.78% 5.54% 1.47% 10.41% -4.14% 2.36% -3.53% 10.60% 2.64% -0.38% 6.83% -3.51% 0.66% 0.32% 5.90% -5.70% -0.08% 2.67% 12.24% -11.81% -3.20% 2.95% 4.18%  
      operating expenses:
                                                                           
      cost of sales
    2,976,000,000 3,082,000,000 3,011,000,000 2,968,000,000 3,112,000,000 3,310,000,000 3,236,000,000 3,200,000,000 3,112,000,000 1,806,000,000 1,813,000,000 1,720,000,000 1,747,000,000 1,588,000,000 1,510,000,000 1,561,000,000 1,718,000,000 1,609,000,000 1,637,000,000 1,490,000,000 1,597,000,000 1,561,000,000 1,488,000,000 1,513,000,000 1,253,000,000 1,036,000,000 1,012,000,000 1,055,000,000 1,096,000,000 1,037,000,000 1,024,000,000 944,000,000 1,059,000,000 990,000,000 1,024,000,000 996,000,000 1,067,000,000 1,027,000,000 1,050,000,000 1,018,000,000 1,071,000,000 1,034,000,000 1,089,000,000 1,033,000,000 1,183,000,000 1,068,000,000 1,081,000,000 1,090,000,000 1,029,000,000 788,000,000 785,000,000 744,000,000 852,000,000 705,000,000 682,000,000 679,000,000 605,000,000 602,000,000 564,000,000 572,000,000 587,000,000 553,000,000 508,000,000 538,000,000 545,000,000 531,000,000 477,000,000 558,000,000 677,000,000 515,000,000 546,000,000 
      research and development
    2,142,000,000 1,900,000,000 1,744,000,000 1,486,000,000 1,724,000,000 1,450,000,000 1,447,000,000 1,343,000,000 1,534,000,000 1,079,000,000 1,113,000,000 1,058,000,000 1,324,000,000 1,112,000,000 1,039,000,000 959,000,000 1,348,000,000 1,422,000,000 1,082,000,000 967,000,000 1,229,000,000 1,062,000,000 964,000,000 952,000,000 1,312,000,000 1,001,000,000 924,000,000 879,000,000 1,182,000,000 926,000,000 869,000,000 760,000,000 1,043,000,000 877,000,000 873,000,000 769,000,000 1,078,000,000 990,000,000 900,000,000 872,000,000 1,093,000,000 1,119,000,000 964,000,000 894,000,000 1,234,000,000 1,018,000,000 1,018,000,000 1,027,000,000 1,249,000,000 989,000,000 967,000,000 878,000,000 938,000,000 880,000,000 826,000,000 736,000,000 761,000,000 819,000,000 736,000,000 854,000,000 719,000,000 675,000,000 646,000,000 891,000,000 647,000,000 693,000,000 633,000,000 798,000,000 729,000,000 809,000,000 694,000,000 
      selling, general and administrative
    1,952,000,000 1,720,000,000 1,691,000,000 1,687,000,000 1,878,000,000 1,625,000,000 1,785,000,000 1,808,000,000 2,274,000,000 1,353,000,000 1,294,000,000 1,258,000,000 1,572,000,000 1,287,000,000 1,327,000,000 1,228,000,000 1,425,000,000 1,305,000,000 1,384,000,000 1,254,000,000 1,773,000,000 1,346,000,000 1,295,000,000 1,316,000,000 1,513,000,000 1,223,000,000 1,260,000,000 1,154,000,000 1,559,000,000 1,293,000,000 1,353,000,000 1,127,000,000 1,427,000,000 1,170,000,000 1,209,000,000 1,064,000,000 1,323,000,000 1,244,000,000 1,292,000,000 1,203,000,000 1,416,000,000 1,244,000,000 1,160,000,000 1,026,000,000 1,327,000,000 1,213,000,000 1,136,000,000 1,023,000,000 1,521,000,000 1,249,000,000 1,256,000,000 1,158,000,000 1,370,000,000 1,127,000,000 1,228,000,000 1,076,000,000 1,125,000,000 1,130,000,000 1,023,000,000 1,156,000,000 957,000,000 986,000,000 884,000,000 1,180,000,000 932,000,000 910,000,000 798,000,000 1,111,000,000 900,000,000 904,000,000 874,000,000 
      other
    76,000,000 329,000,000 77,000,000 830,000,000 61,000,000 71,000,000 11,000,000 105,000,000 5,000,000 644,000,000 82,000,000 148,000,000 -34,000,000 5,000,000 542,000,000 -10,000,000 51,000,000 -8,000,000 90,000,000 61,000,000 27,000,000 1,000,000 136,000,000 25,000,000 71,000,000 1,000,000 -3,000,000 -3,000,000 11,000,000 325,000,000 -19,000,000 -3,000,000 28,000,000 297,000,000 6,000,000 44,000,000 12,000,000 23,000,000 66,000,000 32,000,000 -77,000,000 -13,000,000 81,000,000 58,000,000 128,000,000 266,000,000 43,000,000 17,000,000 25,000,000 34,000,000 121,000,000 16,000,000 100,000,000 110,000,000 79,000,000 6,000,000 854,000,000 3,000,000 16,000,000 -250,000   -1,000,000        10,000,000 
      total operating expenses
    7,146,000,000 7,031,000,000 6,523,000,000 6,971,000,000 6,775,000,000 6,456,000,000 6,479,000,000 6,456,000,000 6,925,000,000 4,882,000,000 4,302,000,000 4,184,000,000 4,609,000,000 3,992,000,000 4,418,000,000 3,738,000,000 4,542,000,000 4,328,000,000 5,698,000,000 3,772,000,000 4,626,000,000 3,970,000,000 3,883,000,000 3,806,000,000 4,149,000,000 3,261,000,000 3,193,000,000 3,085,000,000 3,848,000,000 3,581,000,000 3,227,000,000 2,828,000,000 3,557,000,000 3,334,000,000 3,112,000,000 2,873,000,000 3,480,000,000 3,284,000,000 3,308,000,000 3,125,000,000 3,503,000,000 3,384,000,000 3,294,000,000 3,011,000,000 3,872,000,000 3,565,000,000 3,278,000,000 3,157,000,000 3,824,000,000 3,060,000,000 3,129,000,000 2,796,000,000 3,333,000,000 2,896,000,000 2,888,000,000 2,571,000,000 3,419,000,000 2,627,000,000 2,413,000,000 1,683,750,000 2,337,000,000 2,287,000,000 2,111,000,000 2,686,000,000 2,207,000,000 2,256,000,000 1,987,000,000 2,614,000,000 2,392,000,000 2,585,000,000 2,198,000,000 
      operating income
    2,720,000,000 2,526,000,000 2,656,000,000 1,178,000,000 2,311,000,000 2,047,000,000 1,909,000,000 991,000,000 1,271,000,000 2,021,000,000 2,684,000,000 1,921,000,000 2,230,000,000 2,660,000,000 2,176,000,000 2,500,000,000 2,304,000,000 2,378,000,000 828,000,000 2,129,000,000 2,008,000,000 2,453,000,000 2,323,000,000 2,355,000,000 2,048,000,000 2,476,000,000 2,678,000,000 2,472,000,000 2,382,000,000 2,323,000,000 2,832,000,000 2,726,000,000 2,245,000,000 2,439,000,000 2,698,000,000 2,591,000,000 2,485,000,000 2,527,000,000 2,380,000,000 2,402,000,000 2,033,000,000 2,339,000,000 2,076,000,000 2,022,000,000 1,459,000,000 1,466,000,000 1,902,000,000 1,364,000,000 1,187,000,000 1,688,000,000 1,550,000,000 1,442,000,000 1,088,000,000 1,423,000,000 1,589,000,000 1,477,000,000 525,000,000 1,332,000,000 1,293,000,000 1,119,250,000 1,479,000,000 1,517,000,000 1,481,000,000 1,123,000,000 1,605,000,000 1,457,000,000 1,321,000,000 1,137,000,000 1,483,000,000 1,179,000,000 1,415,000,000 
      yoy
    17.70% 23.40% 39.13% 18.87% 81.83% 1.29% -28.87% -48.41% -43.00% -24.02% 23.35% -23.16% -3.21% 11.86% 162.80% 17.43% 14.74% -3.06% -64.36% -9.60% -1.95% -0.93% -13.26% -4.73% -14.02% 6.59% -5.44% -9.32% 6.10% -4.76% 4.97% 5.21% -9.66% -3.48% 13.36% 7.87% 22.23% 8.04% 14.64% 18.79% 39.34% 59.55% 9.15% 48.24% 22.91% -13.15% 22.71% -5.41% 9.10% 18.62% -2.45% -2.37% 107.24% 6.83% 22.89% 31.96% -64.50% -12.20% -12.69% -0.33% -7.85% 4.12% 12.11% -1.23% 8.23% 23.58% -6.64%     
      qoq
    7.68% -4.89% 125.47% -49.03% 12.90% 7.23% 92.63% -22.03% -37.11% -24.70% 39.72% -13.86% -16.17% 22.24% -12.96% 8.51% -3.11% 187.20% -61.11% 6.03% -18.14% 5.60% -1.36% 14.99% -17.29% -7.54% 8.33% 3.78% 2.54% -17.97% 3.89% 21.43% -7.95% -9.60% 4.13% 4.27% -1.66% 6.18% -0.92% 18.15% -13.08% 12.67% 2.67% 38.59% -0.48% -22.92% 39.44% 14.91% -29.68% 8.90% 7.49% 32.54% -23.54% -10.45% 7.58% 181.33% -60.59% 3.02% 15.52% -24.32% -2.50% 2.43% 31.88% -30.03% 10.16% 10.30% 16.18% -23.33% 25.78% -16.68%  
      operating margin %
    27.57% 26.43% 28.94% 14.46% 25.43% 24.07% 22.76% 13.31% 15.51% 29.28% 38.42% 31.47% 32.61% 39.99% 33.00% 40.08% 33.65% 35.46% 12.69% 36.08% 30.27% 38.19% 37.43% 38.22% 33.05% 43.16% 45.61% 44.48% 38.23% 39.35% 46.74% 49.08% 38.69% 42.25% 46.44% 47.42% 41.66% 43.49% 41.84% 43.46% 36.72% 40.87% 38.66% 40.17% 27.37% 29.14% 36.72% 30.17% 23.69% 35.55% 33.13% 34.03% 24.61% 32.95% 35.49% 36.49% 13.31% 33.64% 34.89% 29.14% 38.76% 39.88% 41.23% 29.48% 42.10% 39.24% 39.93% 30.31% 38.27% 31.32% 39.16% 
      other income:
                                                                           
