Alkermes plc
(NASDAQ:ALKS)

Alkermes plc, a biopharmaceutical company, researches, develops, and commercializes pharmaceutical products to address unmet medical needs of patients in various therapeutic areas in the United States, Ireland, and internationally. Its marketed products include ARISTADA (aripiprazole lauroxil), an e...

Website: http://www.alkermes.com

Founded: 1987

Full Time Employees: 2,235

Sector: Healthcare

Industry: Biotechnology

Pharmaceuticals

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At a glance:

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Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2012-12-31	2012-09-30	2012-06-30	2011-12-31	2011-09-30

revenues:
product sales	338,114,000	315,492,000	317,423,000	307,235,000	244,493,000	307,726,000	272,999,000	269,273,000	233,536,000	241,972,000	231,822,000	231,477,000	214,727,000	216,117,000	199,380,000	190,787,000	171,268,000	178,916,000	157,737,000	160,808,000	129,963,000	148,961,000	142,658,000	130,415,000	129,726,000	149,609,000	138,774,000	136,635,000	99,481,000	132,650,000	116,035,000	109,807,000	91,842,000	103,941,000	93,681,000	88,756,000	76,456,000	79,451,000	69,802,000	57,519,000	49,374,000	42,816,000	37,903,000	37,172,000	31,137,000	25,802,000	21,595,000	17,079,000	19,227,000	17,379,000	15,917,000	15,192,000	12,372,000	10,597,000	9,887,000
manufacturing and royalty revenues	54,797,000	69,055,000	76,762,000	83,422,000	62,017,000	122,260,000	105,144,000	129,858,000	116,833,000	135,500,000	149,113,000	385,913,000	72,862,000	88,546,000	52,941,000	85,326,000	105,170,000	143,372,000	136,294,000	142,294,000	119,847,000	130,893,000	120,351,000	116,505,000	116,251,000	107,287,000	103,783,000	127,897,000	108,915,000	167,422,000	116,411,000	128,241,000	114,601,000	138,700,000	122,677,000	129,252,000	114,679,000	133,803,000	110,250,000	137,034,000	106,159,000	119,310,000	114,072,000	113,162,000	128,744,000	132,028,000	130,366,000	111,280,000	118,571,000	119,788,000	118,274,000	107,327,000	138,380,000	112,780,000	54,039,000
total revenues	392,911,000	384,547,000	394,185,000	390,657,000	306,510,000	429,986,000	378,143,000	399,131,000	350,372,000	377,475,000	380,938,000	617,397,000	287,595,000	304,674,000	252,357,000	276,219,000	278,545,000	324,463,000	294,141,000	303,717,000	251,430,000	279,995,000	265,012,000	247,529,000	246,220,000	412,730,000	255,243,000	279,872,000	223,102,000	315,762,000	248,720,000	304,642,000	225,150,000	275,370,000	217,385,000	218,841,000	191,778,000	213,513,000	180,241,000	195,165,000	156,774,000	163,098,000	152,653,000	151,370,000	161,214,000	159,992,000	153,424,000	130,212,000	139,802,000	138,631,000	135,909,000	123,978,000	152,239,000	125,643,000	71,978,000
yoy	28.19%	-10.57%	4.24%	-2.12%	-12.52%	13.91%	-0.73%	-35.35%	21.83%	23.89%	50.95%	123.52%	3.25%	-6.10%	-14.21%	-9.05%	10.78%	15.88%	10.99%	22.70%	2.12%	-32.16%	3.83%	-11.56%	10.36%	30.71%	2.62%	-8.13%	-0.91%	14.67%	14.41%	39.21%	17.40%	28.97%	20.61%	12.13%	22.33%	30.91%	18.07%	28.93%	-2.75%	1.94%	-0.50%	16.25%	15.32%	15.41%	12.89%	5.03%	-8.17%	10.34%	88.82%
qoq	2.18%	-2.45%	0.90%	27.45%	-28.72%	13.71%	-5.26%	13.92%	-7.18%	-0.91%	-38.30%	114.68%	-5.61%	20.73%	-8.64%	-0.84%	-14.15%	10.31%	-3.15%	20.80%	-10.20%	5.65%	7.06%	0.53%	-40.34%	61.70%	-8.80%	25.45%	-29.34%	26.95%	-18.36%	35.31%	-18.24%	26.67%	-0.67%	14.11%	-10.18%	18.46%	-7.65%	24.49%	-3.88%	6.84%	0.85%	-6.11%	0.76%	4.28%	17.83%	-6.86%	0.84%	2.00%	9.62%	-18.56%	21.17%	74.56%
expenses:
cost of goods manufactured and sold	61,578,000	46,209,000	51,591,000	49,460,000	49,197,000	62,116,000	63,099,000	61,472,000	58,644,000	70,093,000	61,509,000	63,260,000	58,175,000	53,964,000	50,625,000	58,360,000	55,159,000	53,682,000	49,561,000	53,124,000	41,020,000	42,922,000	43,129,000	45,053,000	47,211,000	46,482,000	42,319,000	46,223,000	45,361,000	49,117,000	39,410,000	43,417,000	44,476,000	38,507,000	36,054,000	39,775,000	40,412,000	34,957,000	35,456,000	33,998,000	27,711,000	34,791,000	33,806,000	30,418,000	39,974,000	47,335,000	43,290,000	38,839,000	45,423,000	45,991,000	38,914,000	41,491,000	42,070,000	42,752,000	17,530,000
research and development	103,345,000	93,038,000	81,739,000	77,370,000	71,817,000	58,174,000	59,892,000	59,649,000	67,611,000	-20,759,000	97,140,000	100,788,000	93,637,000	104,586,000	100,430,000	92,873,000	95,953,000	98,374,000	118,411,000	97,473,000	92,268,000	112,107,000	94,980,000	94,222,000	93,279,000	198,157,000	107,671,000	104,435,000	102,570,000	108,972,000	101,265,000	106,823,000	108,346,000	104,490,000	104,411,000	99,153,000	104,835,000	89,625,000	99,444,000	97,006,000	101,072,000	93,686,000	92,558,000	87,882,000	70,278,000	78,263,000	67,207,000	52,140,000	45,947,000	33,462,000	31,319,000	35,088,000	37,806,000	40,493,000	28,160,000
selling, general and administrative	264,593,000	187,196,000	171,773,000	170,849,000	171,704,000	146,994,000	150,382,000	168,113,000	179,749,000	140,570,000	169,446,000	205,258,000	174,477,000	157,541,000	152,777,000	150,377,000	145,052,000	160,408,000	136,213,000	139,188,000	125,168,000	145,778,000	127,653,000	132,025,000	133,372,000	154,453,000	148,701,000	155,075,000	141,220,000	141,227,000	128,777,000	138,257,000	118,147,000	110,896,000	99,633,000	108,950,000	102,099,000	97,145,000	91,145,000	96,121,000	89,719,000	87,472,000	89,497,000	71,539,000	63,050,000	51,888,000	50,663,000	42,550,000	39,454,000	32,933,000	29,867,000	31,428,000	29,784,000	35,469,000	36,234,000
amortization of acquired intangible assets	11,675,000					14,000	14,000	14,000	1,059,000	8,996,000	8,995,000	8,898,000	8,800,000	9,165,000	9,166,000	9,066,000	8,966,000	9,616,000	9,615,000	9,511,000	9,406,000	9,917,000	9,917,000	9,890,000	9,728,000	10,171,000	10,173,000	10,062,000	9,952,000	16,426,000	16,426,000	16,247,000	16,069,000	15,642,000	15,643,000	15,472,000	15,302,000	15,323,000	15,323,000	15,157,000	15,156,000	14,206,000	14,207,000	14,052,000	15,220,000	15,244,000	15,089,000	12,576,000	12,856,000	12,716,000	10,549,000	10,547,000	10,434,000	11,896,000	1,817,000
total expenses	441,191,000	326,443,000	305,103,000	297,679,000	292,718,000	267,298,000	273,387,000	289,248,000	307,063,000	198,900,000	337,090,000	378,204,000	335,089,000	325,256,000	312,998,000	310,676,000	305,130,000	322,080,000	313,800,000	299,296,000	267,862,000	310,724,000	275,679,000	281,190,000	283,590,000	422,664,000	308,864,000	315,795,000	299,103,000	315,742,000	285,878,000	304,744,000	287,038,000	269,535,000	255,741,000	263,350,000	262,648,000	237,050,000	241,368,000	242,282,000	233,658,000	230,155,000	230,068,000	203,891,000	188,522,000	192,730,000	176,249,000	146,105,000	143,680,000	125,102,000	110,649,000	118,554,000	120,094,000	130,610,000	83,741,000
operating income	-48,280,000									178,575,000	43,848,000	239,193,000	-47,494,000	-20,582,000	-60,641,000	-34,457,000	-26,585,000	2,383,000	-19,659,000	4,421,000	-16,432,000	-30,729,000	-10,667,000	-33,661,000	-37,370,000	-9,934,000	-53,621,000	-35,923,000	-76,001,000	20,000	-37,158,000	-102,000	-61,888,000	5,835,000	-38,356,000	-44,509,000	-70,870,000	-23,537,000	-61,127,000	-47,117,000	-76,884,000	-67,057,000	-77,415,000	-52,521,000	-27,308,000					13,529,000	25,260,000	5,424,000	32,145,000		-11,763,000
yoy										-967.63%	-172.31%	-794.18%	78.65%	-963.70%	208.46%	-879.39%	61.79%	-107.75%	84.30%	-113.13%	-56.03%	209.33%	-80.11%	-6.30%	-50.83%	-49770.00%	44.31%	35118.63%	22.80%	-99.66%	-3.12%	-99.77%	-12.67%	-124.79%	-37.25%	-5.54%	-7.82%	-64.90%	-21.04%	-10.29%	181.54%										-314.74%
qoq										307.26%	-81.67%	-603.63%	130.76%	-66.06%	75.99%	29.61%	-1215.61%	-112.12%	-544.67%	-126.90%	-46.53%	188.08%	-68.31%	-9.93%	276.18%	-81.47%	49.27%	-52.73%	-380105.00%	-100.05%	36329.41%	-99.84%	-1160.63%	-115.21%	-13.82%	-37.20%	201.10%	-61.49%	29.73%	-38.72%	14.65%	-13.38%	47.40%	92.33%						-46.44%	365.71%	-83.13%
operating margin %	-12.29%	0%	0%	0%	0%	0%	0%	0%	0%	47.31%	11.51%	38.74%	-16.51%	-6.76%	-24.03%	-12.47%	-9.54%	0.73%	-6.68%	1.46%	-6.54%	-10.97%	-4.03%	-13.60%	-15.18%	-2.41%	-21.01%	-12.84%	-34.07%	0.01%	-14.94%	-0.03%	-27.49%	2.12%	-17.64%	-20.34%	-36.95%	-11.02%	-33.91%	-24.14%	-49.04%	-41.11%	-50.71%	-34.70%	-16.94%	0%	0%	0%	0%	9.76%	18.59%	4.37%	21.11%	0%	-16.34%
other income, net:
interest income	8,539,000	12,130,000	11,943,000	11,090,000	10,141,000	11,400,000	10,916,000	10,735,000	9,399,000	9,749,000	9,370,000	6,769,000	4,966,000	3,921,000	2,239,000	896,000	573,000	453,000	468,000	623,000	864,000	1,481,000	1,376,000	1,788,000	2,760,000	2,696,250	3,509,000	3,706,000	3,570,000	1,486,500	2,561,000	1,900,000	1,485,000	1,362,000	1,173,000	1,171,000	943,000	835,000	912,000	994,000	1,011,000	1,010,000	865,000	795,000	660,000	546,000	323,000	511,000	295,000	161,000	155,000	216,000	299,000	350,000	383,000
