Aldeyra Therapeutics, Inc(NASDAQ:ALDX) 
Aldeyra Therapeutics, Inc., a biotechnology company, develops and commercializes medicines for immune-mediated ocular and systemic diseases. The company's lead product candidate is reproxalap, an ophthalmic solution, which is in Phase III clinical trial for the treatment of dry eye diseases and alle...
Website: http://www.aldeyra.com
Founded: 2004
Full Time Employees: 11
Sector: Healthcare
Industry: Biotechnology
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At a glance:
Bull Thesis:
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Income Statements:
Quarterly
Annual
| Unit: USD | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
operating expenses: | |||||||||||||||||||||||||||||||||||||||||||||||
research and development | 5,430,757 | 8,505,229 | 7,423,324 | 14,630,032 | 12,441,509 | 14,969,743 | 6,183,508 | 4,298,282 | 6,961,669 | 6,962,907 | 11,235,861 | 8,961,472 | 11,539,620 | 14,570,654 | 12,234,320 | 12,841,400 | 12,894,344 | 11,474,446 | 7,726,342 | 7,028,243 | 6,133,580 | 4,885,875 | 6,633,603 | 9,614,431 | 16,223,972 | 10,664,858 | 7,848,590 | 8,548,975 | 7,880,822 | 6,792,974 | 6,600,106 | 5,545,289 | 3,539,368 | 3,848,889 | 3,369,023 | 3,447,176 | 3,379,711 | 2,834,523 | 3,511,477 | 3,112,457 | 2,076,410 | 1,249,097 | 1,136,434 | 1,403,690 | 1,195,668 | 663,908 | 444,278 |
general and administrative | 2,570,375 | 1,663,503 | 3,004,135 | 1,947,752 | 3,696,067 | 3,038,064 | 3,210,357 | 1,799,496 | 2,588,701 | 3,379,750 | 5,567,416 | 4,735,319 | 3,244,936 | 3,144,280 | 4,249,387 | 2,562,843 | 2,546,807 | 3,068,652 | 3,104,702 | 2,504,993 | 2,255,617 | 2,220,003 | 3,004,841 | 3,213,931 | 2,839,319 | 3,116,414 | 2,985,038 | 2,546,002 | 3,065,912 | 2,373,059 | 1,891,303 | 1,501,246 | 1,475,904 | 1,481,792 | 1,726,878 | 1,205,825 | 1,396,734 | 1,462,227 | 1,455,559 | 1,226,533 | 1,261,196 | 954,879 | 972,101 | 1,007,354 | 772,467 | 982,579 | 800,646 |
income from operations | -8,001,132 | -10,168,732 | -10,427,459 | -16,577,784 | -16,137,576 | -18,007,807 | -9,393,865 | -6,097,778 | -9,550,370 | -10,342,657 | -16,803,277 | -13,696,791 | -14,784,556 | -17,714,934 | -16,483,707 | -15,404,243 | -15,441,151 | -14,543,098 | -10,831,044 | -11,287,501 | -8,389,197 | -7,105,878 | -9,638,444 | -12,895,514 | -19,016,189 | -13,731,424 | -17,431,179 | -11,094,977 | -10,946,734 | -9,166,033 | -8,491,409 | -7,046,535 | -5,015,272 | -5,330,681 | -5,095,901 | -4,653,001 | -4,776,445 | -4,296,750 | -4,967,036 | -4,338,990 | -3,337,606 | -2,203,976 | -2,108,535 | -2,411,044 | -1,968,135 | -1,646,487 | -1,244,924 |
yoy | -50.42% | -43.53% | 11.00% | 171.87% | 68.97% | 74.11% | -44.10% | -55.48% | -35.40% | -41.62% | 1.94% | -11.08% | -4.25% | 21.81% | 52.19% | 36.47% | 84.06% | 104.66% | 12.37% | -12.47% | -55.88% | -48.25% | -44.71% | 16.23% | 73.72% | 49.81% | 105.28% | 57.45% | 118.27% | 71.95% | 66.63% | 51.44% | 5.00% | 24.06% | 2.59% | 7.24% | 43.11% | 94.95% | 135.57% | 79.96% | 69.58% | 33.86% | 69.37% | ||||
qoq | -21.32% | -2.48% | -37.10% | 2.73% | -10.39% | 91.70% | 54.05% | -36.15% | -7.66% | -38.45% | 22.68% | -7.36% | -16.54% | 7.47% | 7.01% | -0.24% | 6.18% | 34.27% | -4.04% | 34.55% | 18.06% | -26.28% | -25.26% | -32.19% | 38.49% | -21.22% | 57.11% | 1.35% | 19.43% | 7.94% | 20.50% | 40.50% | -5.92% | 4.61% | 9.52% | -2.58% | 11.16% | -13.49% | 14.47% | 30.00% | 51.44% | 4.53% | -12.55% | 22.50% | 19.54% | 32.26% | |
other income: | |||||||||||||||||||||||||||||||||||||||||||||||
interest income | 788,694 | 872,038 | 981,487 | 1,239,880 | 1,503,845 | 1,637,836 | 1,810,269 | 1,859,080 | 1,902,242 | 1,882,800 | 1,678,885 | 1,255,448 | 648,242 | 344,378 | 101,382 | 62,631 | 59,306 | 39,665 | 23,762 | 5,199 | 5,215 | 71,710 | 210,100 | 278,971 | 330,329 | 432,908 | 499,140 | 525,337 | 163,015 | 141,956 | 122,390 | 124,600 | 56,651 | 48,384 | 31,617 | 27,574 | 27,792 | 21,951 | 24,719 | 3 | |||||||
interest expense | -475,903 | -470,618 | -483,529 | -470,863 | -479,252 | -477,601 | -498,526 | -514,264 | -538,743 | -527,141 | -491,287 | -460,819 | -416,917 | -410,395 | -405,967 | -412,935 | -413,110 | -433,477 | -482,580 | -489,143 | -489,191 | -486,048 | -439,816 | -544,080 | -29,154 | -28,649 | -1,962 | -63,544 | -28,846 | -26,358 | -28,044 | -32,575 | -27,578 | -26,463 | -26,837 | -26,002 | -26,654 | -27,817 | -25,035 | -27,992 | -28,081 | -28,210 | -28,024 | -33,635 | -41,071 | -56,246 | -113,221 |
total other income | 312,791 | 401,420 | 497,958 | 769,017 | 1,024,593 | 1,160,235 | 1,311,743 | 1,344,816 | 1,363,499 | 1,355,659 | 1,187,598 | 794,629 | 231,325 | -66,017 | -304,585 | -350,304 | -353,804 | -393,812 | -458,818 | -483,944 | -483,976 | -414,338 | -229,716 | -265,109 | 301,175 | 404,259 | 497,178 | 461,793 | 134,169 | 115,598 | 94,346 | 92,025 | 29,073 | 21,921 | 4,780 | -1,261 | 1,138 | -5,866 | -316 | -16,866 | -28,081 | -28,210 | -28,024 | -33,635 | -41,071 | 511,342 | 1,646,697 |
net income | -7,688,341 | -9,767,312 | -9,929,501 | -15,808,767 | -15,112,983 | -16,847,572 | -8,082,122 | -4,752,962 | -8,186,871 | -8,986,998 | -15,615,679 | -12,902,162 | -14,553,231 | -17,780,951 | -16,788,292 | -15,754,547 | -15,794,955 | -14,936,910 | -11,289,862 | -11,292,180 | -8,873,173 | -7,520,216 | -9,868,160 | -13,160,623 | -18,715,014 | -13,327,165 | -15,624,028 | -10,633,184 | -10,812,565 | -9,050,435 | -8,397,063 | -6,954,510 | -4,986,199 | -5,308,760 | -5,091,121 | -4,651,429 | -4,775,307 | -4,302,616 | -4,967,352 | ||||||||
yoy | -49.13% | -42.03% | 22.86% | 232.61% | 84.60% | 87.47% | -48.24% | -63.16% | -43.75% | -49.46% | -6.98% | -18.11% | -7.86% | 19.04% | 48.70% | 39.52% | 78.01% | 98.62% | 14.41% | -14.20% | -52.59% | -43.57% | -36.84% | 23.77% | 73.09% | 47.25% | 86.07% | 52.90% | 116.85% | 70.48% | 64.94% | 49.51% | 4.42% | 23.38% | 2.49% | ||||||||||||