      interest expense
    -653,000,000 -685,000,000 -694,000,000 -723,000,000 -747,000,000 -776,000,000 -808,000,000 -824,000,000 -821,000,000 -759,000,000 -752,000,000 -543,000,000 -415,000,000 -368,000,000 -328,000,000 -295,000,000 -335,000,000 -296,000,000 -281,000,000 -285,000,000 318,000,000 302,000,000 296,000,000 346,000,000 301,000,000 313,000,000 332,000,000 343,000,000 352,000,000 355,000,000 347,000,000 338,000,000 332,000,000 325,000,000 321,000,000 326,000,000 328,000,000 325,000,000 313,000,000 294,000,000 284,000,000 282,000,000 277,000,000 252,000,000 261,000,000 269,000,000 282,000,000 259,000,000 261,000,000 257,000,000 241,000,000 263,000,000 291,000,000 271,000,000 256,000,000 235,000,000 158,000,000 122,000,000 135,000,000 110,500,000 150,000,000 147,000,000 145,000,000 142,000,000 139,000,000 150,000,000      
      other income
    -553,000,000 2,080,000,000 -394,000,000 1,518,000,000 -782,000,000 1,830,000,000 -307,000,000 -235,000,000 402,000,000 685,000,000 -318,000,000 2,064,000,000 -67,000,000 100,000,000 -317,000,000 -530,000,000 162,000,000 73,000,000 11,000,000 13,000,000                                                    
      income before income taxes
    1,514,000,000 3,921,000,000 1,568,000,000 1,973,000,000 782,000,000 3,101,000,000 794,000,000 -68,000,000 852,000,000 1,947,000,000 1,614,000,000 3,442,000,000 1,748,000,000 2,392,000,000 1,531,000,000 1,675,000,000 2,131,000,000 2,155,000,000 558,000,000 1,857,000,000 1,877,000,000 2,206,000,000 2,030,000,000 2,020,000,000 1,983,000,000 2,277,000,000 2,564,000,000 2,314,000,000 2,185,000,000 2,094,000,000 2,647,000,000 2,619,000,000 2,214,000,000 2,381,000,000 2,542,000,000 2,460,000,000 2,283,000,000 2,418,000,000 2,204,000,000 2,258,000,000 1,913,000,000 2,192,000,000 1,997,000,000 1,876,000,000 1,286,000,000 1,337,000,000 1,758,000,000 1,204,000,000 1,014,000,000 1,503,000,000 1,405,000,000 1,343,000,000 923,000,000 1,263,000,000 1,457,000,000 1,366,000,000 454,000,000 1,339,000,000 1,306,000,000 1,079,500,000 1,434,000,000 1,464,000,000 1,420,000,000 1,075,000,000 1,540,000,000 1,357,000,000 1,232,000,000 1,154,000,000 1,471,000,000 1,188,000,000 1,437,000,000 
      provision for income taxes
    181,000,000 705,000,000 136,000,000 243,000,000 155,000,000 271,000,000 48,000,000 45,000,000 85,000,000 217,000,000 235,000,000 601,000,000 132,000,000 249,000,000 214,000,000 199,000,000 232,000,000 271,000,000 94,000,000 211,000,000 262,000,000 185,000,000 227,000,000 195,000,000 280,000,000 309,000,000 385,000,000 322,000,000 257,000,000 235,000,000 351,000,000 308,000,000   391,000,000 389,000,000                                    
      net income
    1,333,000,000 3,216,000,000 1,432,000,000 1,730,000,000 627,000,000 2,830,000,000 746,000,000 -113,000,000 767,000,000 1,730,000,000 1,379,000,000 2,841,000,000 1,616,000,000 2,143,000,000 1,317,000,000 1,476,000,000 1,899,000,000 1,884,000,000 464,000,000 1,646,000,000 1,615,000,000 2,021,000,000 1,803,000,000 1,825,000,000 1,703,000,000 1,968,000,000 2,179,000,000 1,992,000,000 1,928,000,000 1,859,000,000 2,296,000,000 2,311,000,000 -4,264,000,000 2,021,000,000 2,151,000,000 2,071,000,000 1,935,000,000 2,017,000,000 1,870,000,000 1,900,000,000 1,800,000,000 1,863,000,000 1,653,000,000 1,623,000,000 1,294,000,000 1,244,000,000 1,547,000,000 1,073,000,000 1,021,000,000 1,368,000,000 1,258,000,000 1,434,000,000 788,000,000 1,107,000,000 1,266,000,000 1,184,000,000 454,000,000 1,170,000,000 1,125,000,000 1,022,000,000 1,236,000,000 1,202,000,000 1,167,000,000 931,000,000 1,386,000,000 1,269,000,000 1,019,000,000 961,000,000 1,158,000,000 941,000,000 1,136,000,000 
      yoy
    112.60% 13.64% 91.96% -1630.97% -18.25% 63.58% -45.90% -103.98% -52.54% -19.27% 4.71% 92.48% -14.90% 13.75% 183.84% -10.33% 17.59% -6.78% -74.27% -9.81% -5.17% 2.69% -17.26% -8.38% -11.67% 5.86% -5.10% -13.80% -145.22% -8.02% 6.74% 11.59% -320.36% 0.20% 15.03% 9.00% 7.50% 8.27% 13.13% 17.07% 39.10% 49.76% 6.85% 51.26% 26.74% -9.06% 22.97% -25.17% 29.57% 23.58% -0.63% 21.11% 73.57% -5.38% 12.53% 15.85% -63.27% -2.66% -3.60% 9.77% -10.82% -5.28% 14.52% -3.12% 19.69% 34.86% -10.30%     
      qoq
    -58.55% 124.58% -17.23% 175.92% -77.84% 279.36% -760.18% -114.73% -55.66% 25.45% -51.46% 75.80% -24.59% 62.72% -10.77% -22.27% 0.80% 306.03% -71.81% 1.92% -20.09% 12.09% -1.21% 7.16% -13.47% -9.68% 9.39% 3.32% 3.71% -19.03% -0.65% -154.20% -310.98% -6.04% 3.86% 7.03% -4.07% 7.86% -1.58% 5.56% -3.38% 12.70% 1.85% 25.43% 4.02% -19.59% 44.18% 5.09% -25.37% 8.74% -12.27% 81.98% -28.82% -12.56% 6.93% 160.79% -61.20% 4.00% 10.08% -17.31% 2.83% 3.00% 25.35% -32.83% 9.22% 24.53% 6.04% -17.01% 23.06% -17.17%  
      net income margin %
    13.51% 33.65% 15.60% 21.23% 6.90% 33.28% 8.89% -1.52% 9.36% 25.06% 19.74% 46.54% 23.63% 32.22% 19.97% 23.66% 27.74% 28.09% 7.11% 27.89% 24.34% 31.47% 29.05% 29.62% 27.48% 34.30% 37.11% 35.85% 30.95% 31.49% 37.89% 41.61% -73.49% 35.01% 37.02% 37.90% 32.44% 34.71% 32.88% 34.38% 32.51% 32.55% 30.78% 32.25% 24.27% 24.73% 29.86% 23.73% 20.38% 28.81% 26.89% 33.84% 17.82% 25.63% 28.28% 29.25% 11.51% 29.55% 30.36% 26.61% 32.39% 31.60% 32.49% 24.44% 36.36% 34.18% 30.80% 25.62% 29.88% 25.00% 31.44% 
      earnings per share:
                                                                           
      basic
    2.47 5.98 2.66 3.22 1.17 5.27 1.39 -0.21 1.44 3.23 2.58 5.32 3.02 4.01 2.46 2.69 3.36 3.32 0.81 2.85 2.79 3.45 3.07 3.09 2.88 3.29 3.59 3.2 3.03 2.88 3.5 3.27 -5.81 2.78 2.93 2.81 2.62 2.7 2.49 2.52 2.39 2.46 2.18 2.13 1.7 1.63 2.04 1.42 1.35 1.81 1.67 1.91 1.04 1.44 1.63 1.5 0.5 1.26 1.21 0.933 1.29 1.25 1.19 0.93 1.36 1.25 0.99 0.91 1.09 0.87 1.04 
      diluted
    2.46 5.93 2.65 3.2 1.16 5.22 1.38 -0.21 1.43 3.22 2.57 5.28 3.98 2.45 2.68 3.35 3.31 0.81 2.83 2.77 3.43 3.05 3.07 2.87 3.27 3.57 3.18 3.01 2.86 3.48 3.25 -5.77 2.76 2.91 2.79 2.61 2.68 2.47 2.5 2.36 2.44 2.15 2.11 1.68 1.61 2.01 1.4 1.33 1.79 1.65 1.88 1.01 1.41 1.61 1.48 0.5 1.25 1.2 0.928 1.28 1.25 1.18 0.93 1.36 1.25 0.98 0.9 1.09 0.87 1.04 
      weighted-average shares used for eps calculation
                                                                           
      basic
    538 538 538 538 537 537                                                                  
      diluted
    542 542 541 541 541 542                                                                  
      shares used in calculation of earnings per share:
                                                                           
      basic
          537 536  535 535 534 -1 535 535 548 -2 567 573 577 -2 585 588 590 -4 599 607 622 -8 645 656 707 -2 728 734 737 -4 747 751 753 -2 757 760 761 761 759 757 754 752 751 -4 771 776 791 907 927 933 241.5 958 959 982 -4 1,016 1,013 1,032 -5 1,058 1,078 1,089 
      diluted
          541 536  538 537 538 -1 538 537 551 -3 570 576 581 -2 589 592 594 -4 602 610 626 -8 649 660 711 -3 733 738 741 -4 753 756 760 -1 764 768 770 771 768 768 766 764 764 -2 783 785 800 914 935 941 242.75 962 964 988 -4 1,022 1,017 1,037 -4 1,064 1,081 1,092 
      acquired in-process research and development
                      1,505,000,000                                                     
      interest and other income
                        187,000,000 55,000,000 3,000,000 11,000,000 236,000,000 114,000,000 218,000,000 185,000,000 155,000,000 126,000,000 162,000,000 231,000,000 301,000,000 267,000,000 165,000,000 195,000,000 126,000,000 216,000,000 137,000,000 150,000,000 164,000,000 135,000,000 198,000,000 106,000,000 88,000,000 140,000,000 138,000,000 99,000,000 88,000,000 72,000,000 96,000,000 164,000,000 126,000,000 111,000,000 124,000,000 124,000,000 87,000,000 129,000,000 148,000,000 70,750,000 105,000,000 94,000,000 84,000,000 94,000,000 74,000,000 50,000,000 -89,000,000   9,000,000  
      dividends paid per share
                                0.99 1.32 1.32 1.32 0.863 1.15 1.15 1.15 0.75 0.593 0.79 0.79 0.79 0.458 0.61 0.61 0.61 0.353 0.47 0.47 0.47 0.27 0.36 0.36 0.36 0.28               
      benefit from income taxes
                                    285,000,000 360,000,000   273,250,000 401,000,000 334,000,000 358,000,000 113,000,000 329,000,000 344,000,000 253,000,000 -8,000,000 93,000,000 211,000,000  -7,000,000 135,000,000 147,000,000  135,000,000 156,000,000 191,000,000 182,000,000  169,000,000  178,250,000 198,000,000 262,000,000 253,000,000 144,000,000 154,000,000 88,000,000 213,000,000 193,000,000 313,000,000 247,000,000 301,000,000 
      benefit for income taxes
                                                   131,000,000    -91,000,000                    
      amortization of certain acquired intangible assets
                                                        73,000,000 74,000,000 73,000,000 74,000,000 74,000,000 73,000,000 74,000,000 73,000,000 74,000,000 73,000,000 74,000,000 73,000,000 74,000,000 73,000,000      
      provisions for income taxes
                                                              181,000,000             
      other charges
                                                                   4,000,000 9,000,000 49,000,000 5,000,000 74,000,000 12,000,000 284,000,000  
      amortization of acquired intangible assets
                                                                      74,000,000 73,000,000 74,000,000 73,000,000 74,000,000 
      write-off of acquired in-process research and development
                                                                           
      interest and other income and (expense)
                                                                       4,750,000 -12,000,000  22,000,000 
    Balance Sheets:
    Quarterly
    Annual
      Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 
                                                                             
        assets
                                                                             
        current assets:
                                                                             