interest expense	-20,892,000					-4,648,000	-6,000,000	-5,952,000	-5,978,000	-6,054,000	-6,006,000	-5,684,000	-5,288,000	-4,769,000	-3,552,000	-2,369,000	-2,350,000	-2,405,000	-2,437,000	-2,407,000	-3,970,000	-1,697,500	-1,811,000	-2,122,000	-2,857,000	-2,601,250	-3,385,000	-3,520,000	-3,500,000	-2,989,750	-3,346,000	-3,126,000	-5,487,000	-3,192,000	-3,129,000	-2,923,000	-2,764,000	-4,896,000	-3,375,000	-3,323,000	-3,295,000	-3,319,000	-3,325,000	-3,315,000	-3,288,000										-7,561,000
other income	-1,293,000	2,420,000	-280,000	771,000	1,556,000	449,000	558,000	2,053,000	182,000	-10,000	149,000	-525,000	-39,000	-258,000	-1,861,000	1,810,000	2,431,000	546,000	288,000	-222,000		4,843,000	9,368,000	2,337,000				1,851,000	-1,721,000				792,000				-1,499,000	-1,515,000	-752,000	-467,000	249,000	-988,000	629,000	585,000								723,000	923,000	345,000	336,000
total other income	-13,646,000	2,273,000	11,663,000	11,861,000	11,697,000	7,201,000	5,474,000	6,836,000	3,603,000	3,685,000	3,513,000	560,000				1,207,000		-2,156,000	-6,876,000	1,234,000	-2,221,000	6,701,750	12,859,000	7,903,000	6,045,000	-7,238,500	-240,000			-6,532,000	3,325,000			4,951,000	2,566,000			-776,000	-4,215,000	-596,000		-5,736,000	-605,000	9,476,000
income before income taxes	-61,926,000	60,377,000	100,745,000	104,839,000	25,489,000	169,889,000	110,230,000	116,719,000	46,912,000	182,260,000	47,361,000	239,753,000	-47,855,000	-21,688,000	-67,368,000		-44,998,000	227,000	-26,535,000	5,655,000	-18,653,000	-41,646,000	2,192,000	-25,758,000	-31,325,000	-2,557,000	-53,861,000	-40,386,000	-100,252,000	-1,691,000	-33,833,000	-24,445,000	-66,998,000	10,786,000	-35,790,000	-45,680,000	-72,590,000	-24,313,000	-65,342,000	-47,713,000	-77,019,000	-72,793,000	-78,020,000	-43,045,000	-30,147,000		2,212,000			10,052,000	20,663,000		23,197,000		-18,605,000
income tax provision	4,554,000	11,036,000	17,984,000	17,741,000	3,025,000	24,152,000	17,435,000	22,061,000	7,964,000			2,688,000		6,566,000	-3,394,000	-3,114,000	-9,095,000	-646,000	2,453,000	3,291,000	3,765,000	3,332,000	2,326,000	3,673,000	7,329,000	-808,250	-983,000	1,604,000		1,080,500	611,000	8,204,000		20,575,000	486,000											3,523,000		3,766,000	233,000		4,405,000	422,000	764,000
net income	-66,480,000	49,341,000	82,761,000	87,098,000	22,464,000	146,503,000	92,381,000	91,358,000	36,828,000	112,779,000	47,758,000	237,065,000	-41,845,000	-28,254,000	-63,974,000	-30,136,000	-35,903,000	873,000	-28,988,000	2,364,000	-22,418,000	-42,642,000	-134,000	-29,431,000	-38,654,000	-5,354,000	-52,878,000	-41,990,000	-96,398,000	-9,713,000	-34,444,000	-32,649,000	-62,505,000	-9,789,000	-36,276,000	-42,999,000	-68,881,000	-21,141,000	-62,687,000	-47,193,000	-77,423,000	-69,382,000	-81,015,000	-46,109,000	-30,657,000	-39,956,000	3,735,000	-24,354,000	-7,762,000	7,334,000	16,258,000	-16,707,000	22,433,000	-14,828,000	-22,255,000
yoy	-395.94%	-66.32%	-10.41%	-4.66%	-39.00%	29.90%	93.44%	-61.46%	-188.01%	-499.16%	-174.65%	-886.65%	16.55%	-3336.43%	120.69%	-1374.79%	60.15%	-102.05%	21532.84%	-108.03%	-42.00%	696.45%	-99.75%	-29.91%	-59.90%	-44.88%	53.52%	28.61%	54.22%	-0.78%	-5.05%	-24.07%	-9.26%	-53.70%	-42.13%	-8.89%	-11.03%	-69.53%	-22.62%	2.35%	152.55%	73.65%	-2269.08%	89.33%	294.96%	-644.81%	-77.03%	45.77%	-134.60%	-149.46%	-173.05%
qoq	-234.74%	-40.38%	-4.98%	287.72%	-84.67%	58.59%	1.12%	148.07%	-67.34%	136.15%	-79.85%	-666.53%	48.10%	-55.84%	112.28%	-16.06%	-4212.60%	-103.01%	-1326.23%	-110.55%	-47.43%	31722.39%	-99.54%	-23.86%	621.96%	-89.87%	25.93%	-56.44%	892.46%	-71.80%	5.50%	-47.77%	538.52%	-73.02%	-15.64%	-37.57%	225.82%	-66.28%	32.83%	-39.05%	11.59%	-14.36%	75.70%	50.40%	-23.27%	-1169.77%	-115.34%	213.76%	-205.84%	-54.89%	-197.31%	-174.48%	-251.29%	-33.37%
net income margin %	-16.92%	12.83%	21.00%	22.30%	7.33%	34.07%	24.43%	22.89%	10.51%	29.88%	12.54%	38.40%	-14.55%	-9.27%	-25.35%	-10.91%	-12.89%	0.27%	-9.86%	0.78%	-8.92%	-15.23%	-0.05%	-11.89%	-15.70%	-1.30%	-20.72%	-15.00%	-43.21%	-3.08%	-13.85%	-10.72%	-27.76%	-3.55%	-16.69%	-19.65%	-35.92%	-9.90%	-34.78%	-24.18%	-49.39%	-42.54%	-53.07%	-30.46%	-19.02%	-24.97%	2.43%	-18.70%	-5.55%	5.29%	11.96%	-13.48%	14.74%	-11.80%	-30.92%
earnings per ordinary share:
earnings per ordinary share- basic	-400
earnings per ordinary share - diluted	-400	290	490	520	130	870	550	530
weighted-average number of ordinary shares outstanding:
basic	166,196,000	164,703,000	165,086,000	164,959,000	163,407,000	165,392,000	163,368,000	168,321,000	167,984	166,223	166,607,000	166,279,000				163,839,000				160,817,000																						149,206,000		148,867,000		145,896,000	144,913,000	143,358,000	136,106,000	134,602,000	132,097,000	131,067,000	130,434,000
diluted	166,196,000	168,743,000	168,510,000	168,357,000	168,737,000	169,198,000	167,025,000	170,977,000	172,981	169,730	171,903,000	171,553,000				163,839,000				163,937,000																						149,206,000		148,867,000		145,896,000	154,300,000	143,358,000	136,106,000	143,369,000	137,497,000	131,067,000	134,945,000
comprehensive income:
holding gain, net of a tax provision of (171), and 168, respectively	-568,000
foreign currency translation loss	-240,000
comprehensive income	-67,288,000	48,300,000	83,102,000	87,153,000	22,976,000	144,111,000	96,396,000	91,369,000	36,337	-247,429,464	49,121,000	237,757,000				-32,390,000				2,092,000																										-40,110,000	-7,021,000	-26,885,000	744,000	6,926,000	16,392,000	-16,576,000	22,220,000
research and development revenue									3,000	3,000	3,000	7,000	6,000	11,000	36,000	106,000	107,000	175,000	110,000	615,000	120,000	141,000	953,000	609,000	243,000	11,084,000	12,686,000	14,340,000	14,706,000	15,570,000	16,274,000	18,344,000	18,707,000	4,729,000	1,027,000	833,000	643,000	259,000	189,000	612,000	1,241,000	972,000	678,000	1,036,000	1,333,000	2,162,000	1,463,000	1,853,000	2,004,000	1,464,000	1,718,000	1,459,000	1,487,000	2,266,000	8,052,000
operating income from continuing operations		58,104,000	89,082,000	92,978,000	13,792,000	162,688,000	104,756,000	109,883,000	43,309,000
net income from continuing operations		49,341,000	82,761,000	87,098,000	22,464,000	145,737,000	92,795,000	94,658,000	38,948,000
loss from discontinued operations, net of tax						766,000	-414,000	-3,300,000	-2,120,000
earnings per ordinary share from continuing operations - basic		300	500	530	140	890	570	560
loss per ordinary share from discontinued operations - basic						10		-20
earnings per ordinary share - basic		300	500	530	140	900	570	540
earnings per ordinary share from continuing operations - diluted		290	490	520	130	870	560	550
loss per ordinary share from discontinued operations - diluted								-20
holding gain, net of a tax provision of 108, 376, 293 and 293, respectively		227,000	341,000
holding gain, net of a tax provision of 16, (8), 184 and (83), respectively				55,000
holding gain, net of a tax provision of 168 and (75), respectively					512,000
holding gain, net of a tax provision of 376, 216, 293 and 803, respectively						883,750	4,015,000
holding gain, net of a tax provision of (8), 99, (83) and 587, respectively								11,000
earnings per share from continuing operations - basic									0.23
loss per share from discontinued operations - basic									-0.01
earnings per share - basic									0.22
earnings per share from continuing operations - diluted									0.23
loss per share from discontinued operations - diluted									-0.01
earnings per share - diluted									0.21
holding gain, net of a tax provision of (75) and 488, respectively									-491
license revenue																	2,000,000	2,000,000			1,500,000		1,050,000			144,750,000		1,000,000		120,000		48,250,000
change in the fair value of contingent consideration															-3,553,000	870,000	-19,067,000	-750,000	-5,195,000	3,240,000	1,278,000	4,156,500	3,926,000	5,900,000	6,800,000	-6,950,000	1,300,000	-6,500,000	-22,600,000	-4,325,000	4,200,000	-19,600,000	-1,900,000	5,700,000	13,600,000			4,800,000	-1,000,000
income tax benefit										-929,750	-397,000		-6,010,000																-3,854,000				-4,493,000			-2,681,000																		98,000	3,650,000
earnings per ordinary share:
basic										365	290	1,430																																		-270	30	-170	-60		120	-130
diluted										355	280	1,380																																		-270	20	-170	-60		120	-130
holding gain, net of a tax provision of 216, (188), 803 and (1,242), respectively										1,203,750	1,363,000