qoq | -21.28% | -1.63% | -37.19% | 4.60% | -10.30% | 108.45% | 70.04% | -41.94% | -8.90% | -42.45% | 21.03% | -11.35% | -18.15% | 5.91% | 6.56% | -0.26% | 5.74% | 32.30% | -0.02% | 27.26% | 17.99% | -23.79% | -25.02% | -29.68% | 40.43% | -14.70% | 46.94% | -1.66% | 19.47% | 7.78% | 20.74% | 39.48% | -6.08% | 4.27% | 9.45% | -2.59% | 10.99% | -13.38% | |||||||||
net income per share | -0.13 | -0.16 | -0.17 | -0.27 | -0.25 | -0.28 | -0.14 | -0.08 | -0.14 | -0.15 | -0.27 | -0.22 | -0.25 | -0.3 | -0.29 | -0.27 | -0.27 | -0.28 | -0.25 | -0.3 | -0.23 | -0.25 | -0.34 | -0.47 | -0.69 | -0.49 | -0.58 | -0.39 | -0.52 | -0.46 | -0.43 | -0.36 | -0.32 | -0.35 | -0.37 | -0.37 | -0.38 | -0.41 | |||||||||
weighted-average common shares outstanding - basic and diluted | 60,126,850 | 60,045,530 | 59,887,277 | 59,484,794 | 59,530,113 | 59,414,489 | 59,414,489 | 58,943,205 | 58,990,189 | 58,791,920 | 58,791,603 | 58,405,897 | 58,457,863 | 58,301,491 | 58,297,861 | 54,042,103 | 58,019,099 | 54,280,393 | 45,630,910 | 33,965,955 | 37,796,946 | 30,118,456 | 29,210,889 | 27,111,840 | 27,111,600 | 26,985,454 | 27,053,842 | 21,685,642 | 20,969,913 | 19,761,352 | 19,366,790 | 15,581,426 | 15,136,399 | 13,797,312 | 12,474,609 | 10,622,411 | |||||||||||
acquired in-process research and development | 67,152 | -47,102 | -49,848 | 6,597,551 | |||||||||||||||||||||||||||||||||||||||||||
income before income taxes | -11,771,445 | -8,873,173 | -7,520,216 | -9,868,160 | -13,160,623 | -18,715,014 | -13,327,165 | -16,934,001 | |||||||||||||||||||||||||||||||||||||||
income tax benefit | 1,309,973 | ||||||||||||||||||||||||||||||||||||||||||||||
net income per share | -0.13 | -0.16 | -0.17 | -0.27 | -0.25 | -0.28 | -0.14 | -0.08 | -0.14 | -0.15 | -0.27 | -0.22 | -0.25 | -0.3 | -0.29 | -0.27 | -0.27 | -0.28 | -0.25 | -0.3 | -0.23 | -0.25 | -0.34 | -0.47 | -0.69 | -0.49 | -0.58 | -0.39 | -0.52 | -0.46 | -0.43 | -0.36 | -0.32 | -0.35 | -0.37 | -0.37 | -0.38 | -0.41 | |||||||||
basic | -0.51 | -0.46 | -0.35 | -0.27 | -0.32 | -0.3 | -0.36 | -1.43 | -0.04 | ||||||||||||||||||||||||||||||||||||||
diluted | -0.51 | -0.46 | -0.35 | -0.27 | -0.32 | -0.2 | -0.36 | -1.56 | -4 | ||||||||||||||||||||||||||||||||||||||
weighted-average common shares outstanding: | |||||||||||||||||||||||||||||||||||||||||||||||
basic | 9,712,521 | 8,633,897 | 9,712,521 | 8,397,713 | 6,667,519 | 3,818,157 | 5,565,413 | 3,737,675 | 327,365 | ||||||||||||||||||||||||||||||||||||||
diluted | 9,712,521 | 8,633,897 | 9,712,521 | 8,397,713 | 6,667,519 | 3,850,612 | 5,565,413 | 3,769,360 | 443,826 | ||||||||||||||||||||||||||||||||||||||
change in fair value of preferred stock warrant liabilities | 567 | 1,759,915 | |||||||||||||||||||||||||||||||||||||||||||||
net loss and comprehensive loss | -1,933,607.75 | -3,365,687 | -2,232,186 | -1,135,145 | |||||||||||||||||||||||||||||||||||||||||||
accretion of preferred stock | -141,513 | -191,568 | |||||||||||||||||||||||||||||||||||||||||||||
deemed dividend | -4,053,570 | ||||||||||||||||||||||||||||||||||||||||||||||
net loss attributable to common stockholders | -4,355,856 | -3,365,687 | -2,232,186 | -2,136,559 | -5,330,228 | -13,237 | |||||||||||||||||||||||||||||||||||||||||
net income and comprehensive income | -2,136,559 | -2,444,679 | -2,009,206 | 401,773 | |||||||||||||||||||||||||||||||||||||||||||
allocation of undistributed earnings to preferred stockholders | -223,442 | ||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of convertible preferred stock rights and rights option liabilities | |||||||||||||||||||||||||||||||||||||||||||||||
other expenses | |||||||||||||||||||||||||||||||||||||||||||||||
net income attributable to common stockholders | -2,444,679 | -2,009,206 | |||||||||||||||||||||||||||||||||||||||||||||
value provided in excess of issuance price of series b preferred stock | |||||||||||||||||||||||||||||||||||||||||||||||
other income | |||||||||||||||||||||||||||||||||||||||||||||||
deemed dividend to series a preferred stockholders |
Balance Sheets:
Quarterly
Annual
| Unit: USD | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 |
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assets | ||||||||||||||||||||||||||||||||||||||||||||||||
current assets: | ||||||||||||||||||||||||||||||||||||||||||||||||
cash and cash equivalents | 70,041,254 | 59,340,599 | 41,241,269 | 50,350,617 | 54,527,092 | 28,120,029 | 31,029,723 | 52,491,900 | 142,823,016 | 143,334,888 | 151,675,561 | 165,028,105 | 144,419,364 | 107,150,541 | 42,012,015 | 93,909,328 | 104,790,989 | 116,368,688 | 124,739,010 | 88,442,379 | 52,858,311 | 71,175,507 | 50,688,834 | 15,542,971 | 16,425,830 | 25,604,203 | 7,399,564 | 5,297,555 | 3,357,472 | 7,008,652 | 7,605,674 | 20,963,541 | 20,023,337 | 33,103,849 | 14,609,742 | 19,302,850 | 12,015,061 | 14,568,508 | 17,607,522 | 10,148,524 | 14,648,866 | 30,618,365 | 33,569,784 | 15,721,097 | 8,527,304 | 10,142,137 | 11,535,788 | 2,145,621 |
marketable securities | 15,956,740 | 40,678,370 | 39,707,460 | 46,624,180 | 44,624,170 | 49,301,960 | 30,545,450 | 29,881,520 | 56,678,860 | 75,677,040 | 57,957,020 | 5,500,975 | 22,833,583 | 28,938,545 | 24,567,074 | 30,057,408 | 37,826,635 | 46,242,220 | 17,133,925 | 17,072,720 | 17,974,600 | 22,923,462 | 14,807,166 | 11,210,796 | 11,909,800 | 12,897,584 | 14,307,073 | 14,940,912 | 12,877,281 | 12,941,776 | ||||||||||||||||||
prepaid expenses and other current assets | 1,742,202 | 2,162,696 | 2,638,589 | 2,670,698 | 2,921,206 | 3,976,564 | 5,317,836 | 7,808,596 | 4,987,317 | 3,875,126 | 3,803,557 | 2,989,115 | 6,722,229 | 4,153,721 | 4,052,355 | 5,488,707 | 2,961,781 | 5,403,261 | 6,521,718 | 8,630,543 | 5,200,957 | 2,017,273 | 5,232,717 | 1,375,129 | 1,804,450 | 849,087 | 3,398,930 | 4,872,067 | 1,169,594 | 1,702,533 | 1,392,905 | 1,666,898 | 1,018,967 | 1,141,727 | 521,483 | 260,683 | 218,682 | 250,206 | 260,087 | 283,509 | 497,552 | 607,335 | 266,850 | 177,074 | 232,568 | 202,612 | 269,541 | 9,741 |