        cash and cash equivalents
      9,129,000,000 9,445,000,000 8,028,000,000 8,810,000,000 11,973,000,000 9,011,000,000 9,301,000,000 9,708,000,000 10,944,000,000 34,741,000,000 34,248,000,000 31,560,000,000 7,629,000,000 9,502,000,000 5,203,000,000 6,528,000,000 7,989,000,000 11,969,000,000 6,630,000,000 6,112,000,000 6,266,000,000 9,087,000,000 9,145,000,000 7,687,000,000 6,037,000,000 11,415,000,000 5,525,000,000 7,358,000,000 6,945,000,000 11,956,000,000 10,131,000,000 9,741,000,000 3,800,000,000 3,000,000,000 2,629,000,000 3,358,000,000 3,241,000,000 3,485,000,000 2,630,000,000 2,896,000,000 4,144,000,000 3,226,000,000 3,795,000,000 2,864,000,000 3,731,000,000 3,677,000,000 4,352,000,000 3,687,000,000 3,805,000,000 8,281,000,000 5,806,000,000 2,530,000,000 3,257,000,000 5,823,000,000 5,849,000,000 4,207,000,000 3,891,000,000 5,998,000,000 1,266,000,000 3,287 2,951,000,000 1,712,000,000 2,266,000,000 2,884,000,000 3,577,000,000 2,968,000,000 2,777,000,000 1,774,000,000 2,522,000,000 3,392,000,000 4,324,000,000 
        trade receivables
      9,570,000,000 8,490,000,000 8,701,000,000 8,132,000,000 6,782,000,000 7,317,000,000 6,934,000,000 6,776,000,000 7,268,000,000 6,145,000,000 5,830,000,000 5,736,000,000 5,563,000,000 5,326,000,000 5,327,000,000 5,077,000,000 4,895,000,000 4,765,000,000 4,479,000,000 4,423,000,000 4,525,000,000 4,094,000,000 5,366,000,000 5,009,000,000 4,057,000,000 3,606,000,000 3,801,000,000 3,771,000,000 3,580,000,000 3,441,000,000 3,504,000,000 3,633,000,000 3,237,000,000 3,404,000,000 3,560,000,000 3,248,000,000 3,165,000,000 3,186,000,000 3,078,000,000 3,078,000,000 2,995,000,000 2,901,000,000 2,779,000,000 2,548,000,000 2,546,000,000 2,355,000,000 2,697,000,000 2,514,000,000 2,697,000,000 2,670,000,000 2,674,000,000 2,528,000,000 2,518,000,000 2,696,000,000 2,708,000,000 2,988,000,000 2,725,000,000 2,713,000,000 2,517,000,000 2,335 2,443,000,000 2,208,000,000 2,271,000,000 2,109,000,000 2,331,000,000 2,182,000,000 2,009,000,000 2,073,000,000 2,114,000,000 2,331,000,000 2,224,000,000 
        inventories
      6,225,000,000 6,346,000,000 6,583,000,000 6,729,000,000 6,998,000,000 7,362,000,000 7,995,000,000 8,724,000,000 9,518,000,000 5,026,000,000 4,978,000,000 5,011,000,000 4,930,000,000 4,757,000,000 4,554,000,000 4,411,000,000 4,086,000,000 4,152,000,000 4,115,000,000 4,017,000,000 3,893,000,000 3,942,000,000 3,840,000,000 3,682,000,000 3,584,000,000 3,243,000,000 3,176,000,000 3,016,000,000 2,940,000,000 3,017,000,000 3,063,000,000 2,952,000,000 2,834,000,000 2,927,000,000 2,961,000,000 2,871,000,000 2,745,000,000 2,681,000,000 2,671,000,000 2,572,000,000 2,435,000,000 2,531,000,000 2,567,000,000 2,686,000,000 2,647,000,000 2,885,000,000 2,954,000,000 2,966,000,000 3,019,000,000 2,838,000,000 2,773,000,000 2,737,000,000 2,744,000,000 2,769,000,000 2,592,000,000 2,499,000,000 2,357,000,000 2,230,000,000 2,098,000,000 2,022 2,044,000,000 2,112,000,000 2,202,000,000 2,220,000,000 2,155,000,000 2,061,000,000 2,080,000,000 2,075,000,000 2,004,000,000 2,134,000,000 2,091,000,000 
        other current assets
      4,133,000,000 3,604,000,000 3,422,000,000 3,258,000,000 3,277,000,000 3,076,000,000 2,976,000,000 2,821,000,000 2,602,000,000 2,565,000,000 2,324,000,000 2,395,000,000 2,388,000,000 2,501,000,000 2,258,000,000 2,488,000,000 2,367,000,000 2,542,000,000 2,423,000,000 2,293,000,000 2,079,000,000 2,265,000,000 2,268,000,000 2,110,000,000 1,888,000,000 3,349,000,000 2,011,000,000 2,063,000,000 1,794,000,000 1,941,000,000 2,008,000,000 1,932,000,000 1,727,000,000 2,070,000,000 2,694,000,000 1,939,000,000 2,015,000,000 1,997,000,000 2,164,000,000 1,816,000,000 1,706,000,000 2,292,000,000 2,397,000,000 2,712,000,000 2,494,000,000 2,733,000,000 2,489,000,000 3,020,000,000 2,250,000,000 2,049,000,000 2,208,000,000 2,159,000,000 1,886,000,000 1,766,000,000 1,787,000,000 1,994,000,000 1,672,000,000 1,366,000,000 1,716,000,000 1,350 1,394,000,000 1,321,000,000 1,219,000,000 1,161,000,000 1,475,000,000 1,488,000,000 1,609,000,000 1,521,000,000 1,745,000,000 1,579,000,000 1,565,000,000 
        total current assets
      29,057,000,000 27,885,000,000 26,734,000,000 26,929,000,000 29,030,000,000 26,766,000,000 27,206,000,000 28,029,000,000 30,332,000,000 48,477,000,000 47,380,000,000 44,703,000,000 22,186,000,000 24,062,000,000 19,322,000,000 18,520,000,000 19,385,000,000 24,380,000,000 19,099,000,000 21,299,000,000 21,144,000,000 22,661,000,000 22,895,000,000 18,813,000,000 18,440,000,000 31,051,000,000 30,746,000,000 35,151,000,000 37,618,000,000 38,320,000,000 37,970,000,000 40,689,000,000 49,476,000,000 49,752,000,000 48,442,000,000 46,456,000,000 46,010,000,000 45,844,000,000 42,947,000,000 42,206,000,000 38,518,000,000 38,844,000,000 37,736,000,000 35,064,000,000 34,713,000,000 36,048,000,000 34,328,000,000 28,302,000,000 27,367,000,000 30,675,000,000 29,673,000,000 28,695,000,000 31,209,000,000 32,605,000,000 29,562,000,000 26,855,000,000 24,430,000,000 25,481,000,000 21,689,000,000 23,129 22,930,000,000 20,164,000,000 19,809,000,000 18,932,000,000 19,974,000,000 17,696,000,000 16,076,000,000 15,221,000,000 15,620,000,000 14,527,000,000 14,527,000,000 
        property, plant and equipment
      7,913,000,000 7,220,000,000 6,855,000,000 6,681,000,000 6,543,000,000 6,156,000,000 6,097,000,000 6,002,000,000 5,941,000,000 5,563,000,000 5,532,000,000 5,460,000,000 5,427,000,000 5,188,000,000 5,158,000,000 5,142,000,000 5,184,000,000 4,982,000,000 4,906,000,000 4,855,000,000 4,889,000,000 4,816,000,000 4,843,000,000 4,879,000,000 4,928,000,000 4,901,000,000 4,882,000,000 4,892,000,000 4,958,000,000 4,899,000,000 4,922,000,000 4,943,000,000 4,989,000,000 4,914,000,000 4,980,000,000 4,960,000,000 4,961,000,000 4,912,000,000 4,884,000,000 4,885,000,000 4,907,000,000 4,988,000,000 5,050,000,000 5,123,000,000 5,223,000,000 5,267,000,000 5,371,000,000 5,365,000,000 5,349,000,000 5,283,000,000 5,293,000,000 5,296,000,000 5,326,000,000 5,381,000,000 5,437,000,000 5,392,000,000 5,391,000,000 5,516,000,000 5,455,000,000 5,522 5,643,000,000 5,630,000,000 5,619,000,000 5,738,000,000 5,743,000,000 5,800,000,000 5,804,000,000 5,879,000,000 5,972,000,000 5,968,000,000 5,949,000,000 
        intangible assets
      22,276,000,000 23,139,000,000 24,614,000,000 25,724,000,000 27,699,000,000 28,920,000,000 30,172,000,000 31,372,000,000 32,641,000,000 13,150,000,000 14,633,000,000 15,393,000,000 16,080,000,000 13,266,000,000 13,927,000,000 14,567,000,000 15,182,000,000 14,659,000,000 15,308,000,000 15,947,000,000 16,587,000,000 17,254,000,000 17,948,000,000 18,653,000,000 19,413,000,000 6,702,000,000 6,813,000,000 7,124,000,000 7,443,000,000 7,782,000,000 8,443,000,000 8,779,000,000 8,609,000,000 8,873,000,000 9,561,000,000 9,922,000,000 10,279,000,000 10,690,000,000 11,068,000,000 11,448,000,000 11,641,000,000 11,613,000,000 11,988,000,000 12,265,000,000 12,693,000,000 13,100,000,000 13,499,000,000 13,566,000,000 13,262,000,000 3,682,000,000 3,776,000,000 3,897,000,000 3,968,000,000 3,680,000,000 3,470,000,000 3,445,000,000 2,683,000,000 2,782,000,000 2,808,000,000 2,230 2,315,000,000 2,421,000,000 2,462,000,000 2,567,000,000 2,674,000,000 2,780,000,000 2,882,000,000 2,988,000,000 3,095,000,000 3,176,000,000 3,271,000,000 
        goodwill
      18,680,000,000 18,676,000,000 18,674,000,000 18,645,000,000 18,637,000,000 18,658,000,000 18,616,000,000 18,570,000,000 18,629,000,000 15,509,000,000 15,531,000,000 15,531,000,000 15,529,000,000 14,845,000,000 14,865,000,000 14,897,000,000 14,890,000,000 14,665,000,000 14,676,000,000 14,673,000,000 14,689,000,000 14,674,000,000 14,678,000,000 14,683,000,000 14,703,000,000 14,705,000,000 14,689,000,000 14,692,000,000 14,699,000,000 14,684,000,000 14,724,000,000 14,771,000,000 14,761,000,000 14,776,000,000 14,766,000,000 14,757,000,000 14,751,000,000 14,802,000,000 14,799,000,000 14,804,000,000 14,787,000,000 14,674,000,000 14,723,000,000 14,721,000,000 14,788,000,000 14,815,000,000 14,844,000,000 14,832,000,000 14,968,000,000 12,572,000,000 12,578,000,000 12,604,000,000 12,662,000,000 12,589,000,000 12,428,000,000 12,121,000,000 11,768,000,000 11,794,000,000 11,504,000,000 11,334 11,334,000,000 11,334,000,000 11,335,000,000 11,335,000,000 11,335,000,000 11,339,000,000 11,336,000,000 11,339,000,000 11,340,000,000 11,338,000,000 11,347,000,000 
        other noncurrent assets
      12,660,000,000 13,221,000,000 11,020,000,000 11,388,000,000 9,930,000,000 10,383,000,000 8,816,000,000 9,007,000,000 9,611,000,000 7,835,000,000 7,193,000,000 7,633,000,000 5,899,000,000 6,339,000,000 6,022,000,000 6,070,000,000 6,524,000,000 6,307,000,000 5,784,000,000               2,016,000,000 1,838,000,000                                     
        total assets
      90,586,000,000 90,141,000,000 87,897,000,000 89,367,000,000 91,839,000,000 90,883,000,000 90,907,000,000 92,980,000,000 97,154,000,000 90,534,000,000 90,269,000,000 88,720,000,000 65,121,000,000 63,700,000,000 59,294,000,000 59,196,000,000 61,165,000,000 64,993,000,000 59,773,000,000 62,539,000,000 62,948,000,000 64,637,000,000 65,011,000,000 61,669,000,000 59,707,000,000 59,535,000,000 59,373,000,000 63,997,000,000 66,416,000,000 67,333,000,000 67,684,000,000 71,164,000,000 79,954,000,000 80,331,000,000 79,587,000,000 77,862,000,000 77,626,000,000 78,150,000,000 75,471,000,000 75,116,000,000 71,576,000,000 71,869,000,000 71,209,000,000 68,952,000,000 69,009,000,000 70,775,000,000 69,534,000,000 67,004,000,000 66,125,000,000 57,073,000,000 52,610,000,000 51,640,000,000 54,298,000,000 55,448,000,000 52,226,000,000 49,250,000,000 45,765,000,000 46,936,000,000 42,714,000,000 43,486 43,534,000,000 40,800,000,000 40,366,000,000 39,629,000,000 40,940,000,000 38,840,000,000      
        liabilities and stockholders’ equity
                                                                             