holding gain, net of a tax provision of 99, 326, 587 and (1,055), respectively												692,000
other expense, net:
total other expense													-361,000	-5,983,250	-6,727,000		-18,413,000											-4,463,000	-24,251,000			-24,343,000	-5,110,000			-1,171,000	-1,720,000				-135,000				-2,839,000
loss per ordinary share:
basic and diluted													-250	-180	-390		-220	10	-180		-140	-270		-190	-240	-30	-340	-270	-620	-60	-220	-210	-400
weighted-average number of ordinary shares outstanding:
basic and diluted													165,085,000	163,541,000	164,282,000		162,483,000	160,942,000	161,456,000		159,634,000	158,803,000	159,062,000	158,895,000	158,095,000	157,051,000	157,199,000	156,991,000	156,336,000	155,112,000	155,328,000	155,176,000	154,424,000	153,415,000	153,684,000	153,392,000	152,704,000	151,484,000	151,652,000	151,301,000	150,825,000		149,512,000		148,089,000									129,670,000	102,474,000
comprehensive loss:
holding gain, net of a tax provision of 488 and (1,382), respectively													2,760,000
comprehensive loss													-39,085,000	-26,306,000	-66,323,000		-40,414,000	-379,000	-29,237,000		-23,019,000	-16,790,750	-793,000	-28,033,000	-38,337,000	-47,406,000	-52,902,000	-41,094,000	-95,628,000	-32,368,000	-34,130,000	-32,501,000	-62,841,000	-10,329,000	-36,193,000	-43,132,000	-68,809,000	-21,607,000	-62,948,000	-46,878,000	-76,488,000	-39,339,250	-81,001,000	-46,189,000	-30,168,000									-14,834,000	-22,687,000
holding loss, net of a tax benefit of 188, 72, 1,242 and 325, respectively														-2,278,500	-2,349,000
earnings before income taxes																-33,250,000
earnings per ordinary share:
basic and diluted																-180				10																																	170
holding loss, net of a tax provision of 326, (79), (1,055) and (253), respectively																-2,254,000
holding loss, net of a tax benefit of (1,382) and (174), respectively																	-4,511,000
holding gain, net of a tax provision of (72), (193), (325) and 303, respectively																		-280,500	-249,000
holding gain, net of a tax provision of (79), 409, (253) and 496, respectively																				-272,000
other expense																					-393,000				-658,000	-383,500	-1,664,000			-703,750	-90,000	-3,517,000		-2,674,000	-9,078,000	-119,000									-211,000
holding gain, net of a tax provision of (174) and 87, respectively																					-601,000
unrealized gain, net of a tax provision of (193), (15), 303 and 479, respectively																						264,000	-659,000
unrealized gain, net of a tax provision of 409, 265, 496 and 494, respectively																								1,398,000
unrealized gain, net of a tax provision of 87 and 229, respectively																									317,000
holding gain, net of a tax provision of (15), 95, 479 and 42, respectively																										410,500	-24,000
holding gain, net of a tax provision of 265, 47, 494 and (53), respectively																												896,000
holding gain, net of a tax provision of 229 and (100), respectively																													770,000
holding gain, net of a tax provision of 95, 35, 42 and (14), respectively																														31,500	314,000
holding gain, net of a tax provision of 47, (71), (53) and (49), respectively																																148,000
holding gain, net of a tax provision of (100) and 23, respectively																																	-336,000
loss per common share:
basic and diluted																																		-242.5	-240	-280	-450	-140	-410	-310	-510	-265	-540		-210									-110	-220
weighted-average number of common shares outstanding:
basic and diluted													165,085,000	163,541,000	164,282,000		162,483,000	160,942,000	161,456,000		159,634,000	158,803,000	159,062,000	158,895,000	158,095,000	157,051,000	157,199,000	156,991,000	156,336,000	155,112,000	155,328,000	155,176,000	154,424,000	153,415,000	153,684,000	153,392,000	152,704,000	151,484,000	151,652,000	151,301,000	150,825,000		149,512,000		148,089,000									129,670,000	102,474,000
holding gain, net of a tax provision of 35, (129), (14) and 445, respectively																																		5,500	83,000
increase in the fair value of contingent consideration																																				700,000	1,600,000			2,200,000	1,900,000	675,000	1,200,000	1,500,000
holding gain, net of a tax provision of (71), 149, (49) and 574, respectively																																				-133,000
provision for income taxes																																					-3,709,000	-3,172,000	-2,655,000	-520,000	404,000	-3,411,000	2,995,000	3,064,000	510,000					2,718,000
holding gain, net of a tax provision of 23 and 425, respectively																																					72,000
gain on the gainesville transaction																																										-301,000	26,000
holding gains, net of a tax provision of (129), , 445 and 165, respectively																																						247,000	-261,000
holding gains, net of a tax provision of 149, (39), 574 and 170, respectively																																								315,000
holding gains, net of a tax provision of 425 and 209, respectively																																									935,000
gain on sale of property, plant and equipment																																														36,000	12,285,000
gain on sale of investment in acceleron pharma inc.																																															15,296,000
holding gains, net of tax of , 89, 165 and 7,715, respectively																																										106,000	14,000
reclassification of unrealized gains to realized gains
gain on gainesville transaction																																												9,911,000
earnings per common share:
basic																																												-310						50
diluted																																												-310						50
weighted-average number of common shares outstanding:
basic	166,196,000	164,703,000	165,086,000	164,959,000	163,407,000	165,392,000	163,368,000	168,321,000	167,984	166,223	166,607,000	166,279,000				163,839,000				160,817,000																						149,206,000		148,867,000		145,896,000	144,913,000	143,358,000	136,106,000	134,602,000	132,097,000	131,067,000	130,434,000
diluted	166,196,000	168,743,000	168,510,000	168,357,000	168,737,000	169,198,000	167,025,000	170,977,000	172,981	169,730	171,903,000	171,553,000				163,839,000				163,937,000																						149,206,000		148,867,000		145,896,000	154,300,000	143,358,000	136,106,000	143,369,000	137,497,000	131,067,000	134,945,000
holding gains, net of tax of (39), 6,174, 170 and 7,627, respectively																																												-80,000
unrealized gains on marketable securities, net of tax:
holding gains, net of tax of 209 and 1,453, respectively																																													489,000
unrealized gains on marketable securities																																													489,000				8,506,000		134,000			27,000	-188,000
restructuring
impairment of long-lived assets
holding gains, net of tax of 89, none, 7,715 and none, respectively
operating (loss) income
other income (expense), net:
other income (expense)																																															518,000
total other income (expense)																																															25,037,000
holding gains (losses), net of tax of 6,174, none, 7,627 and none, respectively																																															4,540,000
other (expense), net:
total other (expense)																																																							-6,842,000
holding gains, net of tax of 1,453 and none, respectively
unrealized gains on derivative contracts																																																				594,000
unrealized holding losses on marketable securities
unrealized losses on derivative contracts
holding gains, net of tax																																																			134,000			27,000	-188,000
less: reclassification adjustment for gains included in net income
unrealized gains on derivative contracts:
less: reclassification adjustment for losses included in net income																																																				594,000
holding gains, net of tax of none in the three and six months ended september 30, 2012 and 111 and 202 in the three and six months ended september 30, 2011, respectively																																																				567,000
unrealized gains on marketable securities:
holding gains, net of tax of none and 313, respectively
unrealized losses on derivative contracts, net of tax																																																							-244,000