total current assets | 71,783,456 | 77,460,035 | 84,558,228 | 92,728,775 | 104,072,478 | 116,720,763 | 125,649,519 | 140,845,946 | 147,810,333 | 147,210,014 | 155,479,118 | 168,017,220 | 181,023,113 | 189,483,122 | 200,741,410 | 222,355,055 | 232,752,770 | 246,771,949 | 256,260,728 | 147,072,922 | 83,059,268 | 88,192,780 | 71,422,526 | 62,751,683 | 75,168,825 | 77,020,364 | 72,855,902 | 86,996,257 | 94,769,286 | 36,845,110 | 43,071,299 | 40,605,039 | 43,965,766 | 49,052,742 | 26,342,021 | 31,473,333 | 25,131,327 | 29,125,787 | 32,808,521 | 23,309,314 | 28,088,194 | 31,225,700 | 33,836,634 | 15,898,171 | 8,759,872 | 10,344,749 | 11,805,329 | 2,155,362 |
deferred offering costs | 267,261 | 267,261 | 86,644 | 43,000 | 165,930 | 138,661 | 77,942 | 45,986 | 36,236 | 36,236 | 20,000 | 14,238 | 735,204 | |||||||||||||||||||||||||||||||||||
right-of-use assets | 275,861 | 340,977 | 404,660 | 466,942 | 266,955 | 329,968 | 391,595 | 451,867 | 510,814 | 64,459 | 127,448 | 189,033 | 249,265 | 181,943 | 239,873 | 296,504 | 351,863 | 406,014 | 118,401 | 175,619 | 233,310 | 52,195 | 103,074 | 152,666 | 201,007 | 248,165 | 294,173 | 377,920 | ||||||||||||||||||||
total assets | 72,059,317 | 77,801,012 | 84,962,888 | 93,195,717 | 104,606,694 | 117,319,352 | 126,043,834 | 141,301,892 | 148,326,911 | 147,282,247 | 155,616,350 | 168,218,792 | 181,291,657 | 189,691,725 | 201,015,324 | 222,692,981 | 233,137,120 | 247,217,570 | 256,427,212 | 147,306,100 | 83,352,503 | 88,324,430 | 71,627,295 | 63,029,099 | 75,518,281 | 77,440,999 | 73,839,014 | 88,128,123 | 95,091,155 | 37,131,593 | 43,286,042 | 40,775,901 | 44,174,958 | 49,229,420 | 26,467,944 | 31,531,617 | 25,187,679 | 29,191,477 | 32,883,548 | 23,436,766 | 28,204,764 | 31,350,399 | 33,877,502 | 15,931,353 | 8,787,103 | 10,350,517 | 11,805,329 | 2,890,566 |
liabilities and stockholders' equity | ||||||||||||||||||||||||||||||||||||||||||||||||
current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||
accounts payable | 158,461 | 13,423 | 1,455,271 | 346,146 | 180,453 | 186,919 | 254,434 | 280,299 | 1,338,057 | 247,194 | 270,816 | 429,685 | 133,625 | 1,306,926 | 264,225 | 2,442,830 | 1,019,702 | 467,932 | 1,094,461 | 448,591 | 381,638 | 123,900 | 216,689 | 1,072,897 | 808,302 | 572,363 | 2,773,987 | 4,013,362 | 3,051,678 | 3,442,370 | 802,125 | 1,618,889 | 1,000,963 | 485,267 | 762,681 | 694,922 | 275,441 | 733,560 | 823,301 | 578,017 | 851,160 | 743,623 | 629,346 | 406,145 | 341,294 | 482,470 | 556,061 | 165,961 |
accrued expenses | 6,120,297 | 6,999,297 | 6,663,580 | 7,684,354 | 12,118,367 | 10,423,297 | 5,842,802 | 5,944,419 | 5,536,464 | 7,843,389 | 9,310,196 | 14,433,679 | 14,065,885 | 10,254,451 | 10,810,155 | 13,675,555 | 10,523,353 | 11,252,075 | 6,196,300 | 5,371,681 | 8,134,765 | 4,018,635 | 3,693,594 | 3,641,724 | 11,873,122 | 11,324,963 | 3,403,789 | 5,257,071 | 5,421,498 | 3,746,037 | 4,159,071 | 1,815,428 | 2,236,465 | 1,507,458 | 1,038,905 | 1,520,322 | 1,946,251 | 1,476,592 | 1,084,591 | 1,035,888 | 1,186,429 | 630,325 | 451,641 | 436,157 | 908,724 | 363,661 | 211,346 | 133,071 |
current portion of debt | 15,249,632 | 15,199,265 | 15,148,897 | 31,372 | 279,957 | 15,242,327 | 15,204,698 | |||||||||||||||||||||||||||||||||||||||||
operating lease liabilities | 280,537 | 271,948 | 263,551 | 255,342 | 271,631 | 263,241 | 255,039 | 247,021 | 239,183 | 65,628 | 129,785 | 190,202 | ||||||||||||||||||||||||||||||||||||
deferred collaboration revenue | 6,000,000 | 6,000,000 | 6,000,000 | 6,000,000 | 6,000,000 | 6,000,000 | 6,000,000 | |||||||||||||||||||||||||||||||||||||||||
total current liabilities | 27,808,927 | 28,483,933 | 29,531,299 | 14,285,842 | 18,601,823 | 17,153,414 | 27,594,602 | 21,676,437 | 22,260,250 | 21,617,319 | 15,605,114 | 16,007,891 | 15,360,538 | 24,195,034 | 16,242,781 | 16,354,433 | 11,772,662 | 11,942,165 | 7,409,162 | 11,090,829 | 12,409,489 | 4,920,449 | 4,886,862 | 12,907,752 | 12,116,279 | 6,389,520 | 9,491,545 | 8,473,176 | 7,653,685 | 5,310,154 | 3,666,956 | 3,353,747 | 2,419,230 | 2,111,771 | 2,409,110 | 2,299,238 | 2,636,657 | 2,373,199 | 1,807,771 | 2,115,135 | 1,373,948 | 1,391,172 | 1,036,168 | 1,327,564 | 846,131 | 1,174,527 | 691,501 | |
long-term debt | 15,098,529 | 15,000,000 | 15,000,000 | 2,657,189 | 10,128,037 | 14,967,688 | 14,923,090 | 3,303,042 | 10,743,535 | 15,586,501 | 15,503,703 | 15,420,904 | 15,338,105 | 10,140,799 | 11,434,456 | 13,917,180 | 14,669,717 | 14,528,212 | 14,386,706 | |||||||||||||||||||||||||||||
total liabilities | 27,808,927 | 28,556,469 | 29,674,746 | 29,597,140 | 33,601,823 | 32,223,648 | 27,733,495 | 27,882,451 | 28,531,881 | 24,274,508 | 25,733,151 | 30,975,579 | 30,283,628 | 27,498,076 | 26,986,316 | 32,004,259 | 27,401,597 | 27,547,668 | 22,747,267 | 21,231,628 | 23,843,945 | 18,837,629 | 19,556,579 | 27,435,964 | 26,561,705 | 6,505,644 | 9,648,353 | 8,473,176 | 8,536,526 | 6,305,445 | 4,774,697 | 4,573,939 | 3,324,483 | 3,128,148 | 3,536,610 | 3,537,862 | 3,519,939 | 3,365,824 | 2,909,739 | 3,326,445 | 2,655,036 | 2,352,721 | 2,104,683 | 2,503,045 | 2,086,959 | 1,990,352 | 4,027,135 | |
commitments and contingencies | ||||||||||||||||||||||||||||||||||||||||||||||||
stockholders' equity: | ||||||||||||||||||||||||||||||||||||||||||||||||
preferred stock, 0.001 par value... | ||||||||||||||||||||||||||||||||||||||||||||||||
common stock, voting, 0.001 par value... | 60,163 | 60,163 | 60,046 | 60,046 | 59,648 | 59,415 | 59,415 | 59,196 | 58,560 | 58,081 | 58,045 | 57,997 | 47,651 | 38,667 | 32,997 | 29,507 | 28,657 | 27,152 | 26,987 | 26,910 | 26,244 | 20,989 | 20,842 | 19,665 | 19,138 | 19,118 | 15,150 | 15,132 | 12,576 | 12,569 | 12,473 | 9,713 | 9,713 | 9,712 | 9,712 | 6,890 | 5,565 | 5,565 | 5,565 | 327 | ||||||||