        current liabilities:
                                                                             
        accounts payable
      2,367,000,000 2,838,000,000 3,010,000,000 2,406,000,000 1,908,000,000 2,147,000,000 2,267,000,000 1,628,000,000 1,590,000,000 1,358,000,000 1,212,000,000 1,320,000,000 1,572,000,000 1,204,000,000 1,256,000,000 1,403,000,000 1,366,000,000 1,171,000,000 1,277,000,000 1,396,000,000 1,421,000,000 1,161,000,000 1,150,000,000 1,338,000,000 1,371,000,000 1,005,000,000 1,001,000,000 1,091,000,000 1,207,000,000 1,042,000,000 1,026,000,000 1,089,000,000 1,352,000,000 879,000,000 883,000,000 902,000,000 917,000,000 825,000,000 870,000,000 818,000,000 965,000,000 1,067,000,000 934,000,000 888,000,000 1,212,000,000 955,000,000 982,000,000 949,000,000 787,000,000 895,000,000 1,006,000,000 940,000,000 905,000,000 878,000,000 884,000,000 891,000,000 734,000,000 870,000,000 832,000,000 716 759,000,000 722,000,000 882,000,000 574,000,000 613,000,000 635,000,000 687,000,000 504,000,000 538,000,000 764,000,000 522,000,000 
        accrued liabilities
      18,523,000,000 16,800,000,000 15,022,000,000 17,234,000,000 17,641,000,000 14,621,000,000 13,722,000,000 14,127,000,000 15,359,000,000 14,168,000,000 13,718,000,000 12,061,000,000 12,524,000,000 11,584,000,000 10,545,000,000 10,639,000,000 10,731,000,000 9,383,000,000 8,984,000,000 9,917,000,000 10,141,000,000 8,701,000,000 9,282,000,000 8,649,000,000 8,511,000,000 7,683,000,000 6,805,000,000 7,910,000,000 7,862,000,000 6,313,000,000 5,891,000,000 7,207,000,000 6,516,000,000 5,315,000,000 5,473,000,000 5,822,000,000 5,884,000,000 4,920,000,000 4,666,000,000 5,458,000,000 5,452,000,000 4,848,000,000 4,707,000,000 4,948,000,000 5,296,000,000 5,096,000,000 4,384,000,000 4,749,000,000 4,655,000,000 3,937,000,000 3,771,000,000 4,195,000,000 4,791,000,000 5,031,000,000 4,732,000,000 5,026,000,000 4,197,000,000 3,629,000,000 3,334,000,000 3,366 3,050,000,000 2,856,000,000 3,302,000,000 3,299,000,000 3,290,000,000 2,913,000,000 2,986,000,000 3,382,000,000 3,413,000,000 3,665,000,000 3,432,000,000 
        current portion of long-term debt
      4,599,000,000 2,153,000,000 2,444,000,000 3,368,000,000 3,550,000,000 3,544,000,000 5,528,000,000 3,959,000,000 1,443,000,000 1,428,000,000 2,167,000,000 834,000,000 1,591,000,000 1,543,000,000 817,000,000 844,000,000 87,000,000 4,288,000,000 4,324,000,000 1,556,000,000 91,000,000 91,000,000 91,000,000 1,840,000,000 2,953,000,000 2,049,000,000 2,816,000,000 3,705,000,000 4,419,000,000 5,077,000,000 4,288,000,000 2,183,000,000    3,799,000,000 4,403,000,000 4,797,000,000 5,294,000,000 2,247,000,000 2,250,000,000 1,250,000,000 1,250,000,000 500,000,000 500,000,000 2,500,000,000 2,500,000,000 2,505,000,000 2,505,000,000 11,000,000 7,000,000 7,000,000 2,495,000,000 2,458,000,000 2,416,000,000 2,381,000,000 84,000,000               
        total current liabilities
      25,489,000,000 21,791,000,000 20,476,000,000 23,008,000,000 23,099,000,000 20,312,000,000 21,517,000,000 19,714,000,000 18,392,000,000 16,954,000,000 17,097,000,000 14,215,000,000 15,687,000,000 14,331,000,000 12,618,000,000 12,886,000,000 12,184,000,000 14,842,000,000 14,585,000,000 12,869,000,000 11,653,000,000 9,953,000,000 10,523,000,000 11,827,000,000 12,835,000,000 10,737,000,000 10,622,000,000 12,706,000,000 13,488,000,000 12,432,000,000 11,205,000,000 10,479,000,000 9,020,000,000 8,193,000,000 7,815,000,000 10,523,000,000 11,204,000,000 10,542,000,000 10,830,000,000 8,523,000,000 8,667,000,000 7,165,000,000 6,891,000,000 6,336,000,000 7,008,000,000 8,551,000,000 7,866,000,000 8,203,000,000 7,947,000,000 4,843,000,000 4,784,000,000 5,142,000,000 8,191,000,000 8,367,000,000 8,032,000,000 8,298,000,000 5,315,000,000 4,582,000,000 4,249,000,000 6,570 6,260,000,000 5,992,000,000 6,562,000,000 3,873,000,000 4,903,000,000 4,548,000,000 4,673,000,000 4,886,000,000 4,951,000,000 5,429,000,000 5,954,000,000 
        long-term debt
      50,005,000,000 52,434,000,000 53,760,000,000 54,013,000,000 56,549,000,000 56,854,000,000 57,117,000,000 60,061,000,000 63,170,000,000 59,040,000,000 59,377,000,000 60,761,000,000 37,354,000,000 37,161,000,000 35,705,000,000 36,010,000,000 33,222,000,000 33,291,000,000 28,458,000,000 31,129,000,000 32,895,000,000 34,196,000,000 34,133,000,000 30,008,000,000 26,950,000,000 27,742,000,000 27,798,000,000 29,319,000,000 29,510,000,000 29,350,000,000 30,209,000,000 33,358,000,000 34,190,000,000 33,777,000,000 33,603,000,000 30,293,000,000 30,193,000,000 30,526,000,000 27,928,000,000 32,060,000,000 29,306,000,000 30,511,000,000 30,702,000,000 29,841,000,000 30,215,000,000 30,480,000,000 30,828,000,000 29,519,000,000 29,623,000,000 27,178,000,000 23,908,000,000 23,885,000,000 24,034,000,000 24,020,000,000 21,962,000,000 19,028,000,000 13,881,000,000               
        long-term deferred tax liabilities
      1,366,000,000 1,458,000,000 1,386,000,000 1,510,000,000 1,616,000,000 1,711,000,000 1,780,000,000 1,862,000,000 2,354,000,000             210,000,000 259,000,000 427,000,000 606,000,000 665,000,000 763,000,000 811,000,000 864,000,000 978,000,000 1,155,000,000 1,215,000,000 1,166,000,000 2,131,000,000 2,299,000,000 2,370,000,000                                    
        long-term tax liabilities
      2,690,000,000 2,616,000,000 2,511,000,000 2,419,000,000 2,349,000,000 2,280,000,000 2,205,000,000 3,964,000,000 4,680,000,000 4,579,000,000 4,478,000,000 5,864,000,000 5,757,000,000 5,680,000,000 5,603,000,000 6,652,000,000 6,594,000,000 6,483,000,000 6,428,000,000 7,037,000,000 6,968,000,000 7,560,000,000 7,556,000,000 8,111,000,000 8,037,000,000 7,921,000,000 7,861,000,000 8,869,000,000 8,770,000,000 8,832,000,000 8,763,000,000 9,166,000,000 9,099,000,000 2,733,000,000 2,605,000,000 2,542,000,000 2,419,000,000                                   
        other noncurrent liabilities
      2,378,000,000 2,223,000,000 2,336,000,000 2,210,000,000 2,349,000,000 2,199,000,000 2,363,000,000 2,357,000,000 2,326,000,000 2,305,000,000 2,536,000,000 2,532,000,000 2,662,000,000 2,875,000,000 2,949,000,000 2,732,000,000 2,465,000,000 2,160,000,000 2,055,000,000 2,170,000,000 2,023,000,000 1,759,000,000 1,881,000,000 1,811,000,000 1,606,000,000 1,543,000,000 1,535,000,000 1,460,000,000 1,284,000,000 1,392,000,000 1,443,000,000 1,326,000,000 1,238,000,000 1,268,000,000 1,543,000,000 1,497,000,000 1,499,000,000 3,897,000,000 3,982,000,000 3,649,000,000 3,281,000,000 3,117,000,000 2,905,000,000 2,939,000,000 2,547,000,000 6,419,000,000 6,458,000,000 6,541,000,000 6,459,000,000 3,324,000,000 3,324,000,000 3,122,000,000 3,013,000,000 3,159,000,000 2,993,000,000 3,050,000,000                
        contingencies and commitments
                                                                             
        stockholders’ equity:
                                                                             