Balance Sheets:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2012-12-31	2012-09-30	2012-06-30	2011-12-31	2011-09-30

assets
current assets:
cash and cash equivalents	351,551,000	388,570,000	616,449,000	521,199,000	399,806,000	291,146,000	396,293,000	535,150,000	420,753,000	457,469,000	647,711,000	665,795,000	321,401,000	292,473,000	263,957,000	254,646,000	282,557,000	337,544,000	310,444,000	258,341,000	205,028,000	272,961,000	240,866,000	189,002,000	176,067,000	203,771,000	261,426,000	195,954,000	225,234,000	266,762,000	216,041,000	155,849,000	186,505,000	191,296,000	165,123,000	158,106,000	181,307,000	186,378,000	202,239,000	196,438,000	199,976,000	181,109,000	222,341,000	196,893,000	209,313,000	136,182,000	188,322,000	156,325,000	173,505,000	116,397,000	135,892,000	132,418,000	85,599,000	85,331,000	89,237,000
restricted cash		731,206,000
investments—short-term	160,311,000	199,645,000	494,665,000	494,540,000	484,211,000	460,522,000	512,571,000	340,967,000	324,295,000	316,022,000	241,439,000	163,254,000	279,058,000	315,992,000	316,225,000	326,321,000	246,315,000	198,767,000	249,856,000	280,004,000	335,967,000	362,066,000	328,516,000	343,561,000	319,927,000	331,208,000	325,756,000	374,340,000	356,894,000	272,533,000	251,046,000	277,658,000	218,057,000	242,208,000	284,977,000	317,001,000	295,112,000	310,856,000	347,218,000	459,543,000
receivables	407,630,000	334,025,000	354,394,000	354,906,000	318,703,000	384,528,000	367,211,000	366,415,000	315,848,000	332,477,000	337,697,000	334,478,000	269,178,000	287,967,000	257,173,000	245,840,000	249,942,000	313,193,000	289,160,000	297,357,000	243,514,000	275,143,000	265,644,000	237,393,000	246,716,000	257,086,000	250,234,000	261,226,000	222,811,000	292,223,000	250,913,000	255,230,000	214,160,000	233,590,000	207,537,000	199,709,000	176,487,000	191,102,000	177,446,000	185,008,000	139,814,000	155,487,000	140,987,000	135,782,000	141,978,000	143,692,000	139,316,000	123,154,000	120,448,000	130,578,000	119,835,000	101,998,000	135,656,000	104,684,000	79,644,000
inventory	336,703,000	196,625,000	190,997,000	191,924,000	183,438,000	182,887,000	191,087,000	194,731,000	198,369,000	186,406,000	192,186,000	189,372,000	184,984,000	181,418,000	166,296,000	155,608,000	154,786,000	150,335,000	138,696,000	136,077,000	134,178,000	125,738,000	122,823,000	116,458,000	109,314,000	101,803,000	100,987,000	94,780,000	92,861,000	90,196,000	88,018,000	87,165,000	84,884,000	93,275,000	85,027,000	77,352,000	63,666,000	62,998,000	54,155,000	49,896,000	44,817,000	38,411,000	36,783,000	38,801,000	49,139,000	50,471,000	57,066,000	55,403,000	40,708,000	39,128,000	45,686,000	40,887,000	41,442,000	46,109,000	47,118,000
prepaid expenses and other current assets	102,449,000	79,090,000	84,442,000	71,295,000	89,843,000	91,282,000	94,047,000	101,435,000	111,539,000	98,166,000	42,982,000	44,452,000	47,008,000	43,527,000	40,041,000	47,090,000	61,018,000	48,967,000	61,341,000	57,186,000	78,043,000	60,662,000	52,697,000	51,705,000	46,361,000	59,716,000	54,493,000	55,607,000	56,492,000	53,308,000	50,265,000	49,639,000	46,463,000	48,475,000	38,887,000	43,458,000	42,279,000	39,344,000	26,204,000	38,369,000	28,539,000	26,286,000	33,378,000	50,424,000	50,768,000	46,174,000	52,048,000	45,941,000	22,998,000	23,838,000	12,697,000	12,583,000	10,939,000	10,916,000	13,382,000
total current assets	1,358,644,000	1,929,161,000	1,741,664,000	1,635,288,000	1,479,050,000	1,415,355,000	1,564,178,000	1,542,190,000	1,468,825,000	1,485,506,000	1,464,781,000	1,397,351,000	1,110,058,000	1,130,306,000	1,053,797,000	1,045,991,000	1,014,830,000	1,062,169,000	1,053,006,000	1,037,758,000	1,006,009,000	1,110,971,000	1,024,941,000	947,359,000	912,584,000	961,970,000	997,918,000	994,597,000	962,739,000	983,252,000	869,759,000	840,123,000	776,138,000	808,844,000	781,551,000	795,626,000	758,851,000	790,678,000	807,262,000	929,254,000	838,560,000	754,962,000	1,000,423,000	1,016,962,000	1,003,548,000	812,906,000	886,919,000	776,771,000	523,580,000	422,085,000	387,522,000	354,919,000	352,408,000	375,136,000	355,708,000
property, plant and equipment	220,587,000	221,722,000	246,982,000	239,399,000	233,920,000	227,564,000	225,422,000	222,738,000	224,590,000	226,943,000	327,517,000	323,801,000	321,109,000	325,361,000	326,350,000	337,146,000	336,740,000	341,054,000	340,594,000	343,949,000	346,327,000	350,003,000	355,215,000	361,807,000	362,539,000	362,168,000	341,406,000	326,230,000	320,004,000	309,987,000	303,087,000	296,635,000	289,621,000	284,736,000	270,666,000	266,484,000	264,915,000	264,785,000	262,181,000	258,354,000	256,326,000	254,819,000	242,675,000	239,258,000	268,760,000	262,128,000	264,247,000	268,992,000	274,377,000	281,253,000	292,186,000	295,374,000	299,536,000	302,612,000
investments—long-term	26,363,000	145,000	27,869,000	38,269,000	32,189,000	73,148,000	18,920,000	86,402,000	62,782,000	39,887,000	106,431,000	78,127,000	92,083,000	131,610,000	166,928,000	179,010,000	229,825,000	229,430,000	187,855,000	131,032,000	86,448,000	24,780,000	27,774,000	7,033,000	53,744,000	79,391,000	21,352,000	23,299,000	43,005,000	80,744,000	111,456,000	127,012,000	137,473,000	157,212,000	118,751,000	85,724,000	112,954,000	121,931,000	75,147,000	21,690,000	93,990,000	264,071,000	43,739,000	55,589,000	58,249,000
right-of-use assets	78,248,000	77,209,000	79,128,000	80,532,000	82,406,000	84,245,000	86,076,000	87,889,000	89,683,000	91,460,000	103,170,000	107,356,000	111,586,000	115,855,000	106,980,000	111,119,000	115,321,000	115,627,000	118,764,000	123,012,000	127,430,000	131,718,000	106,681,000	111,338,000	114,548,000	12,379,000	13,835,000	15,911,000	18,010,000
intangible assets	1,784,040,000								932,000	1,991,000	10,987,000	19,982,000	28,880,000	37,680,000	46,845,000	56,011,000	65,077,000	74,043,000	83,659,000	93,274,000	101,785,000	111,191,000	121,108,000	131,025,000	140,915,000	150,643,000	160,814,000	170,986,000	181,049,000	191,001,000	207,426,000	223,852,000	240,099,000																		586,315,000	596,864,000	607,411,000	675,287,000
goodwill	596,029,000								83,027,000	83,027,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	92,873,000	94,212,000	92,740,000	92,740,000	92,740,000	92,740,000	92,740,000	92,740,000	92,740,000	92,740,000	105,700,000	104,989,000
deferred tax assets	134,808,000	125,815,000	130,344,000	155,533,000	152,144,000	154,835,000	159,960,000	167,382,000	182,536,000	195,888,000	162,184,000	153,152,000	151,232,000	115,602,000	137,149,000	123,702,000	112,515,000	81,833,000	84,498,000	75,643,000	81,124,000	86,228,000	86,336,000	88,453,000	92,781,000	96,558,000	87,615,000	86,894,000	87,605,000	85,807,000	92,279,000	93,066,000	100,504,000	98,560,000	117,453,000	112,332,000	106,748,000	47,768,000	50,296,000	46,870,000	63,886,000
other assets	59,357,000	49,099,000	19,664,000	19,908,000	18,369,000	16,503,000	16,804,000	16,296,000	11,521,000	11,521,000	11,288,000	14,542,000	14,906,000	14,691,000	10,977,000	11,565,000	10,664,000	10,836,000	16,772,000	17,396,000	16,813,000	17,315,000	15,692,000	17,386,000	16,762,000	17,021,000	14,782,000	14,861,000	13,651,000	16,143,000	16,330,000	14,625,000	16,950,000	14,034,000	16,121,000	25,351,000	25,761,000	26,961,000	27,667,000	27,972,000	28,022,000	13,677,000	20,693,000	43,295,000	35,813,000	31,678,000	28,381,000	22,495,000	15,504,000	22,050,000	23,024,000	21,924,000	26,013,000	26,567,000	25,822,000
total assets	4,258,076,000	2,486,993,000	2,329,512,000	2,252,809,000	2,081,977,000	2,055,567,000	2,155,291,000	2,206,842,000	2,123,896,000	2,136,223,000	2,279,231,000	2,187,184,000	1,922,727,000	1,963,978,000	1,941,899,000	1,957,417,000	1,977,845,000	2,024,484,000	1,995,432,000	1,937,569,000	1,878,221,000	1,949,730,000	1,876,820,000	1,802,337,000	1,825,946,000	1,805,403,000	1,757,995,000	1,751,751,000	1,756,536,000	1,825,007,000	1,760,710,000	1,751,486,000	1,736,558,000	1,797,227,000	1,748,326,000	1,731,343,000	1,729,827,000	1,726,423,000	1,707,376,000	1,785,286,000	1,794,887,000	1,855,744,000	1,880,955,000	1,914,676,000	1,924,774,000	1,837,855,000	1,857,592,000	1,835,478,000	1,512,437,000	1,477,854,000	1,411,763,000	1,370,547,000	1,445,667,000	1,505,827,000	1,504,103,000
liabilities and shareholders’ equity
current liabilities:
accounts payable and accrued expenses	292,579,000	289,565,000	214,985,000	245,749,000	186,035,000	185,332,000	160,198,000	239,774,000	205,854,000	240,561,000	243,263,000	242,923,000	190,149,000	220,089,000	211,177,000	186,814,000	173,126,000	445,707,000	428,032,000	357,961,000	339,088,000	412,171,000	354,780,000	295,688,000	313,592,000	373,037,000	357,126,000	320,490,000	313,969,000	333,762,000	295,029,000	279,702,000	268,166,000	286,166,000	251,187,000	219,839,000	205,309,000	207,055,000	185,716,000	170,507,000	157,480,000	168,735,000	132,000,000	125,722,000	105,181,000	100,329,000	93,033,000	83,750,000	64,282,000	63,719,000	67,655,000	58,406,000	58,127,000	88,976,000	83,750,000
accrued sales discounts, allowances and reserves	272,843,000	247,126,000	252,743,000	253,173,000	249,795,000	272,452,000	282,018,000	263,457,000	240,877,000	263,641,000	238,467,000	222,768,000	282,264,000	252,115,000	235,640,000	228,973,000	265,172,000
operating lease liabilities—short-term	7,577,000	6,746,000	6,632,000	6,462,000	6,291,000	6,166,000	6,150,000	6,007,000	5,910,000	5,746,000	15,058,000	15,192,000	15,304,000	15,722,000	15,756,000	15,944,000	16,144,000	16,240,000	15,548,000	15,847,000	15,833,000	15,732,000	13,375,000	15,294,000	16,595,000	8,466,000	8,627,000	8,710,000	8,795,000
current portion of long-term debt	26,500,000						3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	2,843,000
total current liabilities	599,499,000	543,437,000	474,360,000	505,962,000	443,730,000	465,199,000	453,705,000	515,549,000	458,977,000	520,220,000	503,107,000	487,185,000	492,910,000	497,742,000	469,555,000	438,518,000	462,361,000	471,286,000	452,984,000	383,442,000	365,842,000	438,258,000	378,151,000	321,414,000	339,849,000	391,112,000	370,394,000	334,146,000	327,685,000	339,774,000	304,788,000	287,473,000	274,530,000	291,122,000	256,014,000	224,644,000	210,742,000	211,993,000	190,240,000	236,263,000	224,131,000	236,207,000	200,402,000	134,218,000	114,217,000	110,140,000	102,160,000	92,759,000	73,717,000	72,598,000	77,279,000	68,738,000	71,239,000	97,196,000	90,324,000
operating lease liabilities—long-term	63,746,000	63,253,000	64,966,000	66,216,000	67,811,000	69,372,000	71,030,000	72,535,000	74,102,000	75,709,000	78,552,000	82,342,000	86,112,000	89,829,000	95,731,000	99,832,000	104,014,000	104,162,000	107,860,000	111,664,000	115,504,000	119,464,000	96,717,000	99,438,000	101,006,000	5,342,000	6,657,000	8,864,000	11,020,000
contingent consideration	109,494,000																	16,619,000	17,411,000	22,632,000	19,412,000	24,651,000	46,200,000	45,063,000	39,200,000	32,400,000	27,400,000	26,100,000	37,600,000	65,200,000	67,500,000	63,300,000	82,900,000	84,800,000	79,100,000	65,500,000	64,800,000	63,200,000	58,400,000	59,400,000	57,200,000	55,300,000	60,300,000	59,100,000
long-term debt	1,483,837,000						285,823,000	286,459,000	287,095,000	287,730,000	288,366,000	289,001,000	289,635,000	290,270,000	290,904,000	291,537,000	292,171,000	292,804,000	293,437,000	294,070,000	294,702,000	272,118,000	272,663,000	273,207,000	273,751,000	274,295,000	274,838,000	275,381,000	275,923,000	276,465,000	277,007,000	277,548,000	278,088,000	278,436,000	278,994,000	279,552,000	280,109,000	280,666,000	282,576,000	283,120,000	283,664,000	284,207,000	286,512,000	348,056,000	349,638,000	352,801,000	354,382,000	355,963,000	359,122,000	360,690,000	362,349,000	363,847,000	441,083,000	441,668,000	441,859,000
deferred tax liabilities	181,920,000																																								161,000
other long-term liabilities	68,049,000	61,008,000	56,754,000	56,047,000	58,853,000	56,019,000	52,627,000	48,294,000	48,959,000	49,878,000	53,623,000	48,219,000	48,494,000	42,384,000	42,855,000	45,206,000	43,909,000	32,157,000	32,119,000	36,324,000	36,273,000	36,511,000	26,296,000	27,551,000	27,166,000	27,144,000	26,734,000	30,571,000	28,425,000	27,958,000	23,190,000	22,453,000	21,883,000	19,204,000	19,906,000	18,278,000	15,750,000	17,161,000	17,206,000	15,434,000	14,411,000	12,610,000	13,264,000	12,859,000	12,135,000	8,545,000	11,596,000	10,230,000	17,486,000	17,311,000	10,124,000	10,541,000	8,514,000	8,444,000	8,052,000
total liabilities	2,506,545,000	667,698,000	596,080,000	628,225,000	570,394,000	590,590,000	863,185,000	922,837,000	869,133,000	933,537,000	923,648,000	906,747,000	917,151,000	920,225,000	899,045,000	875,093,000	902,455,000	911,900,000	899,264,000	839,667,000	827,066,000	882,748,000	792,462,000	740,491,000	762,928,000	719,961,000	689,811,000	660,583,000	654,395,000	653,722,000	609,995,000	593,331,000	580,667,000	594,419,000	561,046,000	529,256,000	513,123,000	516,942,000	497,682,000	541,760,000	529,809,000	541,469,000	514,150,000	515,685,000	504,355,000	504,263,000	505,767,000	495,977,000	495,460,000	495,914,000	491,824,000	485,539,000	563,181,000	600,974,000	594,423,000