additional paid-in capital | 528,147,480 | 526,679,311 | 525,046,496 | 523,577,026 | 521,018,373 | 519,271,439 | 517,449,424 | 515,704,325 | 513,994,982 | 512,454,738 | 511,143,713 | 509,516,738 | 507,770,045 | 506,235,298 | 503,517,715 | 502,172,392 | 500,369,444 | 498,549,312 | 496,764,448 | 374,232,411 | 296,385,619 | 269,502,290 | 252,615,578 | 247,409,793 | 237,047,752 | 234,779,291 | 232,605,244 | 225,136,127 | 156,481,258 | 154,051,733 | 144,036,909 | 139,241,635 | 138,574,234 | 111,030,501 | 110,377,077 | 98,938,446 | 98,302,346 | 97,372,402 | 84,084,750 | 83,478,851 | 82,931,679 | 82,395,410 | 62,467,936 | 52,790,090 | 52,324,911 | 51,867,123 | 1,276,803 | |
accumulated other comprehensive income | 815 | -10,995 | 1,598 | 37,442 | 66,540 | 4,754 | 57,594 | 5,866 | 5,766 | 13,453 | 6,812 | -17,831 | -1,002 | -4,640 | -4,747 | 129 | ||||||||||||||||||||||||||||||||
accumulated deficit | -483,957,253 | -477,495,746 | -469,807,405 | -460,040,093 | -450,110,592 | -434,301,825 | -419,188,842 | -402,341,270 | -394,259,148 | -389,506,186 | -381,319,315 | -372,332,317 | -356,716,638 | -343,814,476 | -329,261,245 | -311,480,294 | -294,692,002 | -278,937,455 | -263,142,500 | -248,205,590 | -236,915,728 | -216,750,375 | -209,230,159 | -199,361,999 | -186,201,376 | -167,486,361 | -154,159,196 | -138,535,168 | -127,901,984 | -117,089,419 | -108,038,985 | -99,641,923 | -92,687,413 | -87,701,215 | -82,392,455 | -77,301,334 | -72,649,905 | -67,871,854 | -63,569,236 | -58,601,884 | -54,246,028 | -50,880,341 | -48,648,156 | -46,511,597 | -44,066,918 | -42,057,711 | ||
total stockholders’ equity | 44,250,390 | 49,244,543 | 55,288,142 | 63,598,577 | 71,004,871 | 85,095,704 | 98,310,339 | 113,419,441 | 119,795,030 | 123,007,739 | 129,883,199 | 137,243,213 | 151,008,029 | 162,193,649 | 174,029,008 | 190,688,722 | 205,735,523 | 219,669,902 | 233,679,945 | 126,074,472 | 59,508,558 | 52,789,666 | 43,472,520 | 48,082,317 | 50,879,294 | 67,333,370 | 78,479,770 | 86,617,979 | 28,595,067 | 36,980,597 | 36,001,204 | 39,601,019 | 45,904,937 | 23,339,796 | 27,995,007 | 21,649,817 | 25,671,538 | 29,517,724 | 20,527,027 | 24,878,319 | 28,695,363 | 31,524,781 | 13,826,670 | 6,284,058 | 8,263,558 | 9,814,977 | ||
total liabilities and stockholders’ equity | 72,059,317 | 77,801,012 | 84,962,888 | 93,195,717 | 104,606,694 | 117,319,352 | 126,043,834 | 141,301,892 | 148,326,911 | 147,282,247 | 155,616,350 | 168,218,792 | 181,291,657 | 189,691,725 | 201,015,324 | 222,692,981 | 233,137,120 | 247,217,570 | 256,427,212 | 147,306,100 | 83,352,503 | 71,627,295 | 63,029,099 | 75,518,281 | 77,440,999 | 73,839,014 | 88,128,123 | 95,091,155 | 37,131,593 | 43,286,042 | 40,775,901 | 44,174,958 | 49,229,420 | 26,467,944 | 31,531,617 | 25,187,679 | 29,191,477 | 32,883,548 | 23,436,766 | 28,204,764 | 31,350,399 | 33,877,502 | 15,931,353 | |||||
operating lease liabilities, long-term | 72,536 | 143,447 | 212,769 | 70,234 | 138,893 | 206,014 | 271,631 | 63,325 | 125,232 | 184,599 | 116,124 | 156,808 | ||||||||||||||||||||||||||||||||||||
fixed assets | 1,360 | 2,720 | 4,079 | 5,764 | 7,774 | 9,784 | 12,539 | 19,279 | 26,660 | 34,041 | 41,422 | 32,487 | 39,607 | 48,083 | 57,559 | 59,925 | 79,455 | 101,695 | 124,750 | 172,470 | 196,491 | 215,908 | 235,225 | 243,483 | 214,743 | 170,862 | 43,262 | 38,017 | 47,981 | 58,284 | 56,352 | 65,690 | 75,027 | 81,466 | 80,334 | 88,463 | 40,868 | 13,182 | 12,993 | 5,768 | ||||||||
deferred collaboration revenue, long-term | 6,000,000 | 6,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||
cash equivalent - reverse repurchase agreements | 40,000,000 | 40,000,000 | 50,000,000 | 21,500,000 | 79,000,000 | 65,000,000 | 125,000,000 | 125,000,000 | 125,000,000 | 50,000,000 | 25,000,000 | 15,000,000 | 10,000,000 | 23,000,000 | 28,000,000 | 26,000,000 | 32,000,000 | 39,000,000 | 44,000,000 | |||||||||||||||||||||||||||||
common stock, 0.001 par value... | 59,550 | 59,187 | 58,801 | 58,792 | 58,560 | 58,301 | 58,301 | |||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss | -9,658 | -3,029 | -103,938 | -285,733 | -285,763 | -61,677 | -9,224 | -5,196 | -2,559 | -16,385 | ||||||||||||||||||||||||||||||||||||||
current portion of long-term debt | 15,146,546 | 13,461,108 | 5,894,317 | 954,325 | 911,763 | 12,449,058 | 4,925,765 | |||||||||||||||||||||||||||||||||||||||||
current portion of operating lease liabilities | 249,265 | 184,599 | 242,636 | 236,048 | 229,607 | 222,158 | 118,401 | 175,619 | 233,310 | 116,124 | 172,241 | 226,328 | 218,953 | 211,744 | 221,112 | |||||||||||||||||||||||||||||||||
current portion of credit facility | 5,094,938 | 3,659,776 | 894,042 | 465,278 | 348,958 | 232,639 | 116,319 | 426,505 | 310,185 | 193,866 | 77,546 | 426,505 | 310,185 | 193,866 | 77,546 | 310,185 | 193,866 | 77,546 | 407,120 | 232,640 | ||||||||||||||||||||||||||||
property and equipment | 148,449 | |||||||||||||||||||||||||||||||||||||||||||||||
non-current liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||
operating lease liabilities, net of current portion | 58,720 | |||||||||||||||||||||||||||||||||||||||||||||||
debt issuance costs | 492,448 | 538,038 | ||||||||||||||||||||||||||||||||||||||||||||||
credit facility, net of current portion and debt discount | 882,841 | 995,291 | 1,107,741 | 1,220,192 | 905,253 | 1,016,377 | 1,127,500 | 1,238,624 | 883,282 | 992,625 | 1,101,968 | 1,211,310 | 1,281,088 | 961,549 | 1,068,515 | 1,175,481 | 1,240,828 | 815,825 | 972,418 | |||||||||||||||||||||||||||||
cash equivalents - reverse repurchase agreements | 11,000,000 | 17,000,000 | ||||||||||||||||||||||||||||||||||||||||||||||