        common stock and additional paid-in capital; 0.0001 par value per share...
      34,023,000,000    33,533,000,000    33,070,000,000    32,514,000,000    32,096,000,000    31,802,000,000    31,531,000,000    31,246,000,000    30,992,000,000                                       
        accumulated deficit
      -25,107,000,000 -23,800,000,000 -25,708,000,000 -27,140,000,000 -27,590,000,000 -25,530,000,000 -27,124,000,000 -27,870,000,000 -26,549,000,000 -24,971,000,000 -25,540,000,000 -26,919,000,000 -28,622,000,000 -28,066,000,000 -28,252,000,000 -29,568,000,000 -24,600,000,000 -22,964,000,000 -22,762,000,000 -21,639,000,000 -21,408,000,000 -19,851,000,000 -20,168,000,000 -21,378,000,000 -21,330,000,000 -20,136,000,000 -20,054,000,000 -19,895,000,000 -17,977,000,000 -15,987,000,000 -15,266,000,000 -14,387,000,000 -5,072,000,000    -438,000,000  -356,000,000 -1,638,000,000 -2,086,000,000 -2,352,000,000 -2,912,000,000 -4,051,000,000 -4,624,000,000 -4,698,000,000 -5,476,000,000 -7,023,000,000 -7,634,000,000 -7,840,000,000 -8,854,000,000 -10,111,000,000 -10,423,000,000 -9,348,000,000 -9,380,000,000 -9,444,000,000 -4,167,000,000 -1,945,000,000 -2,383,000,000 -3,508 -3,394,000,000 -4,266,000,000 -4,852,000,000 -4,322,000,000 -4,042,000,000 -5,423,000,000 -6,659,000,000 -5,258,000,000 -5,519,000,000 -6,653,000,000 -6,031,000,000 
        accumulated other comprehensive loss
      -258,000,000 -422,000,000 -544,000,000 -231,000,000 -66,000,000 -336,000,000 -155,000,000 -190,000,000 -289,000,000 -126,000,000 -280,000,000 -268,000,000 -231,000,000 -652,000,000 -672,000,000 -763,000,000 -796,000,000 -808,000,000 -868,000,000 -833,000,000 -985,000,000 -903,000,000 -783,000,000 -662,000,000 -528,000,000 -388,000,000 -465,000,000 -516,000,000 -769,000,000 -809,000,000 -873,000,000 -994,000,000 -679,000,000 -443,000,000 -449,000,000 -362,000,000 -471,000,000 -139,000,000 -106,000,000 -268,000,000 -480,000,000 -237,000,000 -68,000,000  -8,000,000 -104,000,000 -123,000,000 -126,000,000                        
        total stockholders’ equity
      8,658,000,000 9,619,000,000 7,428,000,000 6,207,000,000 5,877,000,000 7,527,000,000 5,925,000,000 5,022,000,000 6,232,000,000 7,656,000,000 6,781,000,000 5,348,000,000 3,661,000,000 3,653,000,000 2,419,000,000 916,000,000 6,700,000,000 8,217,000,000 8,247,000,000 9,334,000,000 9,409,000,000 10,959,000,000 10,659,000,000 9,485,000,000 9,673,000,000 10,927,000,000 10,794,000,000 10,832,000,000 12,500,000,000 14,349,000,000 14,909,000,000 15,620,000,000 25,241,000,000 32,229,000,000 31,722,000,000 30,637,000,000 29,875,000,000 30,773,000,000 30,133,000,000 28,682,000,000 28,083,000,000 27,967,000,000 27,484,000,000 26,506,000,000 25,778,000,000 25,325,000,000 24,382,000,000 22,741,000,000 22,096,000,000 21,728,000,000 20,594,000,000 19,491,000,000 19,060,000,000 19,902,000,000 19,239,000,000 18,874,000,000 23,553,000,000 25,614,000,000 24,984,000,000 23,944 24,071,000,000 23,170,000,000  22,667,000,000 22,858,000,000 21,360,000,000 19,967,000,000 20,386,000,000 19,832,000,000 18,533,000,000 19,087,000,000 
        total liabilities and stockholders’ equity
      90,586,000,000 90,141,000,000 87,897,000,000 89,367,000,000 91,839,000,000 90,883,000,000 90,907,000,000 92,980,000,000 97,154,000,000 90,534,000,000 90,269,000,000 88,720,000,000 65,121,000,000 63,700,000,000 59,294,000,000 59,196,000,000 61,165,000,000 64,993,000,000 59,773,000,000 62,539,000,000 62,948,000,000 64,637,000,000 65,011,000,000 61,669,000,000 59,707,000,000 59,535,000,000 59,373,000,000 63,997,000,000 66,416,000,000 67,333,000,000 67,684,000,000 71,164,000,000 79,954,000,000 80,331,000,000 79,587,000,000 77,862,000,000 77,626,000,000 78,150,000,000 75,471,000,000 75,116,000,000 71,576,000,000 71,869,000,000 71,209,000,000 68,952,000,000 69,009,000,000 70,775,000,000 69,534,000,000 67,004,000,000 66,125,000,000 57,073,000,000 52,610,000,000 51,640,000,000 54,298,000,000 55,448,000,000 52,226,000,000 49,250,000,000 45,765,000,000 46,936,000,000 42,714,000,000 43,486 43,534,000,000 40,800,000,000  39,629,000,000 40,940,000,000 38,840,000,000      
        common stock and additional paid-in capital; 0.0001 par value...
       33,841,000,000 33,680,000,000 33,578,000,000  33,393,000,000 33,204,000,000 33,082,000,000  32,753,000,000 32,601,000,000 32,535,000,000  32,371,000,000 31,343,000,000 31,247,000,000  31,989,000,000 31,877,000,000 31,806,000,000  31,713,000,000 31,610,000,000 31,525,000,000  31,451,000,000 31,313,000,000 31,243,000,000  31,145,000,000 31,048,000,000 31,001,000,000  30,898,000,000 30,793,000,000 30,766,000,000 30,784,000,000 30,691,000,000 30,595,000,000 30,588,000,000 30,649,000,000 30,556,000,000 30,464,000,000 30,420,000,000 30,410,000,000 30,127,000,000 29,981,000,000 29,890,000,000 29,891,000,000 29,665,000,000 29,519,000,000 29,465,000,000 29,337,000,000 29,103,000,000 28,468,000,000 28,212,000,000 27,602,000,000 27,514,000,000 27,376,000,000 27,299 27,210,000,000 27,119,000,000 27,031,000,000  26,853,000,000 26,720,000,000 26,526,000,000  25,348,000,000 25,199,000,000 25,088,000,000 
        marketable securities
                 1,000,000 1,676,000,000 1,976,000,000 1,980,000,000 16,000,000 48,000,000 952,000,000 1,452,000,000 4,454,000,000 4,381,000,000 3,273,000,000 2,276,000,000 325,000,000 2,874,000,000 9,438,000,000 16,233,000,000 18,943,000,000 22,359,000,000 17,965,000,000 19,264,000,000 22,431,000,000 37,878,000,000 38,351,000,000 36,598,000,000 35,040,000,000 34,844,000,000 34,495,000,000 32,404,000,000 31,844,000,000 27,238,000,000 27,894,000,000 26,198,000,000 24,254,000,000 23,295,000,000 24,398,000,000 21,836,000,000 16,115,000,000 15,596,000,000 14,277,000,000 16,212,000,000 18,741,000,000 20,804,000,000 19,551,000,000 16,626,000,000 15,167,000,000 13,785,000,000 13,174,000,000 14,092,000,000 14,135 14,098,000,000 12,811,000,000 11,851,000,000 10,558,000,000 10,436,000,000 8,997,000,000 7,601,000,000 7,778,000,000 7,235,000,000 5,091,000,000 4,323,000,000 
        other assets
                         5,765,000,000 5,639,000,000 5,232,000,000 4,647,000,000 4,641,000,000 2,223,000,000 2,176,000,000 2,243,000,000 2,138,000,000 1,698,000,000 1,648,000,000 1,625,000,000 1,982,000,000 2,119,000,000   1,767,000,000 1,625,000,000 1,902,000,000 1,773,000,000 1,773,000,000 1,723,000,000 1,750,000,000 1,712,000,000 1,779,000,000 1,592,000,000 1,545,000,000 1,492,000,000 1,525,000,000 1,767,000,000 1,450,000,000 1,290,000,000 1,148,000,000 1,133,000,000 1,193,000,000 1,329,000,000 1,437,000,000 1,493,000,000 1,363,000,000 1,258,000,000 1,271 1,312,000,000 1,251,000,000 1,141,000,000 1,057,000,000 1,214,000,000 1,225,000,000 1,282,000,000 1,016,000,000 971,000,000 1,052,000,000 1,034,000,000 
        short-term borrowings and current portion of long-term debt
                                      1,152,000,000 1,999,000,000 1,459,000,000                                     
        retained earnings
                                       1,774,000,000 1,378,000,000 233,000,000  221,000,000                                  
        long-term deferred tax liability
                                          2,436,000,000 2,412,000,000 2,598,000,000 2,202,000,000 2,239,000,000 3,109,000,000 3,227,000,000 3,330,000,000 3,461,000,000                           
        accumulated other comprehensive gain/
                                                 137,000,000                            
        restricted investments
                                                     3,414,000,000 3,412,000,000 3,411,000,000                      
        accumulated other comprehensive income
                                                      -161,000,000 -97,000,000 -71,000,000 137,000,000 146,000,000 147,000,000 151,000,000 106,000,000 118,000,000 45,000,000 -9,000,000 153 255,000,000 317,000,000 160,000,000 45,000,000 47,000,000 63,000,000 100,000,000 117,000,000 3,000,000 -13,000,000 30,000,000 
        receivable from sale of investments
                                                       560,000,000                      
        commercial paper borrowings
                                                              300,000,000               
        other non-current liabilities
                                                              3,016,000,000 2,893,000,000 2,657,000,000 2,098 2,362,000,000 2,320,000,000 2,179,000,000 2,488,000,000 2,643,000,000 2,461,000,000 2,332,000,000 1,995,000,000 1,693,000,000 1,543,000,000 1,529,000,000 
        current portion of convertible notes
                                                               83,000,000 83,000,000 2,488 2,451,000,000 2,414,000,000 2,378,000,000         
        convertible notes
                                                               2,279,000,000 2,246,000,000 2,296 2,263,000,000 2,232,000,000 2,201,000,000 4,512,000,000 4,447,000,000 4,383,000,000 4,320,000,000 5,081,000,000 5,081,000,000 5,081,000,000 5,080,000,000 
        other long-term debt
                                                               11,568,000,000  8,578 8,578,000,000 7,086,000,000 7,085,000,000 6,089,000,000 6,089,000,000 6,088,000,000 6,088,000,000 4,095,000,000 5,095,000,000 5,094,000,000 4,097,000,000 
        other long-term debt.
                                                                8,578,000,000             
        liabilities and stockholders' equity
                                                                             
        stockholders' equity:
                                                                             
        total stockholders' equity
                                                                    22,339,000,000         
        total liabilities and stockholders' equity
                                                                    40,366,000,000         
        current portion of other long-term debt
                                                                      1,000,000,000 1,000,000,000 1,000,000,000 1,000,000,000 1,000,000,000 1,000,000,000 2,000,000,000 
        common shares, ...
                                                                             
        0.0001 par value...
                                                                             
        outstanding — 995 shares in 2009 and 1,047 shares in 2008
                                                                     26,944,000,000        
        commitments and contingencies
                                                                             
        contingencies
                                                                             
        stockholders’ equity: common stock and additional paid-in capital; 0.0001 par value...
                                                                         25,527,000,000    
        deferred tax liabilities
                                                                          346,000,000 381,000,000 381,000,000 
      Cashflow Statements:
      Quarterly
      Annual
        Unit: USD2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31 2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31 2018-09-30 2018-06-30 2018-03-31 2017-12-31 2017-09-30 2017-06-30 2017-03-31 2016-12-31 2016-09-30 2016-06-30 2016-03-31 2015-12-31 2015-09-30 2015-06-30 2015-03-31 2014-12-31 2014-09-30 2014-06-30 2014-03-31 2013-12-31 2013-09-30 2013-06-30 2013-03-31 2012-12-31 2012-09-30 2012-06-30 2012-03-31 2011-09-30 2011-06-30 2011-03-31 2010-12-31 2010-09-30 2010-06-30 2010-03-31 2009-12-31 2009-09-30 2009-06-30 2009-03-31 2008-12-31 2008-09-30 2008-06-30 2008-03-31 
                                                                               
          cash flows from operating activities:
                                                                               