commitments and contingent liabilities
shareholders’ equity:
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at march 31, 2026 and december 31, 2025, respectively.
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 183,592,868 and 181,011,166 shares issued; and 166,462,299 and 165,607,028 shares outstanding at march 31, 2026 and december 31, 2025, respectively	1,836,000
treasury shares, at cost	-501,425,000	-450,287,000	-450,021,000	-449,714,000	-448,036,000	-419,255,000	-418,911,000	-303,025,000	-217,685,000	-189,336,000	-186,942,000	-186,146,000	-185,606,000	-160,862,000	-160,561,000	-160,241,000	-159,727,000	-142,658,000	-139,720,000	-137,207,000	-136,500,000	-126,087,000	-125,993,000	-125,792,000	-125,669,000	-118,386,000	-118,300,000	-118,143,000	-117,949,000	-108,969,000	-105,132,000	-105,088,000	-105,071,000	-89,347,000	-89,311,000	-89,221,000	-85,827,000	-72,639,000	-67,255,000	-67,093,000	-61,958,000	-58,661,000	-49,599,000	-49,384,000	-36,746,000
additional paid-in capital	3,055,302,000	3,004,666,000	2,966,842,000	2,940,789,000	2,913,266,000	2,860,890,000	2,831,790,000	2,804,202,000	2,780,992,000	2,736,934,000	3,003,184,000	2,976,365,000	2,938,726,000	2,913,099,000	2,885,594,000	2,858,422,000	2,818,595,000	2,798,325,000	2,778,596,000	2,748,584,000	2,703,234,000	2,685,647,000	2,659,699,000	2,636,194,000	2,609,213,000	2,586,030,000	2,563,157,000	2,533,086,000	2,502,773,000	2,467,323,000	2,433,594,000	2,406,861,000	2,372,083,000	2,338,755,000	2,312,865,000	2,291,388,000	2,259,486,000	2,231,797,000	2,205,028,000	2,175,752,000	2,145,296,000	2,114,711,000	2,087,725,000	2,038,700,000	2,001,312,000	1,908,721,000	1,886,827,000	1,854,596,000	1,524,783,000	1,489,998,000	1,429,573,000	1,409,562,000	1,390,473,000	1,368,444,000	1,358,023,000
accumulated other comprehensive loss	-2,908,000	-2,100,000	-1,059,000	-1,400,000	-1,455,000	-1,967,000		-3,590,000	-3,601,000	-3,110,000	-6,074,000	-7,437,000	-8,129,000	-10,889,000	-12,837,000	-10,488,000	-8,234,000	-3,723,000	-2,471,000	-2,222,000	-1,950,000	-1,349,000	-760,000	-101,000	-1,499,000	-1,816,000	-1,638,000	-1,614,000	-2,510,000	-3,280,000	-3,666,000	-3,980,000	-4,129,000	-3,792,000	-3,253,000	-3,335,000	-3,202,000	-3,274,000	-2,808,000	-2,546,000	-2,861,000	-3,795,000	-2,712,000	-2,725,000	-2,646,000										-2,916,000
accumulated deficit	-801,274,000	-734,794,000	-784,135,000	-866,896,000	-953,994,000	-976,458,000	-1,122,961,000	-1,215,342,000	-1,306,700,000	-1,343,528,000	-1,456,307,000	-1,504,065,000	-1,741,130,000	-1,699,285,000	-1,671,031,000	-1,607,057,000	-1,576,921,000	-1,541,018,000	-1,541,891,000	-1,512,903,000	-1,515,267,000	-1,492,849,000	-1,450,207,000	-1,450,073,000	-1,420,642,000	-1,381,988,000	-1,376,634,000	-1,323,756,000	-1,281,766,000	-1,185,368,000	-1,175,655,000	-1,141,211,000	-1,108,562,000	-1,044,365,000	-1,034,576,000	-998,299,000	-955,301,000	-947,942,000	-926,802,000	-864,115,000	-816,922,000	-739,498,000	-670,117,000	-589,103,000	-542,993,000										-446,721,000
total shareholders’ equity	1,751,531,000	1,819,295,000	1,733,432,000	1,624,584,000	1,511,583,000	1,464,977,000	1,292,106,000	1,284,005,000	1,254,763,000	1,202,686,000	1,355,583,000	1,280,437,000	1,005,576,000	1,043,753,000	1,042,854,000	1,082,324,000	1,075,390,000	1,112,584,000	1,096,168,000	1,097,902,000	1,051,155,000	1,066,982,000	1,084,358,000	1,061,846,000	1,063,018,000	1,085,442,000	1,068,184,000	1,091,168,000	1,102,141,000	1,171,285,000	1,150,715,000	1,158,155,000	1,155,891,000	1,202,808,000	1,187,280,000	1,202,087,000	1,216,704,000	1,209,481,000	1,209,694,000	1,243,526,000	1,265,078,000	1,314,275,000	1,366,805,000	1,398,991,000	1,420,419,000	1,333,592,000	1,351,825,000	1,339,501,000	1,016,977,000	981,940,000	919,939,000	885,008,000	882,486,000	904,853,000	909,680,000
total liabilities and shareholders’ equity	4,258,076,000	2,486,993,000	2,329,512,000	2,252,809,000	2,081,977,000	2,055,567,000	2,155,291,000	2,206,842,000	2,123,896,000	2,136,223,000	2,279,231,000	2,187,184,000	1,922,727,000	1,963,978,000	1,941,899,000	1,957,417,000	1,977,845,000	2,024,484,000	1,995,432,000	1,937,569,000	1,878,221,000	1,949,730,000	1,876,820,000	1,802,337,000	1,825,946,000	1,805,403,000	1,757,995,000	1,751,751,000	1,756,536,000	1,825,007,000	1,760,710,000	1,751,486,000	1,736,558,000	1,797,227,000	1,748,326,000	1,731,343,000	1,729,827,000	1,726,423,000	1,707,376,000	1,785,286,000	1,794,887,000	1,855,744,000	1,880,955,000	1,914,676,000	1,924,774,000	1,837,855,000	1,857,592,000	1,835,478,000	1,512,437,000	1,477,854,000	1,411,763,000	1,370,547,000	1,445,667,000	1,505,827,000	1,504,103,000
contract assets			717,000	1,424,000	3,049,000	4,990,000	2,969,000	3,492,000	1,229,000	706,000	2,766,000		8,429,000	8,929,000	10,105,000	16,486,000	20,212,000	13,363,000	3,509,000	8,793,000	9,279,000	14,401,000	14,395,000	9,240,000	14,199,000	8,386,000	5,022,000	12,690,000	8,447,000	8,230,000	13,476,000	14,582,000	26,069,000
intangible assets, net and goodwill		83,842,000	83,861,000	83,880,000	83,899,000	83,917,000	83,931,000	83,945,000
contract liabilities—short-term				578,000	1,609,000	1,249,000	2,339,000	3,311,000	3,336,000	2,730,000	3,319,000	3,302,000	2,193,000	6,816,000	3,982,000	3,787,000	4,919,000	6,339,000	6,404,000	6,634,000	7,921,000	7,512,000	7,153,000	7,589,000	6,819,000	6,766,000	1,798,000	2,103,000	2,078,000	3,169,000	6,916,000	4,928,000	3,521,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at december 31, 2025 and 2024
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 181,011,166 and 176,670,785 shares issued; and 165,607,028 and 162,176,994 shares outstanding at december 31, 2025 and 2024, respectively		1,810,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at september 30, 2025 and december 31, 2024
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 180,499,470 and 176,670,785 shares issued; and 165,103,891 and 162,176,994 shares outstanding at september 30, 2025 and december 31, 2024, respectively			1,805,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at june 30, 2025 and december 31, 2024
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 180,439,750 and 176,670,785 shares issued; and 165,054,912 and 162,176,994 shares outstanding at june 30, 2025 and december 31, 2024, respectively				1,805,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at march 31, 2025 and december 31, 2024
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 180,181,396 and 176,670,785 shares issued; and 164,853,015 and 162,176,994 shares outstanding at march 31, 2025 and december 31, 2024, respectively					1,802,000
assets held for sale									96,792,000	94,260,000
liabilities related to discontinued operations										4,542,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at december 31, 2024 and 2023
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 176,670,785 and 172,569,051 shares issued; and 162,176,994 and 166,979,833 shares outstanding at december 31, 2024 and 2023, respectively						1,767,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at september 30, 2024 and december 31, 2023
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 176,258,170 and 172,569,051 shares issued; and 161,776,205 and 166,979,833 shares outstanding at september 30, 2024 and december 31, 2023, respectively							1,763,000
accumulated other comprehensive income							425,000																																									8,044,000	5,580,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; and zero issued and outstanding at june 30, 2024 and december 31, 2023
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 175,959,272 and 172,569,051 shares issued; and 165,886,689 and 166,979,833 shares outstanding at june 30, 2024 and december 31, 2023, respectively								1,760,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2024 and december 31, 2023
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 175,734,220 and 172,569,051 shares issued; 169,184,516 and 166,979,833 shares outstanding at march 31, 2024 and december 31, 2023, respectively									1,757,000
assets related to discontinued operations
assets related to discontinued operations—long-term
assets held for sale—long-term
liabilities related to discontinued operations—long-term
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2023 and 2022, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 172,569,051 and 168,951,193 shares issued; 166,979,833 and 164,377,009 shares outstanding at december 31, 2023 and 2022, respectively										1,726,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2023 and december 31, 2022, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 172,218,651 and 168,951,193 shares issued; 166,714,095 and 164,377,009 shares outstanding at september 30, 2023 and december 31, 2022, respectively											1,722,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2023 and december 31, 2022, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 171,975,901 and 168,951,193 shares issued; 166,498,288 and 164,377,009 shares outstanding at june 30, 2023 and december 31, 2022, respectively												1,720,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2023 and december 31, 2022, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 171,518,796 and 168,951,193 shares issued; 166,058,960 and 164,377,009 shares outstanding at march 31, 2023 and december 31, 2022, respectively													1,715,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2022 and 2021, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 168,951,193 and 165,790,549 shares issued; 164,377,009 and 161,937,327 shares outstanding at december 31, 2022 and 2021, respectively														1,690,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2022 and december 31, 2021, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 168,864,804 and 165,790,549 shares issued; 164,303,229 and 161,937,327 shares outstanding at september 30, 2022 and december 31, 2021, respectively															1,689,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2022 and december 31, 2021, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 168,782,701 and 165,790,549 shares issued; 164,232,704 and 161,937,327 shares outstanding at june 30, 2022 and december 31, 2021, respectively																1,688,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2022 and december 31, 2021, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 167,743,842 and 165,790,549 shares issued; 163,212,411 and 161,937,327 shares outstanding at march 31, 2022 and december 31, 2021, respectively																	1,677,000
contract liabilities—long-term																		11,491,000	12,864,000	14,167,000	14,745,000	16,397,000	18,635,000	18,881,000	21,156,000	22,068,000	11,188,000	11,621,000	11,342,000	9,525,000	5,010,000	5,857,000	6,166,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2021 and 2020, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 165,790,549 and 162,269,220 shares issued; 161,937,327 and 159,161,141 shares outstanding at december 31, 2021 and 2020, respectively																		1,658,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2021 and december 31, 2020, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 165,439,188 and 162,269,220 shares issued; 161,686,223 and 159,161,141 shares outstanding at september 30, 2021 and december 31, 2020, respectively																			1,654,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2021 and december 31, 2020, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 164,965,774 and 162,269,220 shares issued; 161,296,126 and 159,161,141 shares outstanding at june 30, 2021 and december 31, 2020, respectively																				1,650,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2021 and december 31, 2020, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 163,835,905 and 162,269,220 shares issued; 160,198,009 and 159,161,141 shares outstanding at march 31, 2021 and december 31, 2020, respectively																					1,638,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2020 and 2019, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 162,269,220 and 160,489,888 shares issued; 159,161,141 and 157,779,002 shares outstanding at december 31, 2020 and 2019, respectively																						1,620,000