liabilities and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity: | ||||||||||||||||||||||||||||||||||||||||||||||||
commitment and contingencies | ||||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive income, net of tax | 6,528 | 1,800 | ||||||||||||||||||||||||||||||||||||||||||||||
accrued deferred offering costs | 155,122 | 604,264 | ||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehjensive income, net of tax | 4,703 | |||||||||||||||||||||||||||||||||||||||||||||||
accumulated other comprehensive loss, net of tax | -8,361 | |||||||||||||||||||||||||||||||||||||||||||||||
liabilities, redeemable convertible preferred stock and stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes payable – related parties | 155,097 | |||||||||||||||||||||||||||||||||||||||||||||||
accrued interest on convertible notes payable – related parties | 4,732 | |||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock warrant liability | 132,373 | |||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock warrant liabilities – related parties | 1,626,579 | |||||||||||||||||||||||||||||||||||||||||||||||
redeemable convertible preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||
series a preferred stock, 0.001 par value... | 29,349,977 | |||||||||||||||||||||||||||||||||||||||||||||||
series b preferred stock, 0.001 par value... | 9,158,889 | |||||||||||||||||||||||||||||||||||||||||||||||
total redeemable convertible preferred stock | 38,508,866 | |||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ equity | ||||||||||||||||||||||||||||||||||||||||||||||||
common stock, non-voting, 0.001 par value... | ||||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, redeemable convertible preferred stock and stockholders’ equity | 8,787,103 | 10,350,517 | 11,805,329 | |||||||||||||||||||||||||||||||||||||||||||||
deferred offering cost | ||||||||||||||||||||||||||||||||||||||||||||||||
convertible notes payable - related parties | ||||||||||||||||||||||||||||||||||||||||||||||||
accrued interest on convertible notes payable - related parties | ||||||||||||||||||||||||||||||||||||||||||||||||
convertible preferred stock warrant liabilities - related parties | ||||||||||||||||||||||||||||||||||||||||||||||||
liabilities, redeemable convertible preferred stock and stockholders’ deficit | ||||||||||||||||||||||||||||||||||||||||||||||||
stockholders’ deficit: | ||||||||||||||||||||||||||||||||||||||||||||||||
deficit accumulated during the development stage | -40,922,565 | |||||||||||||||||||||||||||||||||||||||||||||||
total stockholders’ deficit | -39,645,435 | |||||||||||||||||||||||||||||||||||||||||||||||
total liabilities, redeemable convertible preferred stock and stockholders’ deficit | 2,890,566 |
Cashflow Statements:
Quarterly
Annual
| Unit: USD | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | 2016-12-31 | 2016-09-30 | 2016-06-30 | 2016-03-31 | 2015-12-31 | 2015-09-30 | 2015-06-30 | 2015-03-31 | 2014-12-31 | 2014-09-30 | 2014-06-30 | 2014-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cash flows from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
net loss | -6,461,507 | -7,688,341 | -9,767,312 | -9,929,501 | -15,808,767 | -15,112,983 | -16,847,572 | -8,082,122 | -4,752,962 | -8,186,871 | -8,986,998 | -15,615,679 | -12,902,162 | -14,553,231 | -17,780,951 | -16,788,292 | -15,754,547 | -15,794,955 | -14,936,910 | -11,289,862 | -11,292,180 | -8,873,173 | -7,520,216 | -9,868,160 | -13,160,623 | -18,715,015 | -13,327,165 | -15,624,028 | -10,633,184 | -10,812,565 | -9,050,433 | -8,397,063 | -6,954,510 | -4,986,198 | -5,308,760 | -5,091,121 | -4,651,429 | -4,778,052 | -4,302,617 | -4,967,352 | -4,355,856 | -3,365,686 | ||||||
adjustments to reconcile net loss to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
stock-based compensation | 1,090,081 | 2,580,754 | 196,565 | 2,224,013 | 1,263,339 | 3,225,794 | 1,935,529 | 1,548,837 | -800,341 | 789,216 | 1,573,540 | 4,190,356 | 2,821,292 | 2,236,771 | 1,294,335 | 1,936,578 | 984,473 | 1,418,336 | 2,323,562 | 2,381,656 | 1,630,290 | 1,757,479 | 1,742,389 | 1,953,652 | 1,948,761 | 2,152,938 | 2,094,963 | 1,886,089 | 1,017,934 | 1,273,720 | 984,784 | 868,415 | 592,172 | 659,339 | 605,234 | 858,096 | 600,039 | 877,027 | 673,579 | 609,108 | 547,172 | 536,269 | 463,588 | 640,073 | 465,178 | 457,788 | 748,421 | 365,686 |
non-cash interest expense | 50,367 | 50,368 | 50,368 | 67,157 | 43,915 | 37,630 | 37,629 | 58,152 | 70,749 | 95,943 | 100,341 | 87,160 | 82,753 | 82,800 | 82,799 | 82,798 | 82,799 | 82,799 | 102,368 | 141,505 | 141,504 | 141,506 | 141,505 | 141,505 | ||||||||||||||||||||||||
net amortization of premium on marketable securities | -44,075 | -266,560 | -429,377 | -409,538 | -465,237 | -508,627 | -525,260 | -171,859 | 0 | 0 | 0 | -14,542 | ||||||||||||||||||||||||||||||||||||
depreciation and amortization expense | 65,116 | 63,683 | 62,282 | 60,912 | 64,373 | 62,987 | 61,631 | 60,632 | 66,469 | 64,999 | 64,340 | 66,972 | 66,643 | 65,311 | 64,012 | 62,741 | 68,352 | 66,694 | 67,863 | 73,119 | 72,647 | 72,040 | ||||||||||||||||||||||||||
write-off of deferred offering costs | 0 | 0 | 0 | 267,261 | ||||||||||||||||||||||||||||||||||||||||||||
change in operating assets and liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||
prepaid expenses and other current assets | 420,494 | 50,152 | 457,850 | 250,508 | 1,055,358 | 1,341,272 | 2,490,760 | -2,821,279 | -1,112,191 | -71,569 | -814,442 | 3,733,114 | -2,568,508 | -101,366 | 1,436,352 | -2,526,926 | 2,441,480 | 1,052,457 | 2,174,825 | -3,429,586 | -3,183,684 | 492,548 | -1,134,692 | 429,321 | -858,693 | 2,542,368 | 1,488,737 | -3,626,841 | 532,939 | -309,628 | 273,993 | -647,931 | 122,760 | -620,244 | -260,800 | -42,001 | 31,524 | 9,881 | 23,422 | 214,043 | 109,783 | -340,485 | -89,776 | 55,494 | -29,956 | 66,929 | -259,800 | -1,329 |