          net income
        1,333,000,000 3,216,000,000 1,432,000,000 1,730,000,000 627,000,000 2,830,000,000 746,000,000 -113,000,000 767,000,000 1,730,000,000 1,379,000,000 2,841,000,000 1,616,000,000 2,143,000,000 1,317,000,000 1,476,000,000 1,899,000,000 1,884,000,000 464,000,000 1,646,000,000 1,615,000,000 2,021,000,000 1,803,000,000 1,825,000,000 1,703,000,000 1,968,000,000 2,179,000,000 1,992,000,000 1,928,000,000 1,859,000,000 2,296,000,000 2,311,000,000 -4,264,000,000 2,021,000,000 2,151,000,000 2,071,000,000 1,935,000,000 2,017,000,000 1,870,000,000 1,900,000,000 1,800,000,000 1,863,000,000 1,653,000,000 1,623,000,000 1,294,000,000 1,244,000,000 1,547,000,000 1,073,000,000 1,021,000,000 1,368,000,000 1,258,000,000 1,434,000,000 788,000,000 1,107,000,000 1,266,000,000 1,184,000,000 454,000,000 1,170,000,000 1,125,000,000 1,022,000,000 1,236,000,000 1,202,000,000 1,167,000,000 931,000,000 1,386,000,000 1,269,000,000 1,019,000,000 961,000,000 1,158,000,000 941,000,000 1,136,000,000 
          noncash adjustments to reconcile net income to net cash from operating activities:
                                                                               
          depreciation, amortization and other
        1,132,000,000 1,307,000,000 1,341,000,000 1,387,000,000 1,397,000,000 1,396,000,000 1,400,000,000 1,399,000,000 1,380,000,000 895,000,000 896,000,000 900,000,000 911,000,000 837,000,000 828,000,000 841,000,000 852,000,000 850,000,000 855,000,000 841,000,000 873,000,000 901,000,000 930,000,000 897,000,000 702,000,000 508,000,000 501,000,000 495,000,000                                            
          impairment of intangible assets
        400,000,000 800,000,000                                                                    
          stock-based compensation expense
        125,000,000 127,000,000 157,000,000 85,000,000 134,000,000 136,000,000 157,000,000 103,000,000                                52,000,000 80,000,000 82,000,000 90,000,000 70,000,000 106,000,000 103,000,000 112,000,000 87,000,000 99,000,000 100,000,000 112,000,000 92,000,000 91,000,000 91,000,000 105,000,000 75,000,000 71,000,000 97,000,000 77,000,000 105,000,000 82,000,000 98,000,000 68,000,000 75,000,000 86,000,000 64,000,000 59,000,000     
          deferred income taxes
        -19,000,000 -30,000,000 -422,000,000 -250,000,000 -334,000,000 -110,000,000 -383,000,000 -401,000,000 -623,000,000 -447,000,000 -154,000,000 -49,000,000 -351,000,000 -333,000,000 -263,000,000 -251,000,000 -189,000,000 -127,000,000 -46,000,000 -91,000,000 52,000,000 -78,000,000 -177,000,000 -84,000,000 -117,000,000 -102,000,000 -20,000,000 -50,000,000 -69,000,000 -180,000,000 -42,000,000 -72,000,000 -951,000,000 -199,000,000 -103,000,000 -77,000,000 103,000,000 -165,000,000 313,000,000 -68,000,000 -356,000,000 -125,000,000   -404,000,000                           
          losses on equity securities
          554,000,000 -1,295,000,000   401,000,000 515,000,000 -261,000,000 -135,000,000 661,000,000 -1,830,000,000                                                            
          other items
        250,000,000 -28,000,000 -23,000,000 -50,000,000 -9,000,000 68,000,000 28,000,000 -95,000,000 -286,000,000 678,000,000 184,000,000 -13,000,000 -412,000,000 -200,000,000 196,000,000 240,000,000 -416,000,000 17,000,000 91,000,000 79,000,000 -465,000,000 25,000,000 138,000,000 107,000,000 -355,000,000 137,000,000 8,000,000 24,000,000 -26,000,000 378,000,000 -10,000,000 44,000,000 -47,000,000 272,000,000 94,000,000 15,000,000 -61,000,000 51,000,000 -93,000,000 135,000,000 -178,000,000 7,000,000 13,000,000 -241,000,000 47,000,000 -261,000,000 9,000,000 -8,000,000 -35,000,000 -16,000,000 173,000,000 -38,000,000 -2,000,000 67,000,000 -206,000,000 67,000,000 67,000,000 -50,000,000 14,000,000 21,000,000 47,000,000 62,000,000 10,000,000 -35,000,000 35,000,000   -123,000,000 58,000,000 66,000,000 16,000,000 
          changes in operating assets and liabilities, net of acquisitions:
                                                                               
          trade receivables
        -1,075,000,000 222,000,000 -515,000,000 -1,308,000,000 473,000,000 -342,000,000 -176,000,000 486,000,000 -433,000,000 -342,000,000 -96,000,000 -144,000,000 -180,000,000 -62,000,000 -309,000,000 -195,000,000 -160,000,000 -304,000,000 -56,000,000 91,000,000 -396,000,000 1,146,000,000 -222,000,000 -955,000,000 -441,000,000 165,000,000 -21,000,000 -207,000,000 -144,000,000 114,000,000 36,000,000 -384,000,000 171,000,000 162,000,000 -344,000,000 -47,000,000 -22,000,000 -73,000,000 -21,000,000 -98,000,000 -118,000,000 -103,000,000 -190,000,000 -9,000,000 -209,000,000   180,000,000 94,000,000 1,000,000 -152,000,000 19,000,000 150,000,000 11,000,000 279,000,000 -92,000,000 -17,000,000 -188,000,000 -181,000,000 107,000,000 -218,000,000 63,000,000 -162,000,000 222,000,000 -150,000,000 -172,000,000 64,000,000 49,000,000 216,000,000 -107,000,000 -93,000,000 
          inventories
        119,000,000 240,000,000 239,000,000 288,000,000 323,000,000 681,000,000 722,000,000 806,000,000 573,000,000 -54,000,000 30,000,000 -58,000,000 -91,000,000 -241,000,000 -180,000,000 -230,000,000 50,000,000 -48,000,000 -41,000,000 -126,000,000 101,000,000 -90,000,000 -113,000,000 -113,000,000 35,000,000 17,000,000 -90,000,000 -28,000,000 90,000,000 42,000,000 -28,000,000 -107,000,000 187,000,000 36,000,000 35,000,000 -125,000,000 45,000,000 31,000,000 -23,000,000 -133,000,000 197,000,000 88,000,000 145,000,000 51,000,000 228,000,000 59,000,000 43,000,000 -3,000,000 64,000,000 -37,000,000 -22,000,000 -12,000,000 25,000,000 -107,000,000 -52,000,000 -16,000,000 -79,000,000 -116,000,000 -78,000,000 -11,000,000 44,000,000 99,000,000 21,000,000 -74,000,000 -110,000,000 28,000,000 22,000,000 -37,000,000 47,000,000 -87,000,000 18,000,000 
          other assets
        -577,000,000 -283,000,000 -206,000,000 -201,000,000 -14,000,000 -299,000,000 -250,000,000 -89,000,000 -232,000,000 -263,000,000 70,000,000 -139,000,000 92,000,000 -32,000,000 241,000,000 -43,000,000 136,000,000 -115,000,000 -112,000,000 -146,000,000 65,000,000 -79,000,000 -176,000,000 319,000,000 279,000,000 -111,000,000 91,000,000 -249,000,000 145,000,000 122,000,000 -97,000,000 -135,000,000 86,000,000 84,000,000 -39,000,000 -155,000,000 207,000,000 -5,000,000 -81,000,000 -249,000,000 -37,000,000 107,000,000 224,000,000 -139,000,000 119,000,000 -109,000,000 170,000,000 -181,000,000 115,000,000 -262,000,000 98,000,000 -10,000,000 -89,000,000 -210,000,000 556,000,000 -133,000,000              11,000,000 35,000,000 
          accounts payable
        -484,000,000 -174,000,000 589,000,000 497,000,000 -232,000,000 -122,000,000 643,000,000 23,000,000 -187,000,000 156,000,000 -118,000,000 -253,000,000 296,000,000 -44,000,000 -140,000,000 42,000,000 191,000,000 -104,000,000 -127,000,000 -29,000,000 247,000,000 14,000,000 -191,000,000 -25,000,000 360,000,000 9,000,000 -93,000,000 -112,000,000 168,000,000 18,000,000 -51,000,000 -278,000,000 474,000,000 -7,000,000 -23,000,000 -20,000,000 103,000,000 -47,000,000 50,000,000 -150,000,000 115,000,000 142,000,000 43,000,000 -312,000,000 301,000,000 -21,000,000 33,000,000 92,000,000 -190,000,000 -111,000,000 82,000,000 35,000,000 -28,000,000 1,000,000 -38,000,000 226,000,000 -126,000,000 159,000,000 -38,000,000 -43,000,000 37,000,000 -160,000,000 308,000,000 28,000,000 -5,000,000 4,000,000 44,000,000 -41,000,000 -224,000,000 242,000,000 118,000,000 
          accrued income taxes
        -365,000,000 610,000,000 -2,417,000,000 104,000,000 53,000,000 247,000,000 -1,534,000,000 223,000,000 -2,029,000,000 527,000,000 28,000,000 443,000,000 -155,000,000 193,000,000 -1,003,000,000 318,000,000 -135,000,000 211,000,000 -982,000,000 52,000,000 52,000,000 -753,000,000 315,000,000 137,000,000 -457,000,000 129,000,000 -534,000,000 277,000,000 23,000,000 -70,000,000 -667,000,000 353,000,000 475,000,000 168,000,000 -388,000,000 268,000,000 -161,000,000 188,000,000 -322,000,000 -6,000,000 31,000,000 109,000,000 284,000,000 85,000,000 221,000,000 -193,000,000 -83,000,000 -48,000,000 157,000,000 109,000,000 -186,000,000 -406,000,000 172,000,000 -28,000,000 3,000,000 -60,000,000 -354,000,000 17,000,000 8,000,000 146,000,000 -505,000,000 -108,000,000 -189,000,000 -175,000,000 112,000,000 -255,000,000 176,000,000 -74,000,000 111,000,000 -135,000,000 112,000,000 
          long-term tax liabilities
        75,000,000 74,000,000 92,000,000 70,000,000 69,000,000 76,000,000 78,000,000 -715,000,000 78,000,000 97,000,000 89,000,000 107,000,000 44,000,000 77,000,000 51,000,000 57,000,000 102,000,000 55,000,000 -22,000,000 69,000,000 -592,000,000 4,000,000 32,000,000 74,000,000 116,000,000 60,000,000 -422,000,000 100,000,000 54,000,000                                           
          accrued liabilities
        749,000,000 -200,000,000 824,000,000 -874,000,000 728,000,000 -275,000,000 693,000,000 -1,054,000,000                                                                
          accrued sales incentives and allowance
        -232,000,000 1,184,000,000 627,000,000 486,000,000 658,000,000 929,000,000 -77,000,000 -316,000,000                                                                
          other liabilities
        -76,000,000 -10,000,000 8,000,000 -78,000,000 21,000,000 -39,000,000 23,000,000 -56,000,000 397,000,000 -68,000,000 1,112,000,000 -710,000,000 298,000,000 419,000,000 440,000,000 -396,000,000 137,000,000 99,000,000 402,000,000 -282,000,000 271,000,000 257,000,000 503,000,000 -48,000,000 381,000,000 597,000,000 -185,000,000 -397,000,000 448,000,000 342,000,000 17,000,000 407,000,000 -334,000,000 365,000,000 329,000,000 -129,000,000 303,000,000 79,000,000 375,000,000 11,000,000 -16,000,000 181,000,000 159,000,000 -323,000,000 120,000,000 735,000,000 70,000,000 -568,000,000 236,000,000 367,000,000 -40,000,000 -342,000,000 6,000,000 504,000,000 193,000,000 -538,000,000                
          net cash from operating activities
        1,603,000,000 4,684,000,000 2,280,000,000 1,391,000,000 4,771,000,000 3,571,000,000 2,459,000,000 689,000,000 538,000,000 2,760,000,000 4,109,000,000 1,064,000,000 2,649,000,000 2,978,000,000 1,930,000,000 2,164,000,000 2,808,000,000 2,418,000,000 1,931,000,000 2,104,000,000 2,153,000,000 3,368,000,000 2,842,000,000 2,134,000,000 2,514,000,000 3,377,000,000 1,414,000,000 1,845,000,000 3,194,000,000 3,273,000,000 2,102,000,000 2,727,000,000 3,012,000,000 3,454,000,000 2,326,000,000 2,385,000,000 3,100,000,000 2,662,000,000 2,677,000,000 1,915,000,000 2,060,000,000 2,874,000,000 2,814,000,000 1,329,000,000 2,445,000,000 2,741,000,000 2,227,000,000 1,142,000,000 1,835,000,000 1,807,000,000 1,600,000,000 1,049,000,000 812,000,000 1,723,000,000 2,375,000,000 972,000,000 969,000,000 1,536,000,000 1,030,000,000 2,008,000,000 1,302,000,000 1,564,000,000 913,000,000 1,823,000,000 1,975,000,000 1,679,000,000 859,000,000 1,397,000,000 1,390,000,000 1,619,000,000 1,582,000,000 
          capital expenditures
        -642,000,000 -436,000,000 -369,000,000 -411,000,000 -371,000,000 -257,000,000 -238,000,000 -230,000,000 -249,000,000 -248,000,000 -271,000,000 -344,000,000 -340,000,000 -160,000,000 -246,000,000 -190,000,000 -287,000,000 -242,000,000 -185,000,000 -166,000,000 -173,000,000 -135,000,000 -158,000,000 -142,000,000 -188,000,000 -170,000,000 -144,000,000 -116,000,000 -225,000,000 -171,000,000 -187,000,000 -155,000,000 -153,000,000 -158,000,000 -185,000,000 -168,000,000 -227,000,000 -167,000,000 -188,000,000 -156,000,000 -205,000,000 -138,000,000 -133,000,000 -118,000,000 -203,000,000 -170,000,000 -173,000,000 -172,000,000 -201,000,000 -175,000,000 -159,000,000 -158,000,000 -200,000,000 -173,000,000 -172,000,000 -144,000,000 -120,000,000 -123,000,000 -100,000,000 -182,000,000 -127,000,000 -177,000,000 -94,000,000 -144,000,000 -130,000,000 -139,000,000 -117,000,000 -178,000,000 -159,000,000 -165,000,000 -170,000,000 
          free cash flows
        961,000,000 4,248,000,000 1,911,000,000 980,000,000 4,400,000,000 3,314,000,000 2,221,000,000 459,000,000 289,000,000 2,512,000,000 3,838,000,000 720,000,000 2,309,000,000 2,818,000,000 1,684,000,000 1,974,000,000 2,521,000,000 2,176,000,000 1,746,000,000 1,938,000,000 1,980,000,000 3,233,000,000 2,684,000,000 1,992,000,000 2,326,000,000 3,207,000,000 1,270,000,000 1,729,000,000 2,969,000,000 3,102,000,000 1,915,000,000 2,572,000,000 2,859,000,000 3,296,000,000 2,141,000,000 2,217,000,000 2,873,000,000 2,495,000,000 2,489,000,000 1,759,000,000 1,855,000,000 2,736,000,000 2,681,000,000 1,211,000,000 2,242,000,000 2,571,000,000 2,054,000,000 970,000,000 1,634,000,000 1,632,000,000 1,441,000,000 891,000,000 612,000,000 1,550,000,000 2,203,000,000 828,000,000 849,000,000 1,413,000,000 930,000,000 1,826,000,000 1,175,000,000 1,387,000,000 819,000,000 1,679,000,000 1,845,000,000 1,540,000,000 742,000,000 1,219,000,000 1,231,000,000 1,454,000,000 1,412,000,000 
          cash flows from investing activities:
                                                                               