long-term debt—short-term																							2,843,000	2,843,000	2,843,000	2,843,000	2,843,000	2,843,000	2,843,000	2,843,000	2,843,000	2,843,000	2,843,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	3,000,000	63,913,000	64,825,000	65,737,000	66,712,000	6,750,000	6,750,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2020 and december 31, 2019, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 162,208,145 and 160,489,888 shares issued; 159,105,433 and 157,779,002 shares outstanding at september 30, 2020 and december 31, 2019, respectively																							1,619,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2020 and december 31, 2019, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 162,119,961 and 160,489,888 shares issued; 159,028,355 and 157,779,002 shares outstanding at june 30, 2020 and december 31, 2019, respectively																								1,618,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2020 and december 31, 2019, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 161,768,535 and 160,489,888 shares issued; 158,684,803 and 157,779,002 shares outstanding at march 31, 2020 and december 31, 2019, respectively																									1,615,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2019 and 2018, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 160,489,888 and 158,180,833 shares issued; 157,779,002 and 155,757,344 shares outstanding at december 31, 2019 and 2018, respectively																										1,602,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2019 and december 31, 2018, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 160,203,448 and 158,180,833 shares issued; 157,496,990 and 155,757,344 shares outstanding at september 30, 2019 and december 31, 2018, respectively																											1,599,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2019 and december 31, 2018, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 159,796,116 and 158,180,833 shares issued; 157,096,873 and 155,757,344 shares outstanding at june 30, 2019 and december 31, 2018, respectively																												1,595,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2019 and december 31, 2018, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 159,577,874 and 158,180,833 shares issued; 156,885,028 and 155,757,344 shares outstanding at march 31, 2019 and december 31, 2018, respectively																													1,593,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2018 and 2017, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 158,180,833 and 156,057,632 shares issued; 155,757,344 and 154,009,456 shares outstanding at december 31, 2018 and 2017, respectively																														1,579,000
commitments and contingencies
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2018 and december 31, 2017, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 157,674,736 and 156,057,632 shares issued; 155,363,980 and 154,009,456 shares outstanding at september 30, 2018 and december 31, 2017, respectively																															1,574,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2018 and december 31, 2017, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 157,612,457 and 156,057,632 shares issued; 155,302,753 and 154,009,456 shares outstanding at june 30, 2018 and december 31, 2017, respectively																																1,573,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2018 and december 31, 2017, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 157,313,318 and 156,057,632 shares issued; 155,003,983 and 154,009,456 shares outstanding at march 31, 2018 and december 31, 2017, respectively																																	1,570,000
intangible assets—net																																		256,168,000	271,811,000	287,453,000	302,925,000	318,227,000	333,550,000	348,873,000	364,030,000	379,186,000	393,393,000	407,599,000	464,192,000
deferred revenue—short-term																																		1,956,000	1,827,000	1,805,000	2,433,000	1,938,000	1,524,000	1,843,000	1,826,000	1,735,000	1,690,000	1,746,000	2,286,000
deferred revenue—long-term																																		5,657,000	6,132,000	6,782,000	6,522,000	7,122,000	7,660,000	6,943,000	7,442,000	7,975,000	7,477,000	7,805,000	11,577,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2017 and 2016, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 156,057,632 and 154,191,281 shares issued; 154,009,456 and 152,430,514 shares outstanding at december 31, 2017 and 2016, respectively																																		1,557,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2017 and december 31, 2016, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 155,793,163 and 154,191,281 shares issued; 153,745,656 and 152,430,514 shares outstanding at september 30, 2017, and december 31, 2016, respectively																																			1,555,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2017 and december 31, 2016, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 155,695,975 and 154,191,281 shares issued; 153,650,197 and 152,430,514 shares outstanding at june 30, 2017, and december 31, 2016, respectively																																				1,554,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2017 and december 31, 2016, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 155,109,810 and 154,191,281 shares issued; 153,122,812 and 152,430,514 shares outstanding at march 31, 2017, and december 31, 2016, respectively																																					1,548,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2016 and december 31, 2015, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 154,191,281 and 152,128,941 shares issued; 152,430,514 and 150,700,989 shares outstanding at december 31, 2016, and december 31, 2015, respectively																																						1,539,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2016 and december 31, 2015, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 153,451,571 and 152,128,941 shares issued; 151,805,300 and 150,700,989 shares outstanding at september 30, 2016, and december 31, 2015, respectively																																							1,531,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2016 and december 31, 2015, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 153,145,647 and 152,128,941 shares issued; 151,502,953 and 150,700,989 shares outstanding at june 30, 2016, and december 31, 2015, respectively																																								1,528,000
investments — short-term																																									425,414,000	353,669,000	549,420,000	579,877,000	538,151,000	436,387,000	450,167,000	395,948,000	165,921,000	112,144,000	73,412,000	67,033,000	78,772,000	128,096,000	126,327,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2016 and december 31, 2015, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 152,609,491 and 152,128,941 shares issued; 151,082,475 and 150,700,989 shares outstanding at march 31, 2016, and december 31, 2015, respectively																																									1,523,000
deferred tax assets — current																																											17,514,000	15,185,000	14,199,000
deferred tax assets — long term																																										40,856,000	26,859,000
deferred tax liabilities — long-term																																										470,000									32,932,000	33,568,000	34,199,000	48,969,000	49,829,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2015 and december 31, 2014, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 152,128,941 and 148,545,150 shares issued; 150,700,989 and 147,538,519 shares outstanding at december 31, 2015, and december 31, 2014, respectively																																										1,518,000
deferred tax liabilities, net—long-term																																											6,495,000	12,747,000	16,788,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2015 and december 31, 2014, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 151,134,022 and 148,545,150 shares issued; 149,853,512 and 147,538,519 shares outstanding at september 30, 2015, and december 31, 2014, respectively																																											1,508,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2015 and december 31, 2014, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 150,581,367 and 148,545,150 shares issued; 149,304,016 and 147,538,519 shares outstanding at june 30, 2015, and december 31, 2014, respectively																																												1,503,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2015 and december 31, 2014, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 149,550,933 and 148,545,150 shares issued; 148,479,822 and 147,538,519 shares outstanding at march 31, 2015, and december 31, 2014, respectively																																													1,492,000
intangible assets — net																																														494,656,000	509,900,000	524,989,000	550,421,000	563,277,000
investments — long-term																																														143,747,000	75,405,000	149,491,000	55,815,000	96,449,000	29,976,000	8,726,000	67,559,000	20,525,000	24,990,000
long-term debt — current																																														6,750,000	6,750,000	6,750,000	6,750,000	6,750,000	6,750,000	6,750,000	3,100,000
deferred revenue — current																																														3,061,000	2,377,000	2,259,000	2,685,000	2,129,000	2,874,000	3,582,000	10,012,000	5,120,000	4,249,000
deferred tax liabilities, net — long-term																																														21,258,000	26,122,000	25,061,000	36,014,000	36,404,000
deferred revenue — long-term																																														11,519,000	11,507,000	11,964,000	9,121,000	8,911,000	9,140,000	8,845,000	8,146,000	4,697,000	4,359,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2014 and december 31, 2013, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 147,071,192 and 138,482,571 shares issued; 146,088,467 and 137,792,626 shares outstanding at september 30, 2014 and december 31, 2013, respectively																																														1,468,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2014 and december 31, 2013, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 146,646,177 and 138,482,571 shares issued; 145,663,941 and 137,792,626 shares outstanding at june 30, 2014 and december 31, 2013, respectively																																															1,464,000
preferred shares, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at march 31, 2014 and december 31, 2013, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 145,137,639 and 138,482,571 shares issued; 144,444,951 and 137,792,626 shares outstanding at march 31, 2014 and december 31, 2013, respectively																																																1,448,000
preferred stock, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2013 and march 31, 2013, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 137,242,939 and 134,065,107 shares issued; 136,646,516 and 133,751,610 shares outstanding at september 30, 2013 and march 31, 2013, respectively																																																	1,369,000
treasury stock
preferred stock, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2013 and march 31, 2013, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 135,843,440 and 134,065,107 shares issued; 135,262,090 and 133,751,610 shares outstanding at june 30, 2013 and march 31, 2013, respectively																																																		1,354,000
preferred stock, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at december 31, 2012 and march 31, 2012, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 132,733,001 and 130,212,530 shares issued; 132,419,749 and 130,177,452 shares outstanding at december 31, 2012 and march 31, 2012, respectively																																																			1,324,000
preferred stock, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at september 30, 2012 and march 31, 2012, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 131,805,348 and 130,212,530 shares issued; 131,567,817 and 130,177,452 shares outstanding at september 30, 2012 and march 31, 2012, respectively																																																				1,315,000
preferred stock, par value, 0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at june 30, 2012 and march 31, 2012, respectively
ordinary shares, par value, 0.01 per share; 450,000,000 shares authorized; 130,967,811 and 130,212,530 shares issued; 130,730,280 and 130,177,452 shares outstanding at june 30, 2012 and march 31, 2012, respectively																																																					1,306,000
long-term debt— current																																																						3,100,000	2,325,000
preferred stock, par value, 0.01 per share; 50,000,000 and zero shares authorized; none issued and outstanding at december 31, 2011 and march 31, 2011, respectively
common stock																																																						1,296,000	1,294,000
non-voting common stock, par value, 0.01 per share; none and 450,000 shares authorized; none and 382,632 shares issued and outstanding at december 31, 2011 and march 31, 2011, respectively
property, plant and equipment net																																																							304,611,000
intangible assets net																																																							687,983,000
preferred stock, par value, 0.01 per share; 50,000,000 and zero shares authorized; none issued and outstanding at september 30, 2011 and march 31, 2011, respectively
non-voting common stock, par value, 0.01 per share; none and 450,000 shares authorized; none and 382,632 shares issued and outstanding at september 30, 2011 and march 31, 2011, respectively