accounts payable | 145,038 | -1,016,107 | 683,384 | 165,693 | -6,466 | -67,515 | -25,865 | -1,057,758 | 1,090,863 | -23,622 | -158,869 | 296,060 | -1,173,301 | 1,042,701 | -2,178,605 | 1,423,128 | 551,770 | -626,529 | 645,870 | 66,953 | 257,738 | -92,789 | -856,208 | 264,595 | 235,939 | -2,125,907 | -1,315,092 | 358,918 | -391,825 | 2,640,245 | -816,764 | 617,926 | 515,696 | -277,414 | 67,759 | 419,481 | -458,119 | -89,741 | 245,284 | -273,143 | 107,537 | 114,277 | 223,201 | 64,851 | -141,176 | 103,184 | 213,325 | -175,892 |
accrued expenses and other liabilities | -564,859 | -795,365 | 191,018 | -5,166,204 | 1,816,640 | 3,046,525 | -351,150 | 492,710 | -62,147 | -693,010 | -5,135,748 | -2,187,259 | 2,462,971 | -1,329,438 | -2,871,149 | 2,940,002 | 55,055 | |||||||||||||||||||||||||||||||
net cash from operating activities | -5,299,345 | -7,021,416 | -8,555,222 | -12,469,699 | -12,036,845 | -7,974,917 | -13,224,298 | -9,972,687 | 500,440 | -8,024,914 | -13,357,836 | -9,443,818 | -11,231,177 | -12,574,218 | -19,958,593 | -12,873,199 | -11,577,699 | -8,434,100 | -9,072,367 | -13,471,741 | -8,317,197 | -6,237,452 | -7,579,054 | -15,359,752 | -11,226,323 | -8,315,046 | -12,810,879 | -12,631,978 | -7,968,175 | -7,688,672 | -6,245,691 | -7,954,593 | -5,018,517 | -4,705,604 | -5,311,898 | -4,186,843 | -3,909,462 | -3,503,568 | -3,253,124 | -4,481,358 | -2,983,125 | -2,882,938 | -1,601,826 | -1,843,864 | -1,606,879 | -1,210,769 | -894,454 | -1,063,892 |
capital expenditures | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4,604 | -4,925 | -14,584 | -47,619 | -61,757 | -139,006 | -13,167 | 0 | 0 | -11,592 | 0 | 0 | -2,576 | -9,234 | 0 | -54,243 | -30,435 | -1,441 | -7,955 | 0 | 0 | ||
free cash flows | -5,299,345 | -7,021,416 | -8,555,222 | -12,469,699 | -12,036,845 | -7,974,917 | -13,224,298 | -9,972,687 | 500,440 | -8,024,914 | -13,357,836 | -9,443,818 | -11,231,177 | -12,574,218 | -19,958,593 | -12,873,199 | -11,577,699 | -8,434,100 | -9,072,367 | -13,471,741 | -8,317,197 | -6,237,452 | -7,579,054 | -11,226,323 | -8,315,046 | -12,815,483 | -12,636,903 | -7,982,759 | -7,736,291 | -6,307,448 | -8,093,599 | -5,031,684 | -4,705,604 | -5,311,898 | -4,198,435 | -3,909,462 | -3,503,568 | -3,255,700 | -4,490,592 | -2,983,125 | -2,937,181 | -1,632,261 | -1,845,305 | -1,614,834 | -1,210,769 | -894,454 | ||
cash flows from investing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
purchases of marketable securities | 0 | 0 | -24,554,126 | -15,709,586 | -21,563,871 | -14,737,385 | -30,237,879 | -30,376,620 | 0 | -4,984,024 | -29,938,720 | -58,015,469 | 0 | 0 | 0 | -5,776,090 | -20,907,530 | -15,394,201 | -13,073,370 | -8,392,983 | -38,157,778 | -9,482,683 | -8,081,636 | -4,009,513 | -14,896,808 | -10,927,932 | -6,118,476 | -3,151,867 | -670,053 | -5,658,338 | ||||||||||||||||||
maturities of marketable securities | 16,000,000 | 25,000,000 | 24,000,000 | 23,000,000 | 20,000,000 | 20,000,000 | 0 | 0 | 0 | 30,000,000 | ||||||||||||||||||||||||||||||||||||||
net cash from investing activities | 16,000,000 | 25,000,000 | -554,126 | 7,290,414 | -1,563,871 | 5,262,615 | -18,237,879 | -30,376,620 | 0 | 0 | 0 | 30,000,000 | 27,000,000 | 19,015,976 | -17,938,720 | -58,031,786 | 0 | 0 | 0 | -7,806 | 0 | 5,500,000 | 17,300,000 | 6,223,910 | -4,285,156 | 5,675,527 | 7,922,026 | 9,164,454 | -28,972,362 | -21,302 | 856,607 | 4,801,481 | -8,109,975 | -3,627,932 | 648,524 | 891,541 | 1,319,947 | 566,662 | -2,102,609 | -9,234 | -12,950,137 | -54,243 | -30,435 | -1,441 | -7,955 | |||
cash flows from financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
issuance costs | -50,000 | |||||||||||||||||||||||||||||||||||||||||||||||
proceeds from exercise of stock options | 0 | 120,746 | 0 | 983,194 | 30,188 | 158,649 | 0 | 0 | 12,124 | 606,837 | 4,004,290 | 0 | 998,097 | 50,149 | 10,270 | |||||||||||||||||||||||||||||||||
proceeds from employee stock purchase plan | 0 | 0 | 0 | 19,616 | 0 | 19,869 | 0 | 18,191 | 0 | 58,543 | 0 | 52,559 | 0 | 73,341 | 0 | 23,324 | 0 | 51,654 | 0 | 9,875 | 0 | 57,077 | 0 | 69,889 | 0 | 115,688 | ||||||||||||||||||||||
debt end of term charge paid in cash | ||||||||||||||||||||||||||||||||||||||||||||||||
net cash from financing activities | 0 | 120,746 | 0 | 1,002,810 | 7,779 | -197,392 | 0 | 18,191 | -1,012,312 | -315,759 | 5,292 | 52,559 | 0 | 1,196,768 | 0 | 23,324 | 0 | 63,778 | 120,368,998 | 74,063,615 | 1 | 26,224,125 | 12,424,917 | 3,252,983 | 8,333,106 | 14,844,158 | -9,138 | 407,607 | 66,289,357 | 1,112,952 | 9,031,217 | 4,093,316 | 47,980 | 26,827,643 | -29,734 | 10,583,091 | 36,068 | -102,108 | 12,814,731 | -9,750 | -36,237 | -14,238 | 19,480,948 | 9,039,098 | 1 | -176,775 | 10,284,621 | -52,841 |
net increase in cash and cash equivalents | 10,700,655 | -31,462,177 | -40,331,116 | -13,352,544 | 20,608,741 | 15,768,823 | 7,638,526 | -37,897,313 | -70,881,661 | -11,577,699 | -8,370,322 | 111,296,631 | 60,584,068 | -8,317,196 | 25,486,673 | -4,500,342 | ||||||||||||||||||||||||||||||||
cash and cash equivalents, beginning of period | 0 | 0 | 0 | 54,527,092 | 0 | 0 | 0 | 142,823,016 | 0 | 0 | 0 | 144,419,364 | 0 | 0 | 0 | 229,790,989 | 0 | 0 | 0 | 77,858,311 | 0 | 0 | 0 | 44,425,830 | 0 | 0 | 0 | 47,357,472 | 0 | 0 | 0 | 20,023,337 | 0 | 0 | 0 | 12,015,061 | 0 | 0 | 0 | 14,648,866 | 0 | 0 | 0 | 8,527,304 | 0 | 0 | 0 | 3,262,354 |
cash and cash equivalents, end of period | 10,700,655 | 18,099,330 | -9,109,348 | 50,350,617 | -13,592,937 | -2,909,694 | -31,462,177 | 102,491,900 | -511,872 | -8,340,673 | -13,352,544 | 165,028,105 | 15,768,823 | 7,638,526 | -37,897,313 | 158,909,328 | -11,577,699 | -8,370,322 | 111,296,631 | 138,442,379 | -8,317,196 | 25,486,673 | 22,145,863 | 38,542,971 | -7,178,373 | 12,204,639 | -4,897,991 | 44,297,555 | 29,348,820 | -6,597,022 | 3,642,133 | 20,963,541 | -13,080,512 | 18,494,107 | -4,693,108 | 19,302,850 | -2,553,447 | -3,039,014 | 7,458,998 | 10,148,524 | -15,969,499 | -2,951,419 | 17,848,687 | 15,721,097 | -1,614,833 | -1,393,651 | 9,390,167 | 2,145,621 |