          cash paid for acquisitions, net of cash acquired
                        -890,000,000 -13,000,000                           -50,000,000 -11,000,000 -104,000,000     -400,000,000 -319,000,000 -702,000,000 -969,000,000 -298,000,000 -403,000,000         -6,000,000    
          proceeds from sales of marketable securities
                -2,000,000 1,000,000 1,124,000,000     -1,000,000 405,000,000 3,999,000,000 -1,000,000 24,000,000 2,574,000,000 5,823,000,000 2,802,000,000 92,000,000 125,000,000 297,000,000 4,336,000,000 7,029,000,000 16,694,000,000 5,660,000,000 4,155,000,000 8,813,000,000 5,612,000,000 3,886,000,000 5,009,000,000 5,165,000,000 3,898,000,000 6,245,000,000 3,763,000,000 3,022,000,000 4,999,000,000 5,637,000,000 1,923,000,000 7,326,000,000 1,811,000,000 3,380,000,000 4,775,000,000 4,955,000,000 6,013,000,000 4,828,000,000 3,426,000,000 4,378,000,000 4,740,000,000 4,354,000,000 7,086,000,000 6,933,000,000 2,484,000,000 2,755,000,000 3,076,000,000 2,170,000,000 1,226,000,000 1,661,000,000 1,939,000,000 3,426,000,000 1,760,000,000 1,921,000,000 955,000,000 2,126,000,000 
          proceeds from maturities of marketable securities
                550,000,000 673,000,000 400,000,000 15,000,000 32,000,000 904,000,000 1,399,000,000 3,004,000,000 3,524,000,000 2,043,000,000 2,100,000,000 125,000,000 113,000,000 2,107,000,000 4,824,000,000 3,162,000,000 10,455,000,000 1,531,000,000 2,888,000,000 93,000,000 900,000,000 1,409,000,000 1,481,000,000 1,756,000,000 1,528,000,000 527,000,000 593,000,000 881,000,000 458,000,000 348,000,000 679,000,000 1,299,000,000 1,201,000,000 237,000,000 667,000,000 2,338,000,000 957,000,000 244,000,000 905,000,000 1,017,000,000 2,924,000,000 1,116,000,000 461,000,000 257,000,000 160,000,000 167,000,000 184,000,000 224,000,000 212,000,000 140,000,000 149,000,000 141,000,000 103,000,000 376,000,000 539,000,000 425,000,000 393,000,000 255,000,000 162,000,000 208,000,000 
          purchases of property, plant and equipment
        -642,000,000 -436,000,000 -369,000,000 -411,000,000 -371,000,000 -257,000,000 -238,000,000 -230,000,000 -249,000,000 -248,000,000 -271,000,000 -344,000,000 -340,000,000 -160,000,000 -246,000,000 -190,000,000 -287,000,000 -242,000,000 -185,000,000 -166,000,000 -173,000,000 -135,000,000 -158,000,000 -142,000,000 -188,000,000 -170,000,000 -144,000,000 -116,000,000 -225,000,000 -171,000,000 -187,000,000 -155,000,000 -153,000,000 -158,000,000 -185,000,000 -168,000,000 -227,000,000 -167,000,000 -188,000,000 -156,000,000 -205,000,000 -138,000,000 -133,000,000 -118,000,000 -203,000,000 -170,000,000 -173,000,000 -172,000,000 -201,000,000 -175,000,000 -159,000,000 -158,000,000 -200,000,000 -173,000,000 -172,000,000 -144,000,000 -120,000,000 -123,000,000 -100,000,000 -182,000,000 -127,000,000 -177,000,000 -94,000,000 -144,000,000 -130,000,000 -139,000,000 -117,000,000 -178,000,000 -159,000,000 -165,000,000 -170,000,000 
          other
        2,000,000 22,000,000 -20,000,000 -36,000,000 -31,000,000 47,000,000 21,000,000 13,000,000 151,000,000 -13,000,000 59,000,000 28,000,000 47,000,000 -120,000,000 14,000,000 47,000,000 45,000,000 -18,000,000 17,000,000 -79,000,000 -41,000,000 14,000,000 -47,000,000 -1,000,000 67,000,000 -95,000,000 -13,000,000 -11,000,000 -114,000,000 -37,000,000 4,000,000 2,000,000 -40,000,000 -37,000,000 -30,000,000 -52,000,000 40,000,000 -211,000,000 -56,000,000 5,000,000 -80,000,000 -35,000,000 -174,000,000 -103,000,000 -65,000,000 65,000,000 -91,000,000 -44,000,000 -26,000,000 6,000,000 -44,000,000 -6,000,000 2,000,000 61,000,000   16,000,000 1,000,000 -6,000,000 -23,000,000 -26,000,000 -36,000,000 -12,000,000 5,000,000 78,000,000 -17,000,000 -15,000,000 35,000,000 32,000,000 12,000,000 49,000,000 
          net cash from investing activities
        -693,000,000 -414,000,000 -389,000,000 -447,000,000 -402,000,000 -210,000,000 -217,000,000 -217,000,000 -27,089,000,000 -262,000,000 -211,000,000 1,358,000,000 -3,473,000,000 -267,000,000 -2,193,000,000 -111,000,000 -230,000,000 73,000,000 1,209,000,000 -319,000,000 -1,384,000,000 -1,628,000,000 -2,159,000,000 -230,000,000 -5,963,000,000 5,372,000,000 2,745,000,000 3,555,000,000 -4,637,000,000 1,132,000,000 2,938,000,000 14,906,000,000 -78,000,000 -1,976,000,000 -1,813,000,000 -157,000,000 -1,222,000,000 -2,389,000,000 -657,000,000 -4,390,000,000 -233,000,000 -2,003,000,000 -2,359,000,000 -952,000,000 374,000,000 -2,903,000,000 -2,458,000,000 -765,000,000 -10,118,000,000 -2,119,000,000 1,959,000,000 1,809,000,000 -2,031,000,000 -3,173,000,000 -2,440,000,000 -2,346,000,000 -857,000,000 846,000,000 -555,000,000 -491,000,000 -1,271,000,000 -1,435,000,000 -955,000,000 -339,000,000 -1,421,000,000 -1,581,000,000 139,000,000 -547,000,000 -2,325,000,000 -990,000,000 697,000,000 
          cash flows from financing activities:
                                                                               