Cashflow Statements:

Quarterly

Annual

Unit: USD	2026-03-31	2025-12-31	2025-09-30	2025-06-30	2025-03-31	2024-12-31	2024-09-30	2024-06-30	2024-03-31	2023-12-31	2023-09-30	2023-06-30	2023-03-31	2022-12-31	2022-09-30	2022-06-30	2022-03-31	2021-12-31	2021-09-30	2021-06-30	2021-03-31	2020-12-31	2020-09-30	2020-06-30	2020-03-31	2019-12-31	2019-09-30	2019-06-30	2019-03-31	2018-12-31	2018-09-30	2018-06-30	2018-03-31	2017-12-31	2017-09-30	2017-06-30	2017-03-31	2016-12-31	2016-09-30	2016-06-30	2016-03-31	2015-12-31	2015-09-30	2015-06-30	2015-03-31	2014-09-30	2014-06-30	2014-03-31	2013-09-30	2013-06-30	2012-12-31	2012-09-30	2012-06-30	2011-12-31

cash flows from operating activities:
net income	-66,480,000	49,341,000	82,761,000	87,098,000	22,464,000	146,503,000	92,381,000	91,358,000	36,828,000	112,779,000	47,758,000																						-62,505,000													-39,956,000	3,735,000	-24,354,000	-7,762,000	7,334,000	16,258,000	-16,707,000	22,433,000	-14,828,000
adjustments to reconcile net income to cash flows from operating activities:
depreciation and amortization	19,429,000	3,846,000	8,080,000	7,818,000	7,421,000	6,847,000	6,972,000	6,658,000	8,056,000	18,541,000	18,661,000	19,011,000	18,714,000	19,677,000	19,597,000	19,391,000	19,197,000	21,142,000	19,391,000	18,476,000	19,643,000	20,329,000	20,579,000	20,338,000	20,608,000	20,512,000	20,345,000	19,914,000	19,642,000	25,902,000	26,267,000	25,769,000	25,722,000		25,036,000	24,506,000	23,763,000	24,651,000	23,819,000	23,083,000	22,703,000	21,781,000	20,707,000	20,621,000	22,487,000	25,233,000	24,933,000	22,553,000	23,674,000	23,727,000	18,601,000	18,811,000	18,018,000	20,874,000
amortization of inventory step-up	12,726,000
share-based compensation expense	36,330,000	26,275,000	24,665,000	24,966,000	22,810,000	20,748,000	22,533,000	20,601,000	32,755,000	25,843,000	23,915,000	28,504,000	22,643,000	26,483,000	26,051,000	23,377,000	18,343,000	19,019,000	25,600,000	27,552,000	15,451,000	24,885,000	22,620,000	22,846,000	19,813,000	21,387,000	26,729,000	28,245,000	24,616,000	29,314,000	25,068,000	30,933,000	20,042,000		19,488,000	22,679,000	21,169,000	19,783,000	23,726,000	26,631,000	24,256,000	22,868,000	35,267,000	21,877,000	17,329,000	13,482,000	19,338,000	13,420,000	14,209,000	8,809,000	8,226,000	10,447,000	8,162,000	9,031,000
deferred income taxes	-8,787,000	-1,720,000	31,394,000	-3,407,000	2,507,000	8,209,000	10,589,000	14,209,000	7,515,000	-52,517,000	-9,248,000	-2,020,000	-36,117,000	21,278,000	-13,258,000	-11,514,000	-29,301,000	3,066,000	-8,791,000	5,551,000	5,255,000	46,000	2,274,000	4,000,000	3,665,000	2,706,000	-624,000	824,000	-3,225,000	6,744,000	511,000	7,469,000	-4,101,000		-5,056,000	-5,648,000	-1,215,000	2,856,000	-3,655,000	16,547,000	-25,437,000	-2,507,000	-13,449,000	-17,323,000	-4,301,000
other non-cash charges	1,294,000	915,000	1,151,000	2,971,000	274,000	-282,000	2,658,000	-79,000	2,215,000	4,935,000	703,000	322,000	369,000	1,785,000	3,109,000	266,000	371,000	-204,000	501,000	1,107,000	195,000	409,000	1,415,000	407,000	283,000	-670,000	-585,000	-441,000	1,116,000	-230,000	-189,000	1,473,000	-75,000		-175,000	1,909,000	1,623,000	1,035,000	758,000	471,000	672,000	-1,417,000	501,000	-290,000	-145,000	-44,000	6,263,000	3,702,000	1,008,000	765,000	518,000	2,613,000	1,772,000	1,945,000
changes in assets and liabilities:
receivables	-23,216,000	20,369,000	512,000	-36,203,000	65,825,000	-17,318,000	-795,000	-50,567,000	16,628,000	5,220,000	-3,219,000	-65,300,000	18,789,000	-30,795,000	-11,337,000	4,092,000	63,290,000	-24,020,000	8,203,000	-53,842,000	31,648,000	-9,499,000	-28,282,000	9,361,000	10,370,000	-6,852,000	10,992,000	-38,415,000	69,411,000	-41,310,000	4,318,000	-41,070,000	19,430,000		-7,828,000	-23,221,000	14,615,000	-13,656,000	7,562,000	-45,195,000	15,673,000	-14,500,000	-5,204,000	-6,323,000	9,572,000			11,000,000
contract assets		717,000	707,000	1,625,000	1,941,000	-2,021,000	523,000	-2,263,000	-523,000	2,060,000	-2,766,000	8,429,000	500,000	1,176,000	6,381,000	3,726,000	-6,849,000	-4,855,000	5,285,000	485,000	5,122,000	-6,000	-5,155,000	4,959,000	-5,813,000	-8,363,000	7,667,000	-4,243,000	-217,000	5,246,000	1,105,000	11,488,000	-16,959,000
inventory	-6,427,000	-4,863,000	845,000	-8,292,000	-1,751,000	9,142,000	3,487,000	3,103,000	-12,641,000	7,154,000	-2,987,000	-4,850,000	-2,029,000	-15,375,000	-11,077,000	-284,000	-4,285,000	-11,394,000	-2,143,000	-2,580,000	-8,652,000	-2,185,000	-6,966,000	-6,940,000	-6,842,000	-2,753,000	-6,396,000	-2,228,000	-1,700,000	-69,000	-514,000	-1,651,000	-431,000		-7,258,000	-13,852,000	-733,000
prepaid expenses and other assets	-16,169,000	3,836,000	-19,147,000	17,007,000	-844,000	362,000	3,098,000	6,255,000	-7,461,000	-38,794,000	4,721,000	2,923,000	-3,697,000	-7,200,000	3,858,000	13,365,000	-15,351,000	12,988,000	-3,536,000	18,836,000	-16,807,000	-1,575,000	-2,048,000	-5,970,000	13,615,000	-3,904,000	1,383,000	806,000	-69,000	-2,699,000	-1,676,000	-2,505,000	890,000		3,630,000	-2,673,000	-2,901,000
right-of-use assets	2,165,000	1,921,000	1,915,000	1,873,000	1,840,000	1,831,000	1,813,000	1,794,000	1,777,000	2,702,000	4,187,000	4,229,000	4,269,000	4,099,000	4,139,000	4,202,000	4,129,000	4,160,000	4,296,000	4,418,000	4,177,000	4,085,000	4,657,000	4,668,000	3,926,000	2,093,000	2,077,000	2,098,000	2,131,000
accounts payable and accrued expenses	-119,472,000	73,029,000	-28,245,000	57,790,000	-1,681,000	25,011,000	-81,048,000	36,518,000	-38,448,000	2,051,000	963,000	50,149,000	-30,154,000	10,724,000	33,855,000	-23,587,000	-5,458,000	14,307,000	68,175,000	19,320,000	-71,949,000	56,822,000	62,038,000	-17,006,000	-51,254,000	14,305,000	30,460,000	5,970,000	-15,888,000	33,840,000	15,523,000	11,499,000	-14,123,000		30,030,000	15,130,000	-1,730,000	19,037,000	14,130,000	13,383,000	-680,000	29,864,000	25,153,000	31,441,000	-10,303,000	21,410,000								50,000
accrued sales discounts, allowances and reserves	748,000	-5,617,000	-430,000	3,378,000	-22,657,000	-9,566,000	18,562,000	22,579,000	-22,764,000	25,175,000	15,698,000	-59,495,000	30,148,000
contract liabilities		0	-578,000	-1,030,000	359,000	-1,090,000	-972,000	-1,255,000	-208,000	-202,000	-692,000	-745,000	-4,287,000	2,062,000	-5,120,000	-1,091,000	-2,980,000	-1,438,000	-1,534,000	-1,865,000	-1,243,000	-1,879,000	-681,000	-1,505,000	-859,000	15,848,000	-738,000	305,000	725,000	767,000	1,142,000	1,098,000	245,000
operating lease liabilities	-2,773,000	-2,587,000	-2,596,000	-2,589,000	-2,548,000	-2,529,000	-2,545,000	-2,533,000	-2,516,000	-3,578,000	-4,098,000	-4,092,000	-4,379,000	-19,814,000	-4,500,000	-4,500,000	-4,411,000	-4,273,000	-4,683,000	-3,825,000	-3,996,000	-4,363,000	-4,970,000	-4,562,000	-2,378,000	-2,272,000	-2,252,000	-2,296,000	-2,297,000
other long-term liabilities	4,889,000	4,607,000	638,000	-2,803,000	2,851,000	3,088,000	4,333,000	1,114,000	-105,000	-4,132,000	6,112,000	1,580,000	5,774,000	302,000	9,348,000	1,257,000	1,819,000	20,000	-4,194,000	58,000	-217,000	10,235,000	-1,218,000	303,000	48,000	387,000	-3,908,000	1,774,000	1,765,000	4,675,000	569,000	1,083,000	2,669,000		1,646,000	2,786,000	2,248,000	81,000	1,807,000	810,000	1,889,000	2,233,000	467,000	446,000	146,000	-2,886,000	3,293,000	13,000			-141,000	2,362,000	6,000
cash flows from operating activities	-165,743,000	170,069,000	101,672,000	150,202,000	98,811,000	190,397,000	81,589,000	146,030,000	21,108,000	107,237,000	99,708,000	215,710,000	-21,302,000	1,047,000	625,000	-2,306,000	21,678,000	31,021,000	82,777,000	33,063,000	-45,146,000	67,343,000	60,203,000	-4,432,000	-40,272,000	42,070,000	30,972,000	-23,177,000	22,212,000	60,513,000	33,480,000				19,479,000	-22,451,000	-13,747,000	7,558,000	14,732,000	-28,878,000	-57,214,000	2,415,000	-29,446,000	-15,406,000	2,077,000				41,368,000	12,747,000	26,199,000
cash flows from investing activities:
additions of property, plant and equipment	-4,090,000	20,000	-17,314,000	-13,016,000	-10,110,000	-9,773,000	-8,258,000	-7,111,000	-8,342,000	-17,030,000	-14,453,000	-9,705,000	-6,860,000	-10,028,000	-10,474,000	-9,962,000	-7,791,000	-8,661,000	-4,813,000	-6,560,000	-7,986,000	-5,439,000	-6,408,000	-10,573,000	-19,799,000	-31,970,000	-19,430,000	-15,903,000	-23,639,000	-17,590,000	-16,421,000	-16,935,000	-18,485,000		-12,826,000	-11,274,000	-9,382,000	-9,870,000	-11,507,000	-10,271,000	-12,009,000	-16,148,000	-11,974,000	-14,045,000	-10,710,000
proceeds from the sale of property, plant and equipment	9,000	1,052,000	0	-1,679,000	1,713,000																																									0
business combination, net of cash acquired	-2,085,073,000
purchases of investments	-30,454,000	-55,835,000	-114,728,000	-97,818,000	-95,988,000	-89,652,000	-186,933,000	-95,454,000	-114,508,000	-67,878,000	-156,309,000	-6,386,000	-23,898,000	-52,865,000	-61,927,000	-80,264,000	-114,615,000	-46,048,000	-92,596,000	-79,229,000	-122,545,000	-78,219,000	-65,675,000	-58,437,000	-27,212,000	-135,769,000	-19,940,000	-19,682,000	-102,127,000	-90,124,000	-168,959,000	-102,649,000	-35,995,000		-128,672,000	-130,393,000	-30,161,000	-78,387,000	-127,090,000	-111,094,000	-58,528,000	-158,526,000	-80,710,000	-152,400,000	-117,047,000
sales and maturities of investments	42,608,000	377,109,000	125,305,000	81,591,000	113,487,000	85,500,000	85,839,000	56,459,000	82,488,000	63,578,000	51,400,000	136,936,000	103,608,000	90,633,000	81,069,000	49,146,000	60,779,000	53,928,000	65,583,000	89,306,000	86,193,000	46,912,000	58,230,000	83,359,000	64,500,000	75,143,000	70,355,000	23,126,000	55,978,000	99,832,000	211,523,000	53,601,000	79,500,000		127,850,000	135,642,000	55,000,000	67,285,000	185,567,000	149,729,000	158,224,000	132,404,000	123,026,000	113,216,000	98,927,000	62,094,000	99,946,000	84,500,000	25,000,000	31,400,000	34,796,000	128,706,000	56,686,000	27,241,000
cash flows from investing activities	-2,077,000,000	322,346,000	-6,737,000	-29,214,000	9,102,000	-13,875,000	-109,332,000	51,850,000	-39,951,000	-20,982,000	-119,359,000	120,848,000	72,850,000	27,740,000	8,898,000	-40,538,000	-60,641,000	-742,000	-31,707,000	3,977,000	-37,732,000	-35,097,000	-8,227,000	14,351,000	17,492,000	-101,471,000	31,594,000	-7,253,000	-64,703,000	-7,803,000	26,148,000	-65,884,000	25,344,000		-13,605,000	-6,021,000	15,460,000	-20,878,000	46,989,000	28,438,000	72,694,000	-42,217,000	30,509,000	-2,989,000	-28,789,000						-31,305,000	65,635,000	9,350,000
cash flows from financing activities:
proceeds from the issuance of ordinary shares under share-based compensation arrangements	15,714,000	11,178,000	622,000	2,083,000	29,528,000	8,218,000	5,521,000	2,607,000	11,226,000	1,647,000	3,113,000	9,126,000	2,874,000	780,000	858,000	16,197,000	1,795,000	509,000	4,312,000	18,445,000	2,053,000	654,000	800,000	3,849,000	3,070,000	2,544,000	3,773,000	2,054,000	10,554,000	2,559,000	1,318,000	3,836,000	13,164,000		1,894,000	9,290,000	7,114,000	7,562,000	5,256,000	3,992,000	3,498,000	13,336,000	9,796,000	8,239,000	13,598,000	5,610,000	10,793,000	11,028,000	18,864,000	15,079,000	7,782,000	8,391,000	1,340,000
proceeds from the issuance of debt	1,511,557,000
deferred financing costs paid to third-parties	-1,614,000
employee taxes paid related to net share settlement of equity awards	-23,442,000	-266,000	-307,000	-1,678,000	-28,781,000	-344,000	-293,000	-651,000	-28,349,000	-2,394,000	-796,000	-540,000	-24,744,000	-301,000	-320,000	-514,000	-17,069,000	-2,938,000	-2,513,000	-707,000	-10,413,000	-94,000	-201,000	-123,000	-7,283,000	-87,000	-156,000	-194,000	-8,880,000	-3,837,000	-43,000	-18,000	-15,724,000		-1,000	-3,269,000	-13,148,000	-5,035,000	0	-5,135,000	-3,297,000	-8,839,000	-33,000	-12,339,000	-4,693,000
payment for the repurchase of ordinary shares	-27,696,000					-1,000	-115,592,000
cash flows from financing activities	1,474,519,000	10,912,000	315,000	405,000	747,000	-281,669,000	-111,114,000	-83,483,000	-17,873,000	-276,497,000	1,567,000	7,836,000	-22,620,000	-271,000	-212,000	14,933,000	-16,024,000	-3,179,000	1,033,000	16,273,000	14,945,000	-151,000	-112,000	3,016,000	-4,924,000	1,746,000	2,906,000	1,150,000	963,000	-1,989,000	564,000				1,143,000	5,271,000	-6,784,000	-2,541,000	-55,920,000	-3,098,000	3,387,000	-1,430,000	24,385,000	5,975,000	11,961,000				18,410,000	12,090,000				830,000
net increase in cash and cash equivalents	-768,225,000		95,250,000	121,393,000	108,660,000	-105,147,000	-138,857,000	114,397,000	-36,716,000	-190,242,000	-18,084,000	344,394,000	28,928,000	28,516,000				27,100,000				32,095,000				-57,655,000				50,721,000					7,017,000	-23,201,000	-5,071,000	-15,861,000	5,801,000	-3,538,000	18,867,000								57,108,000	19,436,000	3,474,000	46,819,000	1,998,000	-3,906,000
cash, cash equivalents and restricted cash—beginning of period	1,119,776,000
cash, cash equivalents and restricted cash—end of period	351,551,000
supplemental cash flow disclosure:
cash paid for taxes	1,850,000	2,129,000																																																	958,000	1,268,000	909,000
non-cash investing and financing activities:
purchased capital expenditures included in accounts payable and accrued expenses	5,556,000	-2,135,000	-2,299,000	1,651,000	5,911,000	-799,000	1,404,000	-980,000	2,629,000	-1,564,000	-654,000	3,101,000	1,762,000	260,000	-2,173,000	805,000	4,058,000	3,327,000	1,675,000	28,000	995,000	251,000	-2,262,000	-811,000	5,242,000	-875,000	11,670,000	-4,856,000	7,850,000	4,603,000	-129,000	-270,000	7,516,000		790,000	-447,000	4,978,000	2,124,000	840,000	-297,000	3,099,000	3,645,000	-2,071,000	1,390,000	3,090,000	-800,000	704,000	787,000	128,000	1,056,000	840,000	7,000	827,000	2,008,000
unpaid deferred financing costs to third-parties	1,551,000
unpaid contingent consideration	107,713,000
return of fountain healthcare partners ii, l.p. investment														0	0	0	485,000					0
proceeds from the sale of the athlone facility		0	0			0	0
cash transferred to mural oncology plc at separation
prepayment of long-term debt
principal payments of long-term debt						0	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000	-750,000			-711,000	-711,000	-710,000	-711,000	-711,000	-711,000	-710,000	-711,000	-711,000	-711,000				-750,000	-750,000	-750,000	-750,000	-61,688,000	-1,687,000	-1,688,000	-1,686,000	-1,689,000	-1,687,000	-1,688,000
net increase in cash, cash equivalents and restricted cash
reconciliation of cash, cash equivalents and restricted cash
cash and cash equivalents
restricted cash
total cash, cash equivalents and restricted cash
cash paid for interest																																																			3,163,000	10,626,000	8,642,000
gain on sale of the athlone facility							0
cash and cash equivalents—beginning of period			0	0	291,146,000	0	0	0	457,469,000	0	0	0	292,473,000	0	0	0	337,544,000	0	0	0	272,961,000	0	0	0	203,771,000	0	0	0	266,762,000	0	0	0	191,296,000		0	0	186,378,000	0	0	0	181,109,000	0	0	0	224,064,000
cash and cash equivalents—end of period			95,250,000	121,393,000	399,806,000	-105,147,000	-138,857,000	114,397,000	420,753,000	-190,242,000	-18,084,000	344,394,000	321,401,000	28,516,000	9,311,000	-27,911,000	282,557,000	27,100,000	52,103,000	53,313,000	205,028,000	32,095,000	51,864,000	12,935,000	176,067,000	-57,655,000	65,472,000	-29,280,000	225,234,000	50,721,000	60,192,000	-30,656,000	186,505,000		7,017,000	-23,201,000	181,307,000	-15,861,000	5,801,000	-3,538,000	199,976,000	-41,232,000	25,448,000	-12,420,000	209,313,000
change in the fair value of contingent consideration														0	3,553,000	-870,000	19,067,000	750,000	5,195,000	-3,240,000	-1,278,000	12,681,000	-3,926,000	-5,900,000	-6,800,000	-5,000,000	-1,300,000	6,500,000	22,600,000	2,300,000	-4,200,000	19,600,000	1,900,000					-4,800,000
proceeds from the sale of equipment						7,000	20,000	23,000	411,000	348,000	3,000							10,000	100,000	1,000	176,000	582,000	56,000	2,000	3,000	0	609,000	206,000	85,000	79,000	5,000	99,000	324,000		43,000	4,000	3,000	94,000	19,000	74,000	7,000	354,000	141,000	-1,000	41,000				0	6,000
proceeds from contingent consideration														0	230,000	542,000	501,000	29,000	19,000	1,459,000	6,430,000	1,067,000				0	0	5,000,000	5,000,000
payment made for licensed intellectual property
proceeds from the issuance of long-term debt																		0	0	0	23,567,000																														0			0
payment made for debt extinguishment																		0	-16,000	-715,000	-262,000
net loss													-41,845,000	-28,254,000	-63,974,000	-30,136,000	-35,903,000	873,000	-28,988,000	2,364,000	-22,418,000	-42,642,000	-134,000	-29,431,000	-38,654,000	-5,354,000	-52,878,000	-41,990,000	-96,398,000	-9,713,000	-34,444,000				-36,276,000	-42,999,000	-68,881,000	-21,141,000	-62,687,000	-47,193,000	-77,423,000		-81,015,000	-46,109,000	-30,657,000
adjustments to reconcile net loss to cash flows from operating activities:
loss on debt extinguishment																		0	0	0	171,000
net decrease in cash and cash equivalents																-27,911,000	-54,987,000			53,313,000	-67,933,000			12,935,000	-27,704,000			-29,280,000	-41,528,000			-30,656,000	-4,791,000												-14,751,000
payment made for debt modification																					-248,000
impairment of investment in synchronicity pharma, inc.
acquisition of rodin therapeutics, inc.'s net assets, net of cash acquired
payment made for licensed ip																			0
loss on debt refinancing																														0	0	0	2,298,000
payment made for debt refinancing																														0	0	-411,000	-1,840,000
impairment of property, plant and equipment
changes in assets and liabilities, excluding the effect of acquisitions:
excess tax benefit from share-based compensation																																						889,000	-512,000	268,000	-4,874,000	4,241,000	-16,311,000	-11,762,000	-4,744,000	15,460,000	-179,000	7,163,000	1,239,000	7,217,000	3,967,000	282,000	105,000	0
investment in synchronicity pharma, inc.
impairment of investment in reset therapeutics, inc.
cash flows used in operating activities																																	-26,838,000
cash flows used in financing activities																																	-3,297,000
cash and cash equivalents, beginning of period
cash from operating activities
capital expenditures
free cash flows
cash from investing activities
cash from financing activities
cash and cash equivalents, end of period
deferred revenue																																			-629,000	-368,000	-105,000	-123,000	397,000	-481,000	-442,000	543,000	-384,000	-460,000	-328,000								3,671,000	1,209,000
investment in reset therapeutics, inc.																																						0	0	0	-15,000,000
increase in the fair value of contingent consideration																																				-700,000	-1,600,000			-2,200,000	-1,900,000
gain on sale of investment in civitas therapeutics, inc.
gain on the gainesville transaction																																										301,000
gain on sale of property, plant and equipment																																											-482,000
gain on sale of investment of acceleron pharma inc.
changes in assets and liabilities
net proceeds from the gainesville transaction																																										-301,000	26,000
investment in civitas therapeutics, inc.
proceeds from the issuance of ordinary shares																																														0	0	248,406,000
fair value of warrants received as part of the gainesville transaction																																										0
fair value of contingent consideration received as part of the gainesville transaction																																										0
inventory, prepaid expenses and other assets																																							8,387,000	-15,002,000	-11,651,000	6,076,000	6,530,000	3,991,000	3,021,000
decrease in the fair value of contingent consideration
loss on sale of property, plant and equipment
changes in assets and liabilities, net of divestiture:
increase in fair value of contingent consideration																																											-1,200,000
gain on gainesville transaction
fair value of warrants received as part of gainesville transaction
fair value of contingent consideration received as part of gainesville transaction
impairment of long-lived assets
loss on debt refinancing transaction																																																			0
prepayment penalty in connection with debt refinancing
investment in civitas
cash and cash equivalents — beginning of period																																														0	0	167,562,000	0	96,961,000	0	0	83,601,000	0
cash and cash equivalents — end of period																																														-52,140,000	31,997,000	156,325,000	57,108,000	116,397,000	3,474,000	46,819,000	85,599,000	-3,906,000
(gain) on sale of investment of acceleron pharma inc.
cash flows provided by operating activities
cash flows provided by financing activities
net increase (decrease) in cash and cash equivalents
cash flows from by investing activities
cash flows from provided by financing activities																																																264,909,000
principal payments on long-term debt attributable to original issue discount
purchase of property, plant and equipment
sales of property, plant and equipment																																																			57,000	-1,000	18,000	0
promissory note issued to civitas therapeutics, inc.
acquisition of elan drug technologies, net of cash acquired
investment in acceleron pharmaceuticals, inc.
payment of non-recourse risperdal consta secured 7% notes principal attributable to original issue discount
proceeds from the issuance of common stock for share-based compensation arrangements																																																						830,000
payment of non-recourse risperdal consta secured 7% notes principal

Alkermes plc(NASDAQ:ALKS)

Alkermes plc
(NASDAQ:ALKS)