supplemental disclosures of cash flow information: | ||||||||||||||||||||||||||||||||||||||||||||||||
cash paid during the period for interest | 420,875 | 425,500 | 425,500 | 416,250 | 424,625 | 444,667 | 444,667 | 439,833 | 439,834 | 438,833 | 426,125 | 397,396 | 356,709 | 329,666 | 329,667 | 322,500 | 326,083 | 329,667 | 340,083 | 341,250 | 348,833 | 348,833 | 345,042 | |||||||||||||||||||||||||
proceeds from issuance of common stock, net of issuance costs | 0 | 0 | 119,762,161 | 70,049,450 | 25,168,951 | 12,374,768 | 3,172,824 | 0 | -86,643 | 807,607 | 1,070,338 | 9,031,217 | 4,093,316 | -65,872 | -1 | -14,238 | 19,480,948 | 9,039,098 | 1 | |||||||||||||||||||||||||||||
supplemental information and disclosures of noncash activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
offering costs not yet paid | ||||||||||||||||||||||||||||||||||||||||||||||||
change in right-of-use asset and lease liability due to lease amendment | 0 | 0 | 260,899 | |||||||||||||||||||||||||||||||||||||||||||||
net decrease in cash and cash equivalents | -9,109,348 | -4,176,475 | -13,592,937 | -511,872 | -5,882,859 | |||||||||||||||||||||||||||||||||||||||||||
deferred collaboration revenue | ||||||||||||||||||||||||||||||||||||||||||||||||
tax withholding payments for net share-settled equity awards | 0 | |||||||||||||||||||||||||||||||||||||||||||||||
acquisitions of fixed assets | 0 | 0 | 0 | -16,317 | 0 | 0 | 0 | -7,806 | ||||||||||||||||||||||||||||||||||||||||
common stock issued in connection with helio vision, inc. acquisition milestone | 0 | 0 | 0 | 2,499,991 | ||||||||||||||||||||||||||||||||||||||||||||
net amortization of premium on debt securities available for sale | -17,766 | -5,386 | -3,228 | -166,362 | -175,396 | -2,659 | 9,822 | -36,317 | 35,200 | 50,587 | 79,775 | 83,143 | 69,002 | 39,305 | 74,656 | |||||||||||||||||||||||||||||||||
sales and maturities of marketable securities | 24,000,000 | |||||||||||||||||||||||||||||||||||||||||||||||
acquired in-process research and development | 67,152 | -47,101 | -49,848 | 6,597,551 | ||||||||||||||||||||||||||||||||||||||||||||
deferred taxes | 0 | 0 | 0 | -1,309,973 | ||||||||||||||||||||||||||||||||||||||||||||
depreciation and amortization | ||||||||||||||||||||||||||||||||||||||||||||||||
change in assets and liabilities: | ||||||||||||||||||||||||||||||||||||||||||||||||
sales of marketable securities | 17,300,000 | 12,000,000 | 16,645,000 | 21,000,000 | 21,000,000 | 17,000,000 | 9,200,000 | 9,509,000 | 9,000,000 | 8,950,000 | 6,800,000 | 7,300,000 | 6,767,000 | 4,055,000 | 1,990,000 | 6,225,000 | ||||||||||||||||||||||||||||||||
accrued expenses | 551,224 | -1,410,270 | 3,015,720 | 267,637 | -4,247 | -8,285,485 | 437,249 | 7,957,635 | -1,588,909 | -764,502 | 1,589,950 | -413,034 | 2,343,643 | -421,037 | 729,007 | 468,553 | -481,417 | -425,929 | 469,659 | 392,001 | 51,912 | -153,750 | 570,344 | 178,684 | 21,244 | -478,329 | 530,825 | 152,315 | 78,275 | 15,198 | ||||||||||||||||||
receivable for proceeds from the issuance of common stock, net of issuance costs | ||||||||||||||||||||||||||||||||||||||||||||||||
depreciation | 24,021 | 24,242 | 22,842 | 18,879 | 17,876 | 11,406 | 7,922 | 9,964 | 10,303 | 9,660 | 9,338 | 9,337 | 9,015 | 8,102 | 8,129 | 6,647 | 2,750 | 1,252 | 730 | |||||||||||||||||||||||||||||
cash acquired in helio asset acquisition | -22,626 | 69,728 | 0 | 562,362 | ||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock | 10,583,091 | |||||||||||||||||||||||||||||||||||||||||||||||
proceeds from long-term debt | 0 | |||||||||||||||||||||||||||||||||||||||||||||||
debt issuance costs paid in cash | 0 | 278,470 | -1,656 | -400,000 | ||||||||||||||||||||||||||||||||||||||||||||
cash paid during the period for: | ||||||||||||||||||||||||||||||||||||||||||||||||
interest | 6,995 | 35,091 | 24,195 | 22,682 | 27,609 | 22,382 | 19,406 | 19,619 | 19,619 | 19,484 | 18,524 | 18,045 | 19,410 | 18,320 | 19,188 | 26,027 | 28,897 | 22,682 | ||||||||||||||||||||||||||||||
supplemental disclosures of noncash activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
helio acquisition: | ||||||||||||||||||||||||||||||||||||||||||||||||
assets acquired | 0 | 0 | 0 | 75,632 | ||||||||||||||||||||||||||||||||||||||||||||
liabilities acquired | 0 | 0 | 0 | 637,994 | ||||||||||||||||||||||||||||||||||||||||||||
fair value of securities issued | 81,678 | 0 | 0 | 4,862,731 | ||||||||||||||||||||||||||||||||||||||||||||
accretion on debt securities available for sale | -3,779 | -20,232 | -67,220 | |||||||||||||||||||||||||||||||||||||||||||||
right-of-use assets acquired through operating leases | 0 | 8,140 | 377,920 | |||||||||||||||||||||||||||||||||||||||||||||
debt issuance costs not yet paid | -18,470 | 140,000 | ||||||||||||||||||||||||||||||||||||||||||||||
acquisitions of property and equipment | 0 | 0 | -4,604 | -4,925 | -14,584 | -47,619 | -61,757 | -139,006 | -13,167 | 0 | 0 | -11,592 | 0 | 0 | -2,576 | -9,234 | 0 | -54,243 | -30,435 | -1,441 | -7,955 | |||||||||||||||||||||||||||
amortization of debt discount – non-cash interest expense | 28,776 | 1,962 | 47,714 | 3,870 | 3,869 | 3,869 | 4,753 | 5,196 | 5,196 | 5,196 | 6,383 | 6,977 | 6,976 | 6,978 | 7,768 | 9,354 | 9,353 | 9,354 | 12,199 | 17,883 | 32,790 | 87,980 | ||||||||||||||||||||||||||
extinguishment of long-term debt | ||||||||||||||||||||||||||||||||||||||||||||||||
amortization of debt discount | ||||||||||||||||||||||||||||||||||||||||||||||||
depreciation expense | ||||||||||||||||||||||||||||||||||||||||||||||||
net increase in cash | 12,204,639 | -4,897,991 | -3,059,917 | -13,080,512 | 18,494,107 | -4,693,108 | 7,287,789 | -2,553,447 | -3,039,014 | -15,969,499 | -2,951,419 | 17,848,687 | 7,193,793 | -1,614,833 | -1,393,651 | 9,390,167 | -1,116,733 | |||||||||||||||||||||||||||||||
supplemental disclosures of noncash investing and financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
offering costs of public offerings not yet paid | ||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in employee plans | ||||||||||||||||||||||||||||||||||||||||||||||||
deferred offering costs paid in cash | -27,269 | -60,719 | 45,986 | -9,750 | ||||||||||||||||||||||||||||||||||||||||||||
extinguishment of long term debt | ||||||||||||||||||||||||||||||||||||||||||||||||
net amortization of premium/(discount) on debt securities available for sale | ||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in employee stock purchase plan | 0 | |||||||||||||||||||||||||||||||||||||||||||||||
net change in cash and cash equivalents | -6,597,022 | 3,642,133 | 940,204 | |||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock under equity incentive plans | ||||||||||||||||||||||||||||||||||||||||||||||||
income taxes | ||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock in public offering | ||||||||||||||||||||||||||||||||||||||||||||||||
offering costs of public and private offerings not yet paid | ||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of common stock and exercise of options | ||||||||||||||||||||||||||||||||||||||||||||||||
offering costs of public offering not yet paid | ||||||||||||||||||||||||||||||||||||||||||||||||
offering costs of public and private offferings not yet paid | ||||||||||||||||||||||||||||||||||||||||||||||||
deferred offering costs not yet paid | 20,000 | |||||||||||||||||||||||||||||||||||||||||||||||
change in fair value of warrant liability, purchase rights and warrant purchase rights | 0 | 0 | -567,587 | -1,759,915 | ||||||||||||||||||||||||||||||||||||||||||||
accrued interest on convertible notes related parties | 0 | |||||||||||||||||||||||||||||||||||||||||||||||
borrowings under credit facility | ||||||||||||||||||||||||||||||||||||||||||||||||
repayments of credit facility | ||||||||||||||||||||||||||||||||||||||||||||||||
accretion of redeemable convertible preferred stock | 0 | 0 | 141,514 | 191,568 | ||||||||||||||||||||||||||||||||||||||||||||
conversion of notes payable | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
conversion of series a preferred stock upon closing initial public offering | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
conversion of series b preferred stock upon closing initial public offering | 0 | |||||||||||||||||||||||||||||||||||||||||||||||
net exercise of warrants into common stock | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
warrants issued to underwriter in initial public offering | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
deferred offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||
net income | -2,136,559 | -2,444,679 | -2,009,207 | -1,135,146 | 401,773 | |||||||||||||||||||||||||||||||||||||||||||
adjustments to reconcile net income to net cash from operating activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
decrease | ||||||||||||||||||||||||||||||||||||||||||||||||
cash paid for deferred offering costs | -52,841 | |||||||||||||||||||||||||||||||||||||||||||||||
president and ceo contributed services | ||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from convertible notes payable – related parties | ||||||||||||||||||||||||||||||||||||||||||||||||
proceeds from issuance of restricted common stock | ||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of series b redeemable convertible preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||
allocation of fair value of investor purchase rights to redeemable convertible preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||
fair value warrants in connection with credit facility | ||||||||||||||||||||||||||||||||||||||||||||||||
offeratory costs in connection with series b redeemable convertible preferred stock issuance in accrued expenses | ||||||||||||||||||||||||||||||||||||||||||||||||
exercise of series b warrant purchase rights into warrants | ||||||||||||||||||||||||||||||||||||||||||||||||
security deposit | ||||||||||||||||||||||||||||||||||||||||||||||||
accrued deferred offering costs | ||||||||||||||||||||||||||||||||||||||||||||||||
increase | ||||||||||||||||||||||||||||||||||||||||||||||||
accrued interest on convertible notes payable-related parties | -4,732 | 2,607 | ||||||||||||||||||||||||||||||||||||||||||||||
principal payments on notes | ||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of common stock | ||||||||||||||||||||||||||||||||||||||||||||||||
supplemental disclosures of non cash investing and financing activities: | ||||||||||||||||||||||||||||||||||||||||||||||||
offering costs of initial public offering not yet paid | ||||||||||||||||||||||||||||||||||||||||||||||||
1. | ||||||||||||||||||||||||||||||||||||||||||||||||
interest converted to preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||
value provided in excess of issuance price of series b redeemable convertible preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||
net proceeds from issuance of series a redeemable convertible preferred stock | ||||||||||||||||||||||||||||||||||||||||||||||||
fair value of warrants issued in connection with credit facility | ||||||||||||||||||||||||||||||||||||||||||||||||
fair value of warrants, purchase rights and warrant purchase rights issued in connection with redeemable convertible preferred stock |