          net proceeds from issuance of debt
                3,996,000,000 1,000,000 -18,000,000 23,798,000,000 -19,000,000 2,984,000,000 2,000,000 3,952,000,000 -1,000,000    -88,000,000 4,039,000,000 4,963,000,000         991,000,000   605,000,000 3,805,000,000 -1,000,000 2,909,000,000 1,000,000     4,980,000,000    1,954,000,000     1,482,000,000 989,000,000 1,980,000,000     
          extinguishment of debt
        -81,000,000 -301,000,000 -301,000,000 -249,000,000 -410,000,000 -97,000,000 -130,000,000 -420,000,000                                                           
          repayment of debt
        -1,500,000,000 -1,000,000,000 -2,500,000,000 -2,200,000,000   -750,000,000 -704,000,000         -1,450,000,000 -1,750,000,000 -3,250,000,000 -864,000,000 -2,650,000,000 -1,000,000,000 -621,000,000   -3,800,000,000 -605,000,000 -1,000,000,000 -1,725,000,000 -875,000,000 -125,000,000 -125,000,000 -125,000,000 -2,025,000,000 -125,000,000 -2,125,000,000 -125,000,000 -3,230,000,000 -125,000,000 -871,000,000 -2,500,000,000 -21,000,000 -18,000,000 -84,000,000 -2,500,000,000         -1,000,000,000   
          repurchases of common stock
                    -6,360,000,000 -1,443,000,000 -1,080,000,000 -1,581,000,000 -871,000,000 -1,205,000,000 -765,000,000 -555,000,000 -961,000,000 -1,094,000,000 -1,161,000,000 -2,415,000,000 -3,032,000,000 -2,124,000,000 -1,729,000,000 -3,244,000,000 -10,697,000,000 -789,000,000 -809,000,000 -976,000,000 -586,000,000 -983,000,000 -764,000,000 -542,000,000 -676,000,000 -183,000,000 -744,000,000 -476,000,000 -464,000,000     -832,000,000 -1,217,000,000 -810,000,000 -1,205,000,000 -1,375,000,000 -2,272,000,000 -731,000,000 -14,000,000 -1,192,000,000 -294,000,000 -713,000,000 -1,587,000,000 -1,211,000,000 -1,997,000,000 -700,000,000 -19,000,000   
          dividends paid
        -1,283,000,000 -1,282,000,000 -1,280,000,000 -1,279,000,000 -1,205,000,000 -1,210,000,000 -1,209,000,000 -1,208,000,000 -1,140,000,000 -1,140,000,000 -1,139,000,000 -1,137,000,000 -1,040,000,000 -1,038,000,000 -1,038,000,000 -1,080,000,000 -990,000,000 -999,000,000 -1,008,000,000 -1,016,000,000 -932,000,000 -936,000,000 -942,000,000 -945,000,000 -860,000,000 -868,000,000 -880,000,000 -901,000,000 -840,000,000 -851,000,000 -865,000,000 -951,000,000 -834,000,000 -838,000,000 -846,000,000 -847,000,000 -747,000,000 -747,000,000 -752,000,000 -752,000,000 -596,000,000 -599,000,000 -602,000,000 -599,000,000 -464,000,000 -464,000,000 -463,000,000 -460,000,000 -354,000,000 -354,000,000 -354,000,000 -353,000,000 -274,000,000 -279,000,000 -280,000,000 -285,000,000                
          net cash from financing activities
        -1,226,000,000 -2,853,000,000 -2,673,000,000 -4,107,000,000 -1,407,000,000 -3,651,000,000 -2,649,000,000 -1,708,000,000 2,754,000,000 -2,005,000,000 -1,210,000,000 21,509,000,000 -1,049,000,000 1,588,000,000 -1,062,000,000 -3,514,000,000 -6,558,000,000 2,848,000,000 -2,622,000,000 -1,939,000,000 -3,590,000,000 -1,798,000,000 775,000,000 -254,000,000 -1,929,000,000 -2,859,000,000 -5,992,000,000 -4,987,000,000 -3,568,000,000 -2,580,000,000 -4,650,000,000 -11,692,000,000 -2,134,000,000 -1,107,000,000 -1,242,000,000 -2,111,000,000 -2,122,000,000 582,000,000 -2,286,000,000 1,227,000,000 -909,000,000 -1,440,000,000 476,000,000 -1,244,000,000 -2,765,000,000 -513,000,000 896,000,000 -495,000,000 3,807,000,000 2,787,000,000 -283,000,000 -3,585,000,000 -1,347,000,000 1,424,000,000 1,707,000,000 -1,365,000,000 -2,219,000,000 2,350,000,000 -2,496,000,000 -1,181,000,000 1,208,000,000 -683,000,000 -576,000,000 -2,177,000,000 55,000,000 93,000,000 5,000,000 -1,598,000,000 65,000,000 -1,561,000,000 21,000,000 
          increase in cash and cash equivalents
            2,962,000,000 -290,000,000 -407,000,000 -1,236,000,000 -23,797,000,000 493,000,000 2,688,000,000 23,931,000,000 -1,873,000,000 4,299,000,000   -3,980,000,000 5,339,000,000 518,000,000 -154,000,000 -2,821,000,000 -58,000,000 1,458,000,000 1,650,000,000 -5,378,000,000 5,890,000,000 -1,833,000,000 413,000,000 -5,011,000,000 1,825,000,000 390,000,000 5,941,000,000    117,000,000         54,000,000 -675,000,000   -4,476,000,000 2,475,000,000   -2,566,000,000 -26,000,000   -2,107,000,000   336,000,000 1,239,000,000 -554,000,000 -618,000,000 -693,000,000 609,000,000 191,000,000 1,003,000,000 -748,000,000 -870,000,000 -932,000,000 2,300,000,000 
          cash and cash equivalents at beginning of year
                                                                               
          cash and cash equivalents at end of year
                                                                               
          gains on equity securities
                                                                               
          decrease in cash and cash equivalents
         1,417,000,000 -782,000,000 -3,163,000,000            -1,461,000,000                  371,000,000      -1,248,000,000    -867,000,000    -118,000,000    -727,000,000    -2,739,000,000   -2,021,000,000             
          cash and cash equivalents at beginning of period
         11,973,000,000  10,944,000,000  7,629,000,000  7,989,000,000  6,266,000,000  6,037,000,000  6,945,000,000  3,800,000,000  3,241,000,000 4,144,000,000 3,731,000,000 3,805,000,000 3,257,000,000 6,946,000,000 3,287,000,000 2,884,000,000 1,774,000,000  2,024,000,000 
          cash and cash equivalents at end of period
         1,417,000,000 -782,000,000 8,810,000,000  -290,000,000 -407,000,000 9,708,000,000  493,000,000 2,688,000,000 31,560,000,000  4,299,000,000 -1,325,000,000 6,528,000,000  5,339,000,000 518,000,000 6,112,000,000  -58,000,000 1,458,000,000 7,687,000,000  5,890,000,000 -1,833,000,000 7,358,000,000  1,825,000,000 390,000,000 9,741,000,000  371,000,000 -729,000,000 3,358,000,000 -244,000,000 855,000,000 -266,000,000 2,896,000,000 918,000,000 -569,000,000 931,000,000 2,864,000,000 54,000,000 -675,000,000 665,000,000 3,687,000,000 -4,476,000,000 2,475,000,000 3,276,000,000 2,530,000,000 -2,566,000,000 -26,000,000 1,642,000,000 4,207,000,000 -2,107,000,000 4,732,000,000 1,266,000,000 336,000,000 1,239,000,000 -554,000,000 2,266,000,000 -693,000,000 609,000,000 191,000,000 2,777,000,000  -870,000,000 -932,000,000 4,324,000,000 
          adjustments for equity method investments
            1,000,000 28,000,000 -12,000,000 -27,000,000 28,000,000 -14,000,000 28,000,000 -31,000,000 178,000,000 216,000,000 192,000,000 305,000,000                                                        
          loss on divestiture
                    2,000,000 5,000,000                                                          
          purchases of marketable securities
                   -224,000,000 -387,000,000   1,000,000 -901,000,000 -403,000,000 -7,597,000,000 -3,148,000,000 -3,100,000,000 -2,100,000,000 -129,000,000 -332,000,000 -1,812,000,000 -352,000,000 -6,898,000,000 -6,124,000,000 -5,884,000,000 -4,001,000,000 -2,732,000,000 -6,946,000,000 -7,417,000,000 -12,167,000,000 -7,077,000,000 -5,412,000,000 -7,713,000,000 -6,374,000,000 -8,595,000,000 -6,185,000,000 -6,262,000,000 -6,599,000,000 -6,931,000,000 -5,047,000,000 -5,238,000,000 -12,709,000,000 -2,884,000,000 -4,087,000,000 -7,104,000,000 -3,810,000,000 -6,964,000,000 -7,377,000,000 -6,629,000,000 -6,102,000,000 -6,133,000,000 -5,274,000,000 -6,004,000,000 -7,203,000,000 -2,982,000,000 -4,013,000,000 -4,447,000,000 -3,160,000,000 -1,529,000,000 -3,406,000,000 -3,903,000,000 -3,580,000,000 -2,551,000,000 -4,372,000,000 -1,954,000,000 -1,468,000,000 
          acquired in-process research and development
                                                                             
          purchases of equity method investments
                        -3,000,000 -151,000,000   -65,000,000 -506,000,000 -3,000,000 -2,645,000,000                                                
          proceeds from business divestiture, net of divested cash
                                                                               
          changes in operating assets and liabilities, net of acquisition:
                                                                               
          withholding taxes arising from shares withheld for share-based payments
                                            -6,000,000 8,000,000                                  
          cash paid, net of cash acquired
                                                                               
          cash acquired in acquisition, net of cash paid
                                    -2,000,000 197,000,000                                        
          depreciation and amortization
                                    490,000,000 501,000,000 484,000,000 471,000,000 449,000,000 464,000,000 518,000,000 524,000,000 559,000,000 503,000,000 522,000,000 521,000,000 542,000,000 523,000,000 519,000,000 524,000,000 525,000,000 543,000,000 506,000,000 518,000,000 444,000,000 288,000,000 277,000,000 277,000,000 273,000,000 287,000,000 269,000,000 259,000,000 265,000,000 261,000,000 273,000,000 261,000,000 253,000,000 251,000,000 252,000,000 257,000,000 272,000,000 253,000,000 267,000,000 274,000,000 268,000,000 265,000,000 266,000,000 
          share-based compensation expense
                                     77,000,000 93,000,000 54,000,000  88,000,000 96,000,000 60,000,000  83,000,000                                  
          net change in commercial paper
                                         540,000,000                                      
          long-term tax liability
                                      71,000,000 63,000,000                                        
          proceeds from sales of property, plant and equipment
                                                                               
          settlement of contingent consideration obligations
                                                                               
          changes in operating assets and liabilities:
                                                                               
          purchases of intangible assets
                                                                               
          proceeds from sale of property, plant and equipment
                                                3,000,000 45,000,000                              
          change in restricted investments
                                                                             
          net proceeds from issuance of common stock in connection with the company’s equity award programs
                                                17,000,000 13,000,000 34,000,000 18,000,000  54,000,000 61,000,000 38,000,000  56,000,000 119,000,000 93,000,000  545,000,000 210,000,000 374,000,000   16,000,000 18,000,000 8,000,000   25,000,000 49,000,000 76,000,000 21,000,000     
          proceeds from the sale of property, plant and equipment
                                             1,000,000                                  
          settlement of contingent consideration obligation
                                                 -225,000,000                            
          purchase of intangible assets
                                                                               
          property, plant and equipment impairments
                                                                               
          legal reserve
                                                                               
          net proceeds from issuance of common stock in connection with the company's equity award programs
                                                                      26,000,000         
          restriction of investments
                                                       -329,000,000                        
          net proceeds from issuance of commercial paper
                                                                               
          repayments of commercial paper
                                                                               
          other accrued liabilities
                                                                817,000,000 73,000,000 -108,000,000 241,000,000 287,000,000 143,000,000 -519,000,000 386,000,000 289,000,000 313,000,000 -668,000,000 95,000,000 -230,000,000 428,000,000 -323,000,000 
          other current assets
                                                                 113,000,000 -62,000,000 126,000,000 39,000,000 -86,000,000 -43,000,000 30,000,000 15,000,000 75,000,000 -123,000,000 44,000,000    
          dividend received from equity investee
                                                                               
          deferred revenue
                                                                       45,000,000   -10,000,000 61,000,000 -21,000,000 297,000,000 
          write-off of acquired in-process research and development
                                                                               
          proceeds from issuance of debt
                                                                               
          proceeds from issuance of convertible notes and related transactions
                                                                               
          proceeds from issuance of warrants
                                                                               
          asset impairments
                                                                               
          net proceeds from issuance of common stock in connection with equity award programs
                                                                            81,000,000 5,000,000 28,000,000 
          proceeds from issuance of notes
                                                                              
          asset impairment
                                                                               
          cash paid for acquisition, net of cash acquired
                                                                             -48,000